PubHawk
Am J Physiol Endocrinol Metab June 2007 PMID 17299079

A high-fat, ketogenic diet induces a unique metabolic state in mice.

Adam R Kennedy, Pavlos Pissios, Hasan Otu, Russell Roberson, Bingzhong Xue, Kenji Asakura, Noburu Furukawa, Frank E Marino, Fen-Fen Liu, Barbara B Kahn, Towia A Libermann, Eleftheria Maratos-Flier

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Mentions

57
Peak: 5 in Jan 2019
across 6 sources since Nov 2018

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Nov 2018 – Mar 2024

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AI synopsis

What people are saying

The discussions reflect a strong interest and engagement with the article's findings, exemplified by references to specific research papers, such as the 2007 study on gene expression, and debates about physical laws and biological mechanisms. The tone is often questioning and skeptical, especially when challenging established ideas about thermodynamics and human dieting, indicating a recognition of the potential impact of these findings on dietary science.

AgreementModerate agreement

Most discussions acknowledge the findings of the dietary study, though some challenge its implications for humans or Physics, indicating general support but also skepticism.

InterestHigh interest

Posts show high interest through detailed references to other studies, mechanisms, and challenging ideas, suggesting engagement with the scientific content.

EngagementHigh engagement

Several comments debate the study’s validity and implications, including references to specific data, techniques, and conflicting research, showing deep engagement.

ImpactModerate impact

The discussions suggest this research influences opinions on diet and metabolism, especially in the context of how it questions existing models and beliefs about fat loss and diet effects.

Abstract in brief

  • A high-fat ketogenic diet (KD) causes significant changes in mice's energy use and gene activity, leading to weight loss even when calorie intake is the same as other diets.
  • Mice on KD showed increased fat burning and reduced fat production, with their gene expressions supporting this shift; their weight stabilized at about 85% of their original weight.
  • Transitioning obese mice from a high-sugar, high-fat diet to KD resulted in weight loss, better blood sugar regulation, and higher energy expenditure, indicating KD creates a unique metabolic state that promotes weight loss.]
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Top posts

Most liked on X and Bluesky
Tucker Goodrich
@TuckerGoodrich · X

4/4 "A high-fat, ketogenic diet induces a unique metabolic state in mice" https://t.co/pSf3PsITSK

Oct 23, 2023 · 15 likes · 1 share · 28,294 followers View post →
Peter I-live-in-the-paradoxes InNorfolk
@Peter_InNorfolk · X

@raphaels7 @CharlesMBrenner @davidasinclair And in a mouse model, a ketogenic diet doubles AMPK activation. FFS even an high fat obesogenic diet significantly increases AMPK activation. These are not hypocaloric states. https://t.co/0Injwa4RKk

Oct 15, 2021 · 8 likes · 2 shares · 1,729 followers View post →
KOJI@プライマルコーチ
@kojija · X

【脂質代謝では脂肪合成が停止】 マウスに4種の食餌介入後遺伝子発現を測定 KD、HF（高脂質高糖質）、CR、CH（標準） FAS（脂肪酸合成酵素） SCD-1（一価不飽和を合成する酵素） SREBP-1C（肝臓にてインスリン⇧→mTORC1⇧→中性脂肪合成・貯蔵⇧） UCP2も⇧ https://t.co/IESwrdE8Xn https://t.co/Vyf7nCXe5w

Jun 30, 2021 · 6 likes · 2,311 followers View post →
L. Amber O'Hearn
@KetoCarnivore · X

In the classic from Kennedy et al., https://t.co/elmnMoMDVa, AgRP is only insignificantly higher in ketogenic mice, *unless* they started obese. 2/ https://t.co/Ly4MufGc3a

Oct 31, 2020 · 5 likes · 59,992 followers View post →
David Diamond
@LDLSkeptic · X

@ZKForTre Not arrogant, I just know the rodent research Mice need <10% protein to be in ketosis. That study had 20% protein, which doesn't model human ketosis. With <10% protein mice are keto w/o wt gain Am J Physiol Endocrinol Metab 292: E1724–E1739, 2007. doi:10.1152/ajpendo.00717.2006

Nov 10, 2019 · 4 likes · 44,997 followers View post →
Matthew Hickok
@comebackking1 · X

@TheAlanAragon Anecdotally, it works in humans with no reduction of calories. It certainly hasn’t been disproven. In mice, the effect has been shown definitively and without the myriad of confounders that plague human studies. It was repeated with identical results. https://t.co/cO8snGT2CO

Oct 3, 2022 · 4 likes · 234 followers View post →

All mentions

MacroFour
@MacroFour · X

@DavidMe17661988 How about these mice? I don't think you can blame them for not counting properly or being biased. How do you explain this? https://t.co/kgYN6zwtKn https://t.co/fcu40UPQtd

Mar 26, 2024 · 6,057 followers View post →
MacroFour
@MacroFour · X

@DavidMe17661988 @DaveHPT @DIY_Tardis Is that immutable physics? Still ignoring this? https://t.co/kgYN6zx1zV https://t.co/qiHtfG9YoQ

Dec 29, 2023 · 6,057 followers View post →
BillOckham
@BillOccham0 · X

RT @TuckerGoodrich: 4/4 "A high-fat, ketogenic diet induces a unique metabolic state in mice" https://t.co/pSf3PsITSK

Oct 24, 2023 · 1 share · 584 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

4/4 "A high-fat, ketogenic diet induces a unique metabolic state in mice" https://t.co/pSf3PsITSK

Oct 23, 2023 · 15 likes · 1 share · 28,294 followers View post →
MacroFour
@MacroFour · X

@daedalus0101 @davidludwigmd How do you explain this study with your absolutist position? https://t.co/kgYN6zx1zV https://t.co/ARHGmzI4BE

Sep 4, 2023 · 1 like · 6,057 followers View post →
BillOckham
@BillOccham0 · X

RT @Maratosflier: @CaloriesProper @KCKlatt @kevinnbass @JohnSpeakman4 @KevinH_PhD @JimJohnsonSci @davidludwigmd This one was pretty good. P…

Jun 12, 2023 · 1 share · 584 followers View post →
Terry Maratos-Flier
@Maratosflier · X

@CaloriesProper @KCKlatt @kevinnbass @JohnSpeakman4 @KevinH_PhD @JimJohnsonSci @davidludwigmd This one was pretty good. Published 2007 https://t.co/UQEyZPUQa3

Jun 12, 2023 · 3 likes · 1 share · 2,566 followers View post →
MacroFour
@MacroFour · X

@daedalus0101 @richcollins @MHSJohnWright Are you sure about that? https://t.co/kgYN6zx1zV https://t.co/VqephcwnVE

Jun 8, 2023 · 6,057 followers View post →
Matthew Hickok
@comebackking1 · X

You can’t invoke “Thermodynamics though” when trying to assert that it’s impossible to lose more fat with a low carb diet vs a mixed macronutrient diet because this study shatters it and without the myriad of confounders that plague human studies: https://t.co/cO8snGT2CO

Oct 3, 2022 · 1 like · 234 followers View post →
Matthew Hickok
@comebackking1 · X

@TheAlanAragon Anecdotally, it works in humans with no reduction of calories. It certainly hasn’t been disproven. In mice, the effect has been shown definitively and without the myriad of confounders that plague human studies. It was repeated with identical results. https://t.co/cO8snGT2CO

Oct 3, 2022 · 4 likes · 234 followers View post →
MacroFour
@MacroFour · X

@CapitalistV3GAN Same scientifically CORRECT answer as before. Eating too much or too little creates pressure for weight gain/ loss. That pressure can be met in unexpected ways for an unexpected outcome. Backup: https://t.co/kgYN6zO4BV https://t.co/nPFb1O4zpm

Aug 21, 2022 · 6,057 followers View post →
MacroFour
@MacroFour · X

@CapitalistV3GAN @ClausCarlsen1 @ScepticalDoctor Do you mean like in this study? I think people could indeed behave due to having the same physics & similar biochem. Can you explain it with the flawed model that you cling to? Perhaps the laws of physics in mice differs? https://t.co/kgYN6zO4BV

Aug 21, 2022 · 6,057 followers View post →
Matthew Hickok
@comebackking1 · X

@JohnnyScott234 @BioLayne I’ll leave you to chew on this: If what you just stated was true, then the results of the study below would be impossible, yet that’s exactly what happened. https://t.co/cO8snGBrLg https://t.co/2N48crqrip

May 27, 2022 · 1 like · 234 followers View post →
Eve Beavers is espacetimeCO
@espacetimeCO · X

RT @Maratosflier: @ChristosArgyrop @eva3034385615 @jflier @patrickc Extensive characterization of KD in male mice published 2007: https://t…

Apr 24, 2022 · 1 share · 909 followers View post →
Terry Maratos-Flier
@Maratosflier · X

@ChristosArgyrop @eva3034385615 @jflier @patrickc Extensive characterization of KD in male mice published 2007: https://t.co/9YLBaxJPki. Did not look at GLP1 levels. Analysis of gene expression led to discovery of FGF21 as metabolic regulator. Data on female mice partially reported in another paper. /1

Apr 24, 2022 · 2 likes · 1 share · 2,566 followers View post →
Matthew Hickok
@comebackking1 · X

@SportHackDave Nope. If the law of conservation of energy applies, then the results of this study would be impossible. Whoops. https://t.co/cO8snGBrLg

Feb 15, 2022 · 234 followers View post →
Anna Maria
@AnnaMariaofAlma · X

RT @comebackking1: This is actually the one I meant to share, though both are damning of this failed model: https://t.co/cO8snGBrLg

Feb 15, 2022 · 1 share · 1,075 followers View post →
Matthew Hickok
@comebackking1 · X

@SportHackDave @EDXE47 @BioLayne https://t.co/cO8snGBrLg There you go. Ponder the significance. If you don’t understand the implication, there’s no need for further discussion.

Feb 13, 2022 · 234 followers View post →
Matthew Hickok
@comebackking1 · X

This is actually the one I meant to share, though both are damning of this failed model: https://t.co/cO8snGBrLg

Feb 13, 2022 · 1 like · 1 share · 234 followers View post →
MacroFour
@MacroFour · X

@BiggestComeback @FrogHarmless @winfinancial I'd love @winfinanical to explain this study. It should not be possible in his world, even for mice. https://t.co/kgYN6zO4BV https://t.co/QpuNwy2uNt

Feb 8, 2022 · 1 like · 6,057 followers View post →
Kurt Lass
@KurtLass1 · X

RT @Peter_InNorfolk: @raphaels7 @CharlesMBrenner @davidasinclair And in a mouse model, a ketogenic diet doubles AMPK activation. FFS even a…

Oct 15, 2021 · 2 shares · 1,510 followers View post →
Rich Collins
@richcollins · X

RT @Peter_InNorfolk: @raphaels7 @CharlesMBrenner @davidasinclair And in a mouse model, a ketogenic diet doubles AMPK activation. FFS even a…

Oct 15, 2021 · 2 shares · 2,066 followers View post →
Peter I-live-in-the-paradoxes InNorfolk
@Peter_InNorfolk · X

@raphaels7 @CharlesMBrenner @davidasinclair And in a mouse model, a ketogenic diet doubles AMPK activation. FFS even an high fat obesogenic diet significantly increases AMPK activation. These are not hypocaloric states. https://t.co/0Injwa4RKk

Oct 15, 2021 · 8 likes · 2 shares · 1,729 followers View post →
KOJI@プライマルコーチ
@kojija · X

【脂質代謝では脂肪合成が停止】 マウスに4種の食餌介入後遺伝子発現を測定 KD、HF（高脂質高糖質）、CR、CH（標準） FAS（脂肪酸合成酵素） SCD-1（一価不飽和を合成する酵素） SREBP-1C（肝臓にてインスリン⇧→mTORC1⇧→中性脂肪合成・貯蔵⇧） UCP2も⇧ https://t.co/IESwrdE8Xn https://t.co/Vyf7nCXe5w

Jun 30, 2021 · 6 likes · 2,311 followers View post →
L. Amber O'Hearn
@KetoCarnivore · X

@MichaelMindrum @tednaiman @garytaubes As to protein leverage and protein adequacy, I verified that directly with Simpson and Raubenheimer. There's also the data point that at least in the classic mouse study https://t.co/IJjVKya96n, in the ketogenic condition PL did not hold. KD mice ate 1/3 the protein ad libitum.

Jan 30, 2021 · 1 like · 59,992 followers View post →
L. Amber O'Hearn
@KetoCarnivore · X

In the classic from Kennedy et al., https://t.co/elmnMoMDVa, AgRP is only insignificantly higher in ketogenic mice, *unless* they started obese. 2/ https://t.co/Ly4MufGc3a

Oct 31, 2020 · 5 likes · 59,992 followers View post →
Andrés Suárez Glez.
@serdna975 · X

RT @serdna975: @FITrebelde «si vuelves al nivel calórico anterior engordarás más»: Revisa CR en el estudio de Kennedy et al. (2|3) https://…

Sep 5, 2020 · 1 share · 2,935 followers View post →
Bridget
@TheRealBS2 · X

@Anne_S @morganthetime @WorldHarmony @THEELC @Windoman81 @BXJeffyD @YourKetoDiet https://t.co/njGLQxtN8e

Jan 12, 2020 · 2,167 followers View post →
James C.Coyne
@CoyneoftheRealm · X

RT @GidMK: For some context, here's a study that found a 20% difference in weight for a ketogenic diet in mice compared to normal chow that…

Nov 19, 2019 · 1 share · 9,552 followers View post →
Karageorgos
@Karageorgos15 · X

@ZKForTre @LDLSkeptic @gerdosi I have found conflicting studies + as you said depending on strain, etc. For example, these studies below showed benefits including greater lifespan but yep others show the opposite: https://t.co/z9SOFJAVQw https://t.co/NFZeuysTnq https://t.co/skxDflku1L

Nov 10, 2019 · 610 followers View post →
David Diamond
@LDLSkeptic · X

@ZKForTre Not arrogant, I just know the rodent research Mice need <10% protein to be in ketosis. That study had 20% protein, which doesn't model human ketosis. With <10% protein mice are keto w/o wt gain Am J Physiol Endocrinol Metab 292: E1724–E1739, 2007. doi:10.1152/ajpendo.00717.2006

Nov 10, 2019 · 4 likes · 44,997 followers View post →
Bandit_NC
@StumpTweets · X

@RFeynmann1 @KetoHiking @johndubbya77 @thebiggrog @vincentninja68 @siobhan_huggins @TuckerGoodrich @DaveKeto @glenwhitbeck @schulenburgrun @FatEmperor @LIHF_Living @BioLayne https://t.co/GokFQONIKi

Apr 10, 2019 · 108 followers View post →
Terry Maratos-Flier
@Maratosflier · X

@KetoCarnivore @futu00 @kevinnbass @sarangvjoshi16 @KetoDocCLT @keto_chad @drnickgreiner @shashiiyengar @DaveKeto @virtahealth @JPMcCarter @ChrisMasterjohn https://t.co/eufywUFf9l Measured TSH as the readout of what the pituitary is seeing in terms of peripheral T3. Glucose, insulin super low, Gluconeogenic genes suppressed. Mice don't mind -- they like the ketones.

Feb 26, 2019 · 1 like · 2,566 followers View post →
FitInMyHeart
@FitInMyHeart · X

I liked a @YouTube video https://t.co/DB3EWFc35u Top 3 Benefits of the Keto Diet | Enhance Your Body & Brain

Jan 16, 2019 · 3,058 followers View post →
Bret
@xfactor3000 · X

I liked a @YouTube video https://t.co/x9fawysgKO Top 3 Benefits of the Keto Diet | Enhance Your Body & Brain

Jan 16, 2019 · 249 followers View post →
Andrés Suárez Glez.
@serdna975 · X

@FITrebelde «si vuelves al nivel calórico anterior engordarás más»: Revisa CR en el estudio de Kennedy et al. (2|3) https://t.co/0hRO5NCwdP — NO han vuelto a comer más. — SÍ han sufrido rebote. ¿Por qué el rebote en ratones es fisiológico (CR) y en humanos falta de carácter (dejar la dieta)? https://t.co/Jf4MKEzsXh

Jan 10, 2019 · 2 likes · 1 share · 2,935 followers View post →