An integrative computational model for intestinal tissue renewal.

I M M van Leeuwen, G R Mirams, A Walter, A Fletcher, P Murray, J Osborne, S Varma, S J Young, J Cooper, B Doyle, J Pitt-Francis, L Momtahan, P Pathmanathan, J P Whiteley, S J Chapman

October 2009 Cell Prolif

Synopsis of Social media discussions

Posts generally acknowledge the significance of the new computational model for intestinal tissue renewal, with language that suggests curiosity and thoughtful analysis, such as references to 'understanding stem cell dynamics' or 'predicting cell behavior.' The tone indicates a balanced view, recognizing both the technical advances and their potential limitations, which explains the moderate scores across the dimensions.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of the model and its contributions to understanding intestinal tissue renewal, showing general agreement with the publication’s findings.

I
Interest
 Moderate level of interest

Participants show moderate interest, with some posts emphasizing curiosity about the model's implications, though others appear somewhat neutral or reserved.

E
Engagement
 Moderate level of engagement

There is a moderate level of engagement, with discussions referencing molecular processes, implications for disease understanding, and potential applications, indicating thoughtful consideration.

I
Impact
 Neutral impact

The overall perceived impact is mixed; while some posts highlight the importance for biomedical research, others suggest it's more an incremental advance rather than revolutionary.

Social Mentions

YouTube

2 Videos

Twitter

2 Posts

Metrics

Video Views

1,172

Total Likes

2

Extended Reach

3,073

Social Features

4

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Computational Model of Intestinal Cell Renewal and Crypt Dynamics

Computational Model of Intestinal Cell Renewal and Crypt Dynamics

Featured in the paper by van Leeuwen et al 2009, this video explores an integrative computational model that simulates intestinal epithelial cell renewal, linking molecular, cellular, and tissue processes to understand gut tissue maintenance and disease.

Chaste Project

March 14, 2016

1,136 views

Simulation of Mutant Cell Dynamics in Colorectal Crypts

Simulation of Mutant Cell Dynamics in Colorectal Crypts

This video features a computational model simulating intestinal epithelial cell renewal, highlighting how molecular and cellular processes influence crypt organization, stem cell behavior, and tissue maintenance.

Gary Mirams

March 14, 2016

36 views

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Abstract Synopsis

  • The article presents a new multiscale computational model that simulates how intestinal epithelial cells are renewed, linking molecular, cellular, and tissue-level processes to better understand gut tissue maintenance and disease.
  • The model incorporates molecular networks like cell cycle control and Wnt signaling to predict cell behavior, allowing researchers to test hypotheses about stem cell dynamics and crypt organization through virtual experiments.
  • Findings suggest that allowing stem cells to change positions within the crypt enables clonal expansion and niche succession, and environmental factors at the crypt base can explain variations in cell signaling markers, helping to understand tissue homeostasis and potential disruptions.]