PubHawk
J Psychiatr Pract July 2009 PMID 19625884

Testosterone and depression: systematic review and meta-analysis.

Fahd Aziz Zarrouf, Steven Artz, James Griffith, Cristian Sirbu, Martin Kommor

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Mentions

37
Peak: 5 in Sep 2023
across 5 sources since Jun 2020

Extended reach

157,583
potential audience

Total likes

271

Video views

6,761

Mentions per month

Jun 2020 – Nov 2025

Where it's discussed

  • X / Twitter21 posts
  • News5 articles
  • Facebook4 posts
  • Blogs4 articles
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AI synopsis

What people are saying

Discussions revolve around referencing the systematic review and meta-analysis, emphasizing the significant positive effects of testosterone therapy on depression, with mentions of the controlled studies demonstrating its antidepressant properties. Words like 'significant' and 'pro-social behaviors' reflect a tone of cautious optimism and scientific rigor, although some questions about methodology suggest engagement is still developing.

AgreementModerate agreement

Most discussions support the positive link between testosterone and improved mood, citing studies and meta-analyses that show testosterone therapy has beneficial effects on depression.

InterestModerate interest

Participants show moderate curiosity, engaging with the scientific findings and asking questions about the treatment's efficacy and methodology.

EngagementModerate engagement

Comments include referencing key research and debating methodological issues, indicating a willingness to explore the topic in some depth.

ImpactModerate impact

The discussions highlight the potential significance of the findings for mental health and treatment options, suggesting a modest but meaningful impact.

Abstract in brief

  • This review and meta-analysis examined whether testosterone therapy helps reduce depression symptoms, finding seven high-quality placebo-controlled studies involving 364 participants.
  • The combined data showed that testosterone treatment had a significant positive effect on depression scores, indicating it may serve as an effective antidepressant in certain patients.
  • Subgroup analyses suggest that testosterone's antidepressant effects are especially notable in specific groups, though further details were not provided in this excerpt.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Men Are Human
@men_are_human · X

Citation for testosterone and depression part: https://t.co/oMY9kFxs8A

Jul 29, 2022 · 16 likes · 4 shares · 51,074 followers View post →
RosyKaren
@rosykaren · X

@TheRealPBarry @7News @australian Couple of questions for you: what was the control treatment in this RCT? Was there an alternative treatment or placebo used in the control group to control for the well-known antidepressant effects of testosterone? https://t.co/eyla5UMi9E

Sep 7, 2023 · 16 likes · 2 shares · 1,717 followers View post →
Mehdi Yacoubi
@Mehdiyac · X

Testosterone and depression: systematic review and meta-analysis "Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy on HAM-D response in depressed patients when compared with placebo (z=4.04, P<0.0001)" https://t.co/Nr7ZNo3okZ

Nov 4, 2022 · 5 likes · 4,864 followers View post →
RosyKaren
@rosykaren · X

@noplaceforsheep @twanchovy @TheRealPBarry @7News @australian Yes, and the "control" group received no alternative treatment or placebo, merely stayed on the waitlist for an extra three months. Testosterone also has a known anti-depressant effect. https://t.co/eyla5UMi9E

Sep 7, 2023 · 3 likes · 1,717 followers View post →
Bernie Simon
@Jinzang · X

@BadMedicalTakes Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy in depressed patients when compared with placebo. https://t.co/ry0InuQvCb

Aug 14, 2022 · 3 likes · 455 followers View post →
Christian Schmidt - Alles Evolution
@allesevolution · X

Testosterone and depression: systematic review and meta-analysis Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy on HAM-D response in depressed patients when compared with placebo" https://t.co/JEiMvvSsKA https://t.co/EzrLvLl9G0

Sep 16, 2024 · 2 likes · 4,114 followers View post →

All mentions

yemre
@yunotorious · X

"araba mı çizildi, bi sn kaputtan bi ses mi geliyor, oraya yürürsem yorulurum, uykumu alamadım esniyorum, açım ya enerjim yok, spor amelelik ya, taşırken belim ağrıdı, nefes nefese kaldım" https://t.co/AyFT0ccnZL https://t.co/EA0y1hUUVV https://t.co/q4pp5Rs415

Sep 13, 2025 · 1 like · 277 followers View post →
Mitsu Health
@MitsuMaHealth · X

Think about this for a moment: Men with low testosterone are ~4x more likely to have depression (Zarrouf et al., Psychosomatics, 2009). What kind of help would you be willing to ask for? Zarrouf, F. A., et al. “Testosterone and Depression: Systematic Review and Meta-Analysis.”

Jul 8, 2025 · 499 followers View post →
Mitsu Health
@MitsuMaHealth · X

Something to think about: Men with higher testosterone report greater well-being (Zarrouf et al., Psychosomatics, 2009). What kind of well-being would feel worth cultivating? Zarrouf, F. A., et al. “Testosterone and Depression: Systematic Review and Meta-Analysis.”

Jul 8, 2025 · 499 followers View post →
Mike Hart, M.D
@drmikehart · X

Jun 15, 2025 · 1 like · 66,576 followers View post →
theFaucist
@theFaucist · X

@razibkhan Testosterone is an antidepressent. https://t.co/fBGX5znNYo https://t.co/2v9cmI7VFU

May 3, 2025 · 1 like · 507 followers View post →
Christian Schmidt - Alles Evolution
@allesevolution · X

Testosterone and depression: systematic review and meta-analysis Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy on HAM-D response in depressed patients when compared with placebo" https://t.co/JEiMvvSsKA https://t.co/EzrLvLl9G0

Sep 16, 2024 · 2 likes · 4,114 followers View post →
Unai Aso | Psicólogo Sanitario
@unaiaso · X

Zarrouf, F. A., Artz, S., Griffith, J., Sirbu, C., & Kommor, M. (2009). Testosterone and depression: Systematic review and meta-analysis. Journal of Psychiatric Practice, 15(4), 289-305.

Jul 7, 2024 · 2,265 followers View post →
JaykandaForever
@SozeJay · X

@benryanwriter @BrynnTannehill How do the authors and Tannehill not even mention Testosterone's well established mood altering effects? Yes it's an RCT, but to pretend this study provides strong eveidence of benefit for this treatment is silly. https://t.co/3KYwTog9R8 https://t.co/JT22kDZVJO

Sep 8, 2023 · 1 like · 248 followers View post →
Sab_o_tage
@detrans_de · X

RT @rosykaren: @TheRealPBarry @7News @australian Couple of questions for you: what was the control treatment in this RCT? Was there an alte…

Sep 8, 2023 · 2 shares · 6,492 followers View post →
Kesh XX
@Keshwhatever · X

RT @rosykaren: @TheRealPBarry @7News @australian Couple of questions for you: what was the control treatment in this RCT? Was there an alte…

Sep 8, 2023 · 2 shares · 572 followers View post →
RosyKaren
@rosykaren · X

@noplaceforsheep @twanchovy @TheRealPBarry @7News @australian Yes, and the "control" group received no alternative treatment or placebo, merely stayed on the waitlist for an extra three months. Testosterone also has a known anti-depressant effect. https://t.co/eyla5UMi9E

Sep 7, 2023 · 3 likes · 1,717 followers View post →
RosyKaren
@rosykaren · X

@TheRealPBarry @7News @australian Couple of questions for you: what was the control treatment in this RCT? Was there an alternative treatment or placebo used in the control group to control for the well-known antidepressant effects of testosterone? https://t.co/eyla5UMi9E

Sep 7, 2023 · 16 likes · 2 shares · 1,717 followers View post →
Moonlit Monkey
@MoonlitMonkey69 · X

@bck_dvd @T00NYBOY @TheCriticalDri2 Here's on such study. Testesterone promotes pro-social behaviours outside of the context of perceived threat: https://t.co/dg55QnfFOl Reduces depression: https://t.co/qPe1khkQFn Increases Honesty: https://t.co/dDkyLQZhHU

Dec 4, 2022 · 1 like · 3,755 followers View post →
Mehdi Yacoubi
@Mehdiyac · X

Testosterone and depression: systematic review and meta-analysis "Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy on HAM-D response in depressed patients when compared with placebo (z=4.04, P<0.0001)" https://t.co/Nr7ZNo3okZ

Nov 4, 2022 · 5 likes · 4,864 followers View post →
Bernie Simon
@Jinzang · X

@BadMedicalTakes Meta-analysis of the data from these seven studies showed a significant positive effect of TT therapy in depressed patients when compared with placebo. https://t.co/ry0InuQvCb

Aug 14, 2022 · 3 likes · 455 followers View post →
Ashley
@Ashley41492344 · X

RT @men_are_human: Citation for testosterone and depression part: https://t.co/oMY9kFxs8A

Aug 1, 2022 · 4 shares · 780 followers View post →
Keith Brooker
@KeithBrooker5 · X

RT @men_are_human: Citation for testosterone and depression part: https://t.co/oMY9kFxs8A

Jul 29, 2022 · 4 shares · 1,022 followers View post →
Gay Male Journal (www.gaymalejournal.org)
@Gaymalejournal · X

RT @men_are_human: Citation for testosterone and depression part: https://t.co/oMY9kFxs8A

Jul 29, 2022 · 4 shares · 2,406 followers View post →
Funny Obliterator
@EterniaParodia · X

RT @men_are_human: Citation for testosterone and depression part: https://t.co/oMY9kFxs8A

Jul 29, 2022 · 4 shares · 70 followers View post →
Men Are Human
@men_are_human · X

Citation for testosterone and depression part: https://t.co/oMY9kFxs8A

Jul 29, 2022 · 16 likes · 4 shares · 51,074 followers View post →
Optimale
@OptiMaleUK · X

Several studies indicate that men with low testosterone suffer from low mood, anxiety and depression. Treatment with testosterone replacement therapy dramatically improves mood and reduces feelings of anxiety and depression in these men. Research here - https://t.co/EPh0aWTbuY https://t.co/BNhq1Irygh

Jun 20, 2020 · 862 followers View post →