PubHawk
December 2009 PMID 19843076

Resveratrol is not a direct activator of SIRT1 enzyme activity.

Dirk Beher, John Wu, Suzanne Cumine, Ki Won Kim, Shu-Chen Lu, Larissa Atangan, Minghan Wang

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Mentions

20
Peak: 6 in Jul 2023
across 4 sources since Mar 2021

Extended reach

543,028
potential audience

Total likes

5,513

Video views

336,336

Mentions per month

Mar 2021 – Oct 2025

Where it's discussed

  • X / Twitter13 posts
  • Blogs3 articles
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

This collection of discussions demonstrates a high level of interest through references to scientific experiments and previous misinterpretations, with tone showing skepticism about past claims and curiosity about recent findings. Examples like references to 2009 studies and recent papers on indirect activation strategies illustrate how the discussions probe deeper scientific implications, contributing to moderate engagement and potential shifts in understanding within the scientific community.

AgreementLow agreement

Many discussions highlight that resveratrol does not directly activate SIRT1, reflecting some consensus, but not strong disagreement overall.

InterestHigh interest

The discussions are highly engaging, with participants exploring scientific details and questioning previous claims about resveratrol.

EngagementModerate engagement

Users are actively referencing research, authors, and experimental design, indicating a moderate level of involvement.

ImpactModerate impact

The conversations challenge earlier assumptions about resveratrol’s effects, which could influence future research directions, but the overall impact remains moderate at this stage.

Abstract in brief

  • Resveratrol is not a direct activator of the SIRT1 enzyme
  • ; recent research shows that previous claims of activation might be due to experimental artifacts rather than true enzyme activation.
  • The so-called SIRT1 activation observed with certain peptide substrates, like Fluor de Lys, may be misleading
  • because these substrates are artificially designed and do not reflect how SIRT1 works with natural substrates such as PGC1alpha.
  • The study concludes that resveratrol’s beneficial effects are unlikely to come from directly boosting SIRT1 activity
  • , which questions its use as a tool for targeting SIRT1 in research or therapy.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Charles Brenner, PhD
@CharlesMBrenner · X

journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them. there are more https://t.co/kgvlJZCDPH https://t.co/GWPT3Oh7ac https://t.co/NEUy3dF9w7 https://t.co/ImbJWn0sGu https://t.co/lpxTE4eXuC

Jul 26, 2023 · 64 likes · 5 shares · 57,334 followers View post →
mjoh090
@mjoh090 · X

@PeregrineFn @davidasinclair @IrishIslands4us @YouTube @mdlaplante The activation was indirect, not direct. Indirect activation was described in 2009 https://t.co/EOEaNXAgL8 . The 2021 paper identified LKB1 as a target for resveratrol mediated activation of SIRT1. Also, the physiological implications of LKB1 targeting is of critical importance.

Feb 16, 2022 · 3 likes · 34 followers View post →
文月宵(ケトン人)
@fumizukishou_bc · X

“レスベラトロールはSIRT1酵素活性の直接的な活性化因子ではない” SIRT1を活性化するように見えたのは人工的な蛍光色素に作用していたためで ​蛍光色素を取り除いたらレスベラトロールによるSIRT1の直接的な活性化は一切確認されんかったというw https://t.co/0zSMN4gYMZ

Oct 31, 2025 · 2 likes · 735 followers View post →
Timothy Barnes
@Timothy02483682 · X

@a_musingcat Have you found a version encapsulated in methylated-β-cyclodextrins? https://t.co/e7dNphJJwT

Jun 12, 2023 · 1 like · 99 followers View post →
AMERICAN MIDWEST CULTURAL VICTORY
@how2crankdat · X

@MetabolicFactor The most effective part of Sinclair’s “anti-aging protocol” is the botox. His research is irreproducible, and resveratrol is not at SIRT1 activator: https://t.co/dNRM9KMyey

Jun 29, 2025 · 1 like · 33 followers View post →
JT | Jerry Teixeira
@jerryteixeira · X

@CaloriesProper Of course, resveratrol may not activate sirt1. What do you think of this? https://t.co/1w1rKagojM

May 1, 2022 · 79,422 followers View post →

All mentions

文月宵(ケトン人)
@fumizukishou_bc · X

“レスベラトロールはSIRT1酵素活性の直接的な活性化因子ではない” SIRT1を活性化するように見えたのは人工的な蛍光色素に作用していたためで ​蛍光色素を取り除いたらレスベラトロールによるSIRT1の直接的な活性化は一切確認されんかったというw https://t.co/0zSMN4gYMZ

Oct 31, 2025 · 2 likes · 735 followers View post →
AMERICAN MIDWEST CULTURAL VICTORY
@how2crankdat · X

@MetabolicFactor The most effective part of Sinclair’s “anti-aging protocol” is the botox. His research is irreproducible, and resveratrol is not at SIRT1 activator: https://t.co/dNRM9KMyey

Jun 29, 2025 · 1 like · 33 followers View post →
PT_Thunem
@PT_Thunem · X

RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…

Jul 27, 2023 · 5 shares · 81 followers View post →
Adam Obr
@obradam · X

RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…

Jul 27, 2023 · 5 shares · 8,324 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…

Jul 27, 2023 · 5 shares · 56,052 followers View post →
デルタ9ジェネシス
@takeitou_ishuku · X

RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…

Jul 26, 2023 · 5 shares · 161 followers View post →
Max Unfried
@MaxUnfried · X

RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…

Jul 26, 2023 · 5 shares · 4,205 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them. there are more https://t.co/kgvlJZCDPH https://t.co/GWPT3Oh7ac https://t.co/NEUy3dF9w7 https://t.co/ImbJWn0sGu https://t.co/lpxTE4eXuC

Jul 26, 2023 · 64 likes · 5 shares · 57,334 followers View post →
Timothy Barnes
@Timothy02483682 · X

@a_musingcat Have you found a version encapsulated in methylated-β-cyclodextrins? https://t.co/e7dNphJJwT

Jun 12, 2023 · 1 like · 99 followers View post →
JT | Jerry Teixeira
@jerryteixeira · X

@CaloriesProper Of course, resveratrol may not activate sirt1. What do you think of this? https://t.co/1w1rKagojM

May 1, 2022 · 79,422 followers View post →
Herman
@observeherm · X

@HOM3OSTASIS Previous evidence of resveratrol activating SIRT1 were due to poorly designed experiments. Directly adding resveratrol in a petri dish doesn't activate SIRT1. https://t.co/X3fGrjKujC

Feb 26, 2022 · 68 followers View post →
mjoh090
@mjoh090 · X

@PeregrineFn @davidasinclair @IrishIslands4us @YouTube @mdlaplante The activation was indirect, not direct. Indirect activation was described in 2009 https://t.co/EOEaNXAgL8 . The 2021 paper identified LKB1 as a target for resveratrol mediated activation of SIRT1. Also, the physiological implications of LKB1 targeting is of critical importance.

Feb 16, 2022 · 3 likes · 34 followers View post →
Alban Oπ
@alban_ott · X

@MrSam144 le NAD+ on a pas encore de papiers qui debunk mais es tu aller voir la précédente molécule miracle? https://t.co/K8JOP0KKKY https://t.co/Pf9KPDqjhM source: https://t.co/vlCcUTc6hP

Mar 28, 2021 · 84 followers View post →