Stress signalling pathways that impair prefrontal cortex structure and function.

Amy F T Arnsten

June 2009 Nat Rev Neurosci

Synopsis of Social media discussions

The discussions emphasize the foundational importance of Arnsten's findings for understanding how stress affects brain function, especially the prefrontal cortex, using words like 'revolutionized' and 'motivation' to highlight their perceived significance. Several posts explore broader implications, such as behavior in high-stress situations, demonstrating a moderate level of deep engagement and acknowledgment of the research's potential impact across different areas.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of the research, especially praising its impact on understanding stress and cognition.

I
Interest
 Moderate level of interest

Participants show curiosity and curiosity, with posts referencing the implications of the pathways on mental health and decision-making.

E
Engagement
 Moderate level of engagement

The posts delve into the details of the pathways and their consequences, indicating moderate engagement.

I
Impact
 Moderate level of impact

Many recognize the research as influential in neuroscience, mental health, and even potential applications in competitive contexts like sports or conflict.

Social Mentions

YouTube

13 Videos

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3 Posts

Facebook

11 Posts

Twitter

30 Posts

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21 Articles

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84 Articles

Metrics

Video Views

577,751

Total Likes

23,693

Extended Reach

632,083

Social Features

162

Timeline: Posts about article

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  • Maya
    @HM_T77 (Twitter)

    Références scientifiques principales Arnsten, A. F. T. (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience, 10(6), 410–422.
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    July 12, 2025

  • Michael Price
    @mikestypes.bsky.social (Bluesky)


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    July 9, 2025

  • Isaac
    @Agent_IsaacX (Twitter)

    @princetreeac @bryan_johnson Arnsten's landmark paper 'Stress signalling pathways that impair prefrontal cortex structure and function' was published in Nature Reviews Neuroscience (2009). DOI: 10.1038/nrn2648. The findings revolutionized our understanding of stress impacts on cognition.
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    June 15, 2025

  • Faris al-Nur (فارس النور)
    @alchemetric_ink (Twitter)

    Arnsten, A. F. T. (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience, 10(6), 410-422. Hare, T. A., Camerer, C. F., & Rangel, A. (2009). Self-control in decision-making involves modulation of the vmPFC valuation
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  • @carltonliam96.bsky.social (Bluesky)

    youtu.be/gqCGsTdR_Js
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    March 13, 2025

  • Joe Segal
    @joesegal.bsky.social (Bluesky)

    youtu.be/gqCGsTdR_Js?...
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    February 12, 2025

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    @thmonk_pf (Twitter)

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    @thmonk_pf (Twitter)

    ヒトの前頭前野は進化学的に一番新しい脳の部位であり、個体の発達/老化を通して最後に成熟し、最初に老化する なぜ前頭前野はストレス侵襲や疾患に対して脆弱性があるのかを纏めた総説 #prefrontal #vulnerability #papers https://t.co/71QKKpyrrn https://t.co/fBCLtk7eJ1
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  • Living Empowered®
    @livingempowered (Twitter)

    Stress signalling pathways that impair prefrontal cortex structure and function - PMC https://t.co/F7q8hfQAh6
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    @hashimotoyuro (Twitter)

    @soccer_sky18 引用元もチェケラッチョ！ https://t.co/3hUQn9KEk0
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  • Jordan James Etem
    @JordanJamesEtem (Twitter)

    Arnsten, A.F.T. 2009. Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience 10(6): 410–422. #Biology #FinancialMarkets @intel
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  • タクト
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  • 徳永泰理
    @SJWcjX8P8vJnaTX (Twitter)

    RT @all_life_round: 大きな精神的ストレスを受けると前頭前野の働きが低下する。また長期間ストレスに晒されると脳に構造的変化が起こり機能障害が慢性化する。https://t.co/dlGk8TCFGZ 前頭前野が機能低下すると正確な認識、判断、感情や行動の抑制…
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    @umumeayumi (Twitter)

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  • 近藤拓人
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  • dk360net
    @dk360net (Twitter)


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  • ぽん
    @pondarine052 (Twitter)

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  • Nate Callahan
    @n8callahan (Twitter)

    RT @griz1: Last night's #BrainSPORTDBGBHH #DataBlitz #ZoomJC shows different neural systems under normal situations (cortical) vs stress (a…
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  • 中山 晴雄　Haruo Nakayama
    @haruwonakayame (Twitter)

    RT @griz1: Last night's #BrainSPORTDBGBHH #DataBlitz #ZoomJC shows different neural systems under normal situations (cortical) vs stress (a…
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  • Chris Giza
    @griz1 (Twitter)

    Last night's #BrainSPORTDBGBHH #DataBlitz #ZoomJC shows different neural systems under normal situations (cortical) vs stress (amygdala). @neuroayogi #UCLABrainSPORT @BIRC_at_UCLA @NatRevNeurosci @TheNewANA1 @APAPsychiatric Arnsten @NatRevNeurosci 2009: https://t.co/ZEX3u8mQli https://t.co/gkPp0AVmHz
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  • StateofMind
    @stateofSofi (Twitter)

    Stress signalling pathways that impair prefrontal cortex structure and function https://t.co/OmLL71JbcL
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    October 13, 2019

  • Mike
    @myqrizzo (Twitter)

    Stress signalling pathways that impair prefrontal cortex structure and function https://t.co/Nzlbvc9oHU This seems a motivation for pre-fight trash talking or in ring mental warfare, no? What are other factors for this type of behavior in mma?
    view full post

    May 10, 2019

Abstract Synopsis

  • The prefrontal cortex (PFC) is essential for complex cognitive functions but is highly vulnerable to the negative effects of stress, which can impair its structure and function.
  • Even mild, uncontrollable stress can quickly reduce cognitive abilities associated with the PFC, and prolonged stress can cause physical changes in its dendrites, the branches of nerve cells.
  • Recent studies are uncovering the specific intracellular signaling pathways involved in stress responses, helping to explain how genetic or environmental factors that activate these pathways can lead to mental health issues related to PFC dysfunction.]