Circ Res February 2008 PMID 18309108

Role of mitochondrial dysfunction in insulin resistance.

Jeong-A Kim, Yongzhong Wei, James R Sowers

Mentions

36
Peak: 5 in May 2021
across 4 sources since Aug 2019

Extended reach

20,252,525
potential audience

Total likes

222,751

Video views

20,105,097

Mentions per month

Aug 2019 – Oct 2025

Where it's discussed

  • X / Twitter18 posts
  • Facebook10 posts
  • YouTube5 videos
  • Blogs3 articles

AI synopsis

What people are saying

The discussions demonstrate strong support and curiosity about the role of mitochondria in insulin resistance, with examples like mentions of how exercise may mitigate dysfunction and questions about whether insulin elevation or mitochondrial issues come first. The tone combines scientific acknowledgment with questions, showing moderate engagement and recognition of potential health impacts.

AgreementModerate agreement

Most social discussions recognize mitochondrial dysfunction as a key factor in insulin resistance, supporting the publication’s conclusions.

InterestHigh interest

High interest is evident from the frequent references to interventions like exercise and calorie restriction, and questions about causality and implications.

EngagementModerate engagement

Discussion participants reference specific mechanisms, such as mitochondrial gene expression and morphology, indicating moderate engagement.

ImpactModerate impact

There is a sense that understanding mitochondrial dysfunction could influence broader health strategies, though some posts remain exploratory, so impact is moderate.

Abstract in brief

  • Mitochondrial dysfunction plays a key role in insulin resistance, which is linked to obesity, type 2 diabetes, and cardiovascular diseases, by impairing energy production and increasing harmful reactive oxygen species.
  • Factors like genetic predisposition, aging, and reduced mitochondrial biogenesis contribute to mitochondrial dysfunction, which leads to metabolic issues in tissues such as muscle, fat, liver, and cardiovascular tissues.
  • Improving mitochondrial function through various interventions can enhance insulin sensitivity and potentially reduce the risk of metabolic and cardiovascular complications associated with insulin resistance.]

Top posts

Most liked on X and Bluesky
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Role of Mitochondrial Dysfunction in Insulin Resistance https://t.co/vc0TZO7x51 https://t.co/0NqTz9Y1Wk https://t.co/lu83WBxKBA

Jan 20, 2022 · 11 likes · 3 shares · 134,142 followers View post →
Kirsty Woods
@MetabolicEP · X

⬇️number of mitochondria & mitochondrial gene expression, abnormal morphology of mitochondria, & abnormal functions in oxidative phosphorylation are commonly found in insulin-resistant metabolic tissues (skeletal muscle, liver, and fat) https://t.co/qCUECdgiAQ

May 27, 2021 · 6 likes · 2 shares · 2,052 followers View post →
jon furniss
@furniss_jon · X

Role of Mitochondrial Dysfunction in Insulin Resistance. Discusses how exercise and calorie restriction improve this. Mentions mitochondrial function is important for healthy β-cell function in T2DM pathogenesis. Perjhaps implications for T1DM also? https://t.co/KMb1xHXd50

May 24, 2021 · 1 like · 1 share · 926 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

@WolfCarnivore https://t.co/7WedAe3zWv "Role of Mitochondrial Dysfunction in Insulin Resistance" https://t.co/VGs6OzS1PD "Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype." https://t.co/vxj9DQV4o2 "β-Hydroxybutyrate Prevents Vascular Senescence..."

Aug 8, 2019 · 1 like · 791 followers View post →
十貫坂
@jyukkanzakakai · X

【衝撃】医師も推奨する最速でイボを撃退する㊙方法 https://t.co/AxCpgY9m1L @YouTubeより

Nov 12, 2023 · 1 like · 1 share · 521 followers View post →
Robert Olney
@boretrol · X

Role of Mitochondrial Dysfunction in Insulin Resistance https://t.co/AMPLhn5ivZ

Oct 24, 2025 · 1,702 followers View post →

All mentions

Robert Olney
@boretrol · X

Role of Mitochondrial Dysfunction in Insulin Resistance https://t.co/AMPLhn5ivZ

Oct 24, 2025 · 1,702 followers View post →
Luciana Haddad
@lucianabphaddad · X

TREINO INTERVALADO PARA MELHORAR MEMÓRIA E EVITAR DECLÍNIO COGNITIVO https://t.co/ZcwKDKM9qZ via @YouTube

Nov 18, 2024 · 592 followers View post →
TAKUMI
@saitanarumonoyo · X

RT @jyukkanzakakai: 【衝撃】医師も推奨する最速でイボを撃退する㊙方法 https://t.co/AxCpgY9m1L @YouTubeより

Nov 12, 2023 · 1 share · 1,462 followers View post →
十貫坂
@jyukkanzakakai · X

【衝撃】医師も推奨する最速でイボを撃退する㊙方法 https://t.co/AxCpgY9m1L @YouTubeより

Nov 12, 2023 · 1 like · 1 share · 521 followers View post →
Patrick
@pkamaukinyenje · X

This paper suggest that mitochondrial dysfunction may be a central cause of insulin resistance and associated complications...what is your view @BenBikmanPhD...? Who come first elevated insulin or dysfunction mitochondria..? https://t.co/DI9iw90dCk

Aug 21, 2023 · 714 followers View post →
健康ノート
@JuStADOcToR_Jp · X

Role of Mitochondrial Dysfunction in Insulin Resistance | Circulation Research https://t.co/YNj5VNfcoo.

Aug 11, 2023 · 110 followers View post →
Adi
@Adrian06661136 · X

RT @Grimhood: Role of Mitochondrial Dysfunction in Insulin Resistance https://t.co/vc0TZO7x51 https://t.co/0NqTz9Y1Wk

Jan 21, 2022 · 3 shares · 506 followers View post →
IF COOPER FLAGG WAS BLACK YOUD LOVE HIM
@Velli221 · X

RT @Grimhood: Role of Mitochondrial Dysfunction in Insulin Resistance https://t.co/vc0TZO7x51 https://t.co/0NqTz9Y1Wk

Jan 20, 2022 · 3 shares · 517 followers View post →
Lex, Holistic Herbalist
@ndthenwhat · X

RT @Grimhood: Role of Mitochondrial Dysfunction in Insulin Resistance https://t.co/vc0TZO7x51 https://t.co/0NqTz9Y1Wk

Jan 20, 2022 · 3 shares · 1,061 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Role of Mitochondrial Dysfunction in Insulin Resistance https://t.co/vc0TZO7x51 https://t.co/0NqTz9Y1Wk https://t.co/lu83WBxKBA

Jan 20, 2022 · 11 likes · 3 shares · 134,142 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @LowCarbEP: ⬇️number of mitochondria & mitochondrial gene expression, abnormal morphology of mitochondria, & abnormal functions in oxida…

May 27, 2021 · 2 shares · 335 followers View post →
Paul
@GulagAgos · X

@ArroganterP @littlewisehen https://t.co/exEC0dgeyJ

May 27, 2021 · 152 followers View post →
Kirsty Woods
@MetabolicEP · X

⬇️number of mitochondria & mitochondrial gene expression, abnormal morphology of mitochondria, & abnormal functions in oxidative phosphorylation are commonly found in insulin-resistant metabolic tissues (skeletal muscle, liver, and fat) https://t.co/qCUECdgiAQ

May 27, 2021 · 6 likes · 2 shares · 2,052 followers View post →
Cheryl Coombs
@bantingbrainiac · X

RT @furniss_jon: Role of Mitochondrial Dysfunction in Insulin Resistance. Discusses how exercise and calorie restriction improve this. Ment…

May 24, 2021 · 1 share · 1,190 followers View post →
jon furniss
@furniss_jon · X

Role of Mitochondrial Dysfunction in Insulin Resistance. Discusses how exercise and calorie restriction improve this. Mentions mitochondrial function is important for healthy β-cell function in T2DM pathogenesis. Perjhaps implications for T1DM also? https://t.co/KMb1xHXd50

May 24, 2021 · 1 like · 1 share · 926 followers View post →
MyDiabetes - Control Your Blood Sugar
@MyDiabetes4 · X

RT @DiabetesManage3: Role of #mitochondrial #dysfunction in insulin resistance: implications for mitochondrial #diabetes. https://t.co/b2I…

Feb 24, 2021 · 1 share · 585 followers View post →
Journal of Diabetes Management
@DiabetesManage3 · X

Role of #mitochondrial #dysfunction in insulin resistance: implications for mitochondrial #diabetes. https://t.co/b2IK0zqPOF

Feb 23, 2021 · 1 share · 27 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

@WolfCarnivore https://t.co/7WedAe3zWv "Role of Mitochondrial Dysfunction in Insulin Resistance" https://t.co/VGs6OzS1PD "Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype." https://t.co/vxj9DQV4o2 "β-Hydroxybutyrate Prevents Vascular Senescence..."

Aug 8, 2019 · 1 like · 791 followers View post →