Cochrane Database Syst Rev October 2008 PMID 18843608

St John's wort for major depression.

Klaus Linde, Michael M Berner, Levente Kriston

Mentions

100
Peak: 8 in Mar 2023
across 6 sources since Jan 2019

Extended reach

386,424
potential audience

Total likes

4,881

Video views

196,403

Mentions per month

Jan 2019 – Jul 2025

Where it's discussed

  • X / Twitter31 posts
  • News23 articles
  • Facebook21 posts
  • Blogs20 articles
  • YouTube3 videos
  • Reddit2 posts

AI synopsis

What people are saying

Several posts emphasize the strength of the research, such as references to systematic reviews and meta-analyses, including phrases like 'Cochrane review concluded' and 'demonstrated effectiveness.' Words like 'support,' 'confirmation,' and 'evidence' indicate serious engagement with the scientific findings. The tone throughout reflects enthusiasm about the comparative benefits of St. John's wort over conventional treatments, emphasizing its efficacy and fewer side effects, which underscores the perceived high impact of the publication.

AgreementStrong agreement

Most discussions confirm and support the findings of the publication, emphasizing that St. John's wort is as effective as standard antidepressants and has fewer side effects.

InterestHigh interest

Posts demonstrate high curiosity, referencing detailed research, Cochrane reviews, and meta-analyses, indicating relevance and engagement with the topic.

EngagementHigh engagement

Many discussions cite specific studies, mention meta-analyses, and compare efficacy and side effects, showing deep involvement with the scientific content.

ImpactHigh impact

The tone and content suggest that social discussions see this publication as potentially influential for depression treatment options, highlighting its clinical significance.

Abstract in brief

  • St. John's wort (Hypericum perforatum) is commonly used in some countries to treat major depression, and research aims to compare its effectiveness and side effects with placebos and standard antidepressants.
  • A review of 29 randomized, double-blind trials involving 5489 patients found that St. John's wort is more effective than placebo and similarly effective as conventional antidepressants, with fewer adverse effects.
  • The evidence showed some variability, but overall St. John's wort has comparable response rates to standard antidepressants like SSRIs and tricyclics, and it might cause fewer dropouts due to side effects.]

Top posts

Most liked on X and Bluesky
د. مشوح عبدالله المشوح
@mushawah1 · X

عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في مضاعفات الادويه لاتستخدمها الا بعد استشارة طبيبك حتى لا تتعارض مع الادويه https://t.co/61sZJSkzcZ https://t.co/cAq3zmi4NN

May 29, 2021 · 64 likes · 8 shares · 28,927 followers View post →
Mike Hart, M.D
@drmikehart · X

A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression with fewer side effects (talk to your doctor before starting). https://t.co/iSecnJeuCA

Mar 22, 2023 · 24 likes · 8 shares · 66,562 followers View post →
Krzysztof Kukliński, obrońca praw człowieka
@pamiechomeblog · X

#dziurawiec

Oct 16, 2023 · 3 likes · 2 shares · 3,457 followers View post →
Sheila Rugnao M.D. ⚕️
@Sheila_Rugnao · X

If the weather ❄️

Dec 2, 2022 · 3 likes · 104 followers View post →
Guillermo Ferrer
@fenris1234 · X

@Shora El hipérico tiene evidencia como tratamiento para la depresion moderada,con eficacia mayor que el placebo, similar a los antidepresivos tradicionales, y menos efectos secundarios. https://t.co/dwimCxNrts.

Mar 29, 2022 · 2 likes · 4,367 followers View post →
Stavros Saripanidis, MD
@DrSaripanidis · X

Large Cochrane systematic reviews of all published randomized scientific papers, have clearly demonstrated that St. John's wort is just as effective as the strongest antidepressant medications, without their multiple side effects. https://t.co/vzuqUvvpEc https://t.co/FnoCfOHBQ1

Jan 24, 2019 · 2 likes · 688 followers View post →

All mentions

Crypto Charlie
@Charlene_Mattie · X

@DrNeilStone Biofeedback:

Jul 5, 2025 · 179 followers View post →
Krzysztof Kukliński, obrońca praw człowieka
@pamiechomeblog · X

RT @pamiechomeblog: #dziurawiec

Oct 16, 2023 · 2 shares · 3,457 followers View post →
Adam Socjalny
@Adam_Socjalny · X

RT @pamiechomeblog: #dziurawiec

Oct 16, 2023 · 2 shares · 25 followers View post →
Krzysztof Kukliński, obrońca praw człowieka
@pamiechomeblog · X

#dziurawiec

Oct 16, 2023 · 3 likes · 2 shares · 3,457 followers View post →
Xander Koolman
@XanderKoolman · X

@nicole_hunfeld @NPORadio1 Als je liever een Cochrane review leest: https://t.co/A43nYCz1hM

Aug 18, 2023 · 7,297 followers View post →
ciip (dm/rep, tag ya)
@ciiipsy · X

RT @drmikehart: A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression wi…

Mar 23, 2023 · 8 shares · 297 followers View post →
Javed Alam
@jalam1001 · X

RT @drmikehart: A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression wi…

Mar 23, 2023 · 8 shares · 1,005 followers View post →
KatZ
@B_Kat_777 · X

RT @drmikehart: A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression wi…

Mar 22, 2023 · 8 shares · 396 followers View post →
Susan Wilson
@PTSusie6 · X

RT @drmikehart: A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression wi…

Mar 22, 2023 · 8 shares · 342 followers View post →
Sammy
@themotherfight · X

RT @drmikehart: A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression wi…

Mar 22, 2023 · 8 shares · 322 followers View post →
zoethezombie
@zoethezombie · X

RT @drmikehart: A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression wi…

Mar 22, 2023 · 8 shares · 285 followers View post →
MNoelH
@MNoelH · X

RT @drmikehart: A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression wi…

Mar 22, 2023 · 8 shares · 1,775 followers View post →
Mike Hart, M.D
@drmikehart · X

A Cochrane review has concluded that St. John's Wort is as effective as standard antidepressants for treating depression with fewer side effects (talk to your doctor before starting). https://t.co/iSecnJeuCA

Mar 22, 2023 · 24 likes · 8 shares · 66,562 followers View post →
Sheila Rugnao M.D. ⚕️
@Sheila_Rugnao · X

it seems the web cant find my Cochrane reference. Ode to pubmed. https://t.co/RYSiQ2ydun

Dec 7, 2022 · 104 followers View post →
Sheila Rugnao M.D. ⚕️
@Sheila_Rugnao · X

If the weather ❄️

Dec 2, 2022 · 3 likes · 104 followers View post →
Dr. Psicosófico
@psichosophy · X

@jgarciafotograf @doctormacias Linde K, Berner MM, Kriston L. St John's wort for major depression. Cochrane Database Syst Rev. 2008 Oct 8;2008(4):CD000448. doi: 10.1002/14651858.CD000448.pub3. PMID: 18843608; PMCID: PMC7032678.

Oct 30, 2022 · 1 like · 751 followers View post →
くすりの家庭教師 ™奥村友紀【公式】
@tak_pom · X

システマティックレビューにおいて、セイヨウオトギリソウの摂取は抑うつ症状の改善に寄与する可能性が認められました。 St John's wort for major depression Cochrane Database Syst Rev. 2008 Oct 8;2008(4) PMID: 18843608 PMCID: PMC7032678 https://t.co/s0yh3JGmJp

May 15, 2022 · 1 like · 1 share · 12,898 followers View post →
Guillermo Ferrer
@fenris1234 · X

@Shora El hipérico tiene evidencia como tratamiento para la depresion moderada,con eficacia mayor que el placebo, similar a los antidepresivos tradicionales, y menos efectos secundarios. https://t.co/dwimCxNrts.

Mar 29, 2022 · 2 likes · 4,367 followers View post →
د. مشوح عبدالله المشوح
@mushawah1 · X

RT @mushawah1: عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في م…

May 30, 2021 · 8 shares · 28,927 followers View post →
Murraya32
@Murraya32 · X

RT @mushawah1: عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في م…

May 29, 2021 · 8 shares · 3,772 followers View post →
Legendary Man
@Economist_Sa · X

RT @mushawah1: عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في م…

May 29, 2021 · 8 shares · 755 followers View post →
مس حاسوبة
@MissHasoba · X

RT @mushawah1: عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في م…

May 29, 2021 · 8 shares · 11,369 followers View post →
shooooooosh155
@shooooooosh155 · X

RT @mushawah1: عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في م…

May 29, 2021 · 8 shares · 237 followers View post →
أبو طارق/ عبدالعزيز المشوح
@almohayed98765 · X

RT @mushawah1: عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في م…

May 29, 2021 · 8 shares · 3,370 followers View post →
د. مشوح عبدالله المشوح
@mushawah1 · X

عشبة ال St. John's wort تستخدم في المساعده في تخفيف الاكتئاب و قد وجدت بعض الدراسات انها افضل من مضادات الاكتئاب و اقل في مضاعفات الادويه لاتستخدمها الا بعد استشارة طبيبك حتى لا تتعارض مع الادويه https://t.co/61sZJSkzcZ https://t.co/cAq3zmi4NN

May 29, 2021 · 64 likes · 8 shares · 28,927 followers View post →
Papaver
@Papaver05359070 · X

@PraxisSchenk @_icarliee_ @MonaOberpfalz @martingommel Linde K, et al.: St John‘s wort for major depression. Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD000448. DOI: 10.1002/14651858.CD000448.pub3

Sep 2, 2020 · 11 followers View post →
fungi
@conazole · X

@UnPsyTCC @Ascl_Pios @ConquyF C'est clair que la prise en charge proposée n'est pas adaptée, mais le millepertuis a de vraies propriétés antidépressives et serait très bien toléré : https://t.co/j3Uc8divHU

May 14, 2019 · 390 followers View post →
Stavros Saripanidis, MD
@DrSaripanidis · X

Large Cochrane systematic reviews of all published randomized scientific papers, have clearly demonstrated that St. John's wort is just as effective as the strongest antidepressant medications, without their multiple side effects. https://t.co/vzuqUvvpEc https://t.co/FnoCfOHBQ1

Jan 24, 2019 · 2 likes · 688 followers View post →
Stavros Saripanidis, MD
@DrSaripanidis · X

RT @Un_B_Weavable: St. John's wort has edge over standard antidepressant medications in Cochrane meta-analysis of random control trials htt…

Jan 23, 2019 · 2 shares · 688 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @Un_B_Weavable: St. John's wort has edge over standard antidepressant medications in Cochrane meta-analysis of random control trials htt…

Jan 23, 2019 · 2 shares · 6,704 followers View post →
Brooks Weaver
@Un_B_Weavable · X

St. John's wort has edge over standard antidepressant medications in Cochrane meta-analysis of random control trials https://t.co/TjNFu0vdGI

Jan 23, 2019 · 1 like · 2 shares · 295 followers View post →