I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/MaIR42SMGz https://t.co/QWBkkOb103
"Control" laboratory rodents are metabolically morbid: why it matters.
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Jul 2019 – Jan 2025Where it's discussed
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News21 articles
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X / Twitter20 posts
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Blogs9 articles
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YouTube2 videos
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The discussions reflect a strong consensus on the importance of the article, with participants emphasizing that standard lab rodents are often overfed and metabolically unhealthy, which can compromise research results. Words like 'must read,' 'preaching,' and references to specific studies demonstrate high engagement and a belief in the article's potential to impact research standards and animal management practices.
Most discussions strongly acknowledge the importance of recognizing metabolic issues in control rodents, emphasizing the significance of the article's message.
Participants are highly interested, frequently discussing methodological details, feeding regimens, and implications for research validity.
Many posts show deep engagement by referencing specific studies, calling for change, and advocating for better practices, indicating active participation.
The discussions suggest that the article could influence research practices and experimental design, highlighting its potential to improve scientific accuracy.
Abstract in brief
- Many standard lab rodents used as controls are sedentary, obese, and glucose intolerant, which can influence research results and human study outcomes.
- Overfeeding and lack of exercise in these animals affect critical biological processes like oxidative stress and inflammation, making them less accurate models for healthy humans.
- Treatments successful in sedentary, obese rodents may not work the same way in active, normal-weight humans, potentially leading to misleading conclusions.]
Top posts
Most liked on X and BlueskyMust read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/T6No1KyB7a
“Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/YybaI26eqb Overview of various physiological differences between standard ad libitum–fed control animals and moderately fed lean animals. The percentage difference for numerous variables
"Control" laboratory rodents are metabolically morbid: why it matters Bronwen Martin et al. Proc Natl Acad Sci. 2010. https://t.co/JFg32xcNAE https://t.co/kttEnKijS8
@JohnSpeakman4 @Aging_Scientist @alantomusiak @mkaeberlein I expect a lot of this is about the chow and how the animals are fed, and hence the level of metabolic morbidity https://t.co/9wBlUKk5Ag https://t.co/KF3uFNsgIe https://t.co/2XRZtysLsQ Many other things commonly done poorly in LS studies https://t.co/UzLTML0wRr
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RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…
RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…
RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…
RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…
RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…
Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/T6No1KyB7a
@JohnSpeakman4 @Aging_Scientist @alantomusiak @mkaeberlein I expect a lot of this is about the chow and how the animals are fed, and hence the level of metabolic morbidity https://t.co/9wBlUKk5Ag https://t.co/KF3uFNsgIe https://t.co/2XRZtysLsQ Many other things commonly done poorly in LS studies https://t.co/UzLTML0wRr
RT @via_health9485:
"Control" laboratory rodents are metabolically morbid: why it matters Bronwen Martin et al. Proc Natl Acad Sci. 2010. https://t.co/JFg32xcNAE https://t.co/kttEnKijS8
"“Control” laboratory rodents are metabolically morbid: Why it matters" https://t.co/0zS0CaOxpY
RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…
RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…
RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…
RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…
I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/MaIR42SMGz https://t.co/QWBkkOb103
@mitchellblee33 @longboat789 Thank you. For whether ad lib control mice are "normal weight" or "healthy", I side with https://t.co/20axIe6X3d, + my own xtensive discussion in ↑. Yes, @BittoAlessandro did really nice work on rapa (that I cite, it also reports weight loss). I'd also like to hear his opinion.
RT @agingdoc1: “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/YybaI26eqb Overview of various physiolo…
“Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/YybaI26eqb Overview of various physiological differences between standard ad libitum–fed control animals and moderately fed lean animals. The percentage difference for numerous variables
Are control animals receiving optimal caloric intake or are they generally overfed and thus metabolically morbid, as proposed by Martin and colleagues? https://t.co/kRGLESXjxk
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