Gen Hosp Psychiatry January 2008 PMID 17484949

Nocebo effects with antidepressant clinical drug trial placebos.

Roy R Reeves, Mark E Ladner, Roy H Hart, Randy S Burke

Mentions

92
Peak: 8 in May 2019
across 7 sources since Apr 2019

Extended reach

221,452
potential audience

Total likes

725

Video views

12,692

Mentions per month

Apr 2019 – Dec 2025

Where it's discussed

  • X / Twitter43 posts
  • News20 articles
  • Facebook15 posts
  • Blogs8 articles
  • Bluesky2 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The collective discussions demonstrate strong interest, with examples like a case involving a man who overdosed on placebo pills and experienced severe symptoms, illustrating how negative expectations can produce real health effects. The tone varies from analytical to attentive, emphasizing the importance and potential implications of the nocebo effect for medical practice and research.

AgreementModerate agreement

Most discussions agree that the article highlights important effects of nocebo phenomena, especially regarding symptoms resulting from negative expectations in trials.

InterestHigh interest

Posts show high interest, referencing specific cases of overdose, severe symptoms, and implications for clinical research, indicating engagement with the topic.

EngagementModerate engagement

Many posts deeply analyze the phenomenon, sharing detailed case examples, such as a man experiencing shock after placebo, suggesting active engagement.

ImpactModerate impact

Discussions recognize the significance of the findings, especially with phrases like 'remarkable case' or 'must read,' implying the article's potential influence on understanding placebo/nocebo effects.

Abstract in brief

  • A 26-year-old man experienced severe negative symptoms, including hypotension, after taking placebo capsules in a clinical trial because he believed he was overdosing on an antidepressant.
  • Once it was revealed that the capsules were inert, his symptoms quickly disappeared, demonstrating a nocebo effect—where negative expectations cause real side effects.
  • The report suggests that nocebo effects can have serious impacts on patients and further research is needed to understand this phenomenon better.]

Top posts

Most liked on X and Bluesky
Florian Aigner
@florianaigner.at · Bluesky

Als er das erfuhr, war er extrem erleichtert, und innerhalb von Minuten ging es ihm wieder besser. Es ist ein bemerkenswerter Fall einer Placebo-Überdosis. Originalpublikation: pubmed.ncbi.nlm.nih.gov/17484949/

Oct 26, 2025 · 232 likes · 14 shares View post →
Sara
@saravanaszk · X

okazało się, że pacjent był uczestnikiem badań klinicznych i otrzymywał placebo - po zapoznaniu pacjenta z tą informacją uzyskano prawie natychmiastowo prawidłowe wartości ciśnień a pacjent mogł samodzielnie opuścić placówkę https://t.co/kxf4Onv8cB https://t.co/CN1p2gO1Zr

Jan 17, 2022 · 156 likes · 3 shares · 19,251 followers View post →
Doctor Jack
@DoctorJack16 · X

Depressed man enrolls in antidepressant study. Pills helped at first. Then decided to end it. Took 29 pills. Regretted it. Went to the ER pale, drowsy, shaking with very low blood pressure. No toxins in his labs. He was on placebo pills. https://t.co/Rg80u419iS

Sep 18, 2022 · 23 likes · 3 shares · 58,969 followers View post →
نواف العثمان
@Nawaf_i · X

جرعة زايدة من فكرة

Jan 10, 2024 · 16 likes · 4 shares · 34,990 followers View post →
Jesper
@0x4a45 · X

@knHammarhaj @OlofFlodin Utan att på någotvis uttala mig om kollegan, så kan nocebo (placebo, fast vid förväntade negativa effekter) ge förvånandsvärt starka effekter. Här t.ex. En man som "överdoserar" i en case study, men fick placebo. Fick farligt lågt blodtryck bla. https://t.co/MuQ9Whe2oj

Oct 9, 2023 · 14 likes · 1,683 followers View post →
Dr. Wojak, M.D.
@DrWojakMD · X

@bobw075 Yep, all linked below: 1/10: https://t.co/PAXhDDil62 2/10: https://t.co/pZnUpJ46Gp 3-5/10: https://t.co/zCJqIO6d2e 6/10: https://t.co/DVSc9nShQS 7/10: https://t.co/xnnl4RTt4J 8/10: https://t.co/Yz2GjoRoez 9/10: https://t.co/K5aZfWtQZc

Jan 5, 2025 · 7 likes · 1 share · 12,099 followers View post →

All mentions

Whiteroses_202259168 I identify as woman❤
@Whiteroses20221 · X

RT @DrWojakMD: @bobw075 Yep, all linked below: 1/10: https://t.co/PAXhDDil62 2/10: https://t.co/pZnUpJ46Gp 3-5/10: https://t.co/zCJqIO6d2e…

Dec 5, 2025 · 1 share · 699 followers View post →
Florian Aigner
@florianaigner.at · Bluesky

Als er das erfuhr, war er extrem erleichtert, und innerhalb von Minuten ging es ihm wieder besser. Es ist ein bemerkenswerter Fall einer Placebo-Überdosis. Originalpublikation: pubmed.ncbi.nlm.nih.gov/17484949/

Oct 26, 2025 · 232 likes · 14 shares View post →
Matthew
@Matthew94091812 · X

@KelleyKga @ID_Denmark Perhaps the Nocebo Effect contributes to Long Covid as well. For example, a case study suggests that a person who believes he has ingested something harmful - e.g. overdosing on antidepressants - can get sick, despite having received a placebo May 2007: https://t.co/8nalgq2MrO

May 28, 2025 · 1 like · 1,294 followers View post →
Karen
@tsueyer · X

https://t.co/0hgFDH4nc3

Apr 28, 2025 · 62 followers View post →
Richard Monvoisin
@richardmonvoisin.bsky.social · Bluesky

L'article s'appelle Nocebo effects with antidepressant clinical drug trial placebos. De Roy R. Reeves, Mark E. Ladner, Roy H. Hart, Randy S. Burke,, General Hospital Psychiatry, Vol. 29, Issue 3, May–June 2007, Pages 275-277 doi.org/10.1016/j.ge... Je l'ai mis ici. www.monvoisin.xyz/wp-content/u...

Jan 10, 2025 View post →
Dr. Wojak, M.D.
@DrWojakMD · X

@bobw075 Yep, all linked below: 1/10: https://t.co/PAXhDDil62 2/10: https://t.co/pZnUpJ46Gp 3-5/10: https://t.co/zCJqIO6d2e 6/10: https://t.co/DVSc9nShQS 7/10: https://t.co/xnnl4RTt4J 8/10: https://t.co/Yz2GjoRoez 9/10: https://t.co/K5aZfWtQZc

Jan 5, 2025 · 7 likes · 1 share · 12,099 followers View post →
0minus_Prime
@0minus_Prime · X

@flagellumdei111 @PGPapanikolaou Δες αυτό... https://t.co/elgn5k1qw3 Επίσης, μπορείς να ξεχωρίσεις μεταξύ επίδρασηςιού, φαρμάκου ή φαινομένου nocebo, όταν εμφανίζουν και τα 3 τα ίδια συμπτώματα; https://t.co/DyalY3klHF https://t.co/30pD25Q2va

Aug 24, 2024 · 2,648 followers View post →
дон румината
@chronosta4s · X

бф би лайк "можешь мне найти статью в открытом доступе?", и я такой мол "ну давай", и там нечто абсолютно феноменальное: https://t.co/worWnMiIiz

Aug 20, 2024 · 2 likes · 521 followers View post →
Jesper
@0x4a45 · X

@_King_Turd @1960Ragnar @AlternativH https://t.co/MuQ9WheAdR Det går!

Jun 5, 2024 · 1 like · 1,683 followers View post →
Matt Krause
@prokraustinator · X

@mmoooose @shyam_lab The "effect" observed in the placebo arm of a trial is not necessarily The Placebo Effect; it could be RTM. On the other hand, there's stuff like this that probably can't be. https://t.co/lqZ3hhv1NT

Jan 15, 2024 · 1,068 followers View post →
Matt Krause
@prokraustinator · X

@NeuroStats For example, this cannot possibly be regression to the mean. https://t.co/lqZ3hhv1NT

Jan 12, 2024 · 1,068 followers View post →
moooly
@salahMo13216076 · X

RT @Nawaf_i: جرعة زايدة من فكرة

Jan 10, 2024 · 4 shares · 68 followers View post →
Omar Alsaywed
@OSSaywed · X

RT @Nawaf_i: جرعة زايدة من فكرة

Jan 10, 2024 · 4 shares · 290 followers View post →
سوما ♥️✨️
@soma_369_ · X

RT @Nawaf_i: جرعة زايدة من فكرة

Jan 10, 2024 · 4 shares · 58 followers View post →
nadia
@bigluck888 · X

RT @Nawaf_i: جرعة زايدة من فكرة

Jan 10, 2024 · 4 shares · 88 followers View post →
نواف العثمان
@Nawaf_i · X

جرعة زايدة من فكرة

Jan 10, 2024 · 16 likes · 4 shares · 34,990 followers View post →
Jesper
@0x4a45 · X

@knHammarhaj @OlofFlodin Utan att på någotvis uttala mig om kollegan, så kan nocebo (placebo, fast vid förväntade negativa effekter) ge förvånandsvärt starka effekter. Här t.ex. En man som "överdoserar" i en case study, men fick placebo. Fick farligt lågt blodtryck bla. https://t.co/MuQ9Whe2oj

Oct 9, 2023 · 14 likes · 1,683 followers View post →
Girolamo Le Guin
@billionsmustliv · X

RT @prokraustinator: @ruth_hook_ @zeta_globin @nickcammarata I can’t see how something like this could be *only* a statistical error. http…

Aug 22, 2023 · 1 share · 1,677 followers View post →
Matt Krause
@prokraustinator · X

@ruth_hook_ @zeta_globin @nickcammarata I can’t see how something like this could be *only* a statistical error. https://t.co/lqZ3hhv1NT

Aug 21, 2023 · 7 likes · 1 share · 1,068 followers View post →
Jerrin Philip
@JerrinPhil3529 · X

RT @DrAditya1996: The Power of the Nocebo effect! Case report of a 26/M who thought he consumed 29 tablets of his antidepressant and prese…

May 16, 2023 · 1 share · 2 followers View post →
Aditya Narayan
@DrAditya1996 · X

The Power of the Nocebo effect! Case report of a 26/M who thought he consumed 29 tablets of his antidepressant and presented to the ER with frank shock. Required resuscitation with 6L fluids. 1/2 https://t.co/kXmbE7QuyP

May 16, 2023 · 6 likes · 1 share · 360 followers View post →
Ryan G
@RyanG1919 · X

RT @DoctorJack16: Depressed man enrolls in antidepressant study. Pills helped at first. Then decided to end it. Took 29 pills. Regretted it…

Sep 18, 2022 · 3 shares · 1,418 followers View post →
chillwan ⚔️
@chillwanbro · X

RT @DoctorJack16: Depressed man enrolls in antidepressant study. Pills helped at first. Then decided to end it. Took 29 pills. Regretted it…

Sep 18, 2022 · 3 shares · 836 followers View post →
Judd
@Judd05909343 · X

RT @DoctorJack16: Depressed man enrolls in antidepressant study. Pills helped at first. Then decided to end it. Took 29 pills. Regretted it…

Sep 18, 2022 · 3 shares · 301 followers View post →
Doctor Jack
@DoctorJack16 · X

Depressed man enrolls in antidepressant study. Pills helped at first. Then decided to end it. Took 29 pills. Regretted it. Went to the ER pale, drowsy, shaking with very low blood pressure. No toxins in his labs. He was on placebo pills. https://t.co/Rg80u419iS

Sep 18, 2022 · 23 likes · 3 shares · 58,969 followers View post →
met Ashley
@OhMyGreeneBone · X

RT @beksaIala: okazało się, że pacjent był uczestnikiem badań klinicznych i otrzymywał placebo - po zapoznaniu pacjenta z tą informacją uzy…

Jan 17, 2022 · 3 shares · 2,135 followers View post →
Aleksandra | Sandra ✨
@soy_aleksandra · X

RT @beksaIala: okazało się, że pacjent był uczestnikiem badań klinicznych i otrzymywał placebo - po zapoznaniu pacjenta z tą informacją uzy…

Jan 17, 2022 · 3 shares · 201 followers View post →
Sara
@saravanaszk · X

okazało się, że pacjent był uczestnikiem badań klinicznych i otrzymywał placebo - po zapoznaniu pacjenta z tą informacją uzyskano prawie natychmiastowo prawidłowe wartości ciśnień a pacjent mogł samodzielnie opuścić placówkę https://t.co/kxf4Onv8cB https://t.co/CN1p2gO1Zr

Jan 17, 2022 · 156 likes · 3 shares · 19,251 followers View post →
Nathan Douthit, MD
@Ndouthit · X

This one should be required reading! A weird medical story about the nocebo effect. https://t.co/MlPehFpR1e

Sep 29, 2021 · 1,089 followers View post →
甘茶登志朗
@8nonbiri8 · X

RT @ph_minimal: @S96405539 プラセボ効果って凄いですよね! 一方でノセボ効果の威力も凄いので情報発信には気を使います

Aug 14, 2021 · 2 shares · 1,071 followers View post →
James Leonard
@leonardjbRx · X

@RyanMarino @FormerAntivax Classic case of nocebo. https://t.co/xB2lE33nKs

Aug 7, 2021 · 1 like · 230 followers View post →
Stephen Cook, MD, MPH #MaskUp
@DrSteveCook · X

Nocebo effects with antidepressant clinical drug trial placebos - PubMed https://t.co/zZkXYcxwwK

Mar 22, 2021 · 3,881 followers View post →
Ryan Radecki, MD MS
@emlitofnote · X

RT @drsamko: @emlitofnote @MollyJongFast Nocebo effect can be strong - https://t.co/ioLNppRrIh

Mar 22, 2021 · 1 share · 14,302 followers View post →
Sam Ko MD MBA
@drsamko · X

@emlitofnote @MollyJongFast Nocebo effect can be strong - https://t.co/ioLNppRrIh

Mar 22, 2021 · 2 likes · 1 share · 2,357 followers View post →
Richard Sprague
@sprague · X

Case study (2007) of a 26-year-old suicide attempt hospitalized for drug overdose who immediately recovered when he found he'd taken a placebo. https://t.co/Dc94YRbne1

Feb 13, 2021 · 1 like · 2,111 followers View post →
みに丸
@ph_minimal · X

@S96405539 プラセボ効果って凄いですよね! 一方でノセボ効果の威力も凄いので情報発信には気を使います

Jan 5, 2021 · 5 likes · 2 shares · 928 followers View post →
Charles H. Green
@CharlesHGreen · X

Overdosing on Placebos? Yup, it’s a thing. Nocebo effects with antidepressant clinical drug trial placebos. - PubMed - NCBI https://t.co/sKtdHruQKl

May 31, 2019 · 1 like · 6,115 followers View post →
Martin Schønemann-Lund
@MartinSchnemann · X

RT @broomedocs: Nocebo effects with antidepressant clinical drug trial placebos. - ⁦@First10EM⁩ ⁦@TheSGEM⁩ ⁦@EMManchester⁩ ⁦@srrezaie⁩ BLAC…

May 25, 2019 · 3 shares · 136 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @broomedocs: Nocebo effects with antidepressant clinical drug trial placebos. - ⁦@First10EM⁩ ⁦@TheSGEM⁩ ⁦@EMManchester⁩ ⁦@srrezaie⁩ BLAC…

May 25, 2019 · 3 shares · 6,930 followers View post →
Barbra Backus
@barbrabackus · X

RT @broomedocs: Nocebo effects with antidepressant clinical drug trial placebos. - ⁦@First10EM⁩ ⁦@TheSGEM⁩ ⁦@EMManchester⁩ ⁦@srrezaie⁩ BLAC…

May 25, 2019 · 3 shares · 1,143 followers View post →
Stephen Pimentel
@StephenPiment · X

Nocebo effects with antidepressant clinical drug trial placebos. https://t.co/qBIRKwSCJs

May 24, 2019 · 12,863 followers View post →
Casey Parker
@broomedocs · X

Nocebo effects with antidepressant clinical drug trial placebos. - ⁦@First10EM⁩ ⁦@TheSGEM⁩ ⁦@EMManchester⁩ ⁦@srrezaie⁩ BLACK BOX WARNING: placebo killer #FOAMed https://t.co/1hngwSMy0n

May 24, 2019 · 5 likes · 3 shares · 7,996 followers View post →
Joshua LaMarr
@CotedeCotonou · X

Nocebo effects with antidepressant clinical drug trial placebos. - PubMed - NCBI https://t.co/UScT9Pi3Eb

May 24, 2019 · 68 followers View post →
Leo Reis MD MSc PhD MBA Fulbright UroScience
@ReisLO · X

Nocebo effects with antidepressant clinical drug trial placebos. - PubMed - NCBI https://t.co/9KXYYs5vpg

May 24, 2019 · 489 followers View post →
Sam Ko MD MBA
@drsamko · X

Nocebo effects with antidepressant clinical drug trial placebos https://t.co/Bc2begkC21

Apr 27, 2019 · 2,357 followers View post →