The overall discussion demonstrates a cautious curiosity, with some posters referencing specific drugs and effects, such as isotretinoin's potential epigenetic influence, and contemplating broader societal impacts like autism or reproduction issues. The tone varies from analytical to speculative, reflecting engagement with the article's implications without full consensus or deep controversy.
AgreementNeither agree nor disagree
The discussions reflect a mix of skepticism and curiosity, with some acknowledging the potential importance of epigenetic effects but also emphasizing the need for more evidence.
InterestModerate interest
Most comments show moderate interest, especially among those mentioning specific drugs like isotretinoin and concerns about environmental impacts, indicating curiosity without deep commitment.
EngagementModerate engagement
Participants engage by referencing studies, sharing personal thoughts, and raising questions, suggesting a moderate level of involvement.
ImpactModerate impact
The discussions hint at recognizing the significance of the findings, particularly in terms of drug safety and broader biological implications, but do not express certainty about revolutionary impacts.
Abstract in brief
The article discusses how common drugs can cause long-lasting changes in gene expression through epigenetic modifications, which are changes to DNA and chromatin structure that persist across cell divisions without altering the DNA sequence itself.
These drug-induced epigenetic changes can occur directly, by affecting DNA methylation or chromatin architecture, or indirectly, by altering signaling pathways that influence gene regulators like transcription factors.
The hypothesis suggests that some side effects and certain diseases caused by drugs (like tardive dyskinesia or drug-induced lupus) may be due to these persistent epigenetic modifications, which could have significant implications for how we understand drug safety and treatment strategies.]
It’s not as bad as you think, but it’s worse than you can imagine.
Regular old pharmaceutical drugs and chemicals in the environment likely alter epigenetic factors that permanently change gene expression.
https://t.co/6Wz3BsLn9g
@Maxhedroom23 @ShimmyShai2 @RubeBait The closest I can think of to permanent alterations would be any epigenetic changes (so akin to changes to DNA over time due to environmental factors in a single organism)
Haven't found an open access mirror to this one yet, but it's a good read
https://t.co/2zNjwD4nMb
@PeptideScience Epigenetic side-effects of common pharmaceuticals: A potential newfield in medicine and pharmacology
https://t.co/C6ftJKv76E
https://t.co/C5FmSvlHw8 https://t.co/NOB7mbTCSK
Jun 19, 2020 · 1 like · 1 share · 3,984 followersView post →
A
Arobb
@Arobb52 · X
Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology - ScienceDirect https://t.co/Jnu8jmD7zR
Jun 8, 2024 · 1 like · 1 share · 330 followersView post →
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Nick
@nickbrne · X
@a_enderly @DrCanuckMD @_bonewizard This was one decent paper I found on it a while back
The main medication that I can remember was roaccutane (isotretinoin), particularly in women
The DNA methylation hypothesis iirc I thought at the time could potentially explain the teratogenicity
https://t.co/2zNjwDlqOb
Milan Chavarkar discusses her 25-year nursing journey, her shift towards integrative medicine, and how collaboration enhances patient care. She emphasizes the role of diet and digestion, aligning modern science and…
Explore Milan Chavarkar’s 25-year journey in nursing, focusing on her shift towards integrative and functional medicine. She discusses the microbiome's role in health, highlighting the synergy between modern science and…
CUANTO MENOS FÁRMACOS...MEJOR. Efectos secundarios epigenéticos de productos farmacéuticos comunes: un nuevo campo potencial en medicina y farmacología. https://t.co/ImVmLvkasR
It’s not as bad as you think, but it’s worse than you can imagine.
Regular old pharmaceutical drugs and chemicals in the environment likely alter epigenetic factors that permanently change gene expression.
https://t.co/6Wz3BsLn9g
@a_enderly @DrCanuckMD @_bonewizard This was one decent paper I found on it a while back
The main medication that I can remember was roaccutane (isotretinoin), particularly in women
The DNA methylation hypothesis iirc I thought at the time could potentially explain the teratogenicity
https://t.co/2zNjwDlqOb
@Maxhedroom23 @ShimmyShai2 @RubeBait The closest I can think of to permanent alterations would be any epigenetic changes (so akin to changes to DNA over time due to environmental factors in a single organism)
Haven't found an open access mirror to this one yet, but it's a good read
https://t.co/2zNjwD4nMb
RT @renesugar: @PeptideScience Epigenetic side-effects of common pharmaceuticals: A potential newfield in medicine and pharmacology
https:…
Jun 19, 2020 · 1 share · 6,745 followersView post →
RS
Rene Sugar
@renesugar · X
@PeptideScience Epigenetic side-effects of common pharmaceuticals: A potential newfield in medicine and pharmacology
https://t.co/C6ftJKv76E
https://t.co/C5FmSvlHw8 https://t.co/NOB7mbTCSK
Jun 19, 2020 · 1 like · 1 share · 3,984 followersView post →
RS
Rene Sugar
@renesugar · X
@microbeminded2 @MECFSNews Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology
https://t.co/C6ftJKv76E https://t.co/UdaOkJqjb5
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