December 2006 PMID 17112576

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

Marie Lagouge, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott, Bernard Geny, Markku Laakso, Pere Puigserver, Johan Auwerx

Mentions

35
Peak: 8 in Feb 2025
across 5 sources since Nov 2020

Extended reach

149,352
potential audience

Total likes

35

Video views

177

Mentions per month

Nov 2020 – Feb 2025

Where it's discussed

  • X / Twitter9 posts
  • News9 articles
  • YouTube8 videos
  • Blogs6 articles
  • Facebook3 posts

AI synopsis

What people are saying

This collection of discussions shows a generally positive view of resveratrol's potential, with many emphasizing its role in mitochondrial biogenesis and disease prevention, illustrated by mentions of activating key regulators like PGC1alpha, and comparing findings across different research labs. The tone is optimistic, and the language indicates a belief in meaningful health impacts from the findings.

AgreementModerate agreement

Most messages express support or interest in the positive effects of resveratrol on mitochondrial function and metabolic health.

InterestHigh interest

Discussions show high curiosity, especially about potential health benefits and mechanisms, reflected in comments about PGC1alpha activation and implications for diseases like Alzheimer's.

EngagementModerate engagement

Some posts go beyond simple agreement, referencing related research and mechanisms, indicating a moderate level of detailed engagement.

ImpactModerate impact

The discussions recognize the possible significance of resveratrol in healthspan and lifespan, suggesting it could influence future research and health strategies.

Abstract in brief

  • Resveratrol (RSV) enhances mitochondrial function and increases aerobic capacity in mice by activating SIRT1 and PGC1alpha, leading to improved oxidative phosphorylation and mitochondrial biogenesis.
  • The mechanism involves RSV decreasing PGC1alpha acetylation, which boosts its activity, and this process is dependent on SIRT1, as RSV has no effect in SIRT1-deficient cells.
  • RSV treatment protects mice from diet-induced obesity and insulin resistance, suggesting SIRT1 plays a crucial role in regulating energy and metabolic homeostasis in both mice and humans.]

Top posts

Most liked on X and Bluesky
Nick Norwitz MD PhD
@nicknorwitz · X

Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory could help those at high risk for #Alzheimers disease (#ApoE4) by help glucose metabolism (Ketone good too!) https://t.co/s0QmAoCgIa https://t.co/pjuBLcVcli

Apr 1, 2021 · 21 likes · 5 shares · 108,829 followers View post →
Wilko Strzebor - Raróg
@vayavada_Vedin · X

o czym świadczy wydłużenie czasu biegu i zużycie tlenu we włóknach mięśniowych po jego zastosowaniu - zwiększa ekspresję genów fosforylacji oksydacyjnej i biogenezy mitochondriów Zatem RSV może przeciwdziałać wpływowi bS na mitochondria. https://t.co/saPA5RsQnZ

Jun 20, 2021 · 3 likes · 1 share · 18,754 followers View post →
Christin Glorioso, MD PhD
@DrGlorioso · X

@agingdoc1 @BradStanfieldMD @CharlesMBrenner And papers by labs other than Guarente lab progeny labs such as Brunet lab and Auwerx lab that support a role for Sirtuins and/or Res in lifespan/healthspan https://t.co/YEjQ1bls47 https://t.co/XVT24fA7mh

Apr 15, 2022 · 3 likes · 1,622 followers View post →
tiktak
@taisukun · X

レスベラによってPGC1αの活性化を介してミトコンドリア数が増加する。 https://t.co/NAABzSYv1O

Nov 11, 2020 · 2 likes · 302 followers View post →
Steve Cooksey
@diabeteswarrior · X

RT @nicknorwitz: Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory…

Apr 1, 2021 · 5 shares · 7,810 followers View post →
Americana
@lonestarangle · X

RT @nicknorwitz: Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory…

Oct 18, 2021 · 5 shares · 6,619 followers View post →

All mentions

Christin Glorioso, MD PhD
@DrGlorioso · X

@agingdoc1 @BradStanfieldMD @CharlesMBrenner And papers by labs other than Guarente lab progeny labs such as Brunet lab and Auwerx lab that support a role for Sirtuins and/or Res in lifespan/healthspan https://t.co/YEjQ1bls47 https://t.co/XVT24fA7mh

Apr 15, 2022 · 3 likes · 1,622 followers View post →
Americana
@lonestarangle · X

RT @nicknorwitz: Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory…

Oct 18, 2021 · 5 shares · 6,619 followers View post →
Send Light,Rain
@rain_send · X

RT @nicknorwitz: Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory…

Oct 18, 2021 · 5 shares · 610 followers View post →
Stacking please wait...
@StackingPlsWait · X

RT @dvx_ardorensis: o czym świadczy wydłużenie czasu biegu i zużycie tlenu we włóknach mięśniowych po jego zastosowaniu - zwiększa ekspresj…

Jun 20, 2021 · 1 share · 1,262 followers View post →
Wilko Strzebor - Raróg
@vayavada_Vedin · X

o czym świadczy wydłużenie czasu biegu i zużycie tlenu we włóknach mięśniowych po jego zastosowaniu - zwiększa ekspresję genów fosforylacji oksydacyjnej i biogenezy mitochondriów Zatem RSV może przeciwdziałać wpływowi bS na mitochondria. https://t.co/saPA5RsQnZ

Jun 20, 2021 · 3 likes · 1 share · 18,754 followers View post →
Steve Cooksey
@diabeteswarrior · X

RT @nicknorwitz: Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory…

Apr 1, 2021 · 5 shares · 7,810 followers View post →
@circadianRX
@annavwellness · X

RT @nicknorwitz: Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory…

Apr 1, 2021 · 5 shares · 3,315 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

Fact of day 404: Resveratrol(high-dose, ~2g) activates master regulator of mitochondrial biogenesis, PGC1alpha. In theory could help those at high risk for #Alzheimers disease (#ApoE4) by help glucose metabolism (Ketone good too!) https://t.co/s0QmAoCgIa https://t.co/pjuBLcVcli

Apr 1, 2021 · 21 likes · 5 shares · 108,829 followers View post →
tiktak
@taisukun · X

レスベラによってPGC1αの活性化を介してミトコンドリア数が増加する。 https://t.co/NAABzSYv1O

Nov 11, 2020 · 2 likes · 302 followers View post →