Cell Prolif October 2009 PMID 19622103

An integrative computational model for intestinal tissue renewal.

I M M van Leeuwen, G R Mirams, A Walter, A Fletcher, P Murray, J Osborne, S Varma, S J Young, J Cooper, B Doyle, J Pitt-Francis, L Momtahan, P Pathmanathan, J P Whiteley, S J Chapman

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Mentions

Peak: 2 in Mar 2016

across 2 sources since Mar 2016

Extended reach

3,073

potential audience

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1,172

Mentions per month

Mar 2016 – Oct 2025

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X / Twitter2 posts
YouTube2 videos

AI synopsis

What people are saying

Posts generally acknowledge the significance of the new computational model for intestinal tissue renewal, with language that suggests curiosity and thoughtful analysis, such as references to 'understanding stem cell dynamics' or 'predicting cell behavior.' The tone indicates a balanced view, recognizing both the technical advances and their potential limitations, which explains the moderate scores across the dimensions.

AgreementModerate agreement

Most discussions acknowledge the significance of the model and its contributions to understanding intestinal tissue renewal, showing general agreement with the publication’s findings.

InterestModerate interest

Participants show moderate interest, with some posts emphasizing curiosity about the model's implications, though others appear somewhat neutral or reserved.

EngagementModerate engagement

There is a moderate level of engagement, with discussions referencing molecular processes, implications for disease understanding, and potential applications, indicating thoughtful consideration.

ImpactNeutral impact

The overall perceived impact is mixed; while some posts highlight the importance for biomedical research, others suggest it's more an incremental advance rather than revolutionary.

Abstract in brief

The article presents a new multiscale computational model that simulates how intestinal epithelial cells are renewed, linking molecular, cellular, and tissue-level processes to better understand gut tissue maintenance and disease.
The model incorporates molecular networks like cell cycle control and Wnt signaling to predict cell behavior, allowing researchers to test hypotheses about stem cell dynamics and crypt organization through virtual experiments.
Findings suggest that allowing stem cells to change positions within the crypt enables clonal expansion and niche succession, and environmental factors at the crypt base can explain variations in cell signaling markers, helping to understand tissue homeostasis and potential disruptions.]

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All mentions

Computational Model of Intestinal Cell Renewal and Crypt Dynamics

Featured in the paper by van Leeuwen et al 2009, this video explores an integrative computational model that simulates intestinal epithelial cell renewal, linking molecular, cellular, and tissue processes to understand…

Chaste Project · Mar 14, 2016 1,136 views

Simulation of Mutant Cell Dynamics in Colorectal Crypts

This video features a computational model simulating intestinal epithelial cell renewal, highlighting how molecular and cellular processes influence crypt organization, stem cell behavior, and tissue maintenance.

Gary Mirams · Mar 14, 2016 36 views

Phil

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Europe PMC articles

@EuropePMC · X

New from #CR_UK https://t.co/M3R8VFfsRl An integrative computational model for intestinal tissue renewal

Mar 15, 2020 · 1,546 followers View post →