Synopsis of Social media discussions
This collection of discussions demonstrates a high level of interest through references to scientific experiments and previous misinterpretations, with tone showing skepticism about past claims and curiosity about recent findings. Examples like references to 2009 studies and recent papers on indirect activation strategies illustrate how the discussions probe deeper scientific implications, contributing to moderate engagement and potential shifts in understanding within the scientific community.
Agreement
Low agreementMany discussions highlight that resveratrol does not directly activate SIRT1, reflecting some consensus, but not strong disagreement overall.
Interest
High level of interestThe discussions are highly engaging, with participants exploring scientific details and questioning previous claims about resveratrol.
Engagement
Moderate level of engagementUsers are actively referencing research, authors, and experimental design, indicating a moderate level of involvement.
Impact
Moderate level of impactThe conversations challenge earlier assumptions about resveratrol’s effects, which could influence future research directions, but the overall impact remains moderate at this stage.
Social Mentions
YouTube
2 Videos
13 Posts
Blogs
3 Articles
News
2 Articles
Metrics
Video Views
336,336
Total Likes
5,513
Extended Reach
543,028
Social Features
20
Timeline: Posts about article
Top Social Media Posts
Charles Brenner, PhD
journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them. there are more
https://t.co/kgvlJZCDPH
https://t.co/GWPT3Oh7ac
https://t.co/NEUy3dF9w7
https://t.co/ImbJWn0sGu
https://t.co/lpxTE4eXuC
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mjoh090
@PeregrineFn @davidasinclair @IrishIslands4us @YouTube @mdlaplante The activation was indirect, not direct. Indirect activation was described in 2009 https://t.co/EOEaNXAgL8 . The 2021 paper identified LKB1 as a target for resveratrol mediated activation of SIRT1. Also, the physiological implications of LKB1 targeting is of critical importance.
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文月宵(ケトン人)
“レスベラトロールはSIRT1酵素活性の直接的な活性化因子ではない”
SIRT1を活性化するように見えたのは人工的な蛍光色素に作用していたためで
蛍光色素を取り除いたらレスベラトロールによるSIRT1の直接的な活性化は一切確認されんかったというw
https://t.co/0zSMN4gYMZ
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Timothy Barnes
@a_musingcat Have you found a version encapsulated in methylated-β-cyclodextrins?
https://t.co/e7dNphJJwT
view full post
AMERICAN MIDWEST CULTURAL VICTORY
@MetabolicFactor The most effective part of Sinclair’s “anti-aging protocol” is the botox. His research is irreproducible, and resveratrol is not at SIRT1 activator: https://t.co/dNRM9KMyey
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Posts referencing the article
Resveratrol: Health Benefits or Misconceptions?
What is the truth behind one of the world's most popular antioxidants, resveratrol? This video analyzes significant scientific research regarding its effects on longevity and cardiovascular health, while addressing common myths and facts about this compound. Discover if resveratrol is worth including in your daily routine.
October 7, 2024
335,889 views
Impact of Resveratrol on Lifespan and Cellular Health
In this video, we analyze resveratrol, a natural compound studied for its potential to extend lifespan and impact human cells. Discover how resveratrol induces low-level replicative stress and interacts with DNA damage response genes, challenging previous assumptions about its effects.
August 3, 2025
447 views
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“レスベラトロールはSIRT1酵素活性の直接的な活性化因子ではない” SIRT1を活性化するように見えたのは人工的な蛍光色素に作用していたためで 蛍光色素を取り除いたらレスベラトロールによるSIRT1の直接的な活性化は一切確認されんかったというw https://t.co/0zSMN4gYMZ
view full postOctober 31, 2025
2
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AMERICAN MIDWEST CULTURAL VICTORY
@how2crankdat (Twitter)@MetabolicFactor The most effective part of Sinclair’s “anti-aging protocol” is the botox. His research is irreproducible, and resveratrol is not at SIRT1 activator: https://t.co/dNRM9KMyey
view full postJune 29, 2025
1
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PT_Thunem
@PT_Thunem (Twitter)RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…
view full postJuly 27, 2023
5
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Adam Obr
@obradam (Twitter)RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…
view full postJuly 27, 2023
5
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Stuart Phillips (he/him)
@mackinprof (Twitter)RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…
view full postJuly 27, 2023
5
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デルタ9ジェネシス
@takeitou_ishuku (Twitter)RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…
view full postJuly 26, 2023
5
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Max Unfried
@MaxUnfried (Twitter)RT @CharlesMBrenner: journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them.…
view full postJuly 26, 2023
5
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Charles Brenner, PhD
@CharlesMBrenner (Twitter)journalist asked me for references showing that resveratrol & SRT1720 are not sirtuin activators. here are 5 of them. there are more https://t.co/kgvlJZCDPH https://t.co/GWPT3Oh7ac https://t.co/NEUy3dF9w7 https://t.co/ImbJWn0sGu https://t.co/lpxTE4eXuC
view full postJuly 26, 2023
64
5
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Timothy Barnes
@Timothy02483682 (Twitter)@a_musingcat Have you found a version encapsulated in methylated-β-cyclodextrins? https://t.co/e7dNphJJwT
view full postJune 12, 2023
1
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JT | Jerry Teixeira
@jerryteixeira (Twitter)@CaloriesProper Of course, resveratrol may not activate sirt1. What do you think of this? https://t.co/1w1rKagojM
view full postMay 1, 2022
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Herman
@observeherm (Twitter)@HOM3OSTASIS Previous evidence of resveratrol activating SIRT1 were due to poorly designed experiments. Directly adding resveratrol in a petri dish doesn't activate SIRT1. https://t.co/X3fGrjKujC
view full postFebruary 26, 2022
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mjoh090
@mjoh090 (Twitter)@PeregrineFn @davidasinclair @IrishIslands4us @YouTube @mdlaplante The activation was indirect, not direct. Indirect activation was described in 2009 https://t.co/EOEaNXAgL8 . The 2021 paper identified LKB1 as a target for resveratrol mediated activation of SIRT1. Also, the physiological implications of LKB1 targeting is of critical importance.
view full postFebruary 16, 2022
3
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Alban Oπ
@alban_ott (Twitter)@MrSam144 le NAD+ on a pas encore de papiers qui debunk mais es tu aller voir la précédente molécule miracle? https://t.co/K8JOP0KKKY https://t.co/Pf9KPDqjhM source: https://t.co/vlCcUTc6hP
view full postMarch 28, 2021
Abstract Synopsis
- Resveratrol is not a direct activator of the SIRT1 enzyme
- ; recent research shows that previous claims of activation might be due to experimental artifacts rather than true enzyme activation. -
- The so-called SIRT1 activation observed with certain peptide substrates, like Fluor de Lys, may be misleading
- because these substrates are artificially designed and do not reflect how SIRT1 works with natural substrates such as PGC1alpha. -
- The study concludes that resveratrol’s beneficial effects are unlikely to come from directly boosting SIRT1 activity
- , which questions its use as a tool for targeting SIRT1 in research or therapy.]
文月宵(ケトン人)
@fumizukishou_bc (Twitter)