Aging Cell December 2006 PMID 17054664

Does caloric restriction extend life in wild mice?

James M Harper, Charles W Leathers, Steven N Austad

Mentions

35
Peak: 4 in Feb 2023
across 5 sources since Oct 2020

Extended reach

169,577
potential audience

Total likes

114

Video views

3,641

Mentions per month

Oct 2020 – Dec 2024

Where it's discussed

  • X / Twitter12 posts
  • News10 articles
  • Blogs8 articles
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

This collection of discussions reveals a generally cautious yet engaged response to the publication, with several comments emphasizing that caloric restriction may not have the same effects in wild mice as in laboratory settings. Words like 'probably not' and references to specific mortality data showcase skepticism and analytical engagement, while mentions of broader implications and debates about models reflect the potential impact on future research.

AgreementModerate agreement

Most posts agree that caloric restriction does not significantly extend lifespan in wild mice, with some noting the nuanced findings about mortality rates.

InterestModerate interest

Posts show a moderate level of interest, with some acknowledging new insights, while others dismiss the topic as irrelevant outside lab settings.

EngagementModerate engagement

Discussions include referencing specific studies, debating laboratory versus wild responses, and mentioning methodological details, indicating active engagement.

ImpactNeutral impact

There is some recognition that the findings could influence future research directions, but many view the results as limited or context-specific, resulting in a neutral impact score.

Abstract in brief

  • The study tested whether genetically wild-derived mice show lifespan and hormonal responses to caloric restriction similar to lab mice; they found hormonal changes but no significant increase in average lifespan.
  • Despite no overall lifespan extension, the CR group had a higher early-life mortality but lower late-life mortality, and the longest-lived mice were all from the CR group, indicating some benefit.
  • The authors suggest three possible reasons for these results: wild mice may not respond to CR as lab mice do, the CR diet might have been too severe for wild mice, or genetic differences in wild populations may influence the CR response due to domestication effects.

Top posts

Most liked on X and Bluesky
AKA_Sadrien
@AKA_Sadrien · X

https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan was LOWER in CR wild mice by 2% on average. @Ken__Strain @BioLayne @foundmyfitness @KetoCarnivore Suggestion: inbred lab mice are defective models.

Oct 8, 2020 · 25 likes · 2 shares · 789 followers View post →
Agingdoc
@agingdoc1 · X

Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK3Q0rid

Feb 16, 2023 · 4 likes · 3 shares · 43,785 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

"Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves mid-life metabolic health in [some, biased] animal models." Doesn't work outside a lab. "Does caloric restriction extend life in wild mice?" https://t.co/fU8Mzh8yaN https://t.co/0OTX1VL5lb

Jun 12, 2021 · 4 likes · 2 shares · 28,306 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@jacobmhands @KristerKauppi @mkaeberlein "Does caloric restriction extend life in wild mice?" https://t.co/lYgbAKMxhn

Oct 4, 2023 · 1 like · 28,306 followers View post →
John Speakman
@JohnSpeakman4 · X

@serenedoc @BevTchangMD @JimJohnsonSci @DanielJDrucker @RotonyaC wild mice have been studied for example for their responses to calorie restriction. https://t.co/iMFDUj1Eje

Jan 13, 2022 · 1 like · 1 share · 11,996 followers View post →
Martin Borch Jensen
@MartinBJensen · X

@LammingLab @AlexanderMWolf7 @KristerKauppi Ah cool, I didn't know this study

Oct 2, 2022 · 1 like · 6,790 followers View post →

All mentions

Tucker Goodrich
@TuckerGoodrich · X

@jacobmhands @KristerKauppi @mkaeberlein "Does caloric restriction extend life in wild mice?" https://t.co/lYgbAKMxhn

Oct 4, 2023 · 1 like · 28,306 followers View post →
Steven Austad
@StevenAustad · X

RT @agingdoc1: Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK…

Feb 17, 2023 · 3 shares · 2,149 followers View post →
Richard Harper
@harpersnotes · X

RT @agingdoc1: Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK…

Feb 16, 2023 · 3 shares · 2,197 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK…

Feb 16, 2023 · 3 shares · 32,607 followers View post →
Agingdoc
@agingdoc1 · X

Does caloric restriction extend life in wild mice? (2006) James Harper, Charles Leathers, @StevenAustad https://t.co/tVzK3Q0rid

Feb 16, 2023 · 4 likes · 3 shares · 43,785 followers View post →
Martin Borch Jensen
@MartinBJensen · X

@LammingLab @AlexanderMWolf7 @KristerKauppi Ah cool, I didn't know this study

Oct 2, 2022 · 1 like · 6,790 followers View post →
Beverly G. Tchang, MD
@BevTchangMD · X

RT @JohnSpeakman4: @serenedoc @BevTchangMD @JimJohnsonSci @DanielJDrucker @RotonyaC wild mice have been studied for example for their respo…

Jan 13, 2022 · 1 share · 6,295 followers View post →
John Speakman
@JohnSpeakman4 · X

@serenedoc @BevTchangMD @JimJohnsonSci @DanielJDrucker @RotonyaC wild mice have been studied for example for their responses to calorie restriction. https://t.co/iMFDUj1Eje

Jan 13, 2022 · 1 like · 1 share · 11,996 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

"Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves mid-life metabolic health in [some, biased] animal models." Doesn't work outside a lab. "Does caloric restriction extend life in wild mice?" https://t.co/fU8Mzh8yaN https://t.co/0OTX1VL5lb

Jun 12, 2021 · 4 likes · 2 shares · 28,306 followers View post →
SmartNutrition
@SmartNutrition1 · X

RT @Sadrien_GW2: https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan wa…

Oct 8, 2020 · 2 shares · 2,633 followers View post →
LALA HUTCHISON
@lala_hutchison · X

RT @Sadrien_GW2: https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan wa…

Oct 8, 2020 · 2 shares · 40 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

https://t.co/ogfDjuBVYX Does caloric restriction extend life in wild mice? Answer ? Probably not, the average lifespan was LOWER in CR wild mice by 2% on average. @Ken__Strain @BioLayne @foundmyfitness @KetoCarnivore Suggestion: inbred lab mice are defective models.

Oct 8, 2020 · 25 likes · 2 shares · 789 followers View post →