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Discussions reveal strong agreement and high interest through phrases like 'nearly 10-fold extension' and 'convinced me that radical life extension is possible,' demonstrating enthusiasm and recognition of the research's significance. The tone and context, including references to previous studies and genetic pathways, reflect a deep engagement with the scientific implications of the article.
Most discussions support the findings, emphasizing the significance of the lifespan extension in nematodes.
The topic of longevity and genetic interventions sparks high interest, with many eager to see implications for humans.
Users reference specific studies, mention related genetic pathways, and discuss broader effects, indicating moderate engagement.
Conversations highlight the potential transformative impact of the findings on aging research and biomedical science.
The record for life extension in any animal dates to a 2007 study in PI3K-null mutant C. Elegans worms Nearly 10x extension in lifespan! This paper convinced me that radical life extension is possible (but very hard!!) https://t.co/nHRTHd19Wj https://t.co/fgVOpS2Vxk
@KarlPfleger @LinusPeters @MarkHamalainen @peterottsjo @aubreydegrey @mkaeberlein @realNathanCheng @adamgries @biogerontology @strygah @aocampox @AndreaBMaier @Replacing_Aging @sebastian_gero If daf2 2x lifespan increase is on your list, then Reis’ 10x increase via age1 ko should also be on it — @LauraDeming and @AlexJColville even named their fund after it
I tried looking for the largest increase in lifespan ever achieved for mice, worms, and the like. It seems like 10x worms are a thing! https://t.co/xCawY5mBdc
@guilher93212889 @Noahpinion Here's the paper, TlDr is 10x life extension in worms. The same molecular system exists in humans, and it probably slows down ageing, just not as much. https://t.co/tZ6jxN6cXD
@onelifemax @CharlesMBrenner mutations are neutral, so how many *relevant* genetic changes are required to make a fly live twice as long as its ancestor 80 generations ago is still an open question. I could be just a few — an age-1 knockout alone extends nematode lifespan by 10x. https://t.co/OU2bZ1Em7e
@tpr720 It cites https://t.co/K1ziAWVg6Z which says "They survive to a median of 145-190 days at 20 degrees C, with nearly 10-fold extension of both median and maximum adult lifespan relative to N2DRM, a long-lived wild-type stock into which the null mutant was outcrossed."
Explore the genetics behind aging, including key genetic variants like AGE1 and DAF2, and recent research on extending lifespan based on studies in C. elegans and humans.
This video explores the science behind longevity medicine, including gene control of aging, clinical trials, and societal impacts. It discusses how emerging therapies could influence aging and health in humans, based on…
@omri_drory I came to the same conclusion about a month ago. You might not want to live forever, but you probably don't want dementia. I included some data on how every country is spending much more on health than it used to as well as an mtor pathway beginner: https://t.co/UQ3UHdWZsn
I don’t know exactly when the first longevity drug will be proven safe and effective. But I’m confident of this: you’ll be taking it — even if you don’t care about living longer. Watch: https://t.co/UQ3UHdWZsn
RT @ydeigin: @KarlPfleger @LinusPeters @MarkHamalainen @peterottsjo @aubreydegrey @mkaeberlein @realNathanCheng @adamgries @biogerontology…
RT @ydeigin: @KarlPfleger @LinusPeters @MarkHamalainen @peterottsjo @aubreydegrey @mkaeberlein @realNathanCheng @adamgries @biogerontology…
RT @ydeigin: @KarlPfleger @LinusPeters @MarkHamalainen @peterottsjo @aubreydegrey @mkaeberlein @realNathanCheng @adamgries @biogerontology…
@KarlPfleger @LinusPeters @MarkHamalainen @peterottsjo @aubreydegrey @mkaeberlein @realNathanCheng @adamgries @biogerontology @strygah @aocampox @AndreaBMaier @Replacing_Aging @sebastian_gero If daf2 2x lifespan increase is on your list, then Reis’ 10x increase via age1 ko should also be on it — @LauraDeming and @AlexJColville even named their fund after it
@LidskyPeter @ProfessorANCHA @epsilonklm @schw90 @fedichev PI3K inhibition extends lifespan of nematodes 10-fold https://t.co/FxC3QU4Tui PI3K inhibition in mice leads to diabetes, hyperlipidemia and obesity https://t.co/ee5AEzz3aU
@tpr720 It cites https://t.co/K1ziAWVg6Z which says "They survive to a median of 145-190 days at 20 degrees C, with nearly 10-fold extension of both median and maximum adult lifespan relative to N2DRM, a long-lived wild-type stock into which the null mutant was outcrossed."
They wouldn't develop, and no one wanted to keep a bunch of worms to see if maybe they live 3 months instead of 1 month. When someone bothered to check, it turned out they lived for 10 months instead of typical 1 month). Paper: https://t.co/tZ6jxN6cXD
RT @ben_nashman: The record for life extension in any animal dates to a 2007 study in PI3K-null mutant C. Elegans worms Nearly 10x extensi…
RT @SimonTheNoob: @guilher93212889 @Noahpinion Here's the paper, TlDr is 10x life extension in worms. The same molecular system exists in h…
@guilher93212889 @Noahpinion Here's the paper, TlDr is 10x life extension in worms. The same molecular system exists in humans, and it probably slows down ageing, just not as much. https://t.co/tZ6jxN6cXD
RT @ben_nashman: The record for life extension in any animal dates to a 2007 study in PI3K-null mutant C. Elegans worms Nearly 10x extensi…
The record for life extension in any animal dates to a 2007 study in PI3K-null mutant C. Elegans worms Nearly 10x extension in lifespan! This paper convinced me that radical life extension is possible (but very hard!!) https://t.co/nHRTHd19Wj https://t.co/fgVOpS2Vxk
@Halsted_19 For C.Elegans, 10x increase in lifespan: "nearly 10-fold extension of both median and maximum adult lifespan relative to N2DRM, a long-lived wild-type" https://t.co/vgnjTw58D5 15 years ago (published Jan 2008)
✅ The answer to our question yesterday is 10X. In 2008, Ayyadevara et al. reported in the journal Aging Cell that null mutants of the worm PI3K catalytic subunit gene had extraordinarily long lifespans compared to wild-type controls. https://t.co/mhzMN9LF6B https://t.co/2FYTIypxVq
@onelifemax @CharlesMBrenner mutations are neutral, so how many *relevant* genetic changes are required to make a fly live twice as long as its ancestor 80 generations ago is still an open question. I could be just a few — an age-1 knockout alone extends nematode lifespan by 10x. https://t.co/OU2bZ1Em7e
I tried looking for the largest increase in lifespan ever achieved for mice, worms, and the like. It seems like 10x worms are a thing! https://t.co/xCawY5mBdc
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