Am J Physiol Endocrinol Metab September 2009 PMID 19531645

The Randle cycle revisited: a new head for an old hat.

Louis Hue, Heinrich Taegtmeyer

Mentions

23
Peak: 3 in Feb 2024
across 3 sources since Apr 2019

Extended reach

475,229
potential audience

Total likes

9,143

Video views

428,964

Mentions per month

Apr 2019 – Jan 2026

Where it's discussed

  • X / Twitter10 posts
  • YouTube8 videos
  • Facebook5 posts

AI synopsis

What people are saying

The discussions display a moderate engagement with technical details of the Randle cycle, exemplified by posts discussing glucose toxicity, reactive oxygen species (ROS), and insulin resistance, with words like 'fascinating' and questions about clinical relevance showing genuine interest and recognition of potential impacts in health sciences.

AgreementModerate agreement

Most discussions acknowledge the relevance of revisiting the Randle cycle, with some posts referencing its ongoing significance and potential explanations for metabolic conditions like insulin resistance.

InterestModerate interest

The posts show moderate interest, with some calling the article 'fascinating' and referencing complex mechanisms like electron flow and ROS, indicating curiosity about detailed biochemical processes.

EngagementModerate engagement

People engage by sharing insights about metabolic health and raising questions, such as opinions on insulin resistance theories, but few dive deeply into methodological critique or broader implications.

ImpactModerate impact

While the discussions reflect an appreciation of the cycle's complexity, only a few posts suggest potential impacts on health or treatment approaches, indicating a moderate perceived influence of the ideas.

Abstract in brief

  • The Randle cycle, proposed in 1963, explains how fatty acids inhibit glucose oxidation, and this mechanism has been supported by many studies, but recent research has uncovered additional complexities in how cells regulate glucose and fatty acid use.
  • The paper reviews various short-term and long-term control mechanisms—such as allosteric regulation, reversible phosphorylation, and enzyme expression—that influence fuel utilization in muscle and liver under normal and disease conditions.
  • The authors argue that despite the extensive understanding of the Randle cycle, our knowledge is still incomplete, and there may be more to discover about how fuel selection is regulated at the cellular level.

Top posts

Most liked on X and Bluesky
Tucker Goodrich
@TuckerGoodrich · X

@stathitriadis @exfatloss @Dirk_aus_Hessen @KetoCarnivore @sudas1891 @fire_bottle @Outdoctrination @bendormiki The Randle Cycle runs continuously. The body virtually never runs completely on one or the other fuel. "The Randle Cycle Revisited: A New Head for an Old Hat" https://t.co/k8KCosMQ59

Nov 29, 2023 · 7 likes · 28,292 followers View post →
MacroFour
@MacroFour · X

@krosenque @GregVidua @Gearoidmuar @ceykoloji @ScepticalDoctor https://t.co/D2hXUxY6tJ

Feb 16, 2022 · 1 like · 6,057 followers View post →
UnspecialOne
@Unspecial3 · X

@BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u

Jan 2, 2024 · 1 like · 1 share · 114 followers View post →
#RaviVisvesvarayaSharadaPrasad #Telecom #InfoTech
@rvp · X

RT @Unspecial3: @BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u

Jan 3, 2024 · 1 share · 4,848 followers View post →
Denís Estévez - Dietista
@denis_dietista · X

Ciclo de Randle como posible explicación de la resistencia a la insulina en la Diabetes! Opiniones? https://t.co/1bKiKc7ukq https://t.co/KBaLSOSuyK

Mar 7, 2023 · 2,443 followers View post →
CambridgePT
@cambridge_pt · X

Fascinating article on the Randle Cycle - https://t.co/Do2sc9ikT4

Apr 5, 2019 · 2,308 followers View post →

All mentions

TL
@tennis152 · X

@martykendall2 Google “The Randle cycle revisited: a new head for an old hat”

Apr 28, 2024 · 140 followers View post →
NOTMY46
@agandau1 · X

https://t.co/TfQdTgUefX https://t.co/dSEbGN39j2

Feb 15, 2024 · 570 followers View post →
blubber_bones
@blubber_bones · X

5 “Bro-Science” Fat Loss Methods that ACTUALLY Work (I tried them) https://t.co/zP8XgvKrw9

Feb 3, 2024 · 1,105 followers View post →
#RaviVisvesvarayaSharadaPrasad #Telecom #InfoTech
@rvp · X

RT @Unspecial3: @BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u

Jan 3, 2024 · 1 share · 4,848 followers View post →
UnspecialOne
@Unspecial3 · X

@BellamSwathi @thelowcarb_rd Goto Glucose toxicity.. https://t.co/QYws2fdw1u

Jan 2, 2024 · 1 like · 1 share · 114 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@stathitriadis @exfatloss @Dirk_aus_Hessen @KetoCarnivore @sudas1891 @fire_bottle @Outdoctrination @bendormiki The Randle Cycle runs continuously. The body virtually never runs completely on one or the other fuel. "The Randle Cycle Revisited: A New Head for an Old Hat" https://t.co/k8KCosMQ59

Nov 29, 2023 · 7 likes · 28,292 followers View post →
Denís Estévez - Dietista
@denis_dietista · X

Ciclo de Randle como posible explicación de la resistencia a la insulina en la Diabetes! Opiniones? https://t.co/1bKiKc7ukq https://t.co/KBaLSOSuyK

Mar 7, 2023 · 2,443 followers View post →
alephh
@alephh · X

@richcollins Flooding system with glucose on top of fatty acids induce damage.. carbs & fat force-feed electrons from glucose into respiratory chain (RC), in which already high ΔΨ prevents e-flow. This excess energy worsen jamming of electrons in RC➡️massive ROS+damage https://t.co/357YySSe3H

May 23, 2022 · 388 followers View post →
MacroFour
@MacroFour · X

@krosenque @GregVidua @Gearoidmuar @ceykoloji @ScepticalDoctor https://t.co/D2hXUxY6tJ

Feb 16, 2022 · 1 like · 6,057 followers View post →
CambridgePT
@cambridge_pt · X

Fascinating article on the Randle Cycle - https://t.co/Do2sc9ikT4

Apr 5, 2019 · 2,308 followers View post →