Physiol Rev January 2008 PMID 18195089

Skeletal muscle fatigue: cellular mechanisms.

D G Allen, G D Lamb, H Westerblad

Mentions

29
Peak: 5 in Sep 2021
across 4 sources since Mar 2019

Extended reach

233,768
potential audience

Total likes

4,616

Video views

119,435

Mentions per month

Mar 2019 – May 2025

Where it's discussed

  • X / Twitter18 posts
  • Facebook5 posts
  • News4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight a general agreement on the importance of the publication, with many participants referencing detailed mechanisms like glycogen depletion and calcium release, and mentioning how the research informs sports science and muscle physiology; tone and word choice such as 'complete,' 'classic,' and 'must read' reflect high regard and interest.

AgreementModerate agreement

Most posters express support or recognition of the significance of the publication and its findings.

InterestHigh interest

The discussions demonstrate high curiosity and interest, referencing detailed mechanisms and related literature.

EngagementHigh engagement

Participants show deep engagement by referencing specific methods, mechanisms, and personal educational experiences.

ImpactModerate impact

Many acknowledge the article's influence on understanding muscle fatigue and its relevance to sports and research, indicating moderate to high impact.

Abstract in brief

  • Muscle fatigue occurs after repeated intense use, leading to decreased performance and changes in muscle properties such as ions, action potential, and metabolites.
  • Traditional views focused on lactate and hydrogen ions impairing muscle function, but in mammals, other factors like ionic imbalances, calcium release issues from the sarcoplasmic reticulum, and reactive oxygen species are more significant contributors.
  • Understanding muscle fatigue mechanisms is complex because they vary depending on activity, and most research is done on animal tissues; applying these findings to humans and diseases remains a major challenge.]

Top posts

Most liked on X and Bluesky
Stephen Seiler
@StephenSeiler · X

It is classic (and freely accessible) review article friday here today. First up, Skeletal Muscle Fatigue: Cellular Mechanisms. By Allan, Lamb & Westerblad, 2007 Physiological Reviews. Cited >1300 times https://t.co/bCJ5vUybQ6

Sep 10, 2021 · 48 likes · 5 shares · 33,270 followers View post →
Samuele Marcora
@SamueleMarcora · X

If there is a sport where understanding of muscle fatigue is crucial, that is @CrossFit . I suggest the classic by Allen and colleagues https://t.co/E0LUTOvQYf https://t.co/6qisIfyqfp

Aug 4, 2023 · 24 likes · 9,998 followers View post →
Paul Ansdell
@PaulAnsdell · X

@DrMarkBurnley A series of tutorials with @jeannedekerle during my undergrad. She gave me some light reading (!): the Allen 2008 fatigue review. I didn’t understand much of it but I wanted to learn more about fatigue, so stayed to do my MSc with her. https://t.co/MS7amodYvH

Feb 7, 2021 · 10 likes · 1,176 followers View post →
Spragg Performance
@Spragg_Perform · X

@Toptimum_Perfor @HeWaHippo @Alan_Couzens @AndyBeetroot @DrMarkBurnley @peter__leo @JeroenSwart This intensity will indeed change over time, https://t.co/2h1KczOOyP because of fatigue (which is a huge area) but research suggest the 'largest' factor is probably glycogen depletion which causes inefficiencies in Ca+ handling - see https://t.co/8UPHjEn55n

Aug 14, 2022 · 5 likes · 3,831 followers View post →
Anastasios Makris
@AnastasiosMakr4 · X

@johngetstrong @JonMackey14 Even acidity has been questioned. Read on this section: Lactate and H+ https://t.co/6UyUb7DejG

Aug 22, 2023 · 3 likes · 422 followers View post →
Raúl Celdrán
@NTSAcademia · X

Skeletal Muscle Fatigue: Cellular Mechanisms | Physiological Reviews https://t.co/0RsOQCS6U9

Apr 12, 2020 · 2 likes · 3,087 followers View post →

All mentions

Anastasios Makris
@AnastasiosMakr4 · X

@johngetstrong @JonMackey14 Even acidity has been questioned. Read on this section: Lactate and H+ https://t.co/6UyUb7DejG

Aug 22, 2023 · 3 likes · 422 followers View post →
Samuele Marcora
@SamueleMarcora · X

If there is a sport where understanding of muscle fatigue is crucial, that is @CrossFit . I suggest the classic by Allen and colleagues https://t.co/E0LUTOvQYf https://t.co/6qisIfyqfp

Aug 4, 2023 · 24 likes · 9,998 followers View post →
PFE
@PFEciencia · X

Varios mecanismos involucrados en la fatiga muscular periférica como: Acumulación de metabolitos Reducción del suministro de energía Estrés oxidativo Alteración en la liberación de calcio "Skeletal muscle fatigue: cellular mechanisms" - Allen DG, Lamb GD, Westerblad H. https://t.co/Cry84RlFjk

Apr 16, 2023 · 20 followers View post →
Spragg Performance
@Spragg_Perform · X

@Toptimum_Perfor @HeWaHippo @Alan_Couzens @AndyBeetroot @DrMarkBurnley @peter__leo @JeroenSwart This intensity will indeed change over time, https://t.co/2h1KczOOyP because of fatigue (which is a huge area) but research suggest the 'largest' factor is probably glycogen depletion which causes inefficiencies in Ca+ handling - see https://t.co/8UPHjEn55n

Aug 14, 2022 · 5 likes · 3,831 followers View post →
Camilo Baron
@camilo51633396 · X

https://t.co/WtCCD9CcGv

Mar 25, 2022 · 35 followers View post →
Herb Case
@CaseHerb · X

RT @StephenSeiler: It is classic (and freely accessible) review article friday here today. First up, Skeletal Muscle Fatigue: Cellular Mec…

Sep 10, 2021 · 5 shares · 197 followers View post →
Riccardo Zoidl
@Riccardo_Zoidl · X

RT @StephenSeiler: It is classic (and freely accessible) review article friday here today. First up, Skeletal Muscle Fatigue: Cellular Mec…

Sep 10, 2021 · 5 shares · 2,476 followers View post →
Vitas Gerulaitis
@VGerulaitis · X

RT @StephenSeiler: It is classic (and freely accessible) review article friday here today. First up, Skeletal Muscle Fatigue: Cellular Mec…

Sep 10, 2021 · 5 shares · 153 followers View post →
Meteor0905
@meteor_0905 · X

RT @StephenSeiler: It is classic (and freely accessible) review article friday here today. First up, Skeletal Muscle Fatigue: Cellular Mec…

Sep 10, 2021 · 5 shares · 41 followers View post →
Stephen Seiler
@StephenSeiler · X

It is classic (and freely accessible) review article friday here today. First up, Skeletal Muscle Fatigue: Cellular Mechanisms. By Allan, Lamb & Westerblad, 2007 Physiological Reviews. Cited >1300 times https://t.co/bCJ5vUybQ6

Sep 10, 2021 · 48 likes · 5 shares · 33,270 followers View post →
aquieojapa
@aquieojapa · X

Um dos trabalhos mais completos que eu já li sobre fadiga. https://t.co/hN2pyZpExx

Jun 19, 2021 · 268 followers View post →
Paul Ansdell
@PaulAnsdell · X

@DrMarkBurnley A series of tutorials with @jeannedekerle during my undergrad. She gave me some light reading (!): the Allen 2008 fatigue review. I didn’t understand much of it but I wanted to learn more about fatigue, so stayed to do my MSc with her. https://t.co/MS7amodYvH

Feb 7, 2021 · 10 likes · 1,176 followers View post →
Helena Ereditsh Dr
@ereditsh · X

https://t.co/3ilOsODCeo

Feb 6, 2021 · 1 like · 50,092 followers View post →
Spragg Performance
@Spragg_Perform · X

@_PaulMorgan This is also very good: https://t.co/8UPHjEn55n

May 23, 2020 · 1 like · 3,831 followers View post →
Spragg Performance
@Spragg_Perform · X

@RonGeorge_Dubai @peter__leo @JamiePringle @AndyBeetroot @DrMarkBurnley See https://t.co/8UPHjEn55n

May 3, 2020 · 3,831 followers View post →
Raúl Celdrán
@NTSAcademia · X

Skeletal Muscle Fatigue: Cellular Mechanisms | Physiological Reviews https://t.co/0RsOQCS6U9

Apr 12, 2020 · 2 likes · 3,087 followers View post →
Bernardo N. Ide, Ph.D.
@bernardo_0311 · X

Artigos citados ontem na minha aula online https://t.co/9v9LRPf1kM https://t.co/UZrxYdpxhI https://t.co/XJ4ZTY9niq https://t.co/lP2ZRBRqD1 https://t.co/tgyyocIq89

Mar 22, 2020 · 1 like · 778 followers View post →
Bernardo N. Ide, Ph.D.
@bernardo_0311 · X

Skeletal muscle fatigue: cellular mechanisms. - PubMed - NCBI https://t.co/2aksnFZziD

Mar 23, 2019 · 2 likes · 778 followers View post →