April 2010 PMID 20194732

"Control" laboratory rodents are metabolically morbid: why it matters.

Bronwen Martin, Sunggoan Ji, Stuart Maudsley, Mark P Mattson

Mentions

52
Peak: 6 in Apr 2023
across 4 sources since Jul 2019

Extended reach

78,678
potential audience

Total likes

186

Video views

824

Mentions per month

Jul 2019 – Jan 2025

Where it's discussed

  • News21 articles
  • X / Twitter20 posts
  • Blogs9 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a strong consensus on the importance of the article, with participants emphasizing that standard lab rodents are often overfed and metabolically unhealthy, which can compromise research results. Words like 'must read,' 'preaching,' and references to specific studies demonstrate high engagement and a belief in the article's potential to impact research standards and animal management practices.

AgreementStrong agreement

Most discussions strongly acknowledge the importance of recognizing metabolic issues in control rodents, emphasizing the significance of the article's message.

InterestHigh interest

Participants are highly interested, frequently discussing methodological details, feeding regimens, and implications for research validity.

EngagementHigh engagement

Many posts show deep engagement by referencing specific studies, calling for change, and advocating for better practices, indicating active participation.

ImpactHigh impact

The discussions suggest that the article could influence research practices and experimental design, highlighting its potential to improve scientific accuracy.

Abstract in brief

  • Many standard lab rodents used as controls are sedentary, obese, and glucose intolerant, which can influence research results and human study outcomes.
  • Overfeeding and lack of exercise in these animals affect critical biological processes like oxidative stress and inflammation, making them less accurate models for healthy humans.
  • Treatments successful in sedentary, obese rodents may not work the same way in active, normal-weight humans, potentially leading to misleading conclusions.]

Top posts

Most liked on X and Bluesky
Henning Langer
@HenningLanger · X

I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/MaIR42SMGz https://t.co/QWBkkOb103

Apr 14, 2023 · 25 likes · 4 shares · 1,703 followers View post →
Gilles Gouspillou
@GGouspillou · X

Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/T6No1KyB7a

Dec 31, 2024 · 17 likes · 5 shares · 1,878 followers View post →
Agingdoc
@agingdoc1 · X

“Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/YybaI26eqb Overview of various physiological differences between standard ad libitum–fed control animals and moderately fed lean animals. The percentage difference for numerous variables

Aug 24, 2022 · 3 likes · 1 share · 43,650 followers View post →
Ilkka Heinonen
@ileximius · X

"Control" laboratory rodents are metabolically morbid: why it matters Bronwen Martin et al. Proc Natl Acad Sci. 2010. https://t.co/JFg32xcNAE https://t.co/kttEnKijS8

May 19, 2023 · 2 likes · 1,455 followers View post →
Hob Gadling
@OliveChirper · X

@JohnSpeakman4 @Aging_Scientist @alantomusiak @mkaeberlein I expect a lot of this is about the chow and how the animals are fed, and hence the level of metabolic morbidity https://t.co/9wBlUKk5Ag https://t.co/KF3uFNsgIe https://t.co/2XRZtysLsQ Many other things commonly done poorly in LS studies https://t.co/UzLTML0wRr

Sep 12, 2024 · 2 likes · 277 followers View post →
Real Health
@via_health9485 · X

Sep 14, 2023 · 1 like · 1 share · 501 followers View post →

All mentions

André Katayama Yamada
@KatayamaYamada · X

RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…

Jan 2, 2025 · 5 shares · 405 followers View post →
Shima Taherkhani
@ShimaTaherkhani · X

RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…

Jan 2, 2025 · 5 shares · 352 followers View post →
bioGeorge
@jorgefly777 · X

RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…

Jan 1, 2025 · 5 shares · 159 followers View post →
Vincent Marcangeli
@VMarcangeli · X

RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…

Dec 31, 2024 · 5 shares · 275 followers View post →
Mitchell Sammut
@SammutMitchell · X

RT @GGouspillou: Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically…

Dec 31, 2024 · 5 shares · 204 followers View post →
Gilles Gouspillou
@GGouspillou · X

Must read for anyone working with rodents, including those studying aging: “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/T6No1KyB7a

Dec 31, 2024 · 17 likes · 5 shares · 1,878 followers View post →
Hob Gadling
@OliveChirper · X

@JohnSpeakman4 @Aging_Scientist @alantomusiak @mkaeberlein I expect a lot of this is about the chow and how the animals are fed, and hence the level of metabolic morbidity https://t.co/9wBlUKk5Ag https://t.co/KF3uFNsgIe https://t.co/2XRZtysLsQ Many other things commonly done poorly in LS studies https://t.co/UzLTML0wRr

Sep 12, 2024 · 2 likes · 277 followers View post →
Marc Roberts
@realMarcRoberts · X

RT @via_health9485:

Sep 16, 2023 · 1 share · 1,102 followers View post →
Real Health
@via_health9485 · X

Sep 14, 2023 · 1 like · 1 share · 501 followers View post →
Ilkka Heinonen
@ileximius · X

"Control" laboratory rodents are metabolically morbid: why it matters Bronwen Martin et al. Proc Natl Acad Sci. 2010. https://t.co/JFg32xcNAE https://t.co/kttEnKijS8

May 19, 2023 · 2 likes · 1,455 followers View post →
Reinaldo dos Santos
@rsdossantos13 · X

"“Control” laboratory rodents are metabolically morbid: Why it matters" https://t.co/0zS0CaOxpY

Apr 18, 2023 · 386 followers View post →
Cameron A. Schmidt, PhD
@CAS_ReproLab · X

RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…

Apr 14, 2023 · 4 shares · 1,437 followers View post →
Vasilis Armenis
@vasilisx91 · X

RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…

Apr 14, 2023 · 4 shares · 673 followers View post →
Pablo B Martínez de Morentin / deMorentinLab
@pablomorentin · X

RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…

Apr 14, 2023 · 4 shares · 268 followers View post →
Peter Aldiss, PhD
@Peter_Aldiss · X

RT @HenningLanger: I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are m…

Apr 14, 2023 · 4 shares · 2,653 followers View post →
Henning Langer
@HenningLanger · X

I'm going to keep preaching this until people actually start taking it into account. “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/MaIR42SMGz https://t.co/QWBkkOb103

Apr 14, 2023 · 25 likes · 4 shares · 1,703 followers View post →
Alexander M. Wolf
@AlexanderMWolf7 · X

@mitchellblee33 @longboat789 Thank you. For whether ad lib control mice are "normal weight" or "healthy", I side with https://t.co/20axIe6X3d, + my own xtensive discussion in ↑. Yes, @BittoAlessandro did really nice work on rapa (that I cite, it also reports weight loss). I'd also like to hear his opinion.

Oct 13, 2022 · 1 like · 359 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @agingdoc1: “Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/YybaI26eqb Overview of various physiolo…

Aug 24, 2022 · 1 share · 544 followers View post →
Agingdoc
@agingdoc1 · X

“Control” laboratory rodents are metabolically morbid: Why it matters https://t.co/YybaI26eqb Overview of various physiological differences between standard ad libitum–fed control animals and moderately fed lean animals. The percentage difference for numerous variables

Aug 24, 2022 · 3 likes · 1 share · 43,650 followers View post →
Nick Krontiris
@nick_krontiris · X

Are control animals receiving optimal caloric intake or are they generally overfed and thus metabolically morbid, as proposed by Martin and colleagues? https://t.co/kRGLESXjxk

Jul 23, 2019 · 19,466 followers View post →