December 2009 PMID 19837873

Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta.

Rebecca L Cunningham, Andrea Giuffrida, James L Roberts

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Mentions

Peak: 2 in Dec 2023

across 2 sources since Jul 2022

Extended reach

87,735

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2,086

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85,914

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Jul 2022 – Jun 2024

Where it's discussed

X / Twitter6 posts
YouTube2 videos

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What people are saying

The discussions primarily revolve around opinions on finasteride, with some posters dismissing or criticizing the publication's relevance, as seen in comments like 'He is anti-finasteride' and recommending or condemning treatments without engaging with the scientific content. The tone is dismissive, and the focus remains on personal or ideological perspectives rather than scientific analysis.

AgreementLow agreement

Most discussions question or dismiss the relevance of the publication, highlighting skepticism toward its findings or implications.

InterestNeutral interest

The conversations show limited curiosity about the scientific details, focusing more on biased opinions about treatments like finasteride.

EngagementLow engagement

Interactions are minimal and somewhat dismissive, with few efforts to analyze or deepen the discussion about the scientific article.

ImpactLow impact

The overall tone suggests these discussions have negligible influence on scientific understanding or clinical practices, mainly centered around personal opinions.

Abstract in brief

The study shows that androgens like testosterone and dihydrotestosterone can activate cell pathways that lead to the death of dopamine-producing neurons, which are involved in Parkinson's disease (PD).
The process involves androgens causing mitochondrial dysfunction and activating caspase-3, an enzyme that then cleaves PKCdelta, leading to cell apoptosis (death).
The findings suggest that higher levels of testosterone may specifically harm dopamine neurons, potentially explaining why men are more frequently affected by PD compared to women.]

Read the full abstract

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Finasteride's Role in Reducing Dyskinesia in Parkinson's Disease

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Evaluating Finasteride's Impact on Prostate Cancer Outcomes

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Haircafe · Dec 17, 2023 38,676 views

Sreeman శ్రీమాన్

@IamSreeman · X

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Jun 29, 2024 · 494 followers View post →

ekkJackYouLate

@ekkJackYouLate · X

@bryan_johnson just jump on oral finasteride @bryan_johnson https://t.co/Bql8QMErvq

Mar 11, 2024 · 425 followers View post →

ekkJackYouLate

@ekkJackYouLate · X

@bryan_johnson @bryan_johnson https://t.co/VU6dhynQ74

Feb 22, 2024 · 425 followers View post →

ekkJackYouLate

@ekkJackYouLate · X

@bryan_johnson @bryan_johnson pop finasteride and love forever. https://t.co/VU6dhynQ74

Feb 21, 2024 · 425 followers View post →

Oliver Felix

@OliverFelixRene · X

@bryan_johnson pls watch this! Less than 2% get sides on Finasteride and it is anti aging! You even maintain your hair. Dutasteride would be even better https://t.co/1tZpWliuxY

Jan 1, 2024 · 19 followers View post →

Vinay

@Vin_ay88 · X

@bryan_johnson You should consider Finasteraid. Here is new message for you.

Dec 18, 2023 · 33 followers View post →

Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Finasteride's Role in Reducing Dyskinesia in Parkinson's Disease

Evaluating Finasteride's Impact on Prostate Cancer Outcomes