Overall, these discussions reflect a moderate agreement with the article's premise, as many acknowledge the role of protein in food intake regulation, and some cite influential studies. The tone varies from supportive to inquisitive, emphasizing the hypothesis's relevance in addressing obesity and encouraging further exploration of its implications.
AgreementModerate agreement
Most discussions acknowledge the validity of the protein leverage hypothesis, with some referencing foundational studies by Simpson and Raubenheimer.
InterestModerate interest
Posts show moderate interest, highlighting the paper's relevance but not delving deeply into technical analysis.
EngagementModerate engagement
The discussions include mentions of related research, debate over how protein influences food intake, and references to practical implications, indicating a moderate level of engagement.
ImpactModerate impact
Several posts suggest the research could influence dietary strategies or understanding of obesity, showing a recognition of its potential societal impact.
Abstract in brief
The protein leverage hypothesis suggests that despite protein constituting only around 15% of dietary energy and remaining relatively constant across populations, it may paradoxically influence the obesity epidemic by affecting overall food intake.
The hypothesis proposes that because protein intake is tightly regulated, the body may try to meet a set protein target by increasing the consumption of other macronutrients, leading to overconsumption of calories and obesity.
A mathematical model, along with epidemiological, experimental, and animal data, supports this idea and makes predictions for future research to better understand protein’s role in obesity.
By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to get their protein requirements.
And became obese.
https://t.co/1S3MdPLYpH
Mar 25, 2019 · 75 likes · 9 shares · 309,342 followersView post →
LH
L. Amber O'Hearn
@KetoCarnivore · X
The PLH posits that animals will eat enough of a given food to meet minimum protein needs (~15%), even if that means exceeding energy needs. It says nothing about eating more protein above adequate levels and obesity.
https://t.co/byxBZl8qKl
3/4
Jun 10, 2022 · 23 likes · 1 share · 59,846 followersView post →
JS
John Speakman
@JohnSpeakman4 · X
I can understand why we might have a dietary protein target and why that might lead to caloric over consumption by protein leverage. 4/5 https://t.co/4kUutBrlsk
@DikemanDave @GuillaumeRally @tednaiman @AmDiabetesAssn @Travis_Statham @TuitNutrition @garytaubes @FructoseNo @ProfTimNoakes @DougieReynolds I have two answers to your question, @GuillaumeRally . First is shown in graph below: gearing of #protein leverage means a small dilution of P (e.g. 1.5%) amplifies into a large increase in F and C calories (14%!). So 0.8 % is not trivial:https://t.co/Nfb85hAg61 https://t.co/Y95rBGQG8y
Revisa tu consumo diario de proteína, un profesional ACTUALIZADO es el que podrá darte las mejores pautas y la cantidad adecuada de proteína que necesitas de acuerdo a tus necesidades, estilo de vida, peso y actividad física.
https://t.co/9N7ygJwbeu
#vivefitness #nutrición
Nov 18, 2021 · 4 likes · 11,903 followersView post →
NK
Nick Krontiris
@nick_krontiris · X
d) protein leverage hypothesis (humans prioritize protein
when regulating food intake, our protein intake is too low so we need to eat more)
https://t.co/fyvSG9GwNm
Dec 31, 2020 · 3 likes · 1 share · 19,547 followersView post →
The video explores the role of protein in regulating appetite and its impact on obesity, highlighting how targeted protein intake can aid in belly fat reduction within days. Insights are supported by recent research and…
This video explains the protein leverage hypothesis, suggesting that the body's regulation of protein intake influences overall food consumption and obesity risk. Understanding this connection can help develop better…
This video discusses a new vinegar method that shrinks dormant fat cells, focusing on innovative approaches to stubborn fat reduction. It includes insights from Dr. Dom D'Agostino and explores the role of dietary…
This video explores the role of protein in weight management and obesity. It discusses how protein intake, despite being a small part of the diet, influences overall food consumption through the protein leverage…
May 29, 2025 · 1 like · 23,657 followersView post →
MF
Michael Fitzpatrick
@ItIsMikeFitz · X
@CoachLamby @whitfieldlewis6 @ryanattar @adamwolach @GladstoneB81859 I think you'd be interested in reading about the protein leverage hypothesis. It can absolutely help everyone resolve obesity, this is what I an talking about:
https://t.co/XEM0bxOQiD
@Potatoe_salaad @Will_of_Europa There are some papers by Simpson and Raubenheimer from the 2000s talking about it, here's one:
https://t.co/ippNaef9q5
The general idea is that all animal/human bodies demand a certain amount of protein. Giving it low-protein food (ie high-fat + high-carb -- think potato chips),
@exfatloss @CarnivoreAugust @ChrisStraga @SmileyElmore @The_Keto_Indian @shashiiyengar @KetoCarnivore @KenDBerryMD @SBakerMD @drjasonfung @drandyphung @lowcarbusa @MrSollozzo yes. that's the original 2005 paper. full text here. https://t.co/typQhEBCLK
Nov 8, 2023 · 2 likes · 10,973 followersView post →
LH
L. Amber O'Hearn
@KetoCarnivore · X
@exfatloss @CarnivoreAugust @ChrisStraga @SmileyElmore @The_Keto_Indian @shashiiyengar @KenDBerryMD @SBakerMD @drjasonfung @drandyphung @lowcarbusa @MrSollozzo Yes, I don't remember it being funny, but it was awhile ago. Maybe I'll look again. I'm assuming you mean "Obesity: the protein leverage hypothesis"?
Nov 8, 2023 · 1 like · 59,846 followersView post →
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exfatloss
@exfatloss · X
@CarnivoreAugust @ChrisStraga @SmileyElmore @The_Keto_Indian @shashiiyengar @KetoCarnivore @KenDBerryMD @SBakerMD @drjasonfung @drandyphung @lowcarbusa @MrSollozzo I was sent this one: https://t.co/6VjSXFlhNr
Nov 8, 2023 · 2 likes · 6,874 followersView post →
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exfatloss
@exfatloss · X
@JohnSpeakman4 @PenelopeFigtree @TuckerGoodrich @AsarCadyn @MohammedAlo @HarvardChanSPH @fire_bottle Btw I'm talking about this paper:
https://t.co/6VjSXFlhNr
I don't see your name on it, are we talking about the same thing?
Oct 25, 2023 · 3 likes · 10,973 followersView post →
SP
Susan Hazelwood-Perrel
@la_vache · X
@DoctorChrisVT hello, am listening to your book for the second time (once not enough) and having heard your comments on protein being no more filling than other food, would like to know your opinion on this study https://t.co/eZ0wfpFZJ1
@ErasmasFigaro @TuckerGoodrich @tednaiman @DoctorTro I can't take credit for the science, but you can read it here. https://t.co/hRVCW8DZ2S
Jun 12, 2023 · 1 like · 10,973 followersView post →
MK
Marty Kendall
@martykendall2 · X
@twitevit @tednaiman @eatlikeanimals That's how protein leverage works. A small decrease in protein % aligns with a significant increase in energy to get adequate protein. https://t.co/hRVCW8DZ2S
Jun 12, 2023 · 2 likes · 10,973 followersView post →
MJ
Mike julian
@Mikejulian26 · X
@EvolvingMSA @exfatloss @martykendall2 @KetoCarnivore @luis_villasenor @richcollins @StickmanBleedin @kelly_hogan_zc @BenBikmanPhD @cambridge_pt From this paper https://t.co/TEMXQotVCg
@KetoCarnivore @lchfRD @MacroFour @tednaiman @raphaels7 @FrogHarmless @DrEenfeldt @JimChinnis @siobhan_huggins But according to Simpson and Raubenheimer’s work, humans and most animals strive for a protein % in their diet, which appetite in a perfect world would guide you to. Ted's PE diet in theory leverages this concept.
https://t.co/P3BG51IrJ3
Mar 16, 2023 · 2 likes · 1,350 followersView post →
YX
Yi Xin
@xin_girls · X
'Obesity: The protein leverage hypothesis'
A study done by two Australian researchers, Simpson and Raubenheimer
#diet #food #hacks
@Fadoua_flila kan dwa saber 3la had l blan w ha les études qu'il avait cité
https://t.co/tPlFItYQJo
https://t.co/f3zuzFXslB
https://t.co/zgng3ss7LD https://t.co/4cdjdoiAoE
@EricaHauver @SciTechDaily1 Raubenheimer and Simpson published their protein leverage hypothesis paper in 2005 so this is not new, but happy more people are discovering it.
https://t.co/HtYJ7ZDdYi
Nov 10, 2022 · 2 likes · 1 share · 1,729 followersView post →
The PLH posits that animals will eat enough of a given food to meet minimum protein needs (~15%), even if that means exceeding energy needs. It says nothing about eating more protein above adequate levels and obesity.
https://t.co/byxBZl8qKl
3/4
Jun 10, 2022 · 23 likes · 1 share · 59,846 followersView post →
Revisa tu consumo diario de proteína, un profesional ACTUALIZADO es el que podrá darte las mejores pautas y la cantidad adecuada de proteína que necesitas de acuerdo a tus necesidades, estilo de vida, peso y actividad física.
https://t.co/9N7ygJwbeu
#vivefitness #nutrición
Nov 18, 2021 · 4 likes · 11,903 followersView post →
MM
Michael Mindrum, MD
@MichaelMindrum · X
The P:E diet conceptualized by @eatlikeanimals in ...2005 ? ! https://t.co/HsyToJjfT7 https://t.co/nGlU6Sa4PA
Sep 17, 2021 · 1 like · 10,371 followersView post →
TP
thriving on low carb high protein
@LC_sailor · X
@food_strategy @BorisJohnson @sajidjavid please start over again with the National Food Strategy after reading Simpson, S. J.; Raubenheimer, D. (May 2005). "Obesity: the protein leverage hypothesis". Obesity Reviews. Make the up from people who do not profit from processed food.
@mosca_matthew @StreetSmartRD Facts or assumptions?
Hall: 500 Calories extra a day if you eat processed foods like UPF instant noodles.
https://t.co/5AeRfx6pCS
Simpson & Raubenheimer: Protein Leverage Hypothesis
https://t.co/G1bcBsK5pU
These aren't traditional Asian noodles eaten an energy reduced diet.
@UberBasado @Cernovich Satiety matters — will power goes only so far when the body demands what it needs, which is protein, something sorely lacking for SAD eaters. A study in this direction: https://t.co/LsA2xSRZxJ
@DoctorTro @JohnSpeakman4 @JimJohnsonSci @CaloriesProper @TamarHaspel @davidludwigmd @garytaubes @KevinH_PhD Likely driven by exacerbated protein leverage in obesity (see example 3 in Fig. 4).
https://t.co/Tjyj5uDPcM
I can understand why we might have a dietary protein target and why that might lead to caloric over consumption by protein leverage. 4/5 https://t.co/4kUutBrlsk
This has also led many researchers to form the "protein leverage" hypothesis of obesity.
https://t.co/iAx9C1GJwg
Mar 13, 2021 · 1 like · 19,547 followersView post →
BT
Bhopender Thakur
@TheBhupiThakur · X
RT @nick_krontiris: d) protein leverage hypothesis (humans prioritize protein
when regulating food intake, our protein intake is too low so…
Mar 9, 2021 · 1 share · 1,388 followersView post →
NK
Nick Krontiris
@nick_krontiris · X
d) protein leverage hypothesis (humans prioritize protein
when regulating food intake, our protein intake is too low so we need to eat more)
https://t.co/fyvSG9GwNm
Dec 31, 2020 · 3 likes · 1 share · 19,547 followersView post →
@AlexFerentinos7 @gm7t2 @SaraTirner @doctoringketo @BrianLenzkes True—sorry. Here is the scientific article that best explains nutritional geometry:
https://t.co/aHqyZ0AYgW
However I was serious and you will FOR SURE get the answer to your question even faster by literally Googling “nutritional geometry” and clicking on the 1st link.
@DikemanDave @GuillaumeRally @tednaiman @AmDiabetesAssn @Travis_Statham @TuitNutrition @garytaubes @FructoseNo @ProfTimNoakes @DougieReynolds I have two answers to your question, @GuillaumeRally . First is shown in graph below: gearing of #protein leverage means a small dilution of P (e.g. 1.5%) amplifies into a large increase in F and C calories (14%!). So 0.8 % is not trivial:https://t.co/Nfb85hAg61 https://t.co/Y95rBGQG8y
RT @Mangan150: By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to…
Mar 25, 2019 · 9 shares · 1,005 followersView post →
A
Apollyon
@Apollyon001 · X
RT @Mangan150: By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to…
Mar 25, 2019 · 9 shares · 1,597 followersView post →
DD
Don Donahoe
@deldondo · X
RT @Mangan150: By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to…
Mar 25, 2019 · 9 shares · 310 followersView post →
AA
Autophagy keeps me alive
@SeanFlanderhijn · X
RT @Mangan150: By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to…
Mar 25, 2019 · 9 shares · 334 followersView post →
LH
Lesbian Tipping Habits
@DoLesbiansTip · X
RT @Mangan150: By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to…
Mar 25, 2019 · 9 shares · 2,432 followersView post →
RL
R E B E L
@RebelRancher · X
RT @Mangan150: By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to…
Mar 25, 2019 · 9 shares · 21,274 followersView post →
PM
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X
By promoting consumption of high carb, low fat foods, health authorities promoted low protein foods.
So people ate more to get their protein requirements.
And became obese.
https://t.co/1S3MdPLYpH
Mar 25, 2019 · 75 likes · 9 shares · 309,342 followersView post →
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References | PDF | Low Carbohydrate Diet | Dieting
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FGF21 Signaling in Glutamatergic Neurons Is Required For Weight ...
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The Harms of High Protein | PDF | Dieting | Dietary Supplements
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... 10.1111/j.1467- Renal functional reserve in humans. Effect of protein intake on glomerular 127 62 789X.2005.00178.x. filtration rate, Am. J. Med. 75 (6) ...