Physiol Rev October 2007 PMID 17928583

Life and death: metabolic rate, membrane composition, and life span of animals.

A J Hulbert, Reinald Pamplona, Rochelle Buffenstein, W A Buttemer

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Mentions

Peak: 5 in Dec 2024

across 5 sources since Oct 2020

Extended reach

245,378

potential audience

Total likes

599

Video views

19,371

Mentions per month

Oct 2020 – Oct 2025

Where it's discussed

News23 articles
X / Twitter19 posts
YouTube5 videos
Facebook3 posts
Blogs2 articles

AI synopsis

What people are saying

The discussions often highlight the relationship between PUFA content in membranes and animal lifespans, with phrases like 'shorter lives across animals' and 'unstable PUFAs are horrible for health,' indicating a focus on biological mechanisms and health implications. The tone varies from scientific references to health concerns, which reflects both curiosity and skepticism about dietary impacts, contributing to a generally positive but nuanced view on the research's significance.

AgreementModerate agreement

Most discussions acknowledge the importance of membrane composition and metabolic rate in determining lifespan, showing overarching support for the research findings.

InterestHigh interest

Many social discussions focus on the implications of fatty acids and membrane stability, indicating high curiosity about aging and health influence.

EngagementModerate engagement

Some posts reference specific data and authors, suggesting a moderate level of detailed engagement with the material.

ImpactModerate impact

While not universally revolutionary, the discussions hint at noticeable influence on understanding lifespan mechanisms and dietary considerations.

Abstract in brief

The maximum lifespan differences among animal species are much greater than those achieved through experimental interventions, and these differences were initially linked to variations in their metabolic rate, which is part of the rate-of-living theory of aging.
Recent research shows that the fatty acid composition of cell membranes varies systematically between species and influences both metabolic rate and susceptibility to oxidative damage, providing a mechanistic explanation for differences in maximum lifespan.
The review highlights the connections between metabolic rate, membrane fatty acid composition, and lifespan in mammals and birds, while also touching on ectothermic animals and lifespan-extending treatments like caloric restriction.]

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All mentions

Effective Strategies to Minimize Seed Oil Toxicity and Oxidative Damage

Mike Fave · Apr 4, 2025 5,799 views

Managing Seed Oil Intake for Better Health and Reduced Inflammation

This video discusses the impact of seed oils high in omega 6 on health, including increased lipid peroxidation and inflammation, and presents strategies to optimize fat sources, balance omega 6 to omega 3 ratios, and…

Mike Fave · May 2, 2025 4,817 views

Strategies to Reduce Seed Oil Toxicity and Inflammation

The toxicity of seed oils has been gaining more and more attention in the health world and for good reason. This video explains how to minimize oxidative stress, inflammation, and damage from omega6 polyunsaturated fats…

Mike Fave · Apr 4, 2025 4,536 views

Strategies to Minimize Seed Oil Damage and Oxidative Stress

The toxicity of seed oils has been gaining more and more attention in the health world and for good reason. This video walks you through strategies to protect against damaging omega6 polyunsaturated fats, including…

Mike Fave · Apr 18, 2025 3,908 views

Understanding Animal Lifespan: Metabolism, Membranes, and Aging

This video discusses why animals have vastly different lifespans, focusing on metabolic rate, membrane composition, and aging. Based on scientific research, it explains how these factors influence longevity across…

ExplicaKoi - Guillaume Chero · Oct 17, 2021 312 views

Cuki

@cukipapa · X

@LucyBennet10 @trikomes Did you ever read this one, Lucy? doi:10.1152/physrev.00047.2006. My favourite from Hulbert.

Oct 8, 2025 · 2 likes · 141 followers View post →

Professor_blackpill

@REAL_PROF_BP · X

RT @Metabolicmonstr: #2 PUFA increases inflammatory byproducts like MDA, which are even more harmful than free radicals. They have a much…

May 3, 2025 · 1 share · 138 followers View post →

Metabolic Monster

@Metabolicmonstr · X

May 3, 2025 · 10 likes · 1 share · 2,303 followers View post →

Mike Fave

@MikeFaveScience · X

Sources: https://t.co/2RJZkNVTEu https://t.co/g4WZtuwyXw https://t.co/q1bGZqkXJY https://t.co/rPcxDsKccv https://t.co/eGLYYzkS2P https://t.co/JLIG2pBVQi

Apr 4, 2025 · 1 like · 1,616 followers View post →

Vitality Blueprint ©️

@VitaBlueprint · X

RT @TuckerGoodrich: @nicknorwitz Here's the data: https://t.co/Fj00MyXr4f https://t.co/M0hFJt3sFU

Dec 18, 2024 · 3 shares · 78 followers View post →

TunnelVisionBTC

@TunnelVisionBTC · X

RT @TuckerGoodrich: @nicknorwitz Here's the data: https://t.co/Fj00MyXr4f https://t.co/M0hFJt3sFU

Dec 18, 2024 · 3 shares · 619 followers View post →

Seed Oil Disrespecter™️

@SeedOilDsrspctr · X

RT @TuckerGoodrich: @nicknorwitz Here's the data: https://t.co/Fj00MyXr4f https://t.co/M0hFJt3sFU

Dec 18, 2024 · 3 shares · 107,805 followers View post →

Tucker Goodrich

@TuckerGoodrich · X

@nicknorwitz Here's the data: https://t.co/Fj00MyXr4f https://t.co/M0hFJt3sFU

Dec 18, 2024 · 22 likes · 3 shares · 28,259 followers View post →

Knowbody

@nice2meetIU · X

@hubermanlab https://t.co/VZG7JJOjPh

Dec 10, 2024 · 49 followers View post →

AFreshLitBeacon

@AFreshLitBeacon · X

https://t.co/TGnXHIg2bN

Feb 12, 2024 · 1 like · 411 followers View post →

Ichor Grad Student

@IchorGrad · X

Dec 1, 2023 · 5 likes · 2,738 followers View post →

LucyBennet

@LucyBennet10 · X

@exfatloss @TuckerGoodrich Hurbet has written a series of manuscripts on life span and saturation of membranes in the animal world. Apparently more PUFA in your membranes, the shorter you live across animal species. PUFA content is genetically controlled, in humans it is very low. https://t.co/j6DdeItnAb

Nov 20, 2023 · 963 followers View post →

AFreshLitBeacon

@AFreshLitBeacon · X

@zbitter @BHBEnjoyer @TheNutrivore PUFAs are simply too unstable. That's it, that's why they're horrible for our health. https://t.co/TGnXHIg2bN

Jun 13, 2023 · 1 like · 411 followers View post →

Uri Manor

@manorlaboratory · X

RT @CharlesMBrenner: there's a huge body of literature on this but start with this review https://t.co/wdVgGWfl0K

May 11, 2022 · 1 share · 15,707 followers View post →

Charles Brenner, PhD

@CharlesMBrenner · X

there's a huge body of literature on this but start with this review https://t.co/wdVgGWfl0K https://t.co/falPaOJKD2

May 11, 2022 · 5 likes · 1 share · 57,021 followers View post →

David Wyant

@wyadvd · X

@ProfTimNoakes @ii1111 @nicknorwitz Hey prof this is interesting : https://t.co/iDRJou6W54

Aug 30, 2021 · 2,687 followers View post →

David Wyant

@wyadvd · X

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals | Physiological Reviews https://t.co/iDRJou6W54

Aug 30, 2021 · 1 like · 2,687 followers View post →

あまね

@63QHxFAzN2WW9xA · X

RT @kojija: 【膜脂肪酸不飽和度仮説】膜脂肪酸組成が寿命を決める膜脂肪酸不飽和度⇧→寿命⇩ 膜リン脂質の過酸化指数⇧→酸化ストレス⇧ 酸化ストレスを変数操作しても寿命に影響を与えにくいルブナ―の法則の例外が膜脂肪酸不飽和度で説明されています http…

Oct 20, 2020 · 2 shares · 28 followers View post →

KOJI@プライマルコーチ

@kojija · X

Oct 19, 2020 · 11 likes · 2 shares · 2,307 followers View post →

Life and death: metabolic rate, membrane composition, and life span of animals.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Effective Strategies to Minimize Seed Oil Toxicity and Oxidative Damage

Managing Seed Oil Intake for Better Health and Reduced Inflammation

Strategies to Reduce Seed Oil Toxicity and Inflammation

Strategies to Minimize Seed Oil Damage and Oxidative Stress

Understanding Animal Lifespan: Metabolism, Membranes, and Aging