Annu Rev Pharmacol Toxicol April 2009 PMID 18834313

Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.

Neal L Benowitz

Mentions

39
Peak: 3 in Dec 2021
across 4 sources since Dec 2021

Extended reach

22,804
potential audience

Total likes

37

Video views

341

Mentions per month

Dec 2021 – Dec 2025

Where it's discussed

  • News24 articles
  • X / Twitter8 posts
  • Blogs5 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects a balanced view, with some posts emphasizing nicotine's mood and cognitive benefits, such as improved concentration, while others highlight health concerns like delayed healing and increased diabetes risk, demonstrating a mix of curiosity and caution. Words like 'benefits' and 'risks' indicate a nuanced engagement, but the lack of in-depth discussion results in moderate engagement and impact scores.

AgreementLow agreement

Most posts reveal mixed feelings; some acknowledge benefits like stress reduction and concentration, but others highlight potential harms such as delayed wound healing and increased diabetes risk.

InterestModerate interest

The discussions show curiosity about nicotine's effects, especially regarding benefits, but also some attention to health risks, indicating moderate interest.

EngagementNeutral engagement

The responses are somewhat superficial, mainly sharing statements or quoting benefits and risks without deep analysis or critique.

ImpactModerate impact

The social discussions introduce important health considerations and challenge the perception of nicotine as purely harmful, showing moderate influence in shaping perceptions.

Abstract in brief

  • Nicotine addiction is driven by its binding to nicotinic cholinergic receptors, which triggers the release of neurotransmitters like dopamine, glutamate, and GABA, contributing to dependence, with genetic factors influencing susceptibility.
  • Nicotine metabolism, mainly through CYP 2A6, varies among individuals, affecting their risk of addiction, success in quitting, and lung cancer, and addiction is more prevalent among individuals with mental health and substance abuse issues.
  • Treatment options include nicotine replacement therapy, bupropion, and varenicline, with varenicline acting as a partial agonist at nicotine receptors to help reduce cravings and withdrawal symptoms.

Top posts

Most liked on X and Bluesky
Dr Colin Mendelsohn
@ColinMendelsohn · X

2/6 Benefits “Nicotine... induces stimulation and pleasure and reduces stress and anxiety. Smokers use nicotine to modulate their level of arousal and for mood control in daily life. Smoking may improve concentration, reaction time and performance ” https://t.co/vp8XcU0NM9

Aug 1, 2022 · 14 likes · 1 share · 6,678 followers View post →
Dr Colin Mendelsohn
@ColinMendelsohn · X

@Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels and could increase the risk of diabetes There is no evidence of significant harm from long-term nicotine in #NRT or high-nicotine #snus #SaferNicotine https://t.co/8d5qEfH5JK

Dec 13, 2021 · 6 likes · 3 shares · 6,678 followers View post →
PantherNoster
@PantherNoster · X

RT @ColinMendelsohn: @Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels an…

Dec 13, 2021 · 3 shares · 2,869 followers View post →
Rawg Slinkard
@Rawgster · X

RT @ColinMendelsohn: 2/6 Benefits “Nicotine... induces stimulation and pleasure and reduces stress and anxiety. Smokers use nicotine to mo…

Aug 1, 2022 · 1 share · 2,731 followers View post →
durand benoit
@benoit_durand · X

RT @ColinMendelsohn: @Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels an…

Nov 16, 2022 · 3 shares · 2,078 followers View post →
Joel
@joelsawa · X

RT @ColinMendelsohn: @Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels an…

Dec 13, 2021 · 3 shares · 844 followers View post →

All mentions

Silent Oath
@SilentOath_Z · X

Nicotine increases the firing rate of dopamine neurons which, over time, erodes your ability to enjoy, value, or prioritise anything else. Source: PubMed Central — Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics #TIL #TodayILearnt https://t.co/IOKgBuJafH

Jul 3, 2025 · 3 followers View post →
durand benoit
@benoit_durand · X

RT @ColinMendelsohn: @Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels an…

Nov 16, 2022 · 3 shares · 2,078 followers View post →
Diana
@PharmphoodTM · X

@DrKashmirM https://t.co/9pzBtWUxlA

Aug 8, 2022 · 555 followers View post →
Rawg Slinkard
@Rawgster · X

RT @ColinMendelsohn: 2/6 Benefits “Nicotine... induces stimulation and pleasure and reduces stress and anxiety. Smokers use nicotine to mo…

Aug 1, 2022 · 1 share · 2,731 followers View post →
Dr Colin Mendelsohn
@ColinMendelsohn · X

2/6 Benefits “Nicotine... induces stimulation and pleasure and reduces stress and anxiety. Smokers use nicotine to modulate their level of arousal and for mood control in daily life. Smoking may improve concentration, reaction time and performance ” https://t.co/vp8XcU0NM9

Aug 1, 2022 · 14 likes · 1 share · 6,678 followers View post →
PantherNoster
@PantherNoster · X

RT @ColinMendelsohn: @Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels an…

Dec 13, 2021 · 3 shares · 2,869 followers View post →
Joel
@joelsawa · X

RT @ColinMendelsohn: @Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels an…

Dec 13, 2021 · 3 shares · 844 followers View post →
Dr Colin Mendelsohn
@ColinMendelsohn · X

@Tobaccoharmred1 Nicotine ⬇️blood flow to wounds and can delay healing eg after surgery Can ⬇️blood glucose levels and could increase the risk of diabetes There is no evidence of significant harm from long-term nicotine in #NRT or high-nicotine #snus #SaferNicotine https://t.co/8d5qEfH5JK

Dec 13, 2021 · 6 likes · 3 shares · 6,678 followers View post →