A new look at the 5alpha-reductase inhibitor finasteride.

Abstract in brief

• Finasteride is a medication that inhibits the 5alphareductase enzyme, primarily used to treat benign prostatic hyperplasia (BPH) and male pattern hair loss by reducing the hormone DHT.
• Recent research shows that this enzyme also helps produce steroid compounds called neuroactive steroids, which can influence brain function by enhancing GABA neurotransmission, leading to effects like anticonvulsant, antidepressant, and anti-anxiety actions.
• The studies suggest that normal levels of these neuroactive steroids might be linked to fewer symptoms of mental health issues like depression, anxiety, and disorders related to hormonal changes such as postpartum and premenstrual dysphoric disorder.]