Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study.

Abstract in brief

• This study tested whether an oral cannabis extract (containing THC and CBD) can help reduce spasticity in MS patients.
• It involved 57 patients in a double-blind trial where they received either the cannabis extract or a placebo, with measures including self-reported spasms, mobility tests, and other functional assessments.
• While no significant differences were found overall between the treatment and placebo groups, some improvements in spasm frequency and mobility were observed in patients who strictly followed the protocol, with mild side effects being more common during active treatment.]