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These discussions emphasize the longstanding history of gene transfer research, with several posts referencing the 1990 paper by Wolff et al., describing it as a landmark achievement. The tone varies from academic to skeptical, with some citing the paper's significance using terms like 'groundbreaking' and others pointing out Malone's role as a co-author. Words like 'milestone,' 'foundation,' and mentions of decades of development convey both respect and critical perspectives, illustrating a nuanced understanding of the work's impact over time.
Most discussions recognize the 1990 study as a foundational milestone, indicating general agreement on its historical importance.
The posts show high curiosity and engagement with the historical development of mRNA technologies, suggesting strong interest.
Many comments delve into detailed references, critiques, and historical context, reflecting deep engagement with the subject matter.
While the study is acknowledged as significant historically, the discussions mostly highlight its foundational role rather than immediate revolutionary impact.
The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on a modern catalog, this seems to bear out: https://t.co/aV8FIwgOR0 https://t.co/JB9JmwKrN6
Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on different lipid formulations and construct. He hissed a fit with his supervisor and was discharged from grad school. https://t.co/0sNiEke8KT https://t.co/tmmRE2D8TV
ARN et
@NobelPrize If You connecting this prize to mRNA C19 vaccines, then why You not award Robert Malone who was pionnier of LNP transfection platform and direct gene transfer into mouse muscle in vivo?: https://t.co/iELGzMtYAj
Teraz powoli do ludzi dociera co się wydarzyło podczas covidianizmu. Tacy ludzie jak Malone byli cenzurowani i oczerniani, podczas gdy promowano tylko wąski kąt jednej narracji. To był klasyczne budowanie masowej formacji hipnotyzującej masy. https://t.co/Y1nOJEX26f
@vrcoffeee Tiens, la technologie qui a permis de bosser là dessus vient de ce genre d'articles... qui date de 1990. https://t.co/v8oHWG4ggu
This study examines how RNA activates toll-like receptors in the human immune system and shows that nucleoside modifications like methylation can suppress this activation, reducing immune responses and cytokine…
A new mRNA vaccine shows promising results to help end COVID-19. mRNA vaccines trigger a balanced immune response, activating both cellular and humoral immunity without interacting with DNA, offering a flexible and safe…
@ZoeyFeldman @sjs856 @NonstopGamecock AFAIK, the idea that RNA (and DNA) delivery into muscle cells could be used in vaccine development was first mentioned in a paper where Malone was one of 7 authors. It is not apparent who came up with the idea. https://t.co/HPg2fPDP1B
@OccupyWWIII @bluebeetle_one @mryoung151 @DrPeterBagshaw BTW, this "novel technology" has been in development for decades. https://t.co/jiIfcJPAmK
@oldkheyswag @VictorSinclair3 https://t.co/6bHjfmYPeN
@MinguetGaetan @mthilu @kevinalves73100 @MartinZ_uncut @2_expat @lonnibesancon @MagaliReghezza @QI_181 @KnwldgMedia https://t.co/0v0nmUbdnd
@mkeulemans https://t.co/eCSw0fCTYy Robert Malone - second author
@Ax_The_Crap @AnnRudbeck @CTVNews @grok The paper "Direct Gene Transfer into Mouse Muscle in Vivo" (published in 1990 by Jon A. Wolff, Robert W. Malone, and others in Science) is a landmark study in the development of mRNA and DNA technologies. Here's a simple explanation in layman’s terms: What Was the Study About?
@Ax_The_Crap @AnnRudbeck @CTVNews @grok @grok Can you explain this paper in Laymens terms? "Direct Gene Transfer into Mouse Muscle in Vivo"
@Chamchamat Je crois pas qu'il a fais de lnp c'est la publi de 1990 sur les naked nucleic acid avec wolff https://t.co/3mhWNQ0ttk
@grok @jirisalin @SamiAntinniemi @grok ota huomioon pohdinnassa myös seuraavat lähteet kun punnitset DNA integraation mahdollisuutta: Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990). Direct gene transfer into mouse muscle in vivo. Science (New York, N.Y.),
RT @fraisst: マウス筋肉に直接遺伝子導入 クロラムフェニコールアセチルトランスフェラーゼ、 ルシフェラーゼ、ベータガラクトシダーゼの遺伝子を含むDNA発現ベクターをマウス骨格筋に個別に注入 注射後 ルシフェラーゼ活性は少なくとも2ヶ月間継続… https://t…
@BecriJ5419 @Razgaros @BPartisanss https://t.co/kYXU41jOan Cadeau. 1990 . Soit 35 ans.
RT @alexandrosM: The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on…
RT @GauteNilsen: What consequences does this research have on the plasmid-contaminated mRNA vaccines ???
@LeviganRobert @lonnibesancon @chaparro66x And this next step was important too : Direct Gene Transfer into Mouse Muscle in Vivo https://t.co/EdR3pcQPtQ So, one thing no one can say about Robert W Malone, is that he doesn't know what he's talking about:
RT @fraisst: マウス筋肉に直接遺伝子導入 クロラムフェニコールアセチルトランスフェラーゼ、 ルシフェラーゼ、ベータガラクトシダーゼの遺伝子を含むDNA発現ベクターをマウス骨格筋に個別に注入 注射後 ルシフェラーゼ活性は少なくとも2ヶ月間継続… https://t…
RT @fraisst: マウス筋肉に直接遺伝子導入 クロラムフェニコールアセチルトランスフェラーゼ、 ルシフェラーゼ、ベータガラクトシダーゼの遺伝子を含むDNA発現ベクターをマウス骨格筋に個別に注入 注射後 ルシフェラーゼ活性は少なくとも2ヶ月間継続… https://t…
RT @fraisst: マウス筋肉に直接遺伝子導入 クロラムフェニコールアセチルトランスフェラーゼ、 ルシフェラーゼ、ベータガラクトシダーゼの遺伝子を含むDNA発現ベクターをマウス骨格筋に個別に注入 注射後 ルシフェラーゼ活性は少なくとも2ヶ月間継続… https://t…
RT @fraisst: マウス筋肉に直接遺伝子導入 クロラムフェニコールアセチルトランスフェラーゼ、 ルシフェラーゼ、ベータガラクトシダーゼの遺伝子を含むDNA発現ベクターをマウス骨格筋に個別に注入 注射後 ルシフェラーゼ活性は少なくとも2ヶ月間継続… https://t…
マウス筋肉に直接遺伝子導入 クロラムフェニコールアセチルトランスフェラーゼ、 ルシフェラーゼ、ベータガラクトシダーゼの遺伝子を含むDNA発現ベクターをマウス骨格筋に個別に注入 注射後 ルシフェラーゼ活性は少なくとも2ヶ月間継続… https://t.co/a2w052aqLZ https://t.co/TfSwXKvLUS
RT @tatiann69922625: ARN et
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RT @GauteNilsen: What consequences does this research have on the plasmid-contaminated mRNA vaccines ???
RT @GauteNilsen: What consequences does this research have on the plasmid-contaminated mRNA vaccines ???
RT @GauteNilsen: What consequences does this research have on the plasmid-contaminated mRNA vaccines ???
RT @GauteNilsen: What consequences does this research have on the plasmid-contaminated mRNA vaccines ???
What consequences does this research have on the plasmid-contaminated mRNA vaccines ???
Direct Gene Transfer into Mouse Muscle in Vivo | Science…. Little old Doctor Malone author on this paper, creep mass murder https://t.co/HTCccQd4C0
@FreeXRcise @markharboursha1 I'm an epidemiologist. Tell me I don't do research. Over 30 years of development isn't enough? https://t.co/jiIfcJPAmK Pfizer made no such claim.
@vrcoffeee Tiens, la technologie qui a permis de bosser là dessus vient de ce genre d'articles... qui date de 1990. https://t.co/v8oHWG4ggu
@Deevoee @InvestingMerc @Kevin_McKernan @RWMaloneMD Here’s another bitch slap https://t.co/lyTAchn0FH
RT @virusfantom: 11/n
@WickDa58207 @camipple Literalmente programação https://t.co/AqRCdr8nvd Fabricação https://t.co/H6LQTuxYCm https://t.co/IUT9HqLbXV Copiando rato pra humano https://t.co/NAGowxDZWo De coelho pra rato https://t.co/lB0wK3tbf4 Infecção de doença de um animal pra outra espécie https://t.co/t18ltjyd9s
@FrancoHuaccha @d_equalizer @larepublica_pe Jeje (Copy&Paste)'nt ISBN: 978-3-031-18902-9 978-3-031-18069-9 978-3-030-31433-0 DOI: 10.1002/eji.1830230749 10.1126/science.1690918 Tenia mas data desde el '20 pero este ocio no debe superar mis actividades labores. Una vez mi vocacional salia bueno para R+D pero no hice caso :D
@skepticalraptor Responses provided by Robet W Malone MD substack. https://t.co/OtejDDSBuX [1] https://t.co/Y297lyrQD0 https://t.co/2DzjbhCnoJ
Authors
RT @realJohnMK: Direct Gene transfer into muscle cells generating expression of the genes in the cells. Robert Malone; Williams P; Chong W;…
Direct Gene transfer into muscle cells generating expression of the genes in the cells. Robert Malone; Williams P; Chong W; Acsadi G; Jani A; Philip L. Felgner (1 March 1990). "Direct gene transfer into mouse muscle in vivo" https://t.co/CPVbXxcOBR
@RichChurchil @Sisu4Democracy You simply don't like facts. https://t.co/jiIfcJPAmK
This stuff goes back. 30+ years. This is just what we're allowed to know about. Thankfully some of 'their' plans require the technology to catch up. 'Direct gene transfer into mouse muscle in vivo - J A Wolff et al. Science. 1990. https://t.co/wI3d4JXqlA https://t.co/SUN7iYDj18
RT @AOEvcBreakthru: @realJohnMK Holy Hell! Good question!! Direct Gene transfer into muscle cells generating expression of the genes in the…
@realJohnMK Holy Hell! Good question!! Direct Gene transfer into muscle cells generating expression of the genes in the cells. Robert Malone; Williams P; Chong W; Acsadi G; Jani A; Philip L. Felgner (1 March 1990). "Direct gene transfer into mouse muscle in vivo" Protein expression was -> https://t.co/ov0BnCJqN1
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
@nelsonmaf @bodhi_rio https://t.co/Mzjjht3DDq
RT @virusfantom:
RT @ToeNegro: @NobelPrize If You connecting this prize to mRNA C19 vaccines, then why You not award Robert Malone who was pionnier of LNP t…
RT @ToeNegro: @NobelPrize If You connecting this prize to mRNA C19 vaccines, then why You not award Robert Malone who was pionnier of LNP t…
RT @ToeNegro: @NobelPrize If You connecting this prize to mRNA C19 vaccines, then why You not award Robert Malone who was pionnier of LNP t…
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
This is because it is true! Please stop the spreading of disinformation. He's not the sole inventor but he is the first among authors to author study showing how mRNA could heal humans. https://t.co/V4wl4XhgdS https://t.co/YMyoVu2QPm
@EBarchielliFi @daniel_kraft @RWMaloneMD @xprize @AspenInstitute Whatever you say. https://t.co/BZIewSvOpd https://t.co/35ipqkIk0x
@ministerVWS Ere wie ere toekomt. Das war einmal. Ik geloof de grondlegger v mRNA techniek eerder en bedank met liefde vd "gifprikken". https://t.co/Gu5V73Il1C - https://t.co/EhKDfI2347 - https://t.co/l0WGJFQvVv - https://t.co/KmifaNO4wb - https://t.co/RocgVvaFhW - https://t.co/HJNqGTM2VH https://t.co/oyIgeG4mzA
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
RT @ToeNegro: @NobelPrize If You connecting this prize to mRNA C19 vaccines, then why You not award Robert Malone who was pionnier of LNP t…
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
@seba1337 Malone je bil dejansko soavtor enega prvih člankov o vnosu mRNA v celice, katerega je vodil Philip Felgner, ki si je nagrado Roberta Kocha l. 2022 delil z Drewom Weissmanom. Za delo na Covid19 pa bi si zaslužil Zlato malino
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
@NobelPrize If You connecting this prize to mRNA C19 vaccines, then why You not award Robert Malone who was pionnier of LNP transfection platform and direct gene transfer into mouse muscle in vivo?: https://t.co/iELGzMtYAj
RT @scientistabe: Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on differen…
Post-scriptum: The original paper that was published in Science. At that time, Bob was a grad student working on different lipid formulations and construct. He hissed a fit with his supervisor and was discharged from grad school. https://t.co/0sNiEke8KT https://t.co/tmmRE2D8TV
@muzzleflash120 @BillSobel @Censored4sure Yep. https://t.co/jiIfcJPAmK
@LuvFotos @KarenStrine3 @StephenKite9 It's been in development for over 30 years. Who is gullible? https://t.co/1BkQX6KCWB
@Ham_to_the_Bone @leftwingtwit https://t.co/jiIfcJPAmK
#fvd #cda #vvd #d66 #sgp #groenlinks #bbb #ja21 #pvv #bvnl #op1 #bij1 #beau #jinek #nieuwsuur #tweedekamer #Telegraaf #Nrc #NOS #Rutte Direct Gene Transfer into Mouse Muscle in Vivo https://t.co/x003Vze6ID
生体内で
RT @ToeNegro: Teraz powoli do ludzi dociera co się wydarzyło podczas covidianizmu. Tacy ludzie jak Malone byli cenzurowani i oczerniani, po…
RT @ToeNegro: Teraz powoli do ludzi dociera co się wydarzyło podczas covidianizmu. Tacy ludzie jak Malone byli cenzurowani i oczerniani, po…
RT @ToeNegro: Teraz powoli do ludzi dociera co się wydarzyło podczas covidianizmu. Tacy ludzie jak Malone byli cenzurowani i oczerniani, po…
Teraz powoli do ludzi dociera co się wydarzyło podczas covidianizmu. Tacy ludzie jak Malone byli cenzurowani i oczerniani, podczas gdy promowano tylko wąski kąt jednej narracji. To był klasyczne budowanie masowej formacji hipnotyzującej masy. https://t.co/Y1nOJEX26f
@Intro2PH @Loudoun_Lady @Jusrangers It's been in development for over 30 years. https://t.co/1BkQX6KCWB
@LeeKurtiss @RWMaloneMD https://t.co/ns3cKfhzlm
@BeeJaayCee2 @57chiggins86 @Mangos195 @liedsuddenly @MdBreathe @drpaulmarik1 @RobertApter1 @BoydenGrayAssoc I said development. Another multiple syllable word that is apparently over your head. https://t.co/1BkQX6KCWB
@delasttours @ClaudeSteve6 @raoult_didier Malone ne travaille plus sur l'ARNm depuis son dernier article, en tant que co-auteur, publié en 1990. Soit, la bagatelle de 33 années. https://t.co/aZdnPQLwDI De plus, Malone, n'a jamais travaillé sur la technologie vaccinale à ARNm.
@T_Johnny_ @StabellBenn Jeg har skam hele arsenalet klar til dig, spørgsmålet er om du er rækbar. https://t.co/Z7VW0VwaqW https://t.co/mnEFzQJr0H
RT @willas69: @MilkaWeisz @AngeloLaValle6 @DrPaoloMezzana Le prime ruote del carro erano Karikò, Felgner e Weissman;Malone era solo uno dei…
@MilkaWeisz @AngeloLaValle6 @DrPaoloMezzana Le prime ruote del carro erano Karikò, Felgner e Weissman;Malone era solo uno dei 5 collaboratori di Felgner che hanno scritto questo articolo: https://t.co/iocyJT2fyT Tutta la teoria del "padre" è nata perchè la moglie di Malone era entrata in Wikipedia come editor inserendolo.
@Rogue_Jedi_Theo @KyAngel72 @Lukewearechange https://t.co/YkZTryKwsI https://t.co/AThcDrAgzD https://t.co/VyVZWw41Ns https://t.co/kDz8oPdQay https://t.co/rDEoD6Q5vk https://t.co/zOK9Jjo6Qw https://t.co/ROR7ak9v7h https://t.co/h4vw6qOEWo https://t.co/wK0U16KqtO https://t.co/ROR7ak9v7h
@escira83 @tir98ion @Baskerville_Gui @gisbert_ruben @menudotiarro https://t.co/3EZrTmLf7p
RT @scientistabe: @HeyNurseKat @JohnCallister14 @BerryTartlet @Sharky_vs_Evil @AnnaSova17 @jonathanstea @TravIsScience Said that guy that o…
@HeyNurseKat @JohnCallister14 @BerryTartlet @Sharky_vs_Evil @AnnaSova17 @jonathanstea @TravIsScience Said that guy that only had an accessory role in the work of cationic lipids for nucleic acid delivery in vivo (lightyears away from the actual product) https://t.co/3O426hOKmQ, that lives on Substack subscriptions, and all served to us on Rumble? Bro! https://t.co/wR9D4FsUTk
@tkielecki @Tuathee @PiotrWitczak_ To są podstawy tej platformy: https://t.co/Y1nOJEWugH Warto dowiedzieć się co ma do powiedzenia na temat pseudoszczepionek na covid człowiek stojący za tą platformą, czyli Robert Malone. Ktoś mógłby się zdziwić.
@Tronn206 @HenningTveit @DrAseemMalhotra 1. Normally the 3 phases are done sequentially with analysis between each. These were in parallel. 2. Generally there isn't a large pool of willing participants for studies, but people were clamoring to participate. 3. >30 years isn't enough? https://t.co/1BkQX6LaM9
@johnlundnyvang1 @sebdor Og denne fra Science i 1990: https://t.co/mnEFzQJr0H
@amendez5525 @polindromes @DANIELQT7 https://t.co/I71A7yLBIz Un ejemplo de que el uso de RNA y DNA se puede usar como terapia y no solamente como provocadores de respuestas inmunes. Este dato es para aquellos "anónimos arrogantes con nombres y apellidos falsos.
@Jikkyleaks @Kevin_McKernan https://t.co/9KGTBU9H7l It gets even worse
RT @KSautisticdad: @RWMaloneMD https://t.co/39E3uPvfxt
@RWMaloneMD https://t.co/39E3uPvfxt
@psychoticdream1 @RWMaloneMD Wolff, J.; Malone, R.; Williams, P.; Chong, W.; Acsadi, G.; Jani, A.; Felgner, P. Direct gene transfer into mouse muscle in vivo. Science 1990, 247, 1465–1468. [Google Scholar] [CrossRef] [PubMed]
@truedatdatdamn @SpartaJustice You keep calling Malone "the creator of MRNA <sic>" He is the only one in the natural science field making that claim, including the other authors of his most cited RNA paper (DOI: 10.1126/science.1690918). He's most likely jealous that Weissman and Karikó are up for the Nobel.
@HislopMD I keep this citation on hand for them. https://t.co/1BkQX6LaM9
@alfredfischer17 1990: "Direkter Gentransfer in den Mausmuskel in vivo" Wolff Malone Williams Chong Acsadi Jani Felgner RNA-& DNA-Expressionsvektoren, die Gene für..Luciferase enthielten, wurden #invivo in die Maus-Skelettmuskulatur injiziert Proteinexpression nachweisbar https://t.co/eiJi9IibIM
@WellThtsFabulus It has been in development for over 30 years and is fully approved. It's not experimental. https://t.co/1BkQX6KCWB
@kaye_wadland @RWMaloneMD Just for your edification Kaye. https://t.co/WLqQVLkBMg
This is the 1990’s article on the beginning of experimenting with a temporary messenger to send fake code to RNA, in mice. We should never have messed with this. People are the mice now. https://t.co/ow8Qb8NlSm
amis, pas grave! Voir son passé. 7 auteurs! https://t.co/2j1ylCDPcr https://t.co/eV9l0kuDmg https://t.co/1XfPBpaC02 A travaillé avec Michael Callahan Callahan, Michael DARPA, United States https://t.co/sxPXbZYQ2Y
RT @karinstuiveberg: @Lily4Lily2 1 vd grondleggers vd huidig gebruikte techniek @RWMaloneMD https://t.co/Gu5V73Il1C waarschuwt al vanaf dag…
@Lily4Lily2 1 vd grondleggers vd huidig gebruikte techniek @RWMaloneMD https://t.co/Gu5V73Il1C waarschuwt al vanaf dag 1. Ze wisten precies waar t grootste gevaar zat en zit. https://t.co/2ZEdDwBhwR Om "de message" afgeleverd te krijgen moet het natuurlijk immuunsysteem worden verzwakt. https://t.co/rdLdhbXPES
@Wheezer713 https://t.co/Cxpr2PBY36
@jez_burns @rickitick43 @Vae_____Victis @elonmusk Yes - https://t.co/bFUSNicVJb This is the singular paper that he was not even the lead author on and now claims he is 'the inventor of MRNA vaccines' - a claim that is a ridiculous lie.
@Rossys_Road @JamieSale https://t.co/04Jzqt9jmk (5) > https://t.co/Gu5V73qJD2 - https://t.co/2ZEdDwjG8h https://t.co/EAPmCFV9gn
@cronksciswag @JamieSale @cronksciswag nice article, i will get back to you once I compare with https://t.co/d4BGI01CpW Thank you!
El documento histórico para la investigación de ARNm fue en 1990, que reveló que inyectar partículas virales en una célula, sin ajustes en las partículas virales, hace que la célula comience a reproducir la partícula viral independiente del virus. https://t.co/sJRhTGev7s
@UltiGuard @julbutch @DrEliDavid @elonmusk https://t.co/gs6UuJBOmF
@rt7683 @jason_willz1 (4) Feeling publicly humiliated yet?
@Adamlegend350 @Panpsyche @The13thBox @IRABENIL @peter_donnelly @B_A_Clarke @cantartiepiteti @AlanRMacLeod https://t.co/Xb1dAdcJLV The first "in vivo" study I could find is from 1990 lmao
@Karon25041119 @thesassymicrobe @drsimonegold @RFKHumanRights Graduate student in biology in the late 1980s at the Salk Institute for Biological Studies, he injected genetic material—DNA and RNA—into the cells of mice https://t.co/DyomufbHxD
RT @alexandrosM: It leads to this page, that only shows an affiliation for the first author, who is indeed from the University of Wisconsin…
@GaltJjohn @julie_kelly2 Also, he's wasn't the Principal Investigator on the related publications, nor even the first author. The P.I. appears to have been Philip Felgner. The first author (on the Science paper: https://t.co/3TpBCyiVCG) was Jon Wolff. Malone is listed 4th out of 5 on the patent.
@eshed_lin @AArgoetti אם כבר, אז יחד עם שני הבכירים Wolff and Felgner על המאמר המשותף ב science על הזרקת RNA לשריר עמ לבטא חלבון מסוים https://t.co/8pItscGDjT
@DrLadyShorts @Jimmy_Dee2 https://t.co/bLxknJTWnx RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and β-galactosidase were separately injected into mouse skeletal muscle in vivo.
#5 筋肉内投与によるnaked DNA・RNA送達 DDS技術を有さない裸のDNA・RNAを筋肉内投与したところ、筋細胞で発現が認められた。RNA投与では18時間後で最大に達する一過性の発現であり、DNA投与では60日間持続した、とのこと。 今ではLNPが主流だが、源流たどると面白いな https://t.co/36T5GwvDKu
RT @glopllu69: @Santi_lu5859 @George_Orwelll https://t.co/TrleA7OiLQ https://t.co/QRJIHGyXXf Así que este "tipejo" que le escribe sabe que…
@Santi_lu5859 @George_Orwelll https://t.co/TrleA7OiLQ https://t.co/QRJIHGyXXf Así que este "tipejo" que le escribe sabe que Malone, en su estancia en un laboratorio, hizo eso y nada más. Así que lo de "inventar" es algo exagerado
@HeyNurseKat @reneaafko @DaleEnright2 @AshleyFoxRPN @LMCERL123456 @Answers4Sean @Puppieskitts @DougEyolfson @P_McCulloughMD @CPC_HQ At best, he contributed to the proof of principles of the lipids used for delivering nucleic acid in vivo. He was not the first author, neither the senior author of the seminal paper, and quickly dropped from the project after this publication. https://t.co/3O426hPico
@beefbaloney /3 1990 https://t.co/nQ6eqrnOm7
@nabopi @AgnieszkaSzust3 Technologia transfekcji komórek za pomocą mRNA w otoczkach lipidowych: Pierwszy patent i publikacja należy do Roberta Malone et al. z roku 1988-1989 w Salk Institute: 1. https://t.co/C7S5XUdjF8 2. https://t.co/Y1nOJEWugH
@zerohedge https://t.co/Gu5V73qJD2 - https://t.co/21molH2eSs - https://t.co/IfdnMXoMP2 - https://t.co/ucDBgSOX1R - https://t.co/CunIPmfs3e - https://t.co/nOJhCw9bN4 - https://t.co/hfkYsm2veR - https://t.co/xlqlJNvzHi - https://t.co/gwCwe8OeBy
RT @DarwinEmmiYedek: Gelelim mRNA tarihçesine. mRNA keşfi 1960'a dayanıyor. https://t.co/82m7EO6hmL 1978 yılında lipozom kullanarak mRNA’n…
Gelelim mRNA tarihçesine. mRNA keşfi 1960'a dayanıyor. https://t.co/82m7EO6hmL 1978 yılında lipozom kullanarak mRNA’nın insan ve fare hücresine ilk nakli gerçekleşti. https://t.co/vQB2CdZgx2 Hayvan deneyleri yıl 1990 https://t.co/33vSc7kic6
@YlmazKu19119629 1990 yılında farelerde mRNA transferinin protein oluşturduğunu gösterdiler. https://t.co/fokH2epVYB
RT @NicoleTenev: Dr Malone did the study, https://t.co/Y0vzgFzL5W. https://t.co/7cutJ9Rm8z https://t.co/3lPaVdbX2G
Dr Malone did the study, https://t.co/Y0vzgFzL5W. https://t.co/7cutJ9Rm8z https://t.co/3lPaVdbX2G https://t.co/L3VbG1eLiv
RT @alexandrosM: It leads to this page, that only shows an affiliation for the first author, who is indeed from the University of Wisconsin…
@HeyNurseKat Time to piss off Bob one more time: "Bro, you did not invent mRNA technology. At best you worked on cationic lipids during your time at Vical to deliver nucleic acids and that's it. You are neither an immunologist nor a virologist by training". https://t.co/0sNiEkdAVl
@renkatroussier @StephLaSaleBete Bob a horreur qu'on lui rappel qu'il n'a pas invente l'ARNm, ni le vaccin a ARNm, et que sa seule contribution minime a ete de travailler sur une formulation de lipides cationiques pour la delivrance d'acides nucleiques, avant de quitter sa these. https://t.co/0sNiEkdAVl
@Dr_Pilgrim @Castaway1977 @Juan_Carlos2274 @LekLaial @Buenrollo13 @AngelGarciaMon8 @AlejandroCazo18 @carachisteguiri @NuevoParadigma3 @Seheiha @TanTinTao https://t.co/WpvKXT6vDA
Now let's cover some history... The first production of a protein encoded by RNA was in 1990, on a team which involved Malone, but Wolff was the lead author - this was during his time at Vical, where he was working for Felgner. https://t.co/L48Io8jkjr
@PeretteThomas @EdoxusOne @mochepourdevrai @DeBunKerEtoiles Nouveau? Ca fait plus de 30 ans que les scientifiques travaillent sur ce sujet. A priori vous ne maitrisez pas le sujet. https://t.co/LjTshtIG4e
@GGZ_71 @CherryMcG23 @progs4life @Appledust7 @NEJM @P_McCulloughMD @PierreKory @GVDBossche @NicoleSirotek @richardursomd @akheriaty @molsjames @VPrasadMDMPH @MMcDonaldMD @JamesTodaroMD @stefanireinold @Stuckelberger @lifebiomedguru @DrOz @DrZachBush @MartinKulldorff @DrJBhattacharya @dockaurG I'm sorry, could you please point out the 50 doctors you speak of that are involved in these papers on which Dr. Malone is an author? https://t.co/E5jZ05job3 https://t.co/MZqE0s4wqS https://t.co/smr7PVbpFK
@spursonfifa @StephenMosby @Ianrfc55 @AlBowers1 @RealDeniseWelch @DAzza https://t.co/SFtFsQ6qSH
@spursonfifa @StephenMosby @Ianrfc55 @AlBowers1 @RealDeniseWelch @DAzza https://t.co/SFtFsQ6qSH
RT @HarunCenkErman1: 11/n
11/n
@graham_in_mexic @Mc1978Tom @logosaetos @DrTinaPeers https://t.co/snXGX0zwsD
@juanes_parza 2️⃣ Comprobación de que vectores lipídicos con ARN y ADN, una vez inyectados en células musculares de ratón, logran inducir la expresión de una proteína (Wolff JA, Malone RW, Science 1990). https://t.co/UPIvZeoZ7A Estas fueron sus dichosas contribuciones.
@KarenDober @tedbrassfield @CPC_A1 @indiaarie @Neilyoung https://t.co/lWKWa4BeZ3
@Stephen25730769 @KylieVanHodl @SteveLessner @joerogan https://t.co/Y6ZVmk71kW Here, Malone co-authored a way to insert mRNA into mice. This was not further built upon. This is around when mRNA was "given-up" on as a vaccination method, though others did take from this research and further study the concept.
RT @Very_0wn: Nature: mRNA-based therapeutics — developing a new class of drugs (2014): https://t.co/r3HY2N37jE @RWMaloneMD's "Direct gene…
@RdRoth @alisonsheena1 @LBC "Cationic liposome-mediated RNA transfection" & "Direct Gene Transfer into Mouse Muscle in Vivo" were the papers Malone co-authored in '89 & '90. Far cry from "inventing" a Vaccine.
@Czu21 @susan_lydick @DrEricDing @kurtbardella @SRuhle @Spotify @SpotifyUSA I'm aware he had Moderna and had a severe reaction to second dose (stage 4 hypertension) Robert Malone was the first person to demonstrate mRNA Transfection into the cell; First name on in vitro paper https://t.co/0gjFdUemBY and second name on the In Vivo https://t.co/tkFQVZwYJN
@lea_bradford @DrEricDing @kurtbardella @SRuhle @Spotify @SpotifyUSA Do you really consider being the first person to use a lipid carrier to transfect mRNA into cells as 'did some work' https://t.co/CZOu5DxkYC https://t.co/SYnMbqLenr
@danielle_dk @realist_ron @vlamers 30+ years https://t.co/1BkQX6KCWB
@heburt @Dgarfieldrouen @Poulin2012 •Jon A. Wolff, Phillip Williams, Robert Malone et al., « Direct Gene Transfer into Mouse Muscle in Vivo », Science, vol. 247, no 4949, 1990, p. 1465–1468 (PMID 1690918, DOI 10.1126/science.1690918, Bibcode 1990Sci...247.1465W, lire en ligne [archive])
@LaymansScience @mattletiss7 @GaryLineker @djlange Papers: 1. https://t.co/RN0uxc3Xzn 2. https://t.co/UWD88x61b2 3. https://t.co/pj7uHBe3Dx 4. https://t.co/arSkQlSFbc 5. https://t.co/wi5lJG9ICV 6. https://t.co/gVjoFae2BO 7. https://t.co/1vECCNc2go
@VAS20804492 @JoeDanMedia @CarlsbadDodger Wolff never claimed to be the singular inventor of mRNA like Malone all of a sudden did. The reason that article never mentioned Malone is because he is listed second in The paper. So in no way is Malone the inventor or mRNA, can only be a contributor. https://t.co/6zvPW7QeeO
@Max54239219 @backtolife_2019 NIH also have page showing he working on the tech in 1990. Patent was filed later. https://t.co/oZFdMSuTdT
@BamiWai2 @RaymondArroyo Here you can also see it from NIH webpage :1990. https://t.co/oZFdMSuTdT
@OzeiasSouza19 @revistaoeste @MrciaRo84285603 Esse 1o gráfico não fui eu q fiz, eh verdadeiro, mas ta desatualizado, ja t avisei, e te mandei o q eu acabei de fazer, confere vc! Meu critério busca foram obitos. E em relação ao dr Malone, a lupa esta errada! Segue mais um link https://t.co/IqsT1g1HZI https://t.co/bUs7sYaftx
RT @alexandrosM: The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on…
RT @Very_0wn: Nature: mRNA-based therapeutics — developing a new class of drugs (2014): https://t.co/r3HY2N37jE @RWMaloneMD's "Direct gene…
@HelloAndrew @KellyScaletta @hodgetwins He never said he developed this vaccine he invented the methodology along with 6 other people - here’s the paper. Look through google scholar and tell me he’s not qualified to give his opinion. https://t.co/isSqlVbKHo
RT @realCalamityJen: @_thekidinside @Rothbard1776 @joerogan You're not very bright. https://t.co/NVtMyKlfKQ https://t.co/LnSfRHKKtQ https:/…
@AdamAlfi @Andyjillins_SAS Sorry what? mRNA was discovered by Brenner et al in the 60's. Malone had a tiny contribution years later as part of Wolff et al 1990. https://t.co/rtG0MtrDl0 https://t.co/tI4kZoVHMM
@DirCronicaNorte Direct gene transfer into mouse muscle in vivo. J A Wolff et al. Science. 1990. https://t.co/4oKHKxvwRr Malone, con otros muchos, colaboró en una primera fase en la que se buscaba un canal para transmitir el ARN mensajero
2/ HERE'S WHAT A REAL CITATION LOOKS LIKE: 3 – Wolff et al. (1990) Direct gene transfer into mouse muscle in vivo. Science. 4 – Verbeke et al. (2019) Three decades of messenger RNA vaccine development. Nano Today. 5 – Dimitriadis (1978) Translation of rabbit globin mRNA +
@beverleyturner @percytheparrot Not quite, ribosome protein synthesis is older than plant life. mRNA was discovered by Brenner et al in the 60's. Malone had a tiny contribution years later as part of Wolff et al 1990 https://t.co/rtG0MtrDl0 https://t.co/tI4kZoVHMM
RT @alexandrosM: The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on…
@_thekidinside @Rothbard1776 @joerogan You're not very bright. https://t.co/NVtMyKlfKQ https://t.co/LnSfRHKKtQ https://t.co/5Njb1s2lZB https://t.co/XE1hI3t15O https://t.co/OnNUqCTOSE
@Tenacious__ED @MBOZE @ArtValley818_ And another https://t.co/2tado4PPrZ
RT @alexandrosM: The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on…
@sunnyright Weird flex. That means he's an idiot and it's totally cool to censor him? https://t.co/NVtMyKlfKQ https://t.co/dhVAeL8IjG https://t.co/B6rLX3gg1U https://t.co/XE1hI3t15O https://t.co/vyYFtrr75q
@mholkers @thierrybaudet Ja, en kijk vooral even naar de verwijzing (5)....https://t.co/Gu5V73Il1C https://t.co/lw2BvZA1FS
@mholkers @thierrybaudet Jij hebt toch zo'n grote waffel! Nog geen voetnoot in de ontwikkeling v deze troep? https://t.co/l0WGJFQvVv - https://t.co/04JzqtqUKU - lees 5 ..https://t.co/Gu5V73Il1C daarom dus #domvolk!! https://t.co/rYKb9fz0En
@ptw771 @Riga75050534 @thierrybaudet Ik ken het stuk. Was er niet v onder de indruk. De bedoeling was duidelijk. Wat denk jezelf.. https://t.co/l0WGJFQvVv - https://t.co/04JzqtqUKU zie 5.. https://t.co/Gu5V73Il1C ik lees je later nog een keer...
@Food4ears @thierrybaudet Hier wat voor je fabeltjeskrant blinde klapjosti.. https://t.co/l0WGJFQvVv - https://t.co/04JzqtqUKU ( 5 ) https://t.co/Gu5V73Il1C https://t.co/tTQaDxW8L1
@ptw771 @Riga75050534 @thierrybaudet Speciaal voor jou, het #domvolk.. https://t.co/l0WGJFQvVv - https://t.co/04JzqtqUKU ( 5 ) https://t.co/Gu5V73Il1C https://t.co/Xu5GR9FAHm
Speciaal voor het #domvolk.. https://t.co/l0WGJFQvVv - https://t.co/04JzqtqUKU ( 5 ) https://t.co/Gu5V73Il1C https://t.co/noFVhqDcxY https://t.co/NXBUXemQN2
RT @alexandrosM: The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on…
@GZuckerman The paper by my uncle is here: https://t.co/Qq0IkQJ1ki The book by @GZuckerman is here: https://t.co/ikzN9M8mbW
@Nopanaden @Vuelcabuques En este otro de 1990 también Malone es co-autor Es este https://t.co/JG1saTEPG9 Estos son los pasos de gigante que abrieron el camino hacia las actuales vacunas. En lo anterior al 89 el parecido de familia con las actuales vacunas es muy, muy lejano https://t.co/mROp1wBSIv
@nicopieterse @MarionKoopmans @RWMaloneMD Je moet niet alles geloven wat je pp internet leest. Zeker niet die lachwekkende "fact checkers"
Nature: mRNA-based therapeutics — developing a new class of drugs (2014): https://t.co/r3HY2N37jE @RWMaloneMD's "Direct gene transfer into mouse muscle in vivo", mRNA - 1990. What are genome-editing and CRISPR-Cas9? (2020): https://t.co/BwukMOCazG https://t.co/PHGMFxldPE https://t.co/pijKLUMcEJ
@Rosessells @EricTopol @PennMedicine @moderna_tx @BioNTech_Group @damiangarde @statnews @dgelles @NYTScience https://t.co/2ZEdDwBhwR - "managed to make it work in mice" > @RWMaloneMD & team. https://t.co/Gu5V73Il1C https://t.co/b1a33zYnZ9
@Rosessells @EricTopol @PennMedicine @moderna_tx @BioNTech_Group @damiangarde @statnews @dgelles @NYTScience https://t.co/Gu5V73Il1C https://t.co/CyjBFTOxz9
@itzRichard_K @Theo61116663 @StijnCop86 @AbOsterhaus @kkariko Wat zeg ik nou. Grondlegger vd huidige gebruikte mRNA techniek. Niet zelf dingen gaan verzinnen aub want dan zijn we gauw uitgeluld. https://t.co/04JzqtqUKU - https://t.co/Gu5V73Il1C https://t.co/QuoUNHAf5a
@Jason23328495 @BarryESharp @sj_ca1867 @Twitter They couldn't get it into the marketplace without a reliable way to store it and have a decent shelf life. The animal trials were successful https://t.co/oW2bJPjG87 https://t.co/PXPcL55lsu
Memo Direct gene transfer into mouse muscle in vivo https://t.co/Kp2kGMG5Jj 外来性のmRNAを生体内で翻訳・発現させるというmRNAワクチンのコアコンセプトの実証（1990）
Direct Gene Transfer into Mouse Muscle (in vivo, simulatie onderzoek) https://t.co/z9aERBKvkk
RT @ReasonedScience: @alexandrosM @alainpannetrat Next up is Wolff's paper where they just directly inject DNA and RNA into the muscle of a…
L'article de Stat renvoie à un article de 1990 et le attribue à l'Université du Wisconsin. En effet, si nous regardons le papier sur un catalogue moderne, cela semble confirmer :https://t.co/mRH8RUDpK5 https://t.co/B3TIE6W6bW
#Direct #gene #transfer into mouse muscle in vivo https://t.co/gPE1iNHQ7d
RT @alexandrosM: It leads to this page, that only shows an affiliation for the first author, who is indeed from the University of Wisconsin…
@PPutricide @SexySubmarine @devtrospective The paper cited: https://t.co/jaetEMgczU
RT @alexandrosM: The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on…
RT @alexandrosM: The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on…
@alexandrosM @alainpannetrat Next up is Wolff's paper where they just directly inject DNA and RNA into the muscle of a mouse and show the DNA/RNA was expressed as a protein. No DOTMA used. https://t.co/FKXLFqi2Ch
The Stat article points to a 1990 paper and credits it to the University of Wisconsin. Indeed, if we look at the paper on a modern catalog, this seems to bear out: https://t.co/aV8FIwgOR0 https://t.co/JB9JmwKrN6
RT @gbosslet: The first paper I can find on this was in @ScienceMagazine in 1990 and showed the half-life of RNA in muscle cells to be less…
@johnrich {61}. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, et al. Direct gene transfer into mouse muscle in vivo. Science. 1990;247:1465–8. doi: 10.1126/science.1690918. [PubMed] [CrossRef] [Google Scholar].
@dandridge_jerry @VolumeRose @LBC To say Dr Malone "invented" the mRNA technology is a stretch. He did some seminal work with others in 1989 and 1990 in mice ("Cationic liposome-mediated RNA transfection" & "Direct Gene Transfer into Mouse Muscle in Vivo"). Now he's a discredited crank. https://t.co/QDIehiSbwk
RT @virusfantom: 11/n
@gfpetrarca @SeeingRED111 @facepalmhard @sbb_md @ARadDocDates You’re twisting words, I said a vaccine PRIOR to COVID, not the “COVID vaccine”. mRNA technology has been under study since Robert Malone discovered it in the 1990’s. https://t.co/sUFZ7gWDGc
@jor6s @friznitz5 @7_JS_17 @drdavidsamadi https://t.co/5avKFDpZb5 https://t.co/9EORe5e2u6 Now @jor6s since I have proved my statements that he is an expert, can you please shut the fuck up!!!
FWIW, w/ deluded family & friends
@edizzle422 @liquidcloud9 @ABC so I don't know if "quack" is an accurate term. https://t.co/Vp4NddY9uA
RT @gbosslet: The first paper I can find on this was in @ScienceMagazine in 1990 and showed the half-life of RNA in muscle cells to be less…
RT @gbosslet: The first paper I can find on this was in @ScienceMagazine in 1990 and showed the half-life of RNA in muscle cells to be less…
RT @gbosslet: The first paper I can find on this was in @ScienceMagazine in 1990 and showed the half-life of RNA in muscle cells to be less…
@DenGanglere @Permikin2 @michael97878751 Direct gene transfer into mouse muscle in vivo , Science, Volume 247, 1990, pp. 1465-1468 Cationic liposome-mediated RNA transfection , Methods in Enzymology, Vol. 217, 1993, pp. 644-654
https://pubmed.ncbi.nlm.nih.gov/1690918/ 2/
@RaquelRocoBent1 Si però és el que és hi ha, mirat això: Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, et al. Direct gene transfer into mouse muscle in vivo. Science. (1990) 247:1465–8.
@waltermasterson Wolff, Jon A.; Malone, Robert W.; Williams, Phillip; Chong, Wang; Acsadi, Gyula; Jani, Agnes; Felgner, Philip L. (23 March 1990). "Direct Gene Transfer into Mouse Muscle in Vivo".
@21schilling Gene Therapy. Direct Gene Transfer into Mouse Muscle in Vivo Jon Wolff, Robert Malone, Phillip Williams, Wang Chong, Gyula Acsadi, Agnes Jani, Philip Felgner Departments of Pediatrics and Genetics, Waisman Center, University of Wisconsin, Madison, WI, 1990 https://t.co/QQyD5rb1Um
5) Weide et al. “Direct injection of protamine-protected mRNA: results of a Phase 1/ 2 vaccination trial in metastatic melanoma patients”. J. immunotherapy. 2009 6) Wolff et al. “Direct gene transfer into mouse muscle in vivo”. Science. 1990
@NoWayBa34922355 @RWMaloneMD @Wikipedia @waybackmachine @BigBrotherWatch Direct Gene Transfer into Mouse Muscle in Vivo Jon A. Wolff, Robert W. Malone, Phillip Williams, Wang Chong, Gyula Acsadi, Agnes Jani, Philip L. Felgner | March 1990
@BlueAnonShaman1 @wheezy_dobby @IanGraham1984 @LanFranDang @GregBuckner @CNN Wolff, J., Malone, R., Williams, P., Chong, W., Acsadi, G., Jani, A., and Felgner, P. (1990) Direct gene transfer into mouse muscle in vivo. Science 247(4949): 1465-68
Direct Gene Transfer into Mouse Muscle in Vivo https://t.co/1EowB1GiLP DNAルシフェラーゼ発現ベクターの注射後、ルシフェラーゼ活性は少なくとも2ヶ月間筋肉に存在していました
Direct gene transfer into mouse muscle in vivo https://t.co/jEJkoSHFvV
@gofourth777 @joshschr @naomirwolf See - Direct gene transfer into mouse muscle in vivo https://t.co/oBs99slgfw
@luquejp @allegrettto @AdrianBelinche @juandoluna Este tipo de vacuna no es nada nuevo. Desde 1990 se vienen haciendo experimentos. Fuente: Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, et al. Direct gene transfer into mouse muscle in vivo. Science. (1990) 247:1465–8. https://t.co/43cMfRFbAH
How it started as far as I can tell. Direct gene transfer into mouse muscle in vivo https://t.co/npbUjXOGHT
RT @cassinos_: @grooovybee Also mRNA vaccines were first reported effective in the 1990s, which laid the groundwork for the covid vaccine w…
@grooovybee Also mRNA vaccines were first reported effective in the 1990s, which laid the groundwork for the covid vaccine we have today! Here’s the study https://t.co/nEaYUPn98C
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