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Discussions express high interest in the concept of sequence space, with comments referencing fundamental facts like the number of amino acids and the size of sequence space, exemplified by responses discussing mutation rates and amino acid diversity. Words like 'possible,' 'vast,' and 'sugge!st' convey intrigue, while some users question the study’s implications, indicating a thoughtful engagement with the material.
Most discussions show support for the paper's idea that life's exploration of protein space might be comprehensive, with some skepticism about the number of amino acids in early life.
Participants demonstrate high curiosity, especially concerning the vastness of protein sequence possibilities and the implications of the research.
Conversations include referencing scientific facts and sharing doubts or clarifications, indicating moderate depth of engagement.
The discussions reflect an awareness that the study could influence understanding of molecular evolution, though they tend to be more exploratory than decisively transformational.
@PAOLND Si, esatto. E' anche possibile che in quel periodo non ci fossero 20 amminoacidi, ma non più di 4-5 https://t.co/Vlqf39rjlr
@CT_Bergstrom @jbloom_lab @RELenski That was so awesome of you to answer my question. Thank you! Most of what I read seemed to suggest the same but then I read this paper and wasn't sure if I was missing something. https://t.co/tapduAoWa2
This video discusses whether Earth's life has fully explored the entire protein sequence space, considering genome size, mutation rates, and amino acid diversity, suggesting a largely deterministic process of protein…
Reading how much of protein sequence space has been explored by life on Earth. The study suggests that over 4 billion years, all functional protein sequences may have been sampled, indicating a largely deterministic…
The authors argue that Earth's protein sequence space has likely been fully explored over 4 billion years, suggesting that all functional sequences have been sampled and protein evolution is largely deterministic rather…
@PAOLND Si, esatto. E' anche possibile che in quel periodo non ci fossero 20 amminoacidi, ma non più di 4-5 https://t.co/Vlqf39rjlr
@SmallRobotArmy @Leigh252425 @ericmetaxas I deal with facts. David T.F Dryden (2008): A typical estimate of the size of sequence space is 20^100 (approx. 10^130) for a protein of 100 amino acids in which any of the normally occurring 20 amino acids can be found. This number is indeed gigantic. https://t.co/0tr3x746MK.
@CT_Bergstrom @jbloom_lab @RELenski That was so awesome of you to answer my question. Thank you! Most of what I read seemed to suggest the same but then I read this paper and wasn't sure if I was missing something. https://t.co/tapduAoWa2
https://doi.org/10.1098/ PMLR, 2022, 8946–70. rsif.2008.0085. 129. Dauparas J, Anishchenko I, Bennett N. et al. Robust deep learn- 112. Yu J, Junxi M, Wei T ...
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