https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan was LOWER in CR wild mice by 2% on average. @Ken__Strain @BioLayne @foundmyfitness @KetoCarnivore Suggestion: inbred lab mice are defective models.
Does caloric restriction extend life in wild mice?
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Oct 2020 – Dec 2024Where it's discussed
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X / Twitter12 posts
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News10 articles
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Blogs8 articles
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Facebook3 posts
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YouTube2 videos
AI synopsis
What people are saying
This collection of discussions reveals a generally cautious yet engaged response to the publication, with several comments emphasizing that caloric restriction may not have the same effects in wild mice as in laboratory settings. Words like 'probably not' and references to specific mortality data showcase skepticism and analytical engagement, while mentions of broader implications and debates about models reflect the potential impact on future research.
Most posts agree that caloric restriction does not significantly extend lifespan in wild mice, with some noting the nuanced findings about mortality rates.
Posts show a moderate level of interest, with some acknowledging new insights, while others dismiss the topic as irrelevant outside lab settings.
Discussions include referencing specific studies, debating laboratory versus wild responses, and mentioning methodological details, indicating active engagement.
There is some recognition that the findings could influence future research directions, but many view the results as limited or context-specific, resulting in a neutral impact score.
Abstract in brief
- The study tested whether genetically wild-derived mice show lifespan and hormonal responses to caloric restriction similar to lab mice; they found hormonal changes but no significant increase in average lifespan.
- Despite no overall lifespan extension, the CR group had a higher early-life mortality but lower late-life mortality, and the longest-lived mice were all from the CR group, indicating some benefit.
- The authors suggest three possible reasons for these results: wild mice may not respond to CR as lab mice do, the CR diet might have been too severe for wild mice, or genetic differences in wild populations may influence the CR response due to domestication effects.
Top posts
Most liked on X and BlueskyDoes caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK3Q0rid
"Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves mid-life metabolic health in [some, biased] animal models." Doesn't work outside a lab. "Does caloric restriction extend life in wild mice?" https://t.co/fU8Mzh8yaN https://t.co/0OTX1VL5lb
@jacobmhands @KristerKauppi @mkaeberlein "Does caloric restriction extend life in wild mice?" https://t.co/lYgbAKMxhn
@serenedoc @BevTchangMD @JimJohnsonSci @DanielJDrucker @RotonyaC wild mice have been studied for example for their responses to calorie restriction. https://t.co/iMFDUj1Eje
@LammingLab @AlexanderMWolf7 @KristerKauppi Ah cool, I didn't know this study
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@jacobmhands @KristerKauppi @mkaeberlein "Does caloric restriction extend life in wild mice?" https://t.co/lYgbAKMxhn
RT @agingdoc1: Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK…
RT @agingdoc1: Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK…
RT @agingdoc1: Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK…
Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK3Q0rid
@LammingLab @AlexanderMWolf7 @KristerKauppi Ah cool, I didn't know this study
RT @JohnSpeakman4: @serenedoc @BevTchangMD @JimJohnsonSci @DanielJDrucker @RotonyaC wild mice have been studied for example for their respo…
@serenedoc @BevTchangMD @JimJohnsonSci @DanielJDrucker @RotonyaC wild mice have been studied for example for their responses to calorie restriction. https://t.co/iMFDUj1Eje
"Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves mid-life metabolic health in [some, biased] animal models." Doesn't work outside a lab. "Does caloric restriction extend life in wild mice?" https://t.co/fU8Mzh8yaN https://t.co/0OTX1VL5lb
RT @Sadrien_GW2: https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan wa…
RT @Sadrien_GW2: https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan wa…
https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan was LOWER in CR wild mice by 2% on average. @Ken__Strain @BioLayne @foundmyfitness @KetoCarnivore Suggestion: inbred lab mice are defective models.
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