PubHawk
April 2006 PMID 16779921

A review of issues of dietary protein intake in humans.

Shane Bilsborough, Neil Mann

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Mentions

100
Peak: 9 in Jan 2023
across 6 sources since May 2019

Extended reach

467,875
potential audience

Total likes

243

Video views

3,767

Mentions per month

May 2019 – Aug 2025

Where it's discussed

  • News40 articles
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  • Facebook12 posts
  • Blogs5 articles
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect acknowledgment of safety concerns about high protein consumption, with some referencing scientific studies and thresholds like 'exceeding 35%' or 'maximal safe intake of 3.5-4.5 grams per kilogram,' indicating moderate engagement with the publication. Words like 'danger,' 'risks,' and references to research imply a cautious tone that emphasizes the health implications of excessive protein intake, contributing to a moderate overall impact.

AgreementModerate agreement

Most discussions acknowledge the risks of high protein intake, aligning with the article's caution about safety thresholds.

InterestModerate interest

Participants show moderate interest by referencing specific research, safety guidelines, and scientific studies.

EngagementNeutral engagement

Comments tend to be brief or refer to external sources rather than deep personal analysis, leading to a neutral engagement level.

ImpactModerate impact

The conversations highlight awareness of health risks and suggest practical guidelines, indicating a moderate influence on understanding dietary safety.

Abstract in brief

  • There is ongoing debate about whether increasing dietary protein is safe and beneficial for weight control and muscle growth, with some health advice promoting high-protein diets despite limited scientific evidence on safety.
  • The key concerns involve the body's ability to absorb amino acids efficiently and the liver's capacity to process excess nitrogen, which can be overwhelmed by very high protein intakes and lead to health issues like hyperaminoacidemia, hyperammonemia, or even death.
  • A safe and sensible maximum protein intake is suggested to be around 25% of total energy (roughly 2-2.5 g per kg per day), which is lower than the maximum biological safe limits, thereby reducing risks of toxicity and aligning with the body's needs.]
Read the full abstract

Top posts

Most liked on X and Bluesky
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 34 likes · 9 shares · 124,353 followers View post →
IJSNEMJournal
@IJSNEMJournal · X

IJSNEM Classic - now available in Full Access. Nomination by @proftipper "This protein paper is one I’ve used many times to help develop presentations and cited in papers" https://t.co/1HDPMGgMFN

Jul 21, 2021 · 30 likes · 3 shares · 2,682 followers View post →
ぽん
@yasu0804 · X

『A review of issues of dietary protein intake in humans』によると、タンパク質が総エネルギー摂取量の35%を超える場合、高アミノ酸血症、高アンモニア血症、高インスリン血症、吐き気、下痢、さらには死（「ウサギ飢餓症候群」）に至る危険がある、としている https://t.co/GqzaxnfcaQ

Mar 16, 2022 · 12 likes · 6 shares · 4,606 followers View post →
KENTO/カジュアルに栄養の本質を学べる学校を作る。
@sudokeeen · X

参考 https://t.co/KeX6Jd0RJj

Jun 19, 2024 · 10 likes · 52,123 followers View post →
John Speakman
@JohnSpeakman4 · X

@DoctorTro @tednaiman do you mean an acute study only. I think for chronic intake, levels above 35% protein could raise issues. https://t.co/u7PiLG9aCE).

May 23, 2024 · 4 likes · 11,995 followers View post →
Miki Ben-Dor
@bendormiki · X

@MactatorMaximus @2Min_Keto @ADreyzen @KetoCarnivore @raphaels7 @LogicalLynx @meloegirl @EatLandSalmon @OZmandia @Karageorgos15 @tednaiman @dramerling @DikemanDave @Mangan150 @robbwolf @TuckerGoodrich @puddleg 'Maximal Rates of Excretion and Synthesis of Urea in Normal and Cirrhotic Subjects.' to the results you should add 1 gr/kg structural. A good paper is Bilborough and Mann 2006 A Review of Issues of Dietary Protein Intake in Humans.

Dec 28, 2020 · 3 likes · 4,960 followers View post →

All mentions

FurBearingMammal
@FurryVarmint · X

@BadDietTakes "Dangers of excessive protein, defined as when protein constitutes > 35% of total energy intake, include hyperaminoacidemia, hyperammonemia, hyperinsulinemia nausea, diarrhea, and even death (the "rabbit starvation syndrome"). https://t.co/lBPcND9YbX

Aug 26, 2025 · 1 like · 657 followers View post →
Leo Abstract
@Leo_Abstract · X

@The_Angu @bizlet7 @castizofuturism @spandrell4 here's the first hit i get on sources: https://t.co/UlF5PoEzVO i recommend consensus(dot)app for quick overviews btw

Jul 13, 2025 · 2 likes · 417 followers View post →
Adult carrot
@Adult_Carrot_ · X

@SteveHamel16 @RealLiveAxel @KenDBerryMD https://t.co/48LqQA82Cy

Jan 3, 2025 · 11 followers View post →
Adult carrot
@Adult_Carrot_ · X

@RealLiveAxel @SteveHamel16 @KenDBerryMD Sure, https://t.co/48LqQA82Cy From the abstract "Dangers of excessive protein, defined as when protein constitutes > 35% of total energy intake, include hyperaminoacidemia, hyperammonemia, hyperinsulinemia nausea, diarrhea, and even death (the “rabbit starvation syndrome”).

Jan 3, 2025 · 11 followers View post →
Dehati
@gundappen · X

@viprabuddhi @Manchu__ Insect protein is too lean, it can lead to protein poisoning. Humans need to consume their protein w a fair amount of fat https://t.co/yeF5pDAlc5 https://t.co/PTkRUVXHMw

Nov 22, 2024 · 639 followers View post →
Bart B. Van Bockstaele
@Thamno · X

@HarrisonSea Here is a good article: https://t.co/LgZ4prH3Vs

Aug 13, 2024 · 1 like · 226 followers View post →
KENTO/カジュアルに栄養の本質を学べる学校を作る。
@sudokeeen · X

参考 https://t.co/KeX6Jd0RJj

Jun 19, 2024 · 10 likes · 52,123 followers View post →
John Speakman
@JohnSpeakman4 · X

@DoctorTro @tednaiman do you mean an acute study only. I think for chronic intake, levels above 35% protein could raise issues. https://t.co/u7PiLG9aCE).

May 23, 2024 · 4 likes · 11,995 followers View post →
まいち
@maiti_86 · X

@kksft @komomo_Com https://t.co/hkBiiadGfp ウサギ飢餓ではむしろ高インスリン血症になる。これはむしろタンパク質摂取の過剰で「糖新生が亢進しすぎている」ことを意味する。 抑制しないといけない。

May 17, 2024 · 2 likes · 10,880 followers View post →
飯テロ＠MMDer
@kksft · X

@maiti_86 @morningdietapp @yukwest69684489 @Jimo0404 @chototsumoushin @KDf0y 失礼、ウサギ飢餓はケトアシドーシスではありませんでした。 しかし、タンパク質過剰は高インスリン血症を引き起こすようです インスリン分泌が血糖依存で制御されるのであれば、前段階として高血糖になった結果、過剰にインスリンが分泌されたものと思われます。 https://t.co/B3xg9uVybm https://t.co/asuYeliKMH

May 9, 2024 · 2 likes · 1,358 followers View post →
LLicit
@LLicit_Tweet · X

@CarnivoreWhisp @SBakerMD Dangers of excessive protein (> 35% of energy) include hyperaminoacidemia, hyperammonemia, hyperinsulinemia, nausea, diarrhea, and even death (the “rabbit starvation syndrome” https://t.co/xWGrRcjAVf

Dec 28, 2023 · 145 followers View post →
Justin
@MountainVisions · X

@Thamno @aNorseView @DanielBerglind @ScepticalDoctor Good info on protein intake https://t.co/oKg3iTyfC5

Oct 7, 2023 · 1 like · 241 followers View post →
Mario Fernández
@MarioFrdz7 · X

[1] https://t.co/aB9esbQDZ7 [2] https://t.co/w1yyTqAc6F [3] https://t.co/1UKZEA2MgH [4] https://t.co/Vnae8CK8DH

Aug 15, 2023 · 105 followers View post →
Primal M
@EvolvingMSA · X

@exfatloss @donlayman @Chloe_mrng https://t.co/kTrqd9D95o

Mar 31, 2023 · 177 followers View post →
ルンルン
@HMf4sMotY6RhbHu · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 12, 2023 · 9 shares · 43 followers View post →
エリパパダイエット金森式
@erithin3 · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 11, 2023 · 9 shares · 68 followers View post →
Eulmal
@Eulmal · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 9 shares · 215 followers View post →
さなさな@ダイエット記録
@Ebw95rjNPfCI6r7 · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 9 shares · 232 followers View post →
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 9 shares · 124,353 followers View post →
sh-nuppu
@Nuppu008 · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 9 shares · 475 followers View post →
Hirokazu Ishida
@mptfk329 · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 9 shares · 374 followers View post →
ちえ金森式
@CHIE56552190 · X

RT @ShigekiKanamori: 【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 9 shares · 88 followers View post →
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

【肉じゃなく脂を食べる】 @kojija さん著 Primal Diet 高タンパク❌ 過剰な窒素を尿素に変換する肝臓の能力を超過 Pが総エネルギーの35%超で

Jan 10, 2023 · 34 likes · 9 shares · 124,353 followers View post →
7:NANA ひろかわあきこ
@HIRO90704338 · X

摂取カロリーの35%を超えるタンパク質摂取は、高アミノ酸血症、高アンモニウム血症、下痢、嘔吐、死亡(ウサギ飢餓症候群)を引き起こす。 やはり高タンパク食は人体に危険。 A review of issues of dietary protein intake in humans - PubMed #ケトジェニックダイエット https://t.co/ficJ07NzBi

Nov 22, 2022 · 132 followers View post →
にじのそらた
@nijinosorata · X

RT @yasu0804: 『A review of issues of dietary protein intake in humans』によると、タンパク質が総エネルギー摂取量の35%を超える場合、高アミノ酸血症、高アンモニア血症、高インスリン血症、吐き気、下痢、さらには死…

May 3, 2022 · 6 shares · 696 followers View post →
マークベルバルデ
@DtdsxvDhFLsm7Jz · X

RT @yasu0804: 『A review of issues of dietary protein intake in humans』によると、タンパク質が総エネルギー摂取量の35%を超える場合、高アミノ酸血症、高アンモニア血症、高インスリン血症、吐き気、下痢、さらには死…

Mar 17, 2022 · 6 shares · 105 followers View post →
うさ亀
@ark_pt · X

RT @yasu0804: 『A review of issues of dietary protein intake in humans』によると、タンパク質が総エネルギー摂取量の35%を超える場合、高アミノ酸血症、高アンモニア血症、高インスリン血症、吐き気、下痢、さらには死…

Mar 17, 2022 · 6 shares · 783 followers View post →
にじのそらた
@nijinosorata · X

RT @yasu0804: 『A review of issues of dietary protein intake in humans』によると、タンパク質が総エネルギー摂取量の35%を超える場合、高アミノ酸血症、高アンモニア血症、高インスリン血症、吐き気、下痢、さらには死…

Mar 16, 2022 · 6 shares · 696 followers View post →
sky sky blue
@sumoomo147 · X

RT @yasu0804: 『A review of issues of dietary protein intake in humans』によると、タンパク質が総エネルギー摂取量の35%を超える場合、高アミノ酸血症、高アンモニア血症、高インスリン血症、吐き気、下痢、さらには死…

Mar 16, 2022 · 6 shares · 208 followers View post →
ぽん
@yasu0804 · X

『A review of issues of dietary protein intake in humans』によると、タンパク質が総エネルギー摂取量の35%を超える場合、高アミノ酸血症、高アンモニア血症、高インスリン血症、吐き気、下痢、さらには死（「ウサギ飢餓症候群」）に至る危険がある、としている https://t.co/GqzaxnfcaQ

Mar 16, 2022 · 12 likes · 6 shares · 4,606 followers View post →
LibKey
@libkey_io · X

@tednaiman @Renu95393728 @andreivolt @JoeyDevlin_ Get access rather than a paywall: https://t.co/dpjUB07pX9 Add https://t.co/SXSePSX5De to the DOI URL when sharing articles to promote scholarly communication

Jan 9, 2022 · 553 followers View post →
Ted ⚡️ Naiman
@tednaiman · X

@Renu95393728 @andreivolt @JoeyDevlin_ Theoretical maximum safe intake of protein in humans is in the 3.5 to 4.5 grams per kilogram of ideal body weight range (1.6–2.0 g/lb) and most people never come close to this…I recommend 1 g/lb of ideal body weight and this is never a problem. ☺︎ https://t.co/ze9A5xOTbF

Jan 9, 2022 · 1 like · 95,199 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @IJSNEMJournal: IJSNEM Classic - now available in Full Access. Nomination by @proftipper "This protein paper is one I’ve used many times…

Jul 22, 2021 · 3 shares · 1,395 followers View post →
James Betts
@DrBSteamjets · X

RT @IJSNEMJournal: IJSNEM Classic - now available in Full Access. Nomination by @proftipper "This protein paper is one I’ve used many times…

Jul 22, 2021 · 3 shares · 3,851 followers View post →
Kevin Tipton
@proftipper · X

RT @IJSNEMJournal: IJSNEM Classic - now available in Full Access. Nomination by @proftipper "This protein paper is one I’ve used many times…

Jul 22, 2021 · 3 shares · 18,157 followers View post →
IJSNEMJournal
@IJSNEMJournal · X

IJSNEM Classic - now available in Full Access. Nomination by @proftipper "This protein paper is one I’ve used many times to help develop presentations and cited in papers" https://t.co/1HDPMGgMFN

Jul 21, 2021 · 30 likes · 3 shares · 2,682 followers View post →
Samantha Sadowski
@SamanthaSadows1 · X

@Tom_Sam_son @CarnivoreMD There are definitely more than one cause for kidney stones, but usually Harvard is a pretty reliable source for nutrition. Here’s another one from PubMed. https://t.co/4x000C5G3m Unfortunately you have to pay for the full article, but it does into some detail in the abstract.

Jan 16, 2021 · 32 followers View post →
Miki Ben-Dor
@bendormiki · X

@MactatorMaximus @2Min_Keto @ADreyzen @KetoCarnivore @raphaels7 @LogicalLynx @meloegirl @EatLandSalmon @OZmandia @Karageorgos15 @tednaiman @dramerling @DikemanDave @Mangan150 @robbwolf @TuckerGoodrich @puddleg 'Maximal Rates of Excretion and Synthesis of Urea in Normal and Cirrhotic Subjects.' to the results you should add 1 gr/kg structural. A good paper is Bilborough and Mann 2006 A Review of Issues of Dietary Protein Intake in Humans.

Dec 28, 2020 · 3 likes · 4,960 followers View post →
Karageorgos
@Karageorgos15 · X

@og_BYU @Nutradvance I'm not sure because most studies do not consider possible adaptations, effect on training, genetics, etc. but a nice discussion here. See section on "Maximal Rate of Urea Synthesis and Excretion": https://t.co/59OcCiZsmk

May 12, 2019 · 1 like · 610 followers View post →