October 2008 PMID 18457915

Multi-targeted prevention and therapy of cancer by proanthocyanidins.

Vijayalakshmi Nandakumar, Tripti Singh, Santosh K Katiyar

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Abstract in brief

Proanthocyanidins, natural compounds found in fruits, berries, bark, and seeds, have shown significant potential as cancer-preventive and therapeutic agents due to their antioxidant and anti-inflammatory properties.
Research, including laboratory and animal studies, indicates that proanthocyanidins can target multiple molecular pathways involved in cancer development, such as NF-kappaB, MAP kinases, PI3K/Akt, caspases, cytokines, and processes like angiogenesis and cell cycle regulation.
Despite limited data on their absorption and metabolism, especially in humans, evidence suggests that smaller proanthocyanidin molecules are absorbed in the gut, and their ability to modulate various molecular targets underscores their potential in preventing cancers across different organs.

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