The group collectively emphasizes the paradigm shift presented in the article, pointing out that lactate actually mitigates acidosis and refutes myths about lactic acid causing muscle fatigue, evidenced by references to Robergs' research and detailed biochemical explanations, with an overall tone of curiosity, validation, and eagerness to correct misconceptions.
AgreementStrong agreement
Most discussions support the updated scientific view that lactate is not the cause of exercise-induced acidosis, aligning with the article's findings.
InterestHigh interest
Participants are highly interested, engaging with complex biochemistry concepts, questioning longstanding myths, and citing specific research.
EngagementHigh engagement
The discussions demonstrate deep engagement through references to scientific studies, biochemical mechanisms, and active debate on misconceptions.
ImpactHigh impact
This conversation has a significant impact as it challenges outdated beliefs and promotes scientific literacy on exercise physiology, possibly influencing future research and educational approaches.
Abstract in brief
Traditional view links exercise-induced acidosis to lactic acid production, suggesting that high lactate levels release protons, lowering pH and causing muscle fatigue.
New evidence shows lactate production actually slows down or prevents acidosis; the real cause of acidic conditions is increased proton release from ATP breakdown during intense exercise beyond mitochondrial capacity.
During high-intensity exercise, when ATP demand exceeds mitochondrial supply, glycolysis and phosphagen systems produce more protons, leading to acidosis, with lactate acting to prevent pyruvate buildup and support continued energy production.]
@toxicologist12 @memesMD Thank you!!!
"There is no biochemical support for lactate production causing acidosis"
https://t.co/VBV8X62EjS
Aug 16, 2020 · 29 likes · 1 share · 453 followersView post →
BD
Bernardo N. Ide, Ph.D.
@bernardo_0311 · X
Biochemistry of exercise-induced metabolic acidosis - PubMed https://t.co/0IMRUVbwpg
Jun 9, 2022 · 17 likes · 1 share · 778 followersView post →
BJ
Bio Jo
@BioJo4 · X
Mind blowing from @drmiketodorovic (who does The Best uni lecture biology videos)
lactic acid probably not the cause of exercise induced muscular acidosis…
Aug 23, 2021 · 13 likes · 9 shares · 437 followersView post →
GN
Gorka Nuñez
@gorkanunez · X
(3)
Los ciclistas que toman Bicarbonato Sódico son capaces de desarrollar más Potencia, pero además:
- Presentan mayores concentraciones de Lactato
- Presentan un pH más elevado
¿Más lactato pero menos acidez?
¡SI! ¡Robergs tenía razón!
https://t.co/kk3GCJVYiB
Oct 13, 2020 · 9 likes · 2,762 followersView post →
G
GuruAnaerobic
@GuruAnaerobic · X
@dennishaggblom https://t.co/9VL03hl1Im
Dec 8, 2019 · 7 likes · 2 shares · 41,046 followersView post →
LS
@load-depentent.bsky.social
@load_dependent · X
@rabihmgeha It truly is, my pleasure!
Here's another fascinating one, on lactate production during exercise, pointing out the physiological benefit of producing lactate (consumes H+ and recycles NAD+)
https://t.co/qVRw4KQShm
Dec 8, 2019 · 6 likes · 3,894 followersView post →
For decades lactic acid has taken the blame for muscle pain during exercise but does it truly cause it? Recent research indicates that lactate production actually prevents acidosis, which results from increased proton…
This video explores the science behind exercise-induced acidosis, emphasizing that increased proton release from ATP breakdown, not lactic acid, causes muscle pH decline during intense workouts, supported by recent…
This video explores the biochemistry of exercise-induced metabolic acidosis, highlighting how high-intensity exercise increases proton release from ATP breakdown, and not lactate, which actually prevents acidosis and…
This episode explores the misinformation behind the alkaline diet and the Liver King controversy. Patrick Elliott explains how to identify nutritional misinformation online and clarifies the science on blood pH and…
This video explores the biochemistry of exercise-induced metabolic acidosis, focusing on how proton release from ATP breakdown, not lactic acid, causes acidity during intense exercise, with lactate helping prevent…
@carlabrookprof Essa ideia de que ácido lático é produzido no corpo - via fermentação lática - é obsoleta. O metabolismo produz lactato.
É como dizer que circula ácido clorídrico no sangue por que tem íons cloreto circulando.
Sugestão de leitura:
https://t.co/6y1fsiqlyh
Aug 26, 2024 · 1 like · 30,617 followersView post →
JK
Jaroslav Kaňok
@KanokJaroslav · X
RT @jdostal1: @infektolog Bohužel pane kolego, mýlíte se. Na medicíně se to učí stále špatně i po 20 letech. K. mléčná per se je plně konju…
@infektolog Bohužel pane kolego, mýlíte se. Na medicíně se to učí stále špatně i po 20 letech. K. mléčná per se je plně konjugovaná a v těle se nevyskytuje. Jde o sodnou sůl. Acidóza při tom zapocení vzniká zcela jinde. Ref: https://t.co/we7qK7qtKw
Lactic acid is not the cause of muscle acidosis & one of its functions is actually to mitigate muscle acidosis by preventing the build-up of pyruvic acid.
https://t.co/CqA6JqQcOA https://t.co/Ce2RtbLgZd
@jeffreyboadi_ "Lactate production increases to prevent pyruvate accumulation & supply the NAD(+) needed for phase 2 of glycolysis. If muscle did not produce lactate, acidosis & muscle fatigue would occur more quickly & exercise performance would be severely impaired."
https://t.co/CqA6JqQcOA
The lies that created the alkaline diet & Liver King | Patrick Elliott, BSc, MPH
https://t.co/Ofm8Kg2T3z https://t.co/xWkrEevUtD
May 18, 2023 · 3 likes · 1 share · 1,173 followersView post →
T
Tina Ⓥ
@_islandowl · X
RT @fproofmastery: The lies that created the alkaline diet & Liver King | Full episode out now
We are lucky to be joined by talented nutri…
May 15, 2023 · 2 shares · 5,537 followersView post →
PM
Patrick Elliott, BSc, MPH
@PatrickElliott0 · X
RT @fproofmastery: The lies that created the alkaline diet & Liver King | Full episode out now
We are lucky to be joined by talented nutri…
May 13, 2023 · 2 shares · 881 followersView post →
FM
Foolproof Mastery
@FoolproofMaster · X
The lies that created the alkaline diet & Liver King | Full episode out now
We are lucky to be joined by talented nutrition science communicator @PatrickElliott0 to dive into these 2 case studies and learn how to spot nutribollocks online
https://t.co/Ofm8Kg2T3z
#nutrition
May 13, 2023 · 2 likes · 2 shares · 1,173 followersView post →
@Dr_Oubre @drshahrul80 Biochemically, it is not the lactate that causes the acidosis, but the increased cell work that produces H+ that is not metabolized well. The lactate actually captures H+ and is thus a wrongfully accused underdog. https://t.co/BOhyHHR1nW
RT @AcidosisTubular: Biochemistry of exercise- induced metabolic acidosis.
https://t.co/FJSxJeO65e https://t.co/bLn6IGWxWe
Jun 21, 2022 · 2 shares · 649 followersView post →
DR
Dr J Romero
@dr_romero1 · X
RT @AcidosisTubular: Biochemistry of exercise- induced metabolic acidosis.
https://t.co/FJSxJeO65e https://t.co/bLn6IGWxWe
Jun 21, 2022 · 2 shares · 1,410 followersView post →
A
ATR
@AcidosisTubular · X
Biochemistry of exercise- induced metabolic acidosis.
https://t.co/FJSxJeO65e https://t.co/bLn6IGWxWe
Jun 21, 2022 · 3 likes · 2 shares · 7,081 followersView post →
DA
Dayanne S. Antonio
@dayannesantonio · X
"The correct physiological interpretation of these biochemical facts is that lactate production retards a developing metabolic acidosis, as well as assists in proton removal from the cell"
BIOCHEMISTRY OF METABOLIC ACIDOSIS
https://t.co/PtaygeH6Ki https://t.co/yT1jOx0bXh
Biochemistry of exercise-induced metabolic acidosis - PubMed https://t.co/0IMRUVbwpg
Jun 9, 2022 · 17 likes · 1 share · 778 followersView post →
TP
The Phlegmfighter
@phlegmfighter · X
@AlacrityMD @gostkillr @adamcifu "This review presents clear evidence that there is no biochemical support for lactate production causing acidosis. Lactate production retards, not causes, acidosis." https://t.co/rMlJSLaAFY
Mar 8, 2022 · 5 likes · 1 share · 7,232 followersView post →
CK
Claudio King
@KingClaudioR · X
Não existe "ácido láctico" en tecidos vivos e isso já deveria bastar, mas para além disso, os caras ainda confundem lactato com o "ácido láctico"
https://t.co/4srX6yjICX
RT @criticaloxygen: Sources:
Brooks GA. Lactate doesn't necessarily cause fatigue: why are we surprised?. https://t.co/SXgikdV4hs
Robergs…
Nov 10, 2021 · 1 share · 6,885 followersView post →
PD
Phil Batterson, Ph.D.
@criticaloxygen · X
Sources:
Brooks GA. Lactate doesn't necessarily cause fatigue: why are we surprised?. https://t.co/SXgikdV4hs
Robergs RA, Ghiasvand F, Parker D. Biochemistry of exercise-induced metabolic acidosis. https://t.co/9c4ysuw8f6
Nov 10, 2021 · 2 likes · 1 share · 60 followersView post →
SN
Syed Shahrul Naz
@drshahrul80 · X
RT @load_dependent: Dogmalysis: It's so ingrained that lactate production CAUSES acidosis but is it just a pervasive myth? Glycolysis produ…
Nov 6, 2021 · 11 shares · 6,929 followersView post →
TR
Tony Rostron
@RostronTony · X
RT @load_dependent: Dogmalysis: It's so ingrained that lactate production CAUSES acidosis but is it just a pervasive myth? Glycolysis produ…
Nov 3, 2021 · 11 shares · 800 followersView post →
PC
Paul Ingraham (PainScience.com)
@PainSci · X
@Rob_Tarzwell Yes, acidosis occurs and is relevant. But it's not just not a function of the presence of lactate, it's actually reduced by it.
And this is not my wheelhouse, so I'm just cribbing from Robergs 2004: https://t.co/IWimclUEkM
@mbrowney3 Amazing how many health/ exercise professionals still believe in lactic acidosis particularly for DOMs and peripheral fatigue models. Based on research from 1922 by AV Hill and Otto myerhoff. Been out of date since at least 2004. https://t.co/WX7hGZGbN1
RT @BioJo4: Mind blowing from @drmiketodorovic (who does The Best uni lecture biology videos)
lactic acid probably not the cause of exercis…
Aug 23, 2021 · 9 shares · 1,874 followersView post →
CB
Chat Biology
@chatbiology · X
RT @BioJo4: Mind blowing from @drmiketodorovic (who does The Best uni lecture biology videos)
lactic acid probably not the cause of exercis…
Aug 23, 2021 · 9 shares · 7,338 followersView post →
AM
Anastasios Makris
@AnastasiosMakr4 · X
RT @BioJo4: Mind blowing from @drmiketodorovic (who does The Best uni lecture biology videos)
lactic acid probably not the cause of exercis…
Aug 23, 2021 · 9 shares · 423 followersView post →
BJ
Bio Jo
@BioJo4 · X
Mind blowing from @drmiketodorovic (who does The Best uni lecture biology videos)
lactic acid probably not the cause of exercise induced muscular acidosis…
Aug 23, 2021 · 13 likes · 9 shares · 437 followersView post →
AM
Anastasios Makris
@AnastasiosMakr4 · X
@drmiketodorovic Hey Mike! I'm also trying to convince the exercise scientists that lactic acid has never been observed in the human body. https://t.co/dXgOmtehuI Robergs has more articles on this. You should check them out.
Aug 23, 2021 · 5 likes · 1 share · 423 followersView post →
Y
YoucanAxel
@YoucanAxel · X
@MedCrisis Lactate isn't what is causing the pH drop though ?https://t.co/IVhS7UcDIA https://t.co/HnUvmnyK4i
RT @deNutrients: @C19LongHauler @UnwantedGuest3 Maybe niacin gives a feeling of more energy because it is helping prevent lactic acid build…
Mar 16, 2021 · 4 shares · 1,544 followersView post →
D
Dave.
@UnwantedGuest3 · X
RT @deNutrients: @C19LongHauler @UnwantedGuest3 Maybe niacin gives a feeling of more energy because it is helping prevent lactic acid build…
Mar 16, 2021 · 4 shares · 5,567 followersView post →
JR
Jennifer Depew, RD
@deNutrients · X
RT @deNutrients: @C19LongHauler @UnwantedGuest3 Maybe niacin gives a feeling of more energy because it is helping prevent lactic acid build…
Mar 16, 2021 · 4 shares · 28,665 followersView post →
JR
Jennifer Depew, RD
@deNutrients · X
@C19LongHauler @UnwantedGuest3 Maybe niacin gives a feeling of more energy because it is helping prevent lactic acid build up when NAD+ is limited
https://t.co/zZuRT42weg
Mar 16, 2021 · 5 likes · 4 shares · 28,665 followersView post →
PP
Paulo Azevedo PhD
@paulohsmazevedo · X
@Bicycle_Bryan @fmarino64 I'm surprised that Robergs' paper was not cited.
https://t.co/wTwwj6CvIb
Mar 4, 2021 · 4 likes · 1,125 followersView post →
AM
Anastasios Makris
@AnastasiosMakr4 · X
A great review by Robergs explaining why lactic acid is never produced in our muscle cells. Biochemistry of exercise-induced metabolic acidosis | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology https://t.co/RA0UrWlTFy
@Morgan_Casey @SusannaLHarris And furthermore, lactic acid makes you muscles less acidic by grabbing Hydrogen ions, not more acidic. Lactic acid is your friend! https://t.co/IonsLMWggf more sciency: https://t.co/gyljlyA8F8
@drmiketodorovic There’s evidence from exercise literature that this is true
https://t.co/4JzHCPFkLw
Nov 12, 2020 · 1 like · 115,810 followersView post →
Y
YoucanAxel
@YoucanAxel · X
@MdDavidthomas @REALITYofJNJ @LovelyUniverse0 @ArlenaRio The body doesn't produce lactic acid though https://t.co/IVhS7UcDIA,
also a mask restricting breathing surely would just make the brain stem increase the respetory rate
https://t.co/HnUvmnyK4i
This is a LANDMARK paper in understanding lactate metabolism & intricacies of exercise-induced acidosis.
If you assimilate everything then you're a better biochemist than me (not hard), but you owe it to yourself to try. #lactate #exercise #physiology
https://t.co/lDHiECTxbY https://t.co/pe4BQ7mEoH
Oct 21, 2020 · 5 likes · 10,615 followersView post →
PP
Paulo Azevedo PhD
@paulohsmazevedo · X
@SamueleMarcora @ZKForTre It can help. https://t.co/fsbCjXFDM0
Oct 13, 2020 · 2 likes · 1,125 followersView post →
GN
Gorka Nuñez
@gorkanunez · X
(3)
Los ciclistas que toman Bicarbonato Sódico son capaces de desarrollar más Potencia, pero además:
- Presentan mayores concentraciones de Lactato
- Presentan un pH más elevado
¿Más lactato pero menos acidez?
¡SI! ¡Robergs tenía razón!
https://t.co/kk3GCJVYiB
Oct 13, 2020 · 9 likes · 2,762 followersView post →
D
Daniel
@pemdoc · X
RT @Diana_MY_Smith: @toxicologist12 @memesMD Thank you!!!
"There is no biochemical support for lactate production causing acidosis"
https…
@toxicologist12 @memesMD Thank you!!!
"There is no biochemical support for lactate production causing acidosis"
https://t.co/VBV8X62EjS
Aug 16, 2020 · 29 likes · 1 share · 453 followersView post →
Y
YoucanAxel
@YoucanAxel · X
@chubbyemu @PavlosMsaouel respiration because of the lack of oxygen. This is at least from what I have understood. https://t.co/Yxv5COZbnu
https://t.co/IVhS7TV2k0
(2/2)
@Jenn_A_Andersen @RyanMarino I think metformin induced metabolic acidosis is more correct , lactic acidosis is a myth/misconception at least from what I have read (I'm not medically trained ) https://t.co/IVhS7UcDIA
@TuPlatoFuerte @jos_s0ph0s @buzonale Ahora bien, la acidosis intracelular posiblemente no es causada por lactato, hay autores que postulan que incluso la retarda. La acidosis puede ser causada por otros motivos, en este trabajo se aporta alguna información (no es reciente, pero algo aporta).
https://t.co/y1BHWktbaM
@rabihmgeha It truly is, my pleasure!
Here's another fascinating one, on lactate production during exercise, pointing out the physiological benefit of producing lactate (consumes H+ and recycles NAD+)
https://t.co/qVRw4KQShm
Dec 8, 2019 · 6 likes · 3,894 followersView post →
Robergs, R. A., Ghiasvand, F., & Parker, D. (2004). Biochemistry of exercise-induced metabolic acidosis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 287(3), R502–R516. https://t.co/yVPgCbSyak
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https://doi.org/10.1152/ajpregu. 89. Lattier G, Millet GY, Martin A, Martin V. Fatigue and recovery 00114.2004. after high-intensity exercise. Part II ...