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The discussions highlight various responses to the research, such as the mention of the small difference in efficacy between SSRIs and placebo, with phrases like 'modest benefits' and 'negligible impact' frequently appearing. These word choices and the overall tone, which leans towards skepticism about SSRIs, underscore the perception that while there may be some benefits for severely depressed individuals, the fundamentals of the study raised serious questions about the broader effectiveness of antidepressants.
Many discussions express skepticism about the effectiveness of antidepressants, generally aligning with the article's findings.
Participants show a strong interest in the topic, referencing additional studies and sharing links to related research.
While some posts are dismissive, several engage critically with the content, analyzing the nuances of depression treatment.
The discussions suggest that the publication is viewed as having a significant influence on people's understanding of antidepressant efficacy.
"Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance." https://t.co/IwdjhG2SoT
Pese a esto, lo cierto es que los efectos de los antidepresivos, aunque en algunos casos significativamente diferentes (a nivel estadístico) del placebo, no suelen alcanzar en la mayor parte de casos una significatividad clínica: https://t.co/e3iMkZidzG https://t.co/MYp660iGcx
e.g. a large effect in the most depressed patients... https://t.co/HwQXVYtJlj
ableds: the disabled can hold some authority as long as they are medicated the medications: https://t.co/WaOKSwXt0k https://t.co/jK9pNXs7RR
@OpenMarkNight @UnfortunateDuc2 @JZaitshik68278 @PieAreSqwared @sulmoney “On average, the SSRIs improved the HRSD score of patients by 1.8 points more than the placebo, whereas NICE has defined a significant clinical benefit for antidepressants as a drug–placebo difference in the improvement of the HRSD score of 3 points” https://t.co/7Ep4OuYJf9.
@PaulBetBest @sublimepilgrim Why are you assuming they were given to people who didn't need it, that's false. https://t.co/S3YJEOCPfE. You can search for other studies done by Irving Kirsch. SSRI's are based on the premise of a chemical imbalance, which again, is not true therefore a false premise.
This video analyzes the serotonin hypothesis of depression and its suggested link to low serotonin levels. A systematic review of existing literature indicates that most studies found no significant association between…
This video explores the relationship between initial severity of depression and the efficacy of antidepressants, based on clinical trial data. Findings indicate that antidepressants show minimal benefits over placebo in…
This episode explores the challenges in psychiatry, focusing on Dissociative Identity Disorder (DID). It investigates whether DID states are genuine mental states, supported by differences in brain activity, challenging…
This video explores the benefits of psilocybin as an alternative to traditional antidepressants like SSRIs. While antidepressants may stabilize mood, they often leave patients feeling numb. Psilocybin may offer a…
@raghu_venugopal @SecKennedy Save your sanctimony: Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008). Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration. PLoS Medicine, 5(2), e45.
@DirtyRoofer412 @truthache68 It’s this one: https://t.co/yzTznkIMbM
@thom_ivy_1 @pli_cachete Links for reference: Cippiani 2018 (https://t.co/62jJLAskYx) Kirsch 2008 (https://t.co/NOp7i2eNEB, https://t.co/RN5T0FIYHI) Hengartner 2017 (https://t.co/jycwoD7WKj, https://t.co/uSrfJkkFNT) Munkholm 2022 (https://t.co/ksScqCGmSI, https://t.co/ARtO3aJvzz) https://t.co/Vb1Nrz4Gdj
@jeremykauffman You don't spend much time reading cell biology papers or reports from drug trials. There is terrible work from the US that was NEVER retracted. Go read ": "Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration" By
@Maga4liberty There was a decades-long study done on SSRI’s called “Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration”. Movies like, The Informant, Prozac Nation and The Constant Gardener. The only positive effect is placebo.
@MattWalshBlog https://t.co/2C4T9sVqaj https://t.co/qcwp5Xn7eV https://t.co/eprJ9B3k2J https://t.co/9vKzj7rs8o https://t.co/2zMdP5v7ZM
SSRIs barely outperform placebos, in the short run (which is when they have the highest potency). https://t.co/m9FXUOMqs6 https://t.co/iAHVGPcVOD
@alokvkulkarni @drkeithsiau @carlos_arnaud https://t.co/5ZvbabfDMK https://t.co/OuTgqPa7dJ https://t.co/450YLv4Q3j https://t.co/sKj8f7ujU5 https://t.co/imYJx5VnmG
@iheartjoegillis @BobDobbs656 @OrthoComa14 @esjesjesj https://t.co/hW3PCoKnTt — https://t.co/qdzgFQseEz — https://t.co/By5Smzy6hw — https://t.co/tdHRYegQZU
@lowcarbGP @taperclinic Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008). Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS medicine, 5(2), e45. https://t.co/lXaoSzvqpo
@anarchivistee https://t.co/Xhu0U5BogD y avait cet article de zinzin zine de kirsch qqui résumait en plus court et il avait réectualisé avc des donné +récente mais pr l'étude de base : https://t.co/icStSYu0Mf
-https://t.co/ZSyUPwSbZd -https://t.co/iDRGi2ab8L
wherein the difference between SSRIs and placebo is demonstrated to be minimal and accounted for by depressed patients responding less to placebos, not more to SSRIs https://t.co/ydz1XSiQjE
@nadinebebyx @DrAnnieHickox This was one of the studies they mentioned https://t.co/GzGzQkNmoc
@TheRadiantSky1 @DrAnnieHickox @DudeAdhd But here’s the study: https://t.co/lnFJwOcKTo https://t.co/nENUbh2CbI
@jemoyer @Mad_In_America That's true. You also have to evaluate those studies. We know that the conclusions from a big part of published medical science is wrong and that when money is involved, the risk of bias is bigger. Be careful with drug trials. https://t.co/5ZvbabfDMK https://t.co/Xcie92pXIp
(2008) Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration https://t.co/lzdiUthkSg
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
@cwfrederick @saffronkulfi1 @stclairashley @Cernovich It doesn't work for anyone. Some people get better in spite of using them. That's why you see no difference between SSRI and placebo in the published literature. https://t.co/450YLv4Q3j https://t.co/5ZvbabfDMK https://t.co/OuTgqPa7dJ
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
@JesslovesMJK Well, placebo seem to be as effective as antidepressants for depression so it's a poor comparison. https://t.co/5ZvbabfDMK https://t.co/450YLv4Q3j https://t.co/OuTgqPa7dJ
@Hugo_Baup @MaxiCaveat @MaFamilleDeOuf Kirsch I, Deacon BJ, et al. Initial severity and antidepressant benefits : A meta-analysis of data submitted to the Food and drug administration. PLoS Med 2008;5(2):e45
https://t.co/FcMYQFoQJq Las diferencias fármaco-placebo en la eficacia antidepresiva aumentan en función de la gravedad inicial, pero son relativamente pequeñas incluso para los pacientes gravemente deprimidos. La relación entre la gravedad inicial y la eficacia antidepresiva es
@OpenMarkNight @UnfortunateDuc2 @JZaitshik68278 @PieAreSqwared @sulmoney “On average, the SSRIs improved the HRSD score of patients by 1.8 points more than the placebo, whereas NICE has defined a significant clinical benefit for antidepressants as a drug–placebo difference in the improvement of the HRSD score of 3 points” https://t.co/7Ep4OuYJf9.
@PaulBetBest @sublimepilgrim Why are you assuming they were given to people who didn't need it, that's false. https://t.co/S3YJEOCPfE. You can search for other studies done by Irving Kirsch. SSRI's are based on the premise of a chemical imbalance, which again, is not true therefore a false premise.
Just came in from a half hour in the sun. Did you know that a few minutes in the mid-day sun on your bare body will result in the synthesis and release to the blood of Vitamin D for the next 48 hours? https://t.co/GplM6jZieA
@MakisMD "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance." https://t.co/GplM6jZieA
@DrMcFillin It does not, however, purport that antidepressants are a miracle, and that was not my statement. Now it is true that more recent studies, which I had forgotten about, say the contrary: https://t.co/1Sa8oBpEAW https://t.co/uWO6ncuMFw So I do stand corrected on that.
@DrMcFillin To bring nuance to my point, the effect-size compared to placebo changes depending on the severity of depression initialy, even if it remains relatively small. But my point still stands. Here's the meta-analysis I refer to when I say this: https://t.co/1Sa8oBpEAW
@jemoyer @HarryZeitMD @justin_garson Really worth reading. Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med 2008;5:e45
@stephanieseneff They don't even appear to work better than placebo for depression. If you go slow and use proper support you can get off of them fairly easy in most cases, even after decades of use. But it would be best not to take them at all. https://t.co/5ZvbabfDMK https://t.co/OuTgqPa7dJ
@evolutionarypsy Oh, my. Argumentum ad verecundiam from a shrink? Re-read tweet. I decry poor evidence base, not possible utility of SSRIs. Drug–placebo efficacy differences increase as a function of baseline severity, but remain small even for most severely depressed. https://t.co/pQFsevYOZt
2008 > Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration https://t.co/YbqOSHRFcM via @PLOS #ScienceCQFD
Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration Drug-placebo differences in antidepressant efficacy increase with severity, but are relatively small even for severely depressed patients https://t.co/I3fSaM0qsM
SSRI probably dont work So if you got other options with less side effects (or none) consider those first. A lot of people are depressed due to life circumstances too https://t.co/lXUD6X2sKm
@Proud_Neolib @AutumnThePony Also, I don't think seeking psychiatric help is a wholly neutral or positive experience, hence why avoiding it isn't negative. For examples their willingness to diagnose SSRIs (https://t.co/WaOKSwXt0k) when their effectiveness over placebo is dubious and SSRI have major negatives
RT @NaudetFlorian: e.g. a large effect in the most depressed patients... https://t.co/HwQXVYtJlj
e.g. a large effect in the most depressed patients... https://t.co/HwQXVYtJlj
@tontytrains @Lostwanderfound @GrumpyTheology I don't know if it is, because I have academic access, but the most relevant specific paper is https://t.co/X7cANHaJ17 which one can libgen as needed. However, to read this paper it is vital to look at the statistics carefully, which are very unfavourably analysed in the summary.
@fsufootball1332 @giancotti_m @YayNarwhals @rivatez Suggest a quick look at this to understand that this is not quite true: https://t.co/MDAaYxFrQl
It doesn't look like this new study from @markhoro looked at depression severity or cited this important depression severity study from 2008. GWAS PRS/PGS could be used for severity in future studies, but ignoring severity is a problem. https://t.co/lOXM0di64X
@PoggerzU @lynnbixenspan Yep, got three straight of Google Scholar: https://t.co/TWSeqdJqkE https://t.co/5CQqvn9vbA https://t.co/dlexUp5El2 And the book is here on Z Library: https://t.co/V2K5xifwL6
@essdas You're asking for the link to the research ? This is a good place to start
@lesbiautistic https://t.co/eB9gzPIeod
@Waiting4doggo1 @lesbiautistic je serais pas si catégorique à votre place, exemple : https://t.co/Ekr0IKrYUr
@RPGsquare06 @resye6 @emmamab_ @lesbiautistic Cela dit c'est loin d'être déconnant cette remise en question de l'efficacité réelle des AD, c'est vraiment discuté et étant donné les pb relatifs au systeme de publication x milieu pharma, la surestimation des effets est presque une norme https://t.co/Ekr0IKrYUr
@MagaliMilbergue @lesbiautistic J'y croyais pas trop donc je suis allée vérifier et ça a l'air vrai : https://t.co/PRn9HGvQRp Ça a l'air compliqué de tirer une conclusion certaine, j'ai l'impression que en gros c'est légèrement supérieur au placebo mais de pas bcp, et certaines études disent que c + efficace
@giovanni_ef @bmj_latest @msk_health @Sydney_Uni @SydneyUni_Media For what it's worth, there are several researchers who have called out antidepressants efficacy more generally. One such researcher is Kirsh who has been publishing on the topic for decades now. https://t.co/or5PcLx57W
@e_whitneybuck Well, it's probably more accurate of me to say that serotonin antidepressants are no more effective than a placebo than it is to say the hypothesis is completely disproven. Here's an article that describes it somewhat. I'll see if I can find a better one https://t.co/bp55TXUHpb
@javelinhands @jurigagarini @johhsmith606 @biboofficial on general ineffectiveness; https://t.co/RWO1x2IJTW https://t.co/9CPyronbkw https://t.co/zoejfskK20 on worsening outcomes; https://t.co/BbPZ4d3xzH https://t.co/LJEz55ZS8v https://t.co/k0guf7iE5A https://t.co/LnbxT1Ld54
@Srojasbalta Si claro, el psiquiatra sólo te dice que es por falta de sorotonina y dopamina la que lo causo y chau. Nada más por aborda, cuando ese déficit es una consecuencia y no una causa. Acá, un meta-analisis sobre sus efectos secundarios: https://t.co/xI4PcetvCS
RT @wr0ngf1t: Found a new meta-analysis of FDA SSRI’s trials vs placebo https://t.co/xur9hnB51F
Found a new meta-analysis of FDA SSRI’s trials vs placebo https://t.co/xur9hnB51F
@kit1049 @abouelleill Sorry Bunny, I never replied. Missed this one. I hope all is good. Here's the citation for you: Kirsch, Irving et al. “Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration.” PLoS Medicine 5.2 (2008): 260-268.
@Montastrucjl https://t.co/UdT0tjqIAz
https://t.co/sD7ruXl5Qi
@YvvnTH Te dejo aquí el meta-análisis sobre el tema de los efectos de los antidepresivos, just in case https://t.co/dVSnKoKZQG
RT @ItecPsicologia: Pese a esto, lo cierto es que los efectos de los antidepresivos, aunque en algunos casos significativamente diferentes…
RT @ItecPsicologia: Pese a esto, lo cierto es que los efectos de los antidepresivos, aunque en algunos casos significativamente diferentes…
RT @ItecPsicologia: Pese a esto, lo cierto es que los efectos de los antidepresivos, aunque en algunos casos significativamente diferentes…
Pese a esto, lo cierto es que los efectos de los antidepresivos, aunque en algunos casos significativamente diferentes (a nivel estadístico) del placebo, no suelen alcanzar en la mayor parte de casos una significatividad clínica: https://t.co/e3iMkZidzG https://t.co/MYp660iGcx
RT @Chicken_Face1: ableds: the disabled can hold some authority as long as they are medicated the medications: https://t.co/WaOKSwXt0k ht…
ableds: the disabled can hold some authority as long as they are medicated the medications: https://t.co/WaOKSwXt0k https://t.co/jK9pNXs7RR
@FCDallasMom2 @WOSPW @Duchess_Kez @LaurelsViolin @Manaxium https://t.co/R87YSNlf0Q
@FCDallasMom2 @WOSPW @Duchess_Kez @LaurelsViolin @Manaxium https://t.co/R87YSNlf0Q
@TellySaysStuff @newtinaskneazle @summerbrees84 @Heathercutler98 @Manaxium https://t.co/R87YSNlf0Q
@FCDallasMom2 @Manaxium https://t.co/R87YSNlf0Q
@veritas_z https://t.co/KFUNf7iz1E
@SgtBepis @DystopianRoach thats odd cause this study shows that ssris are no more effective than a placebo https://t.co/BRnv9BFYr3
@mkruk @larsakepersson @paimadhu @drdrtsai The article in question, by Kirsch and colleagues, below! https://t.co/CvVQwguExX
@marikakacare https://t.co/Mmfb2IDQKb I mean
@coitelado @pacotraver Se ha visto que por sí solos pueden ser eficaces, y más eficaces si la gravedad inicial de la depresión es más profunda: https://t.co/4CPvR95OjA Aunque la diferencia con el placebo es pequeña.
@skeptishrink @alyne_duthie https://t.co/k3mpfC2mP5
RT @Le_Goracheck: @Doctor__Del @PxlCtzn @raliyen L'analyse de Kirsch de 2008 : https://t.co/ngcfLoXKSJ /3
From Kirsch et al., 2008: https://t.co/c1bpCTBnOq https://t.co/ULn3CHmjCt
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
RT @Mangan150: "Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished…
"Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance." https://t.co/IwdjhG2SoT
@Awithonelison @IreneCGraham1 @lisabodnar See https://t.co/k3mpfBKLqv https://t.co/q7fjNIvJ3b https://t.co/UhTVDEp1H2
@garwboy Ooh, remind me again what the effect size is for high-fidelity CBT? 0.22 (https://t.co/ta2cra997o). And for antidepressants? 0.32 (https://t.co/97FyXBVd8A - Kirsch, 2008). The idea that somehow drugs are a sticking plaster until you get 'the proper treatment' is not correct.
@Doctor__Del @PxlCtzn @raliyen L'analyse de Kirsch de 2008 : https://t.co/ngcfLoXKSJ /3
@ChrisK300 @blogger4cancer @TheLancet here's the facts to back up that anti-depressants are "about" as effective as placebo. This study show just what the Lancet showed too. Important to note that severity of ilness makes a diff in results. https://t.co/kp6nSyxere