Genome Biol February 2009 PMID 19040769

The Hedgehog protein family.

Thomas R Bürglin

Mentions

12
Peak: 3 in Jun 2020
across 3 sources since Apr 2020

Extended reach

20,927
potential audience

Total likes

138

Video views

4,796

Mentions per month

Apr 2020 – Mar 2025

Where it's discussed

  • X / Twitter8 posts
  • YouTube3 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions demonstrate both fascination and amusement at the biologically humorous names, such as Sonic Hedgehog and Robotnikinin, and include references to the proteins' roles in development and signaling pathways. The tone varies from playful to informative, emphasizing the curiosity and importance of the Hedgehog family without emphasizing wide-reaching implications.

AgreementModerate agreement

Most discussions express admiration for the naming creativity and recognize the significance of the Hedgehog proteins in biology.

InterestHigh interest

Posts show a high level of curiosity, with many mentioning specific proteins and their functions, especially Sonic Hedgehog.

EngagementModerate engagement

The comments reflect personal reflections, humor, and interest in the biological concepts, indicating moderate engagement.

ImpactNeutral impact

While some posts highlight the importance of the protein family in development, the overall influence appears moderate, focused more on curiosity than broad implications.

Abstract in brief

  • The Hedgehog (Hh) pathway is essential for animal development, stem cell maintenance, and cancer progression, involving a protein that has two main parts: an active signaling domain (HhN) and a self-processing domain (HhC) that attaches cholesterol.
  • Hh proteins are unique to animals (metazoans) and have evolved from a family of proteins with a conserved Hint domain found in both bacteria and eukaryotes, though only the Hedgehog family features the signaling properties seen in animals.
  • In the signaling process, the modified Hh protein is released and binds to the Patched receptor, lifting its inhibition on Smoothened, which triggers a cascade that activates specific transcription factors (Ci or Gli) to control gene expression.]

Top posts

Most liked on X and Bluesky
Alix Weasel
@alixwzl.bsky.social · Bluesky

Scientists naming things is just so often delightful, great big buncha nerds. Hey, we have a new protein in the hedgehog protein family, what should we call it? Sonic Hedgehog. Hey, we've found a molecule that inhibits Sonic. What do we call that one? Robotnikinin.

Mar 31, 2025 · 4 likes · 1 share View post →
Zimbleon
@Zimbleon · X

Cool fact: There are proteins with funny names: Sonic Hedgehog (member of the Hedgehog protein family) regulates organogenesis; the Pikachurin protein regulates the comunication eye-brain and MuSK (kinky one) regulates comunication between motor neurons and muscle fibers https://t.co/oum5yu7KO4

Jun 25, 2020 · 2 likes · 160 followers View post →
Communications Biology
@CommsBio · X

Combining sequence conservation, directed mutagenesis and biochemical assays, Purohit et al. analyse the structure and cholesterol transfer function of sterol recognition region (SRR) within the Hedgehog protein family https://t.co/iOoZmTW4GD

Jun 1, 2020 · 1 like · 1 share · 11,256 followers View post →
Lynn MacDonald
@LynnMacDonald · X

@laurauronen My background is physics, but I do love the biology naming creativity as well, especially hedgehog and the like https://t.co/Wpaqc1z61F

Nov 2, 2021 · 1 like · 277 followers View post →
kunsypt
@kunsypt · X

@morphinebandit @ThrowUpTheHorns @bad2sentence https://t.co/NppMYo2b7G This goes on a bit for what i meant there!

Jun 20, 2022 · 2,342 followers View post →
Helen Gavaghan. UK. Photo+Digital Art by me.
@HelenGavaghan · X

2008. The Hedgehog protein family https://t.co/SEYrgnZ5aJ

Apr 29, 2020 · 1,206 followers View post →

All mentions

Alix Weasel
@alixwzl.bsky.social · Bluesky

Scientists naming things is just so often delightful, great big buncha nerds. Hey, we have a new protein in the hedgehog protein family, what should we call it? Sonic Hedgehog. Hey, we've found a molecule that inhibits Sonic. What do we call that one? Robotnikinin.

Mar 31, 2025 · 4 likes · 1 share View post →
Me&Doggo
@dogsnfishing · X

@flinnie There are a set of hedgehog proteins in mammals. There is even one named Sonic. There is hedgehog signaling. https://t.co/Wg2JB8jFf9

Jul 8, 2024 · 531 followers View post →
kunsypt
@kunsypt · X

@morphinebandit @ThrowUpTheHorns @bad2sentence https://t.co/NppMYo2b7G This goes on a bit for what i meant there!

Jun 20, 2022 · 2,342 followers View post →
Lynn MacDonald
@LynnMacDonald · X

@laurauronen My background is physics, but I do love the biology naming creativity as well, especially hedgehog and the like https://t.co/Wpaqc1z61F

Nov 2, 2021 · 1 like · 277 followers View post →
Pedro Gabriel Quispe López
@PedroGabriel_md · X

he sonic hedgehog (SHH) protein of the hedgehog protein family plays a critical role during embryonic development and morphogenesis of the central nervous system, craniofacial structures, and limbs

Sep 4, 2021 · 126 followers View post →
Zimbleon
@Zimbleon · X

Cool fact: There are proteins with funny names: Sonic Hedgehog (member of the Hedgehog protein family) regulates organogenesis; the Pikachurin protein regulates the comunication eye-brain and MuSK (kinky one) regulates comunication between motor neurons and muscle fibers https://t.co/oum5yu7KO4

Jun 25, 2020 · 2 likes · 160 followers View post →
備忘録
@bibourokuabc · X

RT @CommsBio: Combining sequence conservation, directed mutagenesis and biochemical assays, Purohit et al. analyse the structure and choles…

Jun 2, 2020 · 1 share · 228 followers View post →
Communications Biology
@CommsBio · X

Combining sequence conservation, directed mutagenesis and biochemical assays, Purohit et al. analyse the structure and cholesterol transfer function of sterol recognition region (SRR) within the Hedgehog protein family https://t.co/iOoZmTW4GD

Jun 1, 2020 · 1 like · 1 share · 11,256 followers View post →
Helen Gavaghan. UK. Photo+Digital Art by me.
@HelenGavaghan · X

2008. The Hedgehog protein family https://t.co/SEYrgnZ5aJ

Apr 29, 2020 · 1,206 followers View post →