@stathitriadis @exfatloss @Dirk_aus_Hessen @KetoCarnivore @sudas1891 @fire_bottle @Outdoctrination @bendormiki The Randle Cycle runs continuously. The body virtually never runs completely on one or the other fuel. "The Randle Cycle Revisited: A New Head for an Old Hat" https://t.co/k8KCosMQ59
The Randle cycle revisited: a new head for an old hat.
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Apr 2019 – Jan 2026Where it's discussed
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X / Twitter10 posts
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YouTube8 videos
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Facebook5 posts
AI synopsis
What people are saying
The discussions display a moderate engagement with technical details of the Randle cycle, exemplified by posts discussing glucose toxicity, reactive oxygen species (ROS), and insulin resistance, with words like 'fascinating' and questions about clinical relevance showing genuine interest and recognition of potential impacts in health sciences.
Most discussions acknowledge the relevance of revisiting the Randle cycle, with some posts referencing its ongoing significance and potential explanations for metabolic conditions like insulin resistance.
The posts show moderate interest, with some calling the article 'fascinating' and referencing complex mechanisms like electron flow and ROS, indicating curiosity about detailed biochemical processes.
People engage by sharing insights about metabolic health and raising questions, such as opinions on insulin resistance theories, but few dive deeply into methodological critique or broader implications.
While the discussions reflect an appreciation of the cycle's complexity, only a few posts suggest potential impacts on health or treatment approaches, indicating a moderate perceived influence of the ideas.
Abstract in brief
- The Randle cycle, proposed in 1963, explains how fatty acids inhibit glucose oxidation, and this mechanism has been supported by many studies, but recent research has uncovered additional complexities in how cells regulate glucose and fatty acid use.
- The paper reviews various short-term and long-term control mechanisms—such as allosteric regulation, reversible phosphorylation, and enzyme expression—that influence fuel utilization in muscle and liver under normal and disease conditions.
- The authors argue that despite the extensive understanding of the Randle cycle, our knowledge is still incomplete, and there may be more to discover about how fuel selection is regulated at the cellular level.
Top posts
Most liked on X and Bluesky@krosenque @GregVidua @Gearoidmuar @ceykoloji @ScepticalDoctor https://t.co/D2hXUxY6tJ
@BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u
RT @Unspecial3: @BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u
Ciclo de Randle como posible explicación de la resistencia a la insulina en la Diabetes! Opiniones? https://t.co/1bKiKc7ukq https://t.co/KBaLSOSuyK
Fascinating article on the Randle Cycle - https://t.co/Do2sc9ikT4
All mentions
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The Randle cycle explains how fatty acids inhibit glucose oxidation. Recent research highlights additional complexities in cellular regulation of fuel use, including control mechanisms like allosteric regulation…
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Revisiting the Randle Cycle: Fuel Utilization Regulation in Cells
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Understanding the Randle Cycle and Fuel Utilization Regulation
This video analyzes the Randle Cycle, a biological process that regulates the use of fats and carbohydrates as energy sources. We explore how nutrient dominance impacts metabolism and body composition, highlighting…
Revisiting the Randle Cycle: Fuel Regulation in Muscle and Liver
The Randle cycle explains how fatty acids inhibit glucose oxidation, with recent research revealing additional regulatory complexities in fuel utilization in muscle and liver, both in normal and disease states.
@martykendall2 Google “The Randle cycle revisited: a new head for an old hat”
https://t.co/TfQdTgUefX https://t.co/dSEbGN39j2
5 “Bro-Science” Fat Loss Methods that ACTUALLY Work (I tried them) https://t.co/zP8XgvKrw9
RT @Unspecial3: @BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u
@BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u
@stathitriadis @exfatloss @Dirk_aus_Hessen @KetoCarnivore @sudas1891 @fire_bottle @Outdoctrination @bendormiki The Randle Cycle runs continuously. The body virtually never runs completely on one or the other fuel. "The Randle Cycle Revisited: A New Head for an Old Hat" https://t.co/k8KCosMQ59
Ciclo de Randle como posible explicación de la resistencia a la insulina en la Diabetes! Opiniones? https://t.co/1bKiKc7ukq https://t.co/KBaLSOSuyK
@richcollins Flooding system with glucose on top of fatty acids induce damage.. carbs & fat force-feed electrons from glucose into respiratory chain (RC), in which already high ΔΨ prevents e-flow. This excess energy worsen jamming of electrons in RC➡️massive ROS+damage https://t.co/357YySSe3H
@krosenque @GregVidua @Gearoidmuar @ceykoloji @ScepticalDoctor https://t.co/D2hXUxY6tJ
Fascinating article on the Randle Cycle - https://t.co/Do2sc9ikT4
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