Med Hypotheses November 2009 PMID 19501473

Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology.

Antonei B Csoka, Moshe Szyf

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Mentions

23
Peak: 6 in Sep 2023
across 4 sources since Dec 2019

Extended reach

387,752
potential audience

Total likes

79

Video views

191

Mentions per month

Dec 2019 – Sep 2024

Where it's discussed

  • X / Twitter16 posts
  • News4 articles
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

The overall discussion demonstrates a cautious curiosity, with some posters referencing specific drugs and effects, such as isotretinoin's potential epigenetic influence, and contemplating broader societal impacts like autism or reproduction issues. The tone varies from analytical to speculative, reflecting engagement with the article's implications without full consensus or deep controversy.

AgreementNeither agree nor disagree

The discussions reflect a mix of skepticism and curiosity, with some acknowledging the potential importance of epigenetic effects but also emphasizing the need for more evidence.

InterestModerate interest

Most comments show moderate interest, especially among those mentioning specific drugs like isotretinoin and concerns about environmental impacts, indicating curiosity without deep commitment.

EngagementModerate engagement

Participants engage by referencing studies, sharing personal thoughts, and raising questions, suggesting a moderate level of involvement.

ImpactModerate impact

The discussions hint at recognizing the significance of the findings, particularly in terms of drug safety and broader biological implications, but do not express certainty about revolutionary impacts.

Abstract in brief

  • The article discusses how common drugs can cause long-lasting changes in gene expression through epigenetic modifications, which are changes to DNA and chromatin structure that persist across cell divisions without altering the DNA sequence itself.
  • These drug-induced epigenetic changes can occur directly, by affecting DNA methylation or chromatin architecture, or indirectly, by altering signaling pathways that influence gene regulators like transcription factors.
  • The hypothesis suggests that some side effects and certain diseases caused by drugs (like tardive dyskinesia or drug-induced lupus) may be due to these persistent epigenetic modifications, which could have significant implications for how we understand drug safety and treatment strategies.]

Top posts

Most liked on X and Bluesky
Dr. Syed Haider:
@DrSyedHaider · X

It’s not as bad as you think, but it’s worse than you can imagine. Regular old pharmaceutical drugs and chemicals in the environment likely alter epigenetic factors that permanently change gene expression. https://t.co/6Wz3BsLn9g

Sep 16, 2023 · 17 likes · 4 shares · 178,215 followers View post →
Nick
@nickbrne · X

@Maxhedroom23 @ShimmyShai2 @RubeBait The closest I can think of to permanent alterations would be any epigenetic changes (so akin to changes to DNA over time due to environmental factors in a single organism) Haven't found an open access mirror to this one yet, but it's a good read https://t.co/2zNjwD4nMb

Sep 19, 2022 · 2 likes · 187 followers View post →
Rene Sugar
@renesugar · X

@PeptideScience Epigenetic side-effects of common pharmaceuticals: A potential newfield in medicine and pharmacology https://t.co/C6ftJKv76E https://t.co/C5FmSvlHw8 https://t.co/NOB7mbTCSK

Jun 19, 2020 · 1 like · 1 share · 3,984 followers View post →
Arobb
@Arobb52 · X

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology - ScienceDirect https://t.co/Jnu8jmD7zR

Jun 8, 2024 · 1 like · 1 share · 330 followers View post →
Nick
@nickbrne · X

@a_enderly @DrCanuckMD @_bonewizard This was one decent paper I found on it a while back The main medication that I can remember was roaccutane (isotretinoin), particularly in women The DNA methylation hypothesis iirc I thought at the time could potentially explain the teratogenicity https://t.co/2zNjwDlqOb

Sep 26, 2022 · 1 like · 187 followers View post →
Dr. Syed Haider:
@DrSyedHaider · X

RT @DrSyedHaider: It’s not as bad as you think, but it’s worse than you can imagine. Regular old pharmaceutical drugs and chemicals in th…

Sep 16, 2023 · 4 shares · 178,215 followers View post →

All mentions

Luis
@lulopson · X

RT @Arobb52: Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology - ScienceDirect https://…

Jun 8, 2024 · 1 share · 448 followers View post →
Arobb
@Arobb52 · X

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology - ScienceDirect https://t.co/Jnu8jmD7zR

Jun 8, 2024 · 1 like · 1 share · 330 followers View post →
Akane
@Akanegg3 · X

RT @renesugar: Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology https://t.co/sEnWfIiEj…

Mar 4, 2024 · 1 share · 234 followers View post →
Luisa7371
@MluisaSAV · X

CUANTO MENOS FÁRMACOS...MEJOR. Efectos secundarios epigenéticos de productos farmacéuticos comunes: un nuevo campo potencial en medicina y farmacología. https://t.co/ImVmLvkasR

Sep 16, 2023 · 183 followers View post →
mbfrat
@mbfrat · X

RT @DrSyedHaider: It’s not as bad as you think, but it’s worse than you can imagine. Regular old pharmaceutical drugs and chemicals in th…

Sep 16, 2023 · 4 shares · 7,817 followers View post →
Penny Webster-Brown
@poshfrocks · X

RT @DrSyedHaider: It’s not as bad as you think, but it’s worse than you can imagine. Regular old pharmaceutical drugs and chemicals in th…

Sep 16, 2023 · 4 shares · 1,172 followers View post →
Me&G0d
@Child0fSource · X

RT @DrSyedHaider: It’s not as bad as you think, but it’s worse than you can imagine. Regular old pharmaceutical drugs and chemicals in th…

Sep 16, 2023 · 4 shares · 4,782 followers View post →
Dr. Syed Haider:
@DrSyedHaider · X

RT @DrSyedHaider: It’s not as bad as you think, but it’s worse than you can imagine. Regular old pharmaceutical drugs and chemicals in th…

Sep 16, 2023 · 4 shares · 178,215 followers View post →
Dr. Syed Haider:
@DrSyedHaider · X

It’s not as bad as you think, but it’s worse than you can imagine. Regular old pharmaceutical drugs and chemicals in the environment likely alter epigenetic factors that permanently change gene expression. https://t.co/6Wz3BsLn9g

Sep 16, 2023 · 17 likes · 4 shares · 178,215 followers View post →
trillionofcells
@trillionofcells · X

@jonathanstea @cabassog @RobertKennedyJr https://t.co/5MzrsQNfRU

Aug 3, 2023 · 868 followers View post →
Nick
@nickbrne · X

@a_enderly @DrCanuckMD @_bonewizard This was one decent paper I found on it a while back The main medication that I can remember was roaccutane (isotretinoin), particularly in women The DNA methylation hypothesis iirc I thought at the time could potentially explain the teratogenicity https://t.co/2zNjwDlqOb

Sep 26, 2022 · 1 like · 187 followers View post →
Nick
@nickbrne · X

@Maxhedroom23 @ShimmyShai2 @RubeBait The closest I can think of to permanent alterations would be any epigenetic changes (so akin to changes to DNA over time due to environmental factors in a single organism) Haven't found an open access mirror to this one yet, but it's a good read https://t.co/2zNjwD4nMb

Sep 19, 2022 · 2 likes · 187 followers View post →
1KxK
@TmyaTwotter · X

This is probably the root of a lot of our problems already. Autism, low reproduction rates, homosexuality, liberalism, etc. https://t.co/JltuAfNBPy

Jun 17, 2022 · 111 followers View post →
Peptide Sciences
@PeptideScience · X

RT @renesugar: @PeptideScience Epigenetic side-effects of common pharmaceuticals: A potential newfield in medicine and pharmacology https:…

Jun 19, 2020 · 1 share · 6,745 followers View post →
Rene Sugar
@renesugar · X

@PeptideScience Epigenetic side-effects of common pharmaceuticals: A potential newfield in medicine and pharmacology https://t.co/C6ftJKv76E https://t.co/C5FmSvlHw8 https://t.co/NOB7mbTCSK

Jun 19, 2020 · 1 like · 1 share · 3,984 followers View post →
Rene Sugar
@renesugar · X

@microbeminded2 @MECFSNews Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology https://t.co/C6ftJKv76E https://t.co/UdaOkJqjb5

Dec 17, 2019 · 3,984 followers View post →
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