Scientists naming things is just so often delightful, great big buncha nerds. Hey, we have a new protein in the hedgehog protein family, what should we call it? Sonic Hedgehog. Hey, we've found a molecule that inhibits Sonic. What do we call that one? Robotnikinin.
The Hedgehog protein family.
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Apr 2020 – Mar 2025Where it's discussed
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X / Twitter8 posts
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YouTube3 videos
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Bluesky1 posts
AI synopsis
What people are saying
The discussions demonstrate both fascination and amusement at the biologically humorous names, such as Sonic Hedgehog and Robotnikinin, and include references to the proteins' roles in development and signaling pathways. The tone varies from playful to informative, emphasizing the curiosity and importance of the Hedgehog family without emphasizing wide-reaching implications.
Most discussions express admiration for the naming creativity and recognize the significance of the Hedgehog proteins in biology.
Posts show a high level of curiosity, with many mentioning specific proteins and their functions, especially Sonic Hedgehog.
The comments reflect personal reflections, humor, and interest in the biological concepts, indicating moderate engagement.
While some posts highlight the importance of the protein family in development, the overall influence appears moderate, focused more on curiosity than broad implications.
Abstract in brief
- The Hedgehog (Hh) pathway is essential for animal development, stem cell maintenance, and cancer progression, involving a protein that has two main parts: an active signaling domain (HhN) and a self-processing domain (HhC) that attaches cholesterol.
- Hh proteins are unique to animals (metazoans) and have evolved from a family of proteins with a conserved Hint domain found in both bacteria and eukaryotes, though only the Hedgehog family features the signaling properties seen in animals.
- In the signaling process, the modified Hh protein is released and binds to the Patched receptor, lifting its inhibition on Smoothened, which triggers a cascade that activates specific transcription factors (Ci or Gli) to control gene expression.]
Top posts
Most liked on X and BlueskyCool fact: There are proteins with funny names: Sonic Hedgehog (member of the Hedgehog protein family) regulates organogenesis; the Pikachurin protein regulates the comunication eye-brain and MuSK (kinky one) regulates comunication between motor neurons and muscle fibers https://t.co/oum5yu7KO4
Combining sequence conservation, directed mutagenesis and biochemical assays, Purohit et al. analyse the structure and cholesterol transfer function of sterol recognition region (SRR) within the Hedgehog protein family https://t.co/iOoZmTW4GD
@laurauronen My background is physics, but I do love the biology naming creativity as well, especially hedgehog and the like https://t.co/Wpaqc1z61F
@morphinebandit @ThrowUpTheHorns @bad2sentence https://t.co/NppMYo2b7G This goes on a bit for what i meant there!
2008. The Hedgehog protein family https://t.co/SEYrgnZ5aJ
All mentions
Understanding the Hedgehog Protein Family and Its Role in Development and Disease
The Hedgehog pathway is vital for animal development, stem cell maintenance, and cancer progression. This video explains the structure and signaling mechanism of Hedgehog proteins, highlighting their unique features and…
Understanding the Hedgehog Protein Family and Its Role in Development
The Hedgehog pathway is vital for development, stem cell maintenance, and cancer progression. This video explains the structure and function of Hedgehog proteins, including their signaling mechanisms and evolutionary…
Understanding the Role of Sonic Hedgehog in Animal Development and Disease
The Hedgehog pathway is essential for development, stem cell maintenance, and cancer. This pathway involves the Hedgehog protein with signaling and self-processing domains, unique to animals, that activate gene…
Scientists naming things is just so often delightful, great big buncha nerds. Hey, we have a new protein in the hedgehog protein family, what should we call it? Sonic Hedgehog. Hey, we've found a molecule that inhibits Sonic. What do we call that one? Robotnikinin.
@flinnie There are a set of hedgehog proteins in mammals. There is even one named Sonic. There is hedgehog signaling. https://t.co/Wg2JB8jFf9
@morphinebandit @ThrowUpTheHorns @bad2sentence https://t.co/NppMYo2b7G This goes on a bit for what i meant there!
@laurauronen My background is physics, but I do love the biology naming creativity as well, especially hedgehog and the like https://t.co/Wpaqc1z61F
he sonic hedgehog (SHH) protein of the hedgehog protein family plays a critical role during embryonic development and morphogenesis of the central nervous system, craniofacial structures, and limbs
Cool fact: There are proteins with funny names: Sonic Hedgehog (member of the Hedgehog protein family) regulates organogenesis; the Pikachurin protein regulates the comunication eye-brain and MuSK (kinky one) regulates comunication between motor neurons and muscle fibers https://t.co/oum5yu7KO4
RT @CommsBio: Combining sequence conservation, directed mutagenesis and biochemical assays, Purohit et al. analyse the structure and choles…
Combining sequence conservation, directed mutagenesis and biochemical assays, Purohit et al. analyse the structure and cholesterol transfer function of sterol recognition region (SRR) within the Hedgehog protein family https://t.co/iOoZmTW4GD
2008. The Hedgehog protein family https://t.co/SEYrgnZ5aJ