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Neuropsychopharmacology January 2010 PMID 19710631

Neurocircuitry of addiction.

George F Koob, Nora D Volkow

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145
Peak: 16 in Dec 2022
across 5 sources since May 2019

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AI synopsis

What people are saying

In various discussions, participants highlighted specific research findings relating to the neurocircuitry of addiction, such as the dopamine reward pathways and implications for treatment using techniques like repetitive transcranial magnetic stimulation. Phrases like 'must consider' and 'transformative potential' were frequently used, showcasing an engaging and hopeful tone regarding the future of addiction recovery methods.

AgreementModerate agreement

The majority of discussions show a supportive view towards the insights provided by the article, emphasizing its relevance in understanding addiction and treatment strategies.

InterestHigh interest

There's a notable enthusiasm for the topic, with many participants expressing curiosity about the neurocircuitry implications and potential therapeutic avenues.

EngagementModerate engagement

While most discussions touch on the article's content, only some delve deeply into specific methodologies or findings, indicating a moderate level of engagement.

ImpactHigh impact

Many contributors perceive the publication as having substantial implications for addiction treatment and research, reflecting a belief that it could influence future approaches.

Abstract in brief

  • Drug addiction is a complex disorder characterized by compulsive drug-seeking behavior, loss of control over intake, and negative emotions during withdrawal, forming a cycle of binge-intoxication, withdrawal-negative affect, and preoccupation-craving.
  • Various brain circuits, particularly in the ventral tegmental area and ventral striatum, mediate these stages, emphasizing the role of different brain regions in managing addiction.
  • Neuroplastic changes in these brain regions lead to addiction vulnerability, which highlights the importance of understanding the neurocircuitry in developing potential treatments for addiction.
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Joslyn Chaiprasert-Paguio
@JoslynPaguio · X

NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a neural circuit perspective. Get your copy today: https://t.co/dQxd2hijQu https://t.co/T3HDYcfnmA

Dec 12, 2022 · 79 likes · 16 shares · 515 followers View post →
Alexander
@alpamo7 · X

#Neurology #psiquiatria

Mar 23, 2023 · 31 likes · 8 shares · 2,212 followers View post →
The Dr. O’Connell Lab
@KMS_OConnell · X

Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophysiology? Join us @jacksonlab for a co-mentored postdoc with the Kumar lab @Vivekdna! Apply here: https://t.co/Ky5GYikg25

Sep 21, 2021 · 9 likes · 7 shares · 559 followers View post →
Healthline
@Healthline · X

New research demonstrates a common brain network among people with substance use disorder. The brain neurocircuitry of addiction is associated with the dopamine reward neurocircuitry. https://t.co/FcWgyTWCv9

Oct 7, 2023 · 4 likes · 68,149 followers View post →
Marina
@SerketSupernova · X

E vou deixar uma bibliografia que tenho na cabeça agora. É um resumo bem completo e bem complexo sobre o assunto adicção Koob, Volkow. Neurocircuitry of addiction. Acho que é de 2010

Sep 15, 2020 · 4 likes · 266 followers View post →
Felo Anifel
@anifel20 · X

Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 27, 2021 · 3 likes · 6 shares · 71,041 followers View post →

All mentions

Greta Compton Dip DH RCSEd aka Gretsky
@Gretsky_Compton · X

The neurocircuitry of addiction: an overview - PMC https://t.co/maafj6cWMM

Aug 9, 2025 · 1 like · 905 followers View post →
Rodney Leonard
@leonard5691 · X

Neurocircuitry of Addiction | Neuropsychopharmacology https://t.co/UfbPn1oBsf

Aug 2, 2025 · 84 followers View post →
Condita Pionieru
@Conditioparody · X

Johnson, M. W., & Griffiths, R. R. (2017). Potential Therapeutic Effects of Psilocybin. Koob, G. F., & Volkow, N. D. (2010). Neurocircuitry of Addiction. Nutt, D. J., & King, L. A. (2010). The Clinical Importance of the Psychotropic Effects of Drugs.

May 26, 2025 · 20 followers View post →
Heather Burrell Ward, MD
@hbwardMD · X

RT @Meddeviceszone: Repetitive transcranial magnetic stimulation is a tool for probing the #neurocircuitry of #addiction and it could provi…

Oct 18, 2024 · 2 shares · 1,198 followers View post →
Victor Tang, MD
@victormarktang · X

RT @Meddeviceszone: Repetitive transcranial magnetic stimulation is a tool for probing the #neurocircuitry of #addiction and it could provi…

Oct 18, 2024 · 2 shares · 540 followers View post →
Medical Devices Zone
@Meddeviceszone · X

Repetitive transcranial magnetic stimulation is a tool for probing the #neurocircuitry of #addiction and it could provide effective treatment. Learn about the latest research in our Peek Behind the Paper with @victormarktang @UofTPsych @CAMHnews >>> https://t.co/E2iGoQAs40

Oct 18, 2024 · 2 likes · 2 shares · 106 followers View post →
AddictionNews
@AddictionNews · X

The Anticipation Wrinkle, The Expectation Wrinkle, and the Neurocircuitry of Addiction Addicts get hooked on thinking about indulging to a degree that consuming is a letdown. https://t.co/s8hF8C3uAK Another Exclusive from @AddictionNews https://t.co/ZzJOJ7kPnq

Aug 12, 2024 · 25 followers View post →
Healthline
@Healthline · X

New research demonstrates a common brain network among people with substance use disorder. The brain neurocircuitry of addiction is associated with the dopamine reward neurocircuitry. https://t.co/FcWgyTWCv9

Oct 7, 2023 · 4 likes · 68,149 followers View post →
Suzie Bell
@suzie_bell · X

RT @alpamo7: #Neurology #psiquiatria

Sep 11, 2023 · 8 shares · 63 followers View post →
マーキュリー２世
@uranus_2 · X

嗜癖神経科学。神経回路のお話が中心。Neurocircuitry of Addiction　https://t.co/fdki9LXp4X

Apr 8, 2023 · 5,536 followers View post →
dr tlacuache
@dralexismolina · X

RT @alpamo7: #Neurology #psiquiatria

Mar 23, 2023 · 8 shares · 109 followers View post →
Muhammad Abdelshafi
@Muhamma65897791 · X

RT @alpamo7: #Neurology #psiquiatria

Mar 23, 2023 · 8 shares · 52 followers View post →
Roxana Flores A. MD,PhD
@flo_rox · X

RT @alpamo7: #Neurology #psiquiatria

Mar 23, 2023 · 8 shares · 2,149 followers View post →
crisguijarro
@crisguijarro1 · X

RT @alpamo7: #Neurology #psiquiatria

Mar 23, 2023 · 8 shares · 1,876 followers View post →
Héctor A. L.
@avellonlianno · X

RT @alpamo7: #Neurology #psiquiatria

Mar 23, 2023 · 8 shares · 703 followers View post →
Alexander
@alpamo7 · X

#Neurology #psiquiatria

Mar 23, 2023 · 31 likes · 8 shares · 2,212 followers View post →
Antentor Othrell Hinton, Jr PhD (A.J. Hinton)
@phdgprotein86 · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 13, 2022 · 16 shares · 5,191 followers View post →
Joshua OLAMIJU
@thejosholamiju · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 13, 2022 · 16 shares · 464 followers View post →
Greg T Sutherland
@brainomiac · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 13, 2022 · 16 shares · 95 followers View post →
Manus Aeon
@AeonManus · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 13, 2022 · 16 shares · 132 followers View post →
Hipocrates Juniors
@hipocratesjrs · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 13, 2022 · 16 shares · 2,538 followers View post →
Marquis Marc
@_MVPhan · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 13, 2022 · 16 shares · 412 followers View post →
Savyasachi
@drnagu2008 · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 13, 2022 · 16 shares · 164 followers View post →
Out of Time Clockmaker
@InThinIce · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 506 followers View post →
Ryan Logan
@wickedneuro · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 2,941 followers View post →
Lillian J. Brady, PhD
@DrLJBrady · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 3,758 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 384 followers View post →
D. Parker Kelley
@sequencemyneuro · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 721 followers View post →
Vernon García
@vgarciarivas · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 3,568 followers View post →
Siara Rouzer, PhD
@SiaraRouzer · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 1,362 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @JoslynPaguio: NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a n…

Dec 12, 2022 · 16 shares · 10,789 followers View post →
Joslyn Chaiprasert-Paguio
@JoslynPaguio · X

NEW Book! Neurocircuitry of Addiction edited by @The_Gilp is the first book to focus on #addiction #neuroscience from a neural circuit perspective. Get your copy today: https://t.co/dQxd2hijQu https://t.co/T3HDYcfnmA

Dec 12, 2022 · 79 likes · 16 shares · 515 followers View post →
Bengt Erixon
@bengt_erixon · X

RT @ViewsOnDrugsBot: Compounding Vulnerability in the Neurocircuitry of Addiction: Longitudinal Functional Connectivity Changes in Alcohol…

Oct 11, 2022 · 2 shares · 1,016 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @ViewsOnDrugsBot: Compounding Vulnerability in the Neurocircuitry of Addiction: Longitudinal Functional Connectivity Changes in Alcohol…

Oct 11, 2022 · 2 shares · 2,065 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

Compounding Vulnerability in the Neurocircuitry of Addiction: Longitudinal Functional Connectivity Changes in Alcohol Use Disorder 1/5 https://t.co/naF3uc5Bo3

Jul 28, 2022 · 2 likes · 2 shares · 2,065 followers View post →
渕野　裕 (Fuchino Yutaka)
@yfuchino · X

Compounding Vulnerability in the Neurocircuitry of Addiction: Longitudinal Functional Connectivity Changes in Alcoh… https://t.co/rzc1OiJO5N

Jun 28, 2022 · 19 followers View post →
NeuroChoice Initiative
@NeuroChoice · X

Thank you Dr. Greg Sahlem for the terrific talk and conversation about Neurocircuitry of Addiction for @NeuroChoice https://t.co/AR4cG6N6oH

May 4, 2022 · 3 likes · 297 followers View post →
JKExpert
@jkexpert_ · X

RT @anifel20: Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 28, 2021 · 6 shares · 246 followers View post →
Kishoka Mdogo, Ph.D
@DanielKishoka · X

RT @anifel20: Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 28, 2021 · 6 shares · 1,084 followers View post →
temidaniels
@tarrah___ · X

RT @anifel20: Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 28, 2021 · 6 shares · 1,967 followers View post →
Bukola
@bukola_beckley · X

RT @anifel20: Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 27, 2021 · 6 shares · 18,881 followers View post →
simi
@fatherstreet_ · X

RT @anifel20: Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 27, 2021 · 6 shares · 584 followers View post →
Shah Faisalᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠ
@BeingS_faisal · X

RT @anifel20: Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 27, 2021 · 6 shares · 433 followers View post →
Felo Anifel
@anifel20 · X

Postdoc in Neurocircuitry of Addiction, Bar Harbor Maine, Kumar and O'Connell Lab. https://t.co/0ivLTcea6i

Dec 27, 2021 · 3 likes · 6 shares · 71,041 followers View post →
Jennifer Trowbridge
@TrowbridgeLab · X

RT @KMS_OConnell: Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophys…

Sep 23, 2021 · 7 shares · 5,339 followers View post →
JAX Genomic Education
@JAX_Education · X

RT @KMS_OConnell: Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophys…

Sep 23, 2021 · 7 shares · 2,475 followers View post →
Meghali Aich
@meghali_aich · X

RT @KMS_OConnell: Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophys…

Sep 22, 2021 · 7 shares · 676 followers View post →
Kousuke MOURI
@kousuke_mouri · X

RT @KMS_OConnell: Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophys…

Sep 22, 2021 · 7 shares · 75 followers View post →
Mehdi Sanayei
@MehdiSanayei · X

RT @KMS_OConnell: Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophys…

Sep 22, 2021 · 7 shares · 592 followers View post →
Plexon Inc.
@PlexonNeurosci · X

RT @KMS_OConnell: Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophys…

Sep 21, 2021 · 7 shares · 732 followers View post →
Andrew Klein
@AndrewKleinSN · X

RT @KMS_OConnell: Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophys…

Sep 21, 2021 · 7 shares · 439 followers View post →
The Dr. O’Connell Lab
@KMS_OConnell · X

Interested in the neurocircuitry of addiction? Want to learn how to integrate molecular genetics/genomics with neurophysiology? Join us @jacksonlab for a co-mentored postdoc with the Kumar lab @Vivekdna! Apply here: https://t.co/Ky5GYikg25

Sep 21, 2021 · 9 likes · 7 shares · 559 followers View post →
Marina
@SerketSupernova · X

E vou deixar uma bibliografia que tenho na cabeça agora. É um resumo bem completo e bem complexo sobre o assunto adicção Koob, Volkow. Neurocircuitry of addiction. Acho que é de 2010

Sep 15, 2020 · 4 likes · 266 followers View post →
BunchOfChunk
@BunchOfChunk · X

Paraventricular Thalamus Activity during Motivational Conflict Highlights the Nucleus as a Potential Constituent in the Neurocircuitry of Addiction https://t.co/2sctSg8xvo https://t.co/8YAWd0FwTT

Jan 24, 2020 · 59 followers View post →
Marina Picciotto
@MarinaP63 · X

RT @SfNJournals: Journal Club | Paraventricular Thalamus Activity during Motivational Conflict Highlights the Nucleus as a Potential Consti…

Jan 23, 2020 · 1 share · 15,039 followers View post →
SfN Journals
@SfNJournals · X

Journal Club | Paraventricular Thalamus Activity during Motivational Conflict Highlights the Nucleus as a Potential Constituent in the Neurocircuitry of Addiction https://t.co/yczlgg5lI3

Jan 23, 2020 · 3 likes · 1 share · 22,710 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Paraventricular Thalamus Activity during Motivational Conflict Highlights the Nucleus as a Potential Constituent in the Neurocircuitry of Addiction - JNeurosci via BrainSights for iOS https://t.co/4Q4i14wwKG

Jan 22, 2020 · 313 followers View post →
TimeTraveller
@KaellumEridani · X

Using Optogenetics to Understand the Neurocircuitry of Addiction https://t.co/prfXNhdrqk

Jan 8, 2020 · 571 followers View post →
Columbia/Boone Co. Public Health & Human Services
@CoMo_HealthDept · X

Dr. Kieffer's presentation will discuss rapidly evolving areas in opioid research including the key questions of whether we can use opiates to eliminate pain without addiction and how opioid receptors operate within the neurocircuitry of addiction. https://t.co/wx0Tl9sKCy

Jul 23, 2019 · 1 like · 4,411 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Using Optogenetics to Understand the Neurocircuitry of Addiction - Society for Neuroscience via BrainSights https://t.co/59EmjBZ1TJ

May 8, 2019 · 313 followers View post →