Metabolism May 2008 PMID 18442638

Efficacy of berberine in patients with type 2 diabetes mellitus.

Jun Yin, Huili Xing, Jianping Ye

Mentions

198
Peak: 10 in Aug 2021
across 6 sources since May 2020

Extended reach

847,533
potential audience

Total likes

5,217

Video views

159,167

Mentions per month

May 2020 – Aug 2025

Where it's discussed

  • News87 articles
  • X / Twitter59 posts
  • Facebook34 posts
  • YouTube8 videos
  • Blogs8 articles
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a generally positive view of berberine, supported by emphasis on scientific studies and comparisons to metformin, with comments like 'proven to lower blood glucose' and 'similar efficacy to metformin', using authoritative language that underscores perceived importance and safety benefits.

AgreementModerate agreement

Most discussions support the idea that berberine has similar efficacy to metformin, with several posts citing specific studies and comparing their effects.

InterestHigh interest

Posts demonstrate high curiosity about berberine's potential, referencing multiple studies, benefits, and safety profiles, indicating strong interest in this natural supplement.

EngagementModerate engagement

Many users actively reference scientific results, question study validity, and discuss safety, reflecting moderate to deep engagement with the research and its implications.

ImpactModerate impact

The widespread comparison of berberine to established medications like metformin and mentions of health benefits suggest the discussions recognize its potential significance in diabetes management.

Abstract in brief

  • Berberine has been found to effectively lower blood sugar levels and improve lipid profiles in patients with type 2 diabetes, with results similar to the drug metformin, and shows minimal side effects.
  • The study involved both newly diagnosed and poorly controlled diabetes patients, demonstrating that berberine reduces hemoglobin A1c, fasting and postprandial glucose, and cholesterol levels over a 3-month period.
  • Overall, berberine appears to be a promising natural alternative for managing diabetes and lipid levels, with few gastrointestinal side effects and no significant liver or kidney harm observed.

Top posts

Most liked on X and Bluesky
Dr. Jay Wrigley
@hormonedietdoc · X

People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin resistance. It is also anti-inflammatory & helps you lose FAT. Berberine also lowers Triglycerides & HDL levels https://t.co/yQznFu4fnj https://t.co/fO1NXUAtqJ

Aug 18, 2021 · 107 likes · 16 shares · 104,793 followers View post →
د. مشوح عبدالله المشوح
@mushawah1 · X

البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب المعالج قبل تناوله. https://t.co/pbRrlTbm2V https://t.co/ED6kDteinM https://t.co/ACjcPfQtKK

May 31, 2020 · 86 likes · 30 shares · 28,364 followers View post →
Dr. Jay Wrigley
@hormonedietdoc · X

Berberine regulates glucose & lipid metabolism as well as Metformin & is safer. "The main effect of Metformin is inhibition of the mitochondrial transport chain complex-I, which essentially poisons the mitochondria" https://t.co/r4Pw7KWwph https://t.co/WoDLPHVYd5 #Berberine

Jan 5, 2022 · 46 likes · 6 shares · 104,793 followers View post →
Razi Ann Berry
@BerryRazi · X

Berberine Proven to: Lower blood glucose comparably to metformin in type 2 diabetes. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717. https://t.co/uMt28GWyrJ

Apr 29, 2025 · 9 likes · 4 shares · 132,656 followers View post →
Mike Hart, M.D
@drmikehart · X

On the other hand, Berberine is not a prescription drug; it is an over-the-counter supplement. But studies indicate that Berberine is as effective as Metformin for blood glucose control in type 2 diabetics. https://t.co/MqPakR6rgY

Jun 15, 2022 · 6 likes · 1 share · 66,405 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@beejereeno Berberine is a 'natural' form of metformin. So you if you are on berberine you are on medication, likely with same side effects. "Efficacy of berberine in patients with type 2 diabetes mellitus" https://t.co/b1H8LXUHqA So what is your FBG if you don't take berberine? https://t.co/ejrm3J4OCG

Jul 29, 2021 · 1 like · 28,256 followers View post →

All mentions

Alex Leaf
@AlexJLeaf · X

@Chrystalos @jonathanstea Or berberine having similar efficacy as metformin in type 2 diabetes, which is expected given their identical mechanisms of action. https://t.co/8kDRBjNB92

Aug 15, 2025 · 3,933 followers View post →
ASH SAVAGE
@IAMASHALREADY · X

RT @BerryRazi: Berberine Proven to: Lower blood glucose comparably to metformin in type 2 diabetes. Yin J, Xing H, Ye J. Efficacy of berber…

Apr 30, 2025 · 4 shares · 440 followers View post →
Waldeidhexe
@Waldeidhexe · X

RT @BerryRazi: Berberine Proven to: Lower blood glucose comparably to metformin in type 2 diabetes. Yin J, Xing H, Ye J. Efficacy of berber…

Apr 30, 2025 · 4 shares · 345 followers View post →
kourosh
@kourosh15915126 · X

RT @BerryRazi: Berberine Proven to: Lower blood glucose comparably to metformin in type 2 diabetes. Yin J, Xing H, Ye J. Efficacy of berber…

Apr 29, 2025 · 4 shares · 3,810 followers View post →
Razi Ann Berry
@BerryRazi · X

RT @BerryRazi: Berberine Proven to: Lower blood glucose comparably to metformin in type 2 diabetes. Yin J, Xing H, Ye J. Efficacy of berber…

Apr 29, 2025 · 4 shares · 132,656 followers View post →
Razi Ann Berry
@BerryRazi · X

Berberine Proven to: Lower blood glucose comparably to metformin in type 2 diabetes. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717. https://t.co/uMt28GWyrJ

Apr 29, 2025 · 9 likes · 4 shares · 132,656 followers View post →
kumar
@kumar334133 · X

RT @nishantak: @theliverdr @premothi What about all the studies? Efficacy of berberine in patients with type 2 diabetes mellitus - Metabol…

Feb 18, 2025 · 1 share · 57 followers View post →
Ironic Man
@nishantak · X

@theliverdr @premothi What about all the studies? Efficacy of berberine in patients with type 2 diabetes mellitus - Metabolism - Clinical and Experimental https://t.co/SqTliSZTld

Feb 17, 2025 · 1 share · 249 followers View post →
RIV
@rivka_esther_ · X

@DIMENSION_YT @doramoutot On a ça aussi ici par exemple https://t.co/9oSYJkNutO

Oct 22, 2024 · 1 followers View post →
Sydney
@Sydney843 · X

Berberine. It’s only one study but decreasing A1c in Type 2 diabetics from 9.5 to 7.5 seems huge. https://t.co/BPeq3WRXza

Jan 24, 2024 · 2,217 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

@Muller_Lab That's not much...I'm planning on putting 3uM in the mouthwash. How do you rationalize its positive effects on health? For ex, https://t.co/xeis3cA5Lt

Dec 29, 2022 · 9,718 followers View post →
Nuala Woulfe
@Nuala_Woulfe · X

Berberine is a naturally occurring alkaloid found in many different types of plants and shrubs. In 2008, a clinical study determined that within 1 week of daily berberine supplementation, metabolic hormone sensitivity was improved by 44.7% PubMed #health https://t.co/PJcawDqWEr

Sep 3, 2022 · 1,792 followers View post →
jimcatalano
@jimcatalano · X

RT @drmikehart: On the other hand, Berberine is not a prescription drug; it is an over-the-counter supplement. But studies indicate that…

Jun 15, 2022 · 1 share · 439 followers View post →
Mike Hart, M.D
@drmikehart · X

On the other hand, Berberine is not a prescription drug; it is an over-the-counter supplement. But studies indicate that Berberine is as effective as Metformin for blood glucose control in type 2 diabetics. https://t.co/MqPakR6rgY

Jun 15, 2022 · 6 likes · 1 share · 66,405 followers View post →
Jeffrey Wacks, M.D.
@JeffreyWacksMD · X

RT @patriotdirectfm: Yin et al. 2008 showed that in patients with Type 2 Diabetes, the hypoglycemic effect of Berberine was similar to that…

May 10, 2022 · 1 share · 199 followers View post →
PatriotDirect Functional Medicine
@patriotdirectfm · X

Yin et al. 2008 showed that in patients with Type 2 Diabetes, the hypoglycemic effect of Berberine was similar to that of Metformin. https://t.co/qvyz1r4C3u

May 10, 2022 · 1 like · 1 share · 24 followers View post →
Ramona G
@RamonaGorasciuc · X

RT @hormonedietdoc: Berberine regulates glucose & lipid metabolism as well as Metformin & is safer. "The main effect of Metformin is inhi…

Apr 30, 2022 · 6 shares · 652 followers View post →
Vibrant Labs
@VibrantLabs1 · X

RT @hormonedietdoc: Berberine regulates glucose & lipid metabolism as well as Metformin & is safer. "The main effect of Metformin is inhi…

Jan 5, 2022 · 6 shares · 126 followers View post →
@Freeki
@Frikkieb1 · X

RT @hormonedietdoc: Berberine regulates glucose & lipid metabolism as well as Metformin & is safer. "The main effect of Metformin is inhi…

Jan 5, 2022 · 6 shares · 318 followers View post →
The be in behalal is an #EHO #Female
@behalalorg · X

#Cancer #BreastCancerAwareness #estrogenpostive cancers that blocked Low #estrogen can bring on #diabetes #Berberine regulates glucose & lipid metabolism similar #Metformin & is safer. Do your research... https://t.co/xVxXz4jAPB https://t.co/TfVbalXAeM

Jan 5, 2022 · 1 like · 3,219 followers View post →
Carol Hummel, ChE
@turnerhummel · X

RT @hormonedietdoc: Berberine regulates glucose & lipid metabolism as well as Metformin & is safer. "The main effect of Metformin is inhi…

Jan 5, 2022 · 6 shares · 149 followers View post →
Ted Clark
@tedrsa · X

RT @hormonedietdoc: Berberine regulates glucose & lipid metabolism as well as Metformin & is safer. "The main effect of Metformin is inhi…

Jan 5, 2022 · 6 shares · 181 followers View post →
Dr. Jay Wrigley
@hormonedietdoc · X

Berberine regulates glucose & lipid metabolism as well as Metformin & is safer. "The main effect of Metformin is inhibition of the mitochondrial transport chain complex-I, which essentially poisons the mitochondria" https://t.co/r4Pw7KWwph https://t.co/WoDLPHVYd5 #Berberine

Jan 5, 2022 · 46 likes · 6 shares · 104,793 followers View post →
Anonymous Investor
@anony222222 · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 19, 2021 · 16 shares · 365 followers View post →
Shaun
@stat3 · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 19, 2021 · 16 shares · 826 followers View post →
Loretta
@1961hershey · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 19, 2021 · 16 shares · 7 followers View post →
EvaWeaver
@londonevaweaver · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 19, 2021 · 16 shares · 747 followers View post →
Sylvan A
@sylvanashen · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 19, 2021 · 16 shares · 554 followers View post →
Colleen Borgesano
@c_borgesano · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 18, 2021 · 16 shares · 735 followers View post →
Glenn Fincher
@gtfinchy · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 18, 2021 · 16 shares · 3,243 followers View post →
Suz Ashley_LifeCoach_HumanDesign
@SuzAshley · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 18, 2021 · 16 shares · 2,093 followers View post →
Gabino
@JGabinoD · X

RT @hormonedietdoc: People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin re…

Aug 18, 2021 · 16 shares · 331 followers View post →
Dr. Jay Wrigley
@hormonedietdoc · X

People on Metformin. Berberine is a better choice than Metformin for lowering A1c, blood glucose & reversing Insulin resistance. It is also anti-inflammatory & helps you lose FAT. Berberine also lowers Triglycerides & HDL levels https://t.co/yQznFu4fnj https://t.co/fO1NXUAtqJ

Aug 18, 2021 · 107 likes · 16 shares · 104,793 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@beejereeno Berberine is a 'natural' form of metformin. So you if you are on berberine you are on medication, likely with same side effects. "Efficacy of berberine in patients with type 2 diabetes mellitus" https://t.co/b1H8LXUHqA So what is your FBG if you don't take berberine? https://t.co/ejrm3J4OCG

Jul 29, 2021 · 1 like · 28,256 followers View post →
I am Charlie
@CrystlIS · X

@drnickgreiner Just over priced berberine (which may be helpful) from what I can tell. https://t.co/AFR3Q6h36H

Apr 25, 2021 · 365 followers View post →
magic
@magemagic · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Mar 1, 2021 · 30 shares · 481 followers View post →
Khalida Al Ayoub
@KhAlayoub · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jan 27, 2021 · 30 shares · 1,968 followers View post →
د. مشوح عبدالله المشوح
@mushawah1 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Dec 25, 2020 · 30 shares · 28,364 followers View post →
أعشاب علاجHerbal Remedies
@othmanhg12345 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Nov 14, 2020 · 30 shares · 2,015 followers View post →
..
@A_Mush2030 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Nov 9, 2020 · 30 shares · 5 followers View post →
taraf
@TU33858639 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Nov 3, 2020 · 30 shares · 205 followers View post →
hessa-71
@71_hessa · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Oct 31, 2020 · 30 shares · 1,284 followers View post →
magic
@magemagic · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Aug 15, 2020 · 30 shares · 481 followers View post →
السنافيه
@5HJQXrHuJkQtlSC · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 4, 2020 · 30 shares · 33 followers View post →
سالم راشد ال مشرف
@salemAlmoshref · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 2, 2020 · 30 shares · 2,123 followers View post →
shooooooosh155
@shooooooosh155 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 2, 2020 · 30 shares · 237 followers View post →
Radi Abdullah
@radia155 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 1, 2020 · 30 shares · 83 followers View post →
محمد العبدالله
@alshafi111 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 1, 2020 · 30 shares · 1,617 followers View post →
فوزية الحواس
@Fozo3 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 1, 2020 · 30 shares · 263 followers View post →
أنس بن فراج الفراج
@alfarraj4 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 1, 2020 · 30 shares · 573 followers View post →
هياء السعيدان
@ta3alel · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 1, 2020 · 30 shares · 112 followers View post →
Dr. Turki Khalufa Asiri
@turkialasiri · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

Jun 1, 2020 · 30 shares · 1,245 followers View post →
متفائل
@almtfal347 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

May 31, 2020 · 30 shares · 382 followers View post →
Mohammad AlOtaibi
@Mhemet_Otaibi · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

May 31, 2020 · 30 shares · 403 followers View post →
MUTAB⏳
@tm3355 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

May 31, 2020 · 30 shares · 208 followers View post →
المستشار أَنْوَر الحَسَن
@AlhasanAnwar · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

May 31, 2020 · 30 shares · 1,703 followers View post →
عبدالله سليمان المشيقح
@aboood293 · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

May 31, 2020 · 30 shares · 6,358 followers View post →
hessa-71
@71_hessa · X

RT @mushawah1: البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب ا…

May 31, 2020 · 30 shares · 1,284 followers View post →
د. مشوح عبدالله المشوح
@mushawah1 · X

البربرين Berberine مستخلص طبيعي يعمل مثل الميتفورمين metformin يساعد بتقليل مستويات السكر النوع الثاني ويجب استشارة الطبيب المعالج قبل تناوله. https://t.co/pbRrlTbm2V https://t.co/ED6kDteinM https://t.co/ACjcPfQtKK

May 31, 2020 · 86 likes · 30 shares · 28,364 followers View post →