J Intern Med February 2005 PMID 15656873

Immune regulation of central nervous system functions: from sickness responses to pathological pain.

L R Watkins, S F Maier

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Mentions

8
Peak: 4 in May 2024
across 4 sources since Jan 2017

Extended reach

221,034
potential audience

Total likes

6,010

Video views

209,957

Mentions per month

Jan 2017 – May 2024

Where it's discussed

  • Reddit3 posts
  • X / Twitter2 posts
  • YouTube2 videos
  • Facebook1 posts

AI synopsis

What people are saying

The overall tone reflects a high interest and agreement among the commenters, with mentions of supporting research programs and previous scientists like Lisa Goehler and Linda Watkins highlighting the study’s impact. Words such as 'glad' and references to 'research priorities' emphasize appreciation and perceived importance, contributing to a positive and engaged attitude toward the publication.

AgreementModerate agreement

The discussions express support and recognition of the study’s importance, referencing prior research and scientific contributions.

InterestHigh interest

Many posts indicate a high level of curiosity and appreciation for the research, mentioning specific scientists and research programs.

EngagementModerate engagement

Comments show moderate engagement, with some referencing personal knowledge and research history, but limited detailed analysis in the discussions.

ImpactModerate impact

The discussions suggest the research is seen as influential within scientific circles, but not yet transformative on a broad societal scale.

Abstract in brief

  • The traditional view of the central nervous system (CNS) and immune system functioning independently has been revised, showing a dynamic interaction where the immune system can influence CNS activities.
  • The immune-to-brain communication triggers sickness responses like fever, fatigue, and increased pain by activating CNS glial cells to release proinflammatory cytokines, which are involved in these processes.
  • Chronic pathological pain may stem from this ancient immune-glial circuitry being hijacked, involving immune and glial cell activation at various nervous system levels, highlighting potential approaches for treating chronic pain syndromes.

Top posts

Most liked on X and Bluesky
Michael VanElzakker
@MBVanElzakker · X

@Lindy1715 @domsalisbury @cstroeckw Glad they did this study. It's definitely part of a research program based on the work of scientists I knew as an undergrad like Lisa Goehler https://t.co/8WOa3zmv4E and Linda Watkins https://t.co/nXlaZsVaF9. And yes, this is what I wrote about research priorities at that time https://t.co/wDTnYEAEQz

May 17, 2024 · 3 likes · 1 share · 9,747 followers View post →
Hassan Khader Ali Yousef
@hassankhaderali · X

RT @MBVanElzakker: @Lindy1715 @domsalisbury @cstroeckw Glad they did this study. It's definitely part of a research program based on the wo…

May 17, 2024 · 1 share · 1,287 followers View post →

All mentions

Hassan Khader Ali Yousef
@hassankhaderali · X

RT @MBVanElzakker: @Lindy1715 @domsalisbury @cstroeckw Glad they did this study. It's definitely part of a research program based on the wo…

May 17, 2024 · 1 share · 1,287 followers View post →
Michael VanElzakker
@MBVanElzakker · X

@Lindy1715 @domsalisbury @cstroeckw Glad they did this study. It's definitely part of a research program based on the work of scientists I knew as an undergrad like Lisa Goehler https://t.co/8WOa3zmv4E and Linda Watkins https://t.co/nXlaZsVaF9. And yes, this is what I wrote about research priorities at that time https://t.co/wDTnYEAEQz

May 17, 2024 · 3 likes · 1 share · 9,747 followers View post →
פוסט מיוחד למזג האוויר הסגרירי. מה קורה במוח כשאנחנו חולים ... - Facebook
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למעוניינים, מקורות נוספים להרחבה: http://onlinelibrary.wiley. com/doi/10.1111/j.1365-2796.2004.01443. x/abstract https://www.sciencedirect.

Dec 17, 2025 View →
post covid/autoimmune - brain retraining : r/smallfiberneuropathy
Reddit

I really don't think that this is that big a leap. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2796.2004.01443.x. I know a lot of ...

May 8, 2024 View →
post covid/autoimmun – hjärnreträning : r/smallfiberneuropathy
Reddit

... 10.1111/j.1365-2796.2004.01443.x. Jag känner många inom hjärnomträning som haft kronisk borrelia som blivit bättre eller försvunnit med ...

May 8, 2024 View →
Is the immune system as a controller of social Behavior a well ...
Reddit

... 10.1111/j.1365-2796.2004.01443.x/full. My lab has also published several papers on immune regulation of behavior. Ohio State actually has ...

Jan 30, 2017 View →