Cell Metab December 2009 PMID 19945408

Autophagy is required to maintain muscle mass.

Eva Masiero, Lisa Agatea, Cristina Mammucari, Bert Blaauw, Emanuele Loro, Masaaki Komatsu, Daniel Metzger, Carlo Reggiani, Stefano Schiaffino, Marco Sandri

Mentions

49
Peak: 5 in Apr 2019
across 5 sources since Mar 2019

Extended reach

313,000
potential audience

Total likes

713

Video views

13,049

Mentions per month

Mar 2019 – Jun 2024

Where it's discussed

  • Facebook35 posts
  • X / Twitter6 posts
  • Reddit3 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect strong agreement with the publication, citing evidence like muscle-specific gene deletions causing atrophy, and emphasize the importance of autophagy in preventing muscle degeneration as seen in examples such as age-related muscle loss and mitochondrial buildup. The tone and word choices convey a consensus on the critical role of autophagy, with an emphasis on its implications for health and aging.

AgreementStrong agreement

Most discussions agree that autophagy is vital for muscle maintenance and that disrupting it leads to muscle loss.

InterestModerate interest

Posts demonstrate moderate interest, with mentions of the biological mechanisms and implications for aging and muscle health.

EngagementModerate engagement

Participants reference specific research outcomes and connect them to broader biological concepts, indicating active engagement.

ImpactHigh impact

The discussions highlight significant implications for understanding aging and muscle degenerative diseases, emphasizing the importance of autophagy.

Abstract in brief

  • Autophagy is essential for maintaining muscle mass by removing damaged organelles and proteins, with its disruption leading to muscle atrophy and weakness.
  • Deleting the autophagy gene Atg7 specifically in muscles causes severe muscle loss, abnormal mitochondrial buildup, and structural disorganization within muscle cells, especially with age.
  • Inhibiting autophagy worsens muscle deterioration during stress conditions like denervation and fasting, indicating that proper autophagy function is crucial for muscle health and preventing degenerative muscle diseases.]

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound muscle atrophy" Likely one reason for muscle loss in aging. https://t.co/8EiDMcHZk0

Apr 7, 2019 · 38 likes · 8 shares · 298,275 followers View post →
mtbmasaya1, Masaya
@mtbmasaya1 · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 8, 2019 · 8 shares · 743 followers View post →
Fernpick
@Fernpick · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 8, 2019 · 8 shares · 430 followers View post →
Stefan Sladeček
@stefansladecek · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 7, 2019 · 8 shares · 276 followers View post →
molina molina
@molinam36323338 · X

@DrEenfeldt @SkoufosPascal @tednaiman @JoinHava Longer fasts induce autophagy. inhibition/alteration of autophagy can contribute to myofiber degeneration and weakness in muscle disorders characterized by accumulation of abnormal mitochondria and inclusions https://t.co/moJiV9xxjT

Apr 25, 2024 · 79 followers View post →
Der E
@DerE_HHS · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 7, 2019 · 8 shares · 69 followers View post →

All mentions

molina molina
@molinam36323338 · X

@DrEenfeldt @SkoufosPascal @tednaiman @JoinHava Longer fasts induce autophagy. inhibition/alteration of autophagy can contribute to myofiber degeneration and weakness in muscle disorders characterized by accumulation of abnormal mitochondria and inclusions https://t.co/moJiV9xxjT

Apr 25, 2024 · 79 followers View post →
Fernpick
@Fernpick · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 8, 2019 · 8 shares · 430 followers View post →
mtbmasaya1, Masaya
@mtbmasaya1 · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 8, 2019 · 8 shares · 743 followers View post →
Der E
@DerE_HHS · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 7, 2019 · 8 shares · 69 followers View post →
Stefan Sladeček
@stefansladecek · X

RT @Mangan150: Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound mu…

Apr 7, 2019 · 8 shares · 276 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Autophagy Is Required to Maintain Muscle Mass "muscle-specific deletion of a crucial autophagy gene resulted in profound muscle atrophy" Likely one reason for muscle loss in aging. https://t.co/8EiDMcHZk0

Apr 7, 2019 · 38 likes · 8 shares · 298,275 followers View post →