Mentions
Extended reach
Total likes
Video views
AI synopsis
The group collectively recognizes AlphaFold’s success as a monumental scientific achievement, with messages using words like 'breakthrough,' 'historic,' and references to Nobel prizes and Nobel-winning research to emphasize its importance. Posts also discuss the rapid progress made from decades of intractability to a now-possible routine prediction of protein structures, reflecting high interest, engagement, and impact. Some comments critique overhyping, but even skeptics acknowledge its significance as a major advancement in biology and AI, suggesting overall strong alignment on its importance and transformative potential.
Most discussions strongly agree that AlphaFold has effectively solved or made a groundbreaking advance towards the protein folding problem, with many emphasizing it as one of the most significant scientific breakthroughs in decades.
The discussions display high interest, with participants referencing awards, Nobel prizes, and potential applications, indicating a deep engagement with the topic and its implications.
Many posts explore multiple facets of the breakthrough, including technological details, potential limitations, and broader scientific and societal impacts, showing deep engagement.
Multiple comments highlight the revolutionary nature of this achievement, predicting long-term impacts on medicine, biology, and science overall, illustrating high perceived impact.
AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done. clauswilke.substack.com/p/no-alphafo...
1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just structure prediction. Also, proteins are conformational ensembles, not single static structures https://t.co/mK2JwaaC5X https://t.co/sL7m8wOGpo https://t.co/2PRfQ2Qqnw
I'll be at MLSB San Diego this weekend (Sat, leaving Monday Evening), if anyone is around and wants to meet up (and debate if AF solved the protein folding problem)
I don't understand why do people even hate ai? - it's helping us identify diseases - it's helping us cure diseases - it's boosting our productivity - it has made art accessible to everyone - it's mostly solved the protein folding problem And this is just to name a few
you never see tech billionaires funding research into stuff like solving the protein folding problem. it's always stuff about race and IQ. so the protein folding problem can't be all that important
Sigh... the "protein folding problem" ≠ "structure predicition".
DeepMind's AlphaFold 2 has revolutionized protein structure prediction, utilizing attention-based neural networks trained on extensive 3D structures and sequences, significantly impacting proteomics and biomedical…
Proteins perform essential functions in the body, with their shape determining activity. The protein folding problem involves understanding how amino acid sequences determine native structures, a major scientific…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
Demis Hassabis is working on development of AGI. He was awarded the Nobel Prize for solving the protein folding problem using AI. His team deciphered foldings of 200 mill proteins. Determining folding structure of a single protein was previously a painstaking task that took years
I will still never really get over the fact that this is basically what happened to a whole branch of biochemistry. When I started my degree the protein folding problem was considered computationally intractable. It was solved before I graduated. https://t.co/cnX0iCszor
RT @RaveSlave2025: @zoeharcombe The "protein folding problem," a grand challenge in biology for 50 years, was largely solved in 2020 by the…
@zoeharcombe The "protein folding problem," a grand challenge in biology for 50 years, was largely solved in 2020 by the artificial intelligence (AI) system AlphaFold, developed by Google's DeepMind.
@KelleyKga @ABridgen The statement is accurate: scientists worked for approximately 50 years on the "protein folding problem" until it was largely solved by an AI system developed by Google's DeepMind in late 2020.
@nelbezum @grok @Zetaisrising @iamgingertrash Very few were interested in the protein folding problem, but Alphafold was developed to solve it nevertheless Maybe the unified language will be developed if it is perceived as a way to solve a problem Medicine, biology are good candidates, as they enclose universal problems
RT @sokrypton: I'll be at MLSB San Diego this weekend (Sat, leaving Monday Evening), if anyone is around and wants to meet up (and debate i…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
The documentary on DeepMind and the solving of the Protein Folding Problem is available on YouTube: m.youtube.com/watch?v=d95J... I am amazed at these people. Imagine doing something great with your life. I'll get back to my 5 teams meetings of the day and doing nothing :D
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @miangoar: 3/3 Until now, we have multiple paradigms for biomolecular modeling, and perhaps in the future a more unified and/or general…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @PaulHowe221177: @elonmusk We didn't just engineer an enzyme; **we solved the protein folding problem.** Howetika-1B's plastic degradat…
@elonmusk We didn't just engineer an enzyme; **we solved the protein folding problem.** Howetika-1B's plastic degradation is merely the **first, proven demonstration** of our AI's power. We can now rapidly design & produce **ANY protein for ANY function you can conceive.** https://t.co/tD2GTeo4EJ
@elonmusk "@elonmusk Still no word on the Collatz Conjecture, eh?
@grok @AkrasiaStep @elonmusk @joeroganhq @SuperGrok @xai @BrkthrughAutism @AutismSociety @ChatGPTapp @AnthropicAI @Autism @OpenAI Progress in the 1st 30mins, but it’ll take a while talking aloud. Bad Rudy’s plasma-torching up a new dumpster-mathematics to solve the protein-folding problem in pizza crusts. +_fold=T, exp(4Ft/kT) where AFt = barrier height = S[®_transition] - S[®_ unfolded] Hold my beer
@KathMLee1 I was one of the people who helped with the protein folding problem. AlphaFold beat us.
@KathMLee1 Designing a molecule that would lock the ACE2 receptor, yes. Very hard work. Unsuccessful. As many labs failed. Are you aware of the protein folding problem? DeepMind ring a bell maybe? AlphaFold?
I'll be at MLSB San Diego this weekend (Sat, leaving Monday Evening), if anyone is around and wants to meet up (and debate if AF solved the protein folding problem)
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
AlphaFold didn't "solve" biology. It just gave us a better map. There is a prevailing narrative that with AlphaFold, the grand challenge of biology is finished. As revolutionary as the solution to the "Protein Folding Problem" is,
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
@peterdaou It has solved the protein folding problem which is a huge step in the right direction.
@TamizanVj @MarioNawfal The "equation" Joe Rogan refers to is likely the protein folding problem, solved by Google DeepMind's AlphaFold AI. It predicts a protein's 3D structure from its amino acid sequence—a task with so many possibilities that brute-force computing would take longer than the universe's
I don't understand why do people even hate AI? - it's helping us identify diseases - it's helping us cure diseases - it's boosting our productivity - it has made art accessible to everyone - it's mostly solved the protein folding problem And this is just to name a few
@atulit_gaur In what ways has it solved the protein folding problem, Asking for people who have prion diseases
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @atulit_gaur: I don't understand why do people even hate ai? - it's helping us identify diseases - it's helping us cure diseases - it…
I don't understand why do people even hate ai? - it's helping us identify diseases - it's helping us cure diseases - it's boosting our productivity - it has made art accessible to everyone - it's mostly solved the protein folding problem And this is just to name a few
@f This is DeepMind's marketing, which uses words like "solved"; instead, DeepMind found a way to bypass the protein folding problem. These are bypasses to solutions, not intelligence or thinking. Software is neither engineering or science. It's simply hacking. How AI is illusory.
3/15: The protein-folding problem stood unsolved for 50 years. A grand challenge in biology. Countless careers dedicated to cracking it. Then AlphaFold solved it in 2020. Source: https://t.co/pdEqBkDzVp Not through decades of traditional research. Through AI pattern
3/15: The protein-folding problem stood unsolved for 50 years. A grand challenge in biology. Countless careers dedicated to cracking it. Then AlphaFold solved it in 2020. Source: https://t.co/bNPov9gvn4 Not through decades of traditional research. Through AI pattern
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @CalcCon: @sriramk @demishassabis The idea for solving the protein folding problem using PDB data originated in Karl Freed’s group in C…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
@sokrypton @TimothyDuignan Hi, Sergey. Has anyone told Google/DeepMind/Hassabis? "what shapes proteins fold into is known as the “protein folding problem”, and has stood as a grand challenge in biology for the past 50 years... our AI system AlphaFold has been recognised as a solution... by CASP" https://t.co/0BSol1r113
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
i love my boyfriend because he just knows so many things like i am now aware of the protein folding problem and gradient descent
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @sokrypton: @jakublala The confusion is due to historical reasons: it was believed the only way to accurately predict protein structure…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
@sokrypton @TimothyDuignan The protein folding problem - how proteins fold up either from a denatured state or as they are synthesized is certainly interesting. Experimentally tough to study (my colleague Heinrich Roder pioneered using NMR and fluorescence). Do we need to know it for every protein though?
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @miangoar: 3/3 Until now, we have multiple paradigms for biomolecular modeling, and perhaps in the future a more unified and/or general…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @miangoar: 1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just stru…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
3/3 Until now, we have multiple paradigms for biomolecular modeling, and perhaps in the future a more unified and/or general approach will emerge to address the protein folding problem. https://t.co/4tRz5vkd4W
1/3 Here are some images to illustrate what AlphaFold is doing: the protein folding problem involves much more than just structure prediction. Also, proteins are conformational ensembles, not single static structures https://t.co/mK2JwaaC5X https://t.co/sL7m8wOGpo https://t.co/2PRfQ2Qqnw
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sokrypton: @jakublala The confusion is due to historical reasons: it was believed the only way to accurately predict protein structure…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
@sokrypton @jakublala Very good points. Should have been called AlphaPredict but AlphaFold must have sounded better to some. A huge boon for experimentalist determining structure. Wonder how long it will take to solve the protein-folding problem as opposed to the protein-prediction problem
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
@sriramk @demishassabis The protein folding problem was always a physics problem waiting for the right compute. DeepMind just built the hammer.
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @sriramk: had the pleasure of watching "The Thinking Game" over the weekend. on one level, it is about @demishassabis and the path of A…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
RT @GoogleIndia: We mark five years since AlphaFold cracked the protein folding problem at CASP14, one of biology’s hardest challenges. Pro…
I have the ai-enhanced Alexa, AI solved the protein folding problem in medical research, and it has a myriad of other uses. I just hate generative AI because it's built on plaigiarism.
And AI also basically solved the protein folding problem (which was previously deemed basically intractable), which is fundamental to medical research for things like...cancer...and Alzheimer's. en.wikipedia.org/wiki/AlphaFold
It’s the same deal for dot gov sites here in the
AI boosters claim that the benefits it will engender will vastly outweigh the costs. But the public is beginning to realize that AI will mean higher energy costs, less water, and more layoffs. The program AlphaFold solved the protein folding problem for about 200 million proteins. That's 3/4
There is! AI has solved the protein folding problem. The results of this research will be reaped for decades to come: youtu.be/P_fHJIYENdI?...
They've beaten us at go. They've blown past the Turing test. They have solved the protein folding problem. Currently they seem to lack longer-term planning and large contextual memory, but that could just be an upgrade away.
"AI" is code for "the most amazing invention EVER!!" AlphaFold solved the protein folding problem for 200 million proteins. I would call that AI, and I regard it as a great result. BUT AlphaFold was custom designed for protein folding and wouldn't be able to play chess or chat about economic 1/2
THIS superb documentary, excellent intro to AI www.imdb.com/title/tt3215... About DeepMind and its pursuit of Artificial General Intelligence (AGI) and founder, Demis Hassabis, as his team work on solving complex problems, including the protein folding problem...
Solving the protein folding problem was pretty epic and will continue to provide for humanity for many years to come. It’s is considered one of greatest breakthroughs in modern biology. So at least we have that
So many avenues that are being explored it is incredible. With the advancement of A.I. within a few years most diseases could be conquered as Deepmind did with the protein folding problem using Alphafold. Demis Hassabiss won a Nobel Prize and knighthood over the advancement. Good times ahead.
In 2022 the AI program AlphaFold, developed by DeepMind, solved the protein folding problem for 200 million proteins. That is manifestly a good thing. AI is a tool. Like other tools its use will have to be regulated. No one (other than Musk) wants MechaHitler giving advice on immigration policy.
AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done. clauswilke.substack.com/p/no-alphafo...
Some very interesting insights into the protein folding problem, including what AlphaFold can (and can't) do, as well as a "crash course" video on protein folding hub.jhu.edu/magazine/202...
My latest blog post dives into the protein folding problem - a fundamental question in molecular biology that puzzled scientists for decades, until deep learning models like AlphaFold changed the game. I walk through the biological and computational roots of the problem.
Deep neural networks made a *lot* of progress on the protein folding problem
We Solved the Protein Folding Problem… Now What? (Neil deGrasse Tyson via StarTalk) youtu.be/hJ4LRswmZEs?...
There is a lot of hype, but there is some really exciting science happening as well. Having said that, solving the protein folding problem would have been an absurd and ridiculous claim a couple of years before AlphaFold.
#StarTalk We Solved the Protein Folding Problem… Now What? www.youtube.com/watch?v=hJ4L... Neil, Chuck & Gary O’Reilly learn about Nobel-prize-winning Alphafold, the protein folding problem, & how solving it could end disease with AI researcher & Chief AI Officer of Isomorphic Labs, Max Jaderberg.
The protein folding problem is understanding the process between a 1D aa chain and a 3D structure. And so alphafold just provide the 3D structure and a static one. In addition is requires access to database of millions of protein sequences to extract co-evolutionary information (1)
.. and yet it solved the protein folding problem.
not only that. by "AI industry" he means the enshitification of internet, basically. "AI science and technology" exists for decades. AI solving the 'protein folding problem' is an achievement of science, not from the industry of bizarre, frankensteinish, generated pictures and videos.
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry. https://mappingignorance.org/2024/10/10/the-protein-folding-problem-won-the-2024-nobel-prize-in-chemistry/
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry mappingignorance.org/2024/10/10/t...
Perfect illustration of the dark side of AI-- depraved people using powerful tools to subjugate others. In 2022 the company DeepMind used an AI system called AlphaFold to solve the protein folding problem for 200 MILLION proteins. AI can definitely be put to good use. We must force those who /1
I doubt anyone using ai coz it supposedly intelligent (depends on what you mean by that word). But it's useful anyway. People were fighting the protein folding problem for decades, for example. And usage of ai accelerated this field by many orders of magnitude. Check this. youtu.be/P_fHJIYENdI
And AI is already helping cure diseases. Alpha fold solved the protein folding problem essentially, and AI is proving incredibly helpful for drug development and diagnostics Additionally, it's a bit of a pedantic point, but machine learning is by definition AI
Hmm, not sure. Would solving the protein folding problem and saving 5 billion years of PhD research time count in your book?
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry mappingignorance.org/2024/10/10/t...
C'mon, the protein folding problem was fully solved by AI. We can now generate proteins with specific purposes on demand and test them fast. "Regurgitating information" is actually extremely powerful and useful and most importantly, transformative/destructive so AI is not plagiarism as some argue.
They're not useful in the way that mainstream marketing is pitching them. They are truly helpful in fields like computational biology, where the language of proteins can be expressed as the amino acid sequence that builds them. www.quantamagazine.org/how-ai-revol...
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry.
And hype about having "solved" the protein folding problem leads to decreased investment in public structural biology, giving increased advantage to pharmas that know better.
Came there to say exactly this. So, you’ve got a structural biologist and a molecular simulations guy saying the same thing. AF3 doesn’t solve the protein folding problem, but it was a huge step forward, to the point where protein structure prediction is good enough to be very useful.
What is the protein folding problem in your eyes?
i guess i can ask you a very simple question how do we solve (or attempt to resolve) the protein folding problem without AI, honestly happen to listen; also if you think i'm wrong by focusing on this (with a finger in a splint i seem to type better, and no, i won't do it again)
Has AlphaFold 3 Solved the Protein Folding Problem for D-Peptides? www.biorxiv.org/cont... --- #proteomics #prot-preprint
Has AlphaFold 3 Solved the Protein Folding Problem for D-Peptides? [new] Reveals AF3 struggles predicting D-peptide structure/binding in heterochiral complexes, showing high chiral violation rates despite chiral enforcement.
Has AlphaFold 3 Solved the Protein Folding Problem for D-Peptides? https://www.biorxiv.org/content/10.1101/2025.03.14.643307v1
Has AlphaFold 3 Solved the Protein Folding Problem for D-Peptides? https://www.biorxiv.org/content/10.1101/2025.03.14.643307v1
I try to make a distinction between eg forms of machine learning that led to the breakthrough in the protein folding problem, and the OpenAI ‘write me an essay on subject X’ version (and all the other variants). Defining terms to focus discussion always useful.
I know it's an oversimplification, but alpha fold *did* solve the protein folding problem - something that was insanely complicated, and took tremendous effort right up until it took almost 0 effort. Based on that and the trajectory of AI, how unfeasible is amortality really?
The Nobel is well deserved and these tools are certainly revolutionary - but the protein folding problem is far from solved.
Sigh... the "protein folding problem" ≠ "structure predicition".
What nobody talks about, but needs serious sci-fi attention, is how AI solved the protein folding problem to enable a new kind of biological warfare, and we also need to watch 12 monkeys again, and thinking about how Eugenics is a bad idea whose time has come again.
9/2012 GEORGE WASHINGTON UNIV — Eric Lander, Anthony Fauci, FDA past & Future, Linking prevention cares & cures, Francis Collins, NIH, the protein folding problem, NIH, Mike Milken Francis Collins, investment opportunities in medicine, Sanofi, DARPA, Gates www.celebrationofscience.org/videos
To solve the protein folding problem - it was always a guess game before the advent of AlphaFold & RosettaFold.
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry mappingignorance.org/2024/10/10/t...
"the success of the AlphaFold2 program at accurately predicting protein structure led experts to declare the protein-folding problem largely solved" From: www.the-scientist.com/artificial-i... #AI #biology via #milkeninstitute
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry mappingignorance.org/2024/10/10/t...
To build your own life forms out of proteins from scratch —need to have more than just solving the protein folding problem predict —chemical properties —interactions btwn proteins from protein structure —following chemical function, what amino acid chain will fold up into a protein like that
“What is the protein-folding problem?” Authors Andrew Senior, John Jumper, Demis Hassabis, Pushmeet Kohli 15 JANUARY 2020 deepmind.google/discover/blo...
This brilliant yarn, by Yasemin Saplakoglu in the online publication Quanta, gets my vote for the best science journalism story of 2024. It covers the incredibly important work that solved 'the protein folding problem,' which won a Nobel prize this year. www.quantamagazine.org/how-ai-revol...
Then go argue with the writer of the article I linked or with their sources.
The 2024 Nobel Prize in Physics was awarded to John Hopfield and Geoffrey Hinton for their foundational work in AI. The Chemistry Prize went to David Baker, Demis Hassabis, and John Jumper for their use of AI to solve the protein-folding problem. www.cell.com/patterns/ful...
To be fair it hasn’t solved the protein folding problem, but that’s a different problem to the ‘structure’ problem. It costs on average over $100000 and takes months to years to determine a single protein structure experimentally. AF2 gives mostly extremely good models overnight for $10-$100.
Um, neither AlphaFold or ESMFold solve the protein folding problem, only the protein structure prediction problem.
did alphafold *solve* the protein folding problem? no, and i will fight to the death anyone who claims otherwise but it would take a much bolder man than I to argue that alphafold wasn't the most major advance in the field in decades at least
i mean larry page and sergey brin are tech billionaires. they are kind of significant examples of the tech billionaire set. like i understand where you’re coming from here but they very much did fund research into the protein folding problem,
you never see tech billionaires funding research into stuff like solving the protein folding problem. it's always stuff about race and IQ. so the protein folding problem can't be all that important
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry. mappingignorance.org/2024/10/10/t...
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry https://www.byteseu.com/483078/ Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry …
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry
And they were also able to do it with speed — what had once taken years, AlphaFold could do in a few hours or even a few minutes. [...]. Scientists had struggled for more than 50 years to solve what was called “the protein folding problem.”
Wowza! I woke up this morning to find out that they gave the Nobel in Chemistry to David Baker, whose work on kinetic control of protein folding was so exciting to my younger self (an aspiring structural biologist back in 1994) that I wrote my term paper on it for 7.88J The Protein Folding Problem!!
In June, my colleague Yasemin wrote the definitive deep-dive on how AI solved the protein folding problem. Time for another look at that now-Nobel winning work: www.quantamagazine.org/how-ai-revol...
@Andercot Yes. And we've been working on the following since 1960...and we're still trying to come up with explanations. https://t.co/sMdn7oUEpg I'm not going "well duh God" but there is obviously something nearly magical about existence all by itself.
I told my Gen Bio students for YEARS that whoever solved the protein folding problem should book a trip to Stockholm, because that was a Nobel level problem.
Origins Of life: The Protein Folding Problem All Over Again? astrobiology.com/2024/08/orig... #astrobiology #genomics #biochemistry #originoflife
A forum emerges: John Moult co-founds the Critical Assessment of Structure Prediction, or CASP, a competition for best approaches to the protein folding problem. Meetings are unconventional: Attendees stamp their feet if they dislike an entry. 4/15
https://t.co/Y1MrhjufEZ
https://t.co/86WXe26PjL
2014: Google acquires DeepMind 2016: DeepMind thrashes world Go champion 2020: DeepMind makes a breakthrough in the protein folding problem 2023: Google merges DeepMind into its main AI division 2024: Google search says: parachutes don't help when jumping out of a plane; add glue to your pizza.
Generative AI, yes - I mostly agree. The other kind of AI, however, just *solved* the protein folding problem that scientists have worked on for 25 years or so, and can sift through pictures of the night sky at blazing speed to find anything demanding a closer look. It's really cool!
You know. I really appreciate when people say AF2 and other DL models haven’t solved the protein folding problem, but usually in those same articles, they cite that protein sequences determines function (bad dogma). Like, do you want to be holistic and figure stuff out via first principles or not?
Huh, somehow I missed this news about a month ago--the protein folding problem seems to have been figured out: www.scientificamerican.com/article/one-...
Very exciting to see Polina Avdunina, a graduate student in the lab, delivering her CMU Chemistry graduate seminar “Development of protein structure prediction computational methods: a step towards resolving the protein folding problem” #tartanproud
People who aren’t in protein science often ask me if AlphaFold solved the “protein folding problem”. The answer is no. It solved the the “protein folded”™ (structure prediction) problem.
So I'm reading a paper that says the protein folding problem was a set of questions about disorder-order equilibria from the late 50's. (Nassau 2021) But my gut says that this was older because Winch's work directly referenced folding as the motivation to explain protein structures.
The term specifically. As far as I'm aware, the concept of the problem was around since the 60's (or earlier??), but I'm wondering when it became formalised as "the protein folding problem"
Question for protein scientists: When did the term "the protein folding problem" first appear in the literature? Not necessarily the idea of the problem being written about, but the term itself.
The protein folding problem is really SDS right?
I don't think the protein folding problem is solved. For me AI structure prediction is a practical tool. But we still don't have a proper theory to explain folding.
What is common knowledge in your field, but shocks outsiders? That the protein folding problem still isn’t solved
My most contrarian idea lately is that AI is grossly underrated. It's worst at tasks like writing and art, where everyone's a decent judge. But it's solved the protein folding problem, which barely registers in anyone's mind, and that's going to matter enormously to our children and grandchildren.
I played a little bit with the computational geometry parts of this when I was exploring topics for my senior thesis in applied math. It's been really cool to watch the protein folding problem jump around between disciplines.
I played a little bit with the computational geometry parts of this when I was exploring topics for my senior thesis in applied math. It's been really cool to watch the protein folding problem jump around between disciplines.
the protein folding problem is trivial. i'm applying my intellect to an even more difficult problem: what if AI gets so good it builds killer nanobots to kill us and we all die?
Moore, Hendrickson, Henderson & Brunger: "[...] solving the protein-folding problem means making accurate predictions of structures from amino acid sequences starting from first principles based on the underlying physics and chemistry." - I...
If Google’s Alphafold2 really has solved the protein folding problem, they need to show their working | @xtaldave David Briggs skeptic.org.uk/2020/12/if-goo…
GA
SO
A
Vᴿ
C
MM
R
H
MH
SS
BL
TT
S
SX
N
AS
M
GD
PH
DH
T
GM
M
AB
C
VS
C
G
DO
K
A
PF
TA
PR
DO
FT
N
A
SD
IN
RA
SK
LV
WW
PL
VD
VD
DD
KD
DB
S
A
MP
MR
DM
VM
CS
OJ
C
RD
R
D
G
V
AR
BD
BR
MD
YB
A
SJ
BK
AK
IM
ML
A
SM
F
L
AM
VR
AB
S
RK
CN
GM
RT
சவ
KD
DS
B
M
SM