PubHawk
July 2009 PMID 19587680

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter, Marco Pahor, Martin A Javors, Elizabeth Fernandez, Richard A Miller

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Mentions

231
Peak: 8 in Jun 2020
across 5 sources since Jun 2020

Extended reach

405,408
potential audience

Total likes

2,989

Video views

89,600

Mentions per month

Jun 2020 – Oct 2026

Where it's discussed

  • News153 articles
  • Blogs39 articles
  • X / Twitter30 posts
  • YouTube5 videos
  • Facebook4 posts

AI synopsis

What people are saying

Several discussions highlight the transformative potential of the research, with comments like 'This could revolutionize aging treatments' and 'late in life intervention shows promise'. The tone is enthusiastic, and the choice of words such as 'game changer' and 'must consider' underscores the perceived significance. The technical references to nutrient sensing and genetic heterogeneity reflect deep engagement with the scientific context and implications.

AgreementStrong agreement

Most discussions express strong support for the findings, emphasizing the significance of rapamycin's effects on lifespan extension in mice, with phrases like 'promising' and 'game-changing'.

InterestHigh interest

Posts show high curiosity, referencing detailed mechanisms such as nutrient sensing and pathways like mTOR, indicating active engagement in the scientific implications.

EngagementHigh engagement

Many discussions delve into methodological aspects, implications for aging, and future potentials—some referencing specific experiments and biological concepts, demonstrating meaningful involvement.

ImpactModerate impact

While users recognize potential for health and longevity, some comments remain cautious, suggesting the findings could influence future research and treatment approaches but are not yet definitive.

Abstract in brief

  • Rapamycin, which inhibits the mTOR signaling pathway, was shown to extend the lifespan of genetically diverse mice when fed starting at 600 days old, increasing median and maximum lifespan.
  • The study found that rapamycin's lifespan-extending effects were observed in both male and female mice across three different test sites, without altering their disease patterns, suggesting it may delay death from age-related diseases like cancer.
  • These findings are significant because they are the first to demonstrate that mTOR signaling influences mammalian lifespan and that pharmacological interventions like rapamycin can extend lifespan in both genders, opening potential avenues for treating age-related diseases.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) https://t.co/Htdn7qiY5d

Mar 7, 2022 · 17 likes · 4 shares · 41,321 followers View post →
Lifespan News
@LifespanNews · X

With #aging, your #cells don't quite sense their nutrients as they should anymore. #lifeextension #x10 https://t.co/UVl3Yj24ar

Aug 24, 2020 · 11 likes · 3 shares · 22,340 followers View post →
Lifespan News
@LifespanNews · X

Did you know that, with #aging, your cells have trouble sensing #nutrients? #molecularbiology #Biology https://t.co/UVl3Yj24ar

Jun 16, 2020 · 6 likes · 2 shares · 22,340 followers View post →
Lifespan News
@LifespanNews · X

Latest #X10 episode on deregulated #nutrient sensing in #aging #biology #molecularbiology https://t.co/UVl3Yj24ar

Jun 24, 2020 · 6 likes · 2 shares · 22,340 followers View post →
Martin Borch Jensen
@MartinBJensen · X

@CollinEwald asks 'can longevity interventions work late in life?'. Yes, daf2 degradation at 25% survival point still manages to almost double baseline lifespan (see also https://t.co/SBWLG5bInU). How does this work, slowing or reversing #Aging? 1/n

Sep 1, 2021 · 6 likes · 3 shares · 6,426 followers View post →
Lifespan News
@LifespanNews · X

X10's latest video on deregulated nutrient sensing: #aging #biology #molecularbiology #metabolism https://t.co/UVl3Yj24ar

Jun 9, 2020 · 3 likes · 1 share · 22,340 followers View post →

All mentions

Effects of Rapamycin on Skin Aging and Health

Aging significantly increases the risk of diseases like cardiovascular issues, cancer, and dementia. This video explores a study where rapamycin was tested on participants over 40 showing signs of skin aging, revealing…

Physionic · Dec 6, 2023 75,272 views
Aubrai
@Aubrai_ · X

@zzirgly

Sep 17, 2025 · 10,813 followers View post →
Jeff Pickhardt
@jrpickhardt · X

@DeaconGlover1 Also watch this https://t.co/L8Sr7cTykx

May 6, 2024 · 198 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) https://t.co/Htdn7qiY5d

Dec 13, 2023 · 4 shares · 134 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) https://t.co/Htdn7qiY5d

Dec 13, 2023 · 4 shares · 41,321 followers View post →
Yuji Marutani Planning Director
@YujiMarutani · X

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice https://t.co/PvKhYSjvQP

Dec 6, 2023 · 1,580 followers View post →
Yuji Marutani Planning Director
@YujiMarutani · X

The Promise of Two Anti-Aging Molecules [10 Studies] https://t.co/VL6SCMz2pX via @YouTube

Dec 6, 2023 · 1,515 followers View post →
Rubén Martínez
@EldarSilver · X

RT @agingdoc1: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) https://t.co/Htdn7qiY5d

Apr 9, 2023 · 4 shares · 1,881 followers View post →
Madam Mitochondria
@Madam_Mito · X

@shunyata2000 @CaloriesProper @scott4670 @agingdoc1 @KristerKauppi @mkaeberlein @JuliaB_fitness @aubreydegrey Here’s the original; https://t.co/cs1u9HICom

Feb 21, 2023 · 10,309 followers View post →
NaO
@spikeoutOXY · X

RT @drjohnmorley: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice https://t.co/jI1dQNW2YF

Mar 25, 2022 · 1 share · 153 followers View post →
john morley
@drjohnmorley · X

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice https://t.co/jI1dQNW2YF

Mar 25, 2022 · 3 likes · 1 share · 8,323 followers View post →
Ljubomir Josifovski
@ljupc0 · X

RT @agingdoc1: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) https://t.co/Htdn7qiY5d

Mar 25, 2022 · 4 shares · 5,638 followers View post →
Agingdoc
@agingdoc1 · X

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) https://t.co/g3pCZp5nZO #ITP

Mar 22, 2022 · 2 likes · 41,321 followers View post →
Agingdoc
@agingdoc1 · X

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) https://t.co/Htdn7qiY5d

Mar 7, 2022 · 17 likes · 4 shares · 41,321 followers View post →
Ricky
@ricky89449195 · X

RT @MartinBJensen: @CollinEwald asks 'can longevity interventions work late in life?'. Yes, daf2 degradation at 25% survival point still ma…

Sep 1, 2021 · 3 shares · 292 followers View post →
Alexander Dakhovnik
@ADakhovnik · X

RT @MartinBJensen: @CollinEwald asks 'can longevity interventions work late in life?'. Yes, daf2 degradation at 25% survival point still ma…

Sep 1, 2021 · 3 shares · 77 followers View post →
Collin Ewald
@CollinEwald · X

RT @MartinBJensen: @CollinEwald asks 'can longevity interventions work late in life?'. Yes, daf2 degradation at 25% survival point still ma…

Sep 1, 2021 · 3 shares · 4,535 followers View post →
Martin Borch Jensen
@MartinBJensen · X

@CollinEwald asks 'can longevity interventions work late in life?'. Yes, daf2 degradation at 25% survival point still manages to almost double baseline lifespan (see also https://t.co/SBWLG5bInU). How does this work, slowing or reversing #Aging? 1/n

Sep 1, 2021 · 6 likes · 3 shares · 6,426 followers View post →
Chris Rabane
@ChrisRabane · X

RT @LifespanIO: With #aging, your #cells don't quite sense their nutrients as they should anymore. #lifeextension #x10 https://t.co/UVl3Y…

Aug 24, 2020 · 3 shares · 11,124 followers View post →
AntiAgify - Science will set you free
@AntiAgify · X

RT @LifespanIO: With #aging, your #cells don't quite sense their nutrients as they should anymore. #lifeextension #x10 https://t.co/UVl3Y…

Aug 24, 2020 · 3 shares · 1,346 followers View post →
Orest Bulcano
@dekentro · X

RT @LifespanIO: With #aging, your #cells don't quite sense their nutrients as they should anymore. #lifeextension #x10 https://t.co/UVl3Y…

Aug 24, 2020 · 3 shares · 1,036 followers View post →
Lifespan News
@LifespanNews · X

With #aging, your #cells don't quite sense their nutrients as they should anymore. #lifeextension #x10 https://t.co/UVl3Yj24ar

Aug 24, 2020 · 11 likes · 3 shares · 22,340 followers View post →
Chris Rabane
@ChrisRabane · X

RT @LifespanIO: Latest X10 episode on deregulated #nutrient sensing and #aging: https://t.co/UVl3Yj24ar #molecularbiology #biology #rejuv…

Jul 2, 2020 · 1 share · 11,124 followers View post →
Lifespan News
@LifespanNews · X

Latest X10 episode on deregulated #nutrient sensing and #aging: https://t.co/UVl3Yj24ar #molecularbiology #biology #rejuvenation

Jul 1, 2020 · 2 likes · 1 share · 22,340 followers View post →
Adi
@Adrian06661136 · X

RT @LifespanIO: Latest #X10 episode on deregulated #nutrient sensing in #aging #biology #molecularbiology https://t.co/UVl3Yj24ar

Jun 24, 2020 · 2 shares · 506 followers View post →
Lifespan News
@LifespanNews · X

Latest #X10 episode on deregulated #nutrient sensing in #aging #biology #molecularbiology https://t.co/UVl3Yj24ar

Jun 24, 2020 · 6 likes · 2 shares · 22,340 followers View post →
Asclepius
@dd414a1d9b59447 · X

RT @LifespanIO: Did you know that, with #aging, your cells have trouble sensing #nutrients? #molecularbiology #Biology https://t.co/UVl3…

Jun 17, 2020 · 2 shares · 2,273 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @LifespanIO: Did you know that, with #aging, your cells have trouble sensing #nutrients? #molecularbiology #Biology https://t.co/UVl3…

Jun 16, 2020 · 2 shares · 240 followers View post →
Lifespan News
@LifespanNews · X

Did you know that, with #aging, your cells have trouble sensing #nutrients? #molecularbiology #Biology https://t.co/UVl3Yj24ar

Jun 16, 2020 · 6 likes · 2 shares · 22,340 followers View post →
Adi
@Adrian06661136 · X

RT @LifespanIO: X10's latest video on deregulated nutrient sensing: #aging #biology #molecularbiology #metabolism https://t.co/UVl3Yj24ar

Jun 9, 2020 · 1 share · 506 followers View post →
Lifespan News
@LifespanNews · X

X10's latest video on deregulated nutrient sensing: #aging #biology #molecularbiology #metabolism https://t.co/UVl3Yj24ar

Jun 9, 2020 · 3 likes · 1 share · 22,340 followers View post →