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Overall, the collection shows high interest and moderate agreement, with numerous posts detailing cellular mechanisms like nuclear envelope reform during telophase, its structural role in gene regulation, and its relevance to diseases such as progeria and cancer. The tone is technical yet accessible, emphasizing recent advances and the broader implications of nuclear envelope research.
Most discussions acknowledge and support the importance of the nuclear envelope in cellular processes, with some emphasizing its role in health and disease.
The majority express high interest, referencing specific mechanisms, recent research, and potential clinical implications.
Posts involve detailed explanations of processes like mitosis, gene expression regulation, and the effects of metabolic stress, showing moderate to deep engagement.
Discussions highlight the nuclear envelope's significance in understanding cancer, aging, and viral infections, indicating moderate impact on broader scientific and medical fields.
Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & rebuild the nuclear envelope in coordination with spindle poles. But what is the relevance of this coordination? Follow this thread to find out
Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00P35eDh https://t.co/fZn6UoAtfL
Happy #FluorescenceFriday! Today we're celebrating a crowd-favorite - Lamin B1! This cell line and plasmid illuminates the nuclear envelope. Our entire Allen Cell Collection is available for just the cost of shipping from @coriellinstitute.bsky.social and @addgene.bsky.social. #CellLineOfTheWeek
Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org
Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org
In their Review, Suzan Kors and Anne-Lore Schlaitz highlight the dynamic remodelling of the ER for mitosis and discuss how these changes support cell division. journals.biologists.com/jcs/article/...
RT @FnqSilver: @janiesaysyay Visual confirmation the nuclear envelope reforms around the DNA during telophase & is incorporated into the nu…
@hemo_shk @IhabFathiSulima Progeria - Hutchinson–Gilford progeria syndrome (HGPS) is a very rare genetic disorder that causes features of dramatic premature aging in children. Most cases are due to a point mutation in the LMNA gene, which encodes lamin A, a key structural protein of the nuclear envelope.
Hutchinson–Gilford Progeria Syndrome (HGPS) Progeria is a rare autosomal dominant de novo LMNA gene mutation - abnormal progerin that destabilizes the nuclear envelope. Affected children appear normal at birth but develop premature aging by age 1–2. - accelerated https://t.co/FbydX0gJSg
@DIY_Tardis @gemoscatelli @Jikkyleaks If mRNA (reverse-transcribed to DNA) or a plasmid fragment integrated into a cell's genome during mitosis—when the nuclear envelope breaks down—it could cause insertional mutagenesis, potentially disrupting genes and leading to issues like cancer or instability (per studies like
Really exciting study! We also didn’t find any membrane protein components for extraction of the nuclear envelope protein SUN2 (ubiquitylated by SCF E3). We discussed that this could be due to redundancy or that pulling force by p97 alone is sufficient. https://t.co/Z6xfr0SuXH https://t.co/MTtMRVZV49
RT @jonlieffmd: Segmented shape of neutrophil with changes in nuclear morphology, coordinated changes in how the DNA is organized, which ge…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
@sciqst @weillinstitute @Cornell We have. The resealing involves escort proteins and BAF. See for example https://t.co/a7YMgAaYX3 and work by several other groups. We explored this as potential therapy but normal cell use the same or similar mechanism to reseal the nuclear envelope after mitosis.
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
@ManuelSConde 1. That doesn't change the species the DNA belongs to. 2. Cellular respiration occurs from day one. 3. The nuclear envelope protects against reactive oxygen species.
Trend up+19: Le Bozec B, ..., Legube G (Mol Cell) __Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope__ https://t.co/03sc9e6VyZ
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
Emerging research suggests GLP-1 medications can help maintain the health and function of the nuclear envelope. This supports stable gene expression and robust cellular resilience throughout the body. #GLP1Benefits #CellularResilience #HealthBeyondWeight
The nuclear envelope's integrity is crucial for regulating gene expression and cellular communication. Metabolic stress can compromise it, impacting how cells function and adapt. #NuclearEnvelope #DNAProtection #MetabolicScience
Many focus on GLP-1s for metabolism, but their influence extends to a less-discussed, fundamental structure within our cells: the nuclear envelope. This vital barrier protects our DNA. #GLP1 #CellularHealth #GeneExpression
Segmented shape of neutrophil with changes in nuclear morphology, coordinated changes in how the DNA is organized, which genes are active, how the nuclear envelope is structured for key task of rapid migration through tight tissue spaces https://t.co/0AwwSVf5jr https://t.co/peWeP8mjl1
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
I’m surrounded by a double layered membrane called the nuclear envelope so if you think I don’t have thick skin… guess again #smh #wordscanthurtme
Euchromatin regions are located tomarda the inner part of the nucleus, heterochromatin regions are located around the nucleon in the nuclear envelope wall.
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope Online now:
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
RT @MolecularCell: Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00…
Online Now: Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope https://t.co/py00P35eDh https://t.co/fZn6UoAtfL
watching a fucking video on meiosis for my biology class and i feel like im watching "how the plumbus is made" from rick and morty, it's all just buzzwords like wdym "the spindle fibers being to form and the nuclear envelope fragments" genuine mental flashbang
RT @FnqSilver: @janiesaysyay Visual confirmation the nuclear envelope reforms around the DNA during telophase & is incorporated into the nu…
@janiesaysyay Visual confirmation the nuclear envelope reforms around the DNA during telophase & is incorporated into the nucleus. https://t.co/HaxVBCYQ5a https://t.co/w6ofAhZyk5
RT @biorxiv_cellbio: Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenes…
Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis https://t.co/r2qpWAsoSE #metabolism #ROS
Our heart project
deformation of the nuclear envelope (NE), increased DNA damage, shortened telomeres, cell cycle arrest, and reduced ability to divide. Interestingly, growing evidence suggests that small amounts of progerin are also present during natural aging and in chronic kidney disease (CKD)
Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis https://t.co/HAgKYYwEGG #biorxiv_cellbio
Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis https://www.biorxiv.org/content/10.1101/2025.11.07.687155v1
Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis https://www.biorxiv.org/content/10.1101/2025.11.07.687155v1
By fine-tuning the nuclear envelope's rigidity or flexibility, these peptides can physically influence chromatin accessibility and the efficiency of DNA damage response pathways. This impacts cellular resilience at a fundamental level. #Biohacking #CellularOptimization #DNArepair
The nuclear envelope isn't just a passive barrier; its mechanical stiffness and fluidity are critical for gene expression and DNA repair. A profound insight reveals certain peptides can subtly modulate these biophysical properties. #PeptideScience #NuclearMechanics
POM121 is one of the transmembrane nucleoporins that anchors the Nuclear Pore to the nuclear envelope. The Rodriguez-Bravo+labs identified a nuclear-soluble pool of POM121 that enhances the aggressiveness of prostate cancer, offering new therapeutic opportunities for this disease. shorturl.at/Z2Ked
RT @janiesaysyay: @Kevin_McKernan @RWMaloneMD @DrPaulOffit Never underestimate the ignorance of a public health official. It's entirely p…
In theory the Canon law formula was limited to a religious formula buf the bio explosive effects originates from the nuclear envelope https://t.co/9GwG5d9Qz2
@Kevin_McKernan @RWMaloneMD @DrPaulOffit Never underestimate the ignorance of a public health official. It's entirely possible Offit has gone his entire career without ever understanding what happens to the nuclear envelope in mitosis.
The simplest way is saying "God is the first and only point" but without metaphor the mind can be impermeable to this type of simplification. It’s the convergence point, focal point. If you zoom mentally on the point, you’ll imagine a cell -the nuclear envelope of the cell, the https://t.co/d3YDmfUdeP https://t.co/XEEvAn1KVT
More deeper info: The "nuclear barrier" of a cell is the nuclear envelope, a double membrane that separates the nucleus from the cytoplasm. It is a highly regulated barrier, with nuclear pores controlling the passage of materials like proteins and RNA in and out of the nucleus.
RT @gglinskii: A DNA-containing phase-separated compartment links the nuclear envelope to chromosome axes to promote homolog pairing in C.…
A DNA-containing phase-separated compartment links the nuclear envelope to chromosome axes to promote homolog pairing in C. elegans | Science Advances https://t.co/7vyW3gwQkm
@michael_trumper @dbdugger @dr_andrealove I don’t have confirmation bias because I’m repeating facts. Again, NLP’s are too large to cross the nuclear envelope and lack any signaling to be able to do so. That’s basic biology. Educate yourself
@michael_trumper @dbdugger @dr_andrealove Well, then you would’ve also learned that the LNP’s are too large to cross the nuclear envelope and lack any nuclear signaling to be able to do so
@michael_trumper @dbdugger @dr_andrealove You again reveal how little you understand about biology DNA plasma can’t cross the nuclear envelope
@michael_trumper @dbdugger @dr_andrealove There’s no biological mechanism or viral protein in SARS-CoV-2 that allows it to penetrate the nuclear envelope or import its genome.
RT @WeeklyRich: 1st point of misinformation. Marks states there is no way for the mRNA to get into the nucleus. Wrong During mitosis, the n…
Beyond DNA, the cell's nucleus relies on the *nuclear lamina* – a vital structural meshwork just inside the nuclear envelope. This isn't just scaffolding; it's a critical regulator of gene expression and cellular integrity, often overlooked. #CellularHealth #NuclearLamina
@US_FDA @US_FDA that benzene ring, idk what its called with Mimosine, has a nitrogen group. I think it is somewhat similar to rapamycin in that sense, but thats technically like a reference to MTOC's on the nuclear envelope. Fungi have a closed nuclear envelope, not as much genes.
@MarioNawfal Sanctions may freeze banks and oil — but they don’t freeze ambition. Iran has shown it will push the nuclear envelope despite global pressure. The real test now: can diplomacy outpace escalation, or are we watching the deal’s final collapse?
@DopplerEffect93 ..it can fuse with cell DNA if it passes through the nuclear envelope.
@TurkishCentury The nuclear envelope should extend to Turkiye. All Muslims Nations should pitch in. By funding Pakistan's nuclear program, warhead production can be increased.
#DBFeature
An ESCRT-LEM domain inner nuclear membrane protein surveillance system is poised to directly monitor the integrity of the nuclear envelope barrier and nuclear transport system published as: https://t.co/YJBpvmM1Z6 @eLife #biorxiv
The nuclear envelope is more than a barrier; its mechanical properties and pore function are critical for genome stability, DNA repair, and precise gene regulation. Peptides influencing this structure can profoundly impact cellular resilience. #NuclearEnvelope #GenomeStability
Beyond influencing gene expression or transport, some research peptides are revealing a deeper role: subtly modulating the structural integrity of the nuclear envelope itself. This isn't just about DNA; it's about the cell's core architecture. #PeptideScience #CellularBiology
EM tomography by Jane confirmed that the nuclear envelope and the secretory machinery were all clustered where TCR was accumulating at the plasma membrane, giving credence to this idea of a "TCR bridge". 10/11 https://t.co/XbkMsqW50d
As well as facilitating an early transcriptional burst, Jane and I noticed that the nuclear envelope/ER was chock full of T cell receptors. Polarisation of this organelle to the synapse therefore could provide a bridge to rapidly deliver TCR to the synapse for signalling. 9/11 https://t.co/HeZVLzgNRo
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
Happy to share our work in @embojournal
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
RT @Sachin_mitosis: Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & reb…
Excited to share our work in @embojournal! https://t.co/27LqQ3hjBf For decades, we’ve known that cells dismantle & rebuild the nuclear envelope in coordination with spindle poles. But what is the relevance of this coordination? Follow this thread to find out
Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging
Excited to share the preprint from my postdoc work @ellenberglab.bsky.social!
We saw similar defects in mutants of arp3 or actin-bundling protein fimbrin. Fission yeasts undergo closed mitosis and the MTOC or spindle pole body (SPB) duplicates in interphase and just before mitotic onset, is inserted into a fenestra on the nuclear envelope and spindle microtubules nucleate. 3/
@MichaelAndre81 @GiggaMAGA @CarolKennon4 @MarivicVillaMD5 @AndrewZywiecMD @IreneMavrakakis @AbraxasHudson @P_McCulloughMD @NicHulscher @AaronKheriatyMD @DrPaulEMarik @jathorpmfm @ted_macie What happens to the nuclear envelope upon cell division? (I’ll help… there is none) Also, SV40 they left in the jabs is an NLS and likely facilitates dna integration. You’re not very well read on this topic. Pity.
We further demonstrate how chromosome condensation generates a mechanical signal on the nuclear envelope during prophase. This signal coordinates the multiple steps required for mitotic entry such as cyclin B1 nuclear translocation and dynein binding to nuclear pores.
We further demonstrate how mitotic chromosome condensation generates a mechanical signal on the nuclear envelope during prophase. This mechanical signal coordinates the multiple steps required for mitotic entry such as cyclin B1 nuclear translocation and dynein binding to nuclear pores.
RT @CatsRule2023: @Kevin_McKernan @DrPaulOffit @MdBreathe @RWMaloneMD @DrJackKruse @KONCRETE Kevin, excellent format & explanation. Would…
1️⃣ Prophase – Chromosomes condense & become visible. The nuclear envelope breaks down. Spindle fibers start to form.
@MeganSuspended @Sontaran_Dawn You're asking me Megan (you're far more knowlegable)? Perhaps start here if you haven't already: "Virus strategies for passing the nuclear envelope barrier".
Discover how the small GTPase Ran dictates the asymmetry of nuclear pore complexes (NPCs), crucial for directional nucleocytoplasmic transport! Over 30 nucleoporins cooperate on NPCs that span the nuclear envelope, supporting the intricate orchestration of macromolecular
@NicHulscher A meme won’t cut it Nic; especially one that says”..MAY cause..”. I’m not one of your gullible marks; what is the mechanism.? Let’s roll with 1; Have you done any sequencing showing inclusion? Or 2: how does spike protein enter the nuclear envelope?
F-Actin maintains spindle orientation against cellular geometry. In WT, spindle poles aligned with the PPB, while LatB-treated and act7-4 cells showed spindle misalignment at metaphase.
RT @AsIhaveforgiven: Nucleolus: a structure within the nucleus where ribosomes are assembled "Adam's RIB" Nuclear Pores: CHANNELS in the nu…
Nucleolus: a structure within the nucleus where ribosomes are assembled "Adam's RIB" Nuclear Pores: CHANNELS in the nuclear envelope that allow for the transport of molecules like mRNA & proteins *The Nucleus houses the cell's DNA which contains the GENETIC INSTRUCTIONS for the
@Blkdrps @libraryofgodwin Not chatgpt, my medical school lectures. Yes it is messenger RNA and is made in the nucleus, but after it is transported to the cytoplasm it never re-enters the nucleus. mRNA from vaccines stays in the cytoplasm and never crosses the nuclear envelope
@IAmRandom30 @maxgull @McFaul So that's your grand plan ? Keep pushing the nuclear envelope? and one-day the sun will rise at 02:00AM briefly enough for you to see the light. & Then R.I.P oh oh I thought. Oh we thought we said f*ck you, I thought he was bluffing.
@Millbstrd @nicknorwitz I feel like the mitochondria aren’t just responding to chaos, they’re listening for field cues coming from the ER and the nucleus . And THAT ER? It’s not just a calcium dump. It’s a timing scaffold and a light guide. It’s literally connected to the nuclear envelope, same
@NafisehChalabi @aribidopsis Mito outer membrane protein is TOMM-20, nuclear membrane protein is Lamin-A. Actually, it's not all that uncommon to see mitochondria at invaginations in the nuclear envelope: https://t.co/CiVkRjuYsS
These "Tipless" Mud variants localize to the nuclear envelope and play unexpected roles in promoting fertility, including antagonizing the localization of the nucleoskeletal protein Lamin.
ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️
No small potatoes! ASCI member Martin E. Fernandez-Zapico & team identify the nuclear envelope protein Emerin as a regulator of nuclear size in KRAS-driven pancreatic cancer. Complete report: buff.ly/G9cZcBQ
No small potatoes! Martin E. Fernandez-Zapico & team identify the nuclear envelope protein Emerin as a regulator of nuclear size in KRAS-driven pancreatic cancer. Complete report: buff.ly/G9cZcBQ
Exciting paper on how the nuclear envelope talks to chromatin!
Really excited to be back in my home away from home, Berlin, for my first conference in Germany: "Life at the Edge: The nuclear envelope in nucleocytoplasmic transport and genome organisation" Really looking forward to it!
Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org
Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org
Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org
We exploited the system to discover that Tel1, ATM in humans, congregates at the nuclear envelope during the early steps of DNA break sensing… combined with our previous finding that Tel1/ATM bind lipids (doi.org/10.15252/emb...), this hints at nuclear envelope lipids as key in DNA damage detection!
We’re pleased to support Dr Christina Toomey with a pilot project. They’ll be exploring how lipid cause damage to the nuclear envelope in FTD. Understanding the underlying disease mechanisms could reveal targets for new treatments.
Coming Thursday: Dr. Alexander von Appen (MPI-CBG) will share groundbreaking research showing how a protein-DNA hydrogel forms a protective hydrogel at the nuclear envelope, visualized and tested by cryo-ET and optical tweezers. Join us this Thursday, June 26 at 4PM (GMT+2) for a deep dive!
Researchers found that LITUS at 1 MHz disrupts cancer cell structure, breaking the nuclear envelope and causing DNA damage. This activates a signaling pathway called cGAS-STING.
Elegant work by my colleagues Jenna & Anna Erzberger: information transfer across cellular compartment boundaries can be encoded in the distribution of surface-embedded particles (integrins, GPCRs…) True for the nuclear envelope too - we provide data on NPC-microtubule interactions in Ichthyosporea
Not discussed so much but those tubules pressed up against the nuclear envelope are certainly unique.
A dynamic barrier: remodeling of the nuclear envelope during closed mitosis in malaria parasites | mSphere journals.asm.org/doi/10.1128/...
A dynamic barrier: remodeling of the nuclear envelope during closed mitosis in malaria parasites pubmed.ncbi.nlm.nih.gov/40488521/ #cryoEM
Nesprin-2’s BH3-Like Motifs Trigger Cell Death In a groundbreaking development that could reshape our understanding of cellular demise, researchers have uncovered a pivotal role for Nesprin-2, a component of the nuclear envelope, in the regulation of programmed cell death. This study, recently…
How does the nuclear envelope protect the genome under stress? Dr Alexander von Appen team saw that DNA + proteins form a co-condensate that reinforces the nucleus under force.
The two pronuclei then, completely separately (but in apposition), enter S-phase, each becoming diploid for the parental genome. (?!?) then a completely separate (though again apposed) mitosis occurs, with two sets of spindles, in which the chromosomes do not 'mix'. 9/
As the #nucleus is heavily deformed inside this confinement, we asked what was more important for this #differentiation response- A) active force applied on the nuclear envelope or B) simple deformation of the nucleus itself? (6/n)
The evening session for Day 3 of the Canadian Developmental Biology Conference continues with a talk from Arif Ashraf, University of British Columbia entitled "Function of nuclear envelope proteins beyond the nuclear envelope". #CDBC2025 @socdevbio.bsky.social
ICYMI Research in #OpenBiology on how Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells: royalsocietypublishing.org/doi/10.1098/... #CellBiology
It is the left one, but it is not seen because it is too perfect, but because the nuclear envelope is triple or even, more surrounded by multiple membranes!!
☕Taniguchi et al. structurally analyse #NuclearPore complex architecture in situ during differentiation, which is associated with mechanical constraints on the nuclear envelope. They link nuclear pore complex elasticity to nuclear envelope integrity in differentiation. go.nature.com/42PJurY
Happy #FluorescenceFriday! Today we're celebrating a crowd-favorite - Lamin B1! This cell line and plasmid illuminates the nuclear envelope. Our entire Allen Cell Collection is available for just the cost of shipping from @coriellinstitute.bsky.social and @addgene.bsky.social. #CellLineOfTheWeek
ER-resident IRE1 plays a role in #cancer development via enzymatic activation of XPB1 TFs and regulated #RNAdecay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote #CellCycle progression & tumor growth @plosbiology.org
ER-resident IRE1 plays a role in #cancer development via enzymatic activation of XPB1 TFs and regulated #RNAdecay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote #CellCycle progression & tumor growth @plosbiology.org
ER-resident IRE1 plays a role in #cancer development via enzymatic activation of XPB1 TFs and regulated #RNAdecay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote #CellCycle progression & tumor growth @plosbiology.org
A paper using RRID:AB_528427 (from DSHB) was just published in Nature Cell Biology see "Nuclear pores safeguard the integrity of the nuclear envelope". Thank you for making your methods matter! #STMpublishing #RRID
(3/3) We propose a model, where the NPC dynamically acts to buffer tension applied to the nuclear envelope, thereby protecting it from potential rupture. Aberrations of the NPC scaffold would cause a reduced buffering capacity and result in NPC disintegration and potential rupture.
✍️ The @vdoye.bsky.social Lab contributed to the publication of a new article
RanGDP is allowed to translocate through the nuclear envelope independently of NTF2. [6/6 of https://arxiv.org/abs/2504.06452v1]
N/C ratio homeostasis in growing cells. Our model shows that the permeability of the nuclear envelope needs to grow in line with the cell to maintain a nearly constant N/C ratio, that several parameters involved in the nucleocytoplasmic transport [4/6 of https://arxiv.org/abs/2504.06452v1]
Nuclear pores safeguard the integrity of the nuclear envelope www.nature.com/articles/s41...
Nuclear pores safeguard the integrity of the nuclear envelope ->Nature | More info from EcoSearch
New in @elife.bsky.social: LJI Instructor Dawid Zyla (@dzyla.bsky.social) highlights recent research into how herpes simplex virus type 1 assembles within infected cells — revealing the roles of essential viral proteins in viral assembly and exit. elifesciences.org/articles/106... #virology
8/ The U.S. held nuclear dominance when Truman used similar threats. Truman, despite his bluster, fired MacArthur for pushing nuclear war. Now, no one is stopping the Fascist. If he pushes the nuclear envelope, we’re not in a Cold War standoff—we’re in freefall.
Complex mechanical response of stomatocyte morphology: Implications for the nuclear envelope. https://www.biorxiv.org/content/10.1101/2025.03.10.642015v1
Complex mechanical response of stomatocyte morphology: Implications for the nuclear envelope. https://www.biorxiv.org/content/10.1101/2025.03.10.642015v1
Beautiful ultrastructure with exquisite preservation of the nuclear envelope and its pores.
Cells delayed in this prophase-like state display hallmarks of normal prophase: condensing chromosomes, increased microtubule dynamics, and reorganization of the actin cortex, while the nuclear envelope remains intact.
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium www.biorxiv.org/content/10.1...
Explore nuclear autophagy in yeast!
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope www.nature.com/articles/s41...
A new study reveals how alternative splicing fine-tunes dynein cargo specificity! ZYG-12/Hook uses different isoforms to recruit dynein to either early endosomes or the nuclear envelope, showcasing a clever mechanism for organelle-specific transport. #journalclub www.molbiolcell.org/doi/abs/10.1...
At the nucleus of cancer: how the nuclear envelope controls tumor progression onlinelibrary.wiley.com/doi/10.1002/...
Registration is open for a great meeting in Potsdam, Germany (July 23-27) ... for everyone interested in the biology of the nuclear envelope and related topics (events.gwdg.de/event/1012/)
Researchers found that chromosome misalignment during cell replication strains the nuclear envelope, triggering the tumor suppressor p53. This discovery may clarify links between chaotic chromosomes, aging, and cancer www.nature.com/articles/s41...
H. Lachuer, O. Faklaris, S. Hénon, F. Montel, D. Pereira, Nuclear pore complex distribution on the nuclear envelope: insights into curvature, chromatin, and actin contributions. bioRxiv 2025.01.09.632019 (2025). https://www.biorxiv.org/content/10.1101/2025.01.09.632019v1
Since Russia’s 2022 invasion of Ukraine, Putin & the Kremlin's spin doctors have repeatedly pushed the nuclear envelope as a blatant & immoral intimidation tactic. But we have been keeping track of their dirty tricks. #DontBeDeceived, read more: euvsd.info/vmjfW3tx
Showcasing this exciting paper from our good friends Fachinetti lab @institutcurie.bsky.social. #Centromere inactivation triggers #senescence: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with #cGAS and some key suggestions. doi.org/10.1038/s415...
Nuclear pore complex distribution on the nuclear envelope: insights into curvature, chromatin, and actin contributions https://www.biorxiv.org/content/10.1101/2025.01.09.632019v1
Nuclear pore complex distribution on the nuclear envelope: insights into curvature, chromatin, and actin contributions https://www.biorxiv.org/content/10.1101/2025.01.09.632019v1
Interesting new paper out showing #chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a #mechanosensitive #checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension. www.nature.com/articles/s41...
Nicely visualized in this art, Brewers yeast have a closed mitosis, meaning that the nuclear envelope is maintained throughout the cell cycle
Dutcher bodies, associated with Multiple Myeloma, formed by accumulation of immunoglobulin in the space between the inner and outer membranes of the nuclear envelope of neoplastic plasma cells.
I can't believe its been 13 years since our first CRISPR worm in the lab. Everything changed that year, allowing us to do so much cool stuff! Yay CRISPR!
Also in Issue 22: - Research Highlights on cell cycle ID, matrix mechanics, ER-lysosome contact sites and the kinetochore - Interview with Florian Jug @bioimagecomputing.com - Trouble in Flatland III from Mole - Review on ER remodelling for mitosis journals.biologists.com/jcs/issue/13...
In their Review, Suzan Kors and Anne-Lore Schlaitz highlight the dynamic remodelling of the ER for mitosis and discuss how these changes support cell division. journals.biologists.com/jcs/article/...
Together, our findings provide direct evidence of a mechanosensitive ion channel in detecting/responding to events originating in the oocyte nucleus. This suggests a new surveillance mechanism and sets up the stage for exploring how the dynamic nuclear envelope promotes meiotic quality control. 8/10
Mechanosensitive channel PEZO-1 spreads across the nuclear envelope of late pachytene oocytes but redistributes to form clusters/foci during synapsis checkpoint activation. Interestingly, this redistribution depends on PCH-2/TRIP13, a conserved AAA+ATPase important to meiosis in many organisms. 7/10
Pioneering work by @needhibhalla.bsky.social shows that synapsis failure triggers apoptosis ("synapsis checkpoint"), which requires Pairing Centers (PCs) of chromosomes in
Yep, they start out binucleate and the whole cell gets larger. Mitosis proceeds semi-normally until they break down the nuclear envelope and try to establish the mitotic spindle. They get weird spindle attachments and chromosomes go in all sorts of different directions.
Ministers from Netanyahu's Likud party and Knesset members from the government coalition held a conference on the Gaza border calling for the return of settlements to the #Gaza Strip. Nice meeting of all the extremists you got there... #Palestine #Nakba2024
Upcoming seminar by Helen McNeill: Function of Nemp1 in mechanotransduction at the nuclear envelope at Institut Necker Enfants Malades, Friday 21 June 2024 at 12:00. More info
Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling biorxiv.org/content/10.110…
Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling https://www.biorxiv.org/content/10.1101/2024.05.31.596474v1
Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling https://www.biorxiv.org/content/10.1101/2024.05.31.596474v1
They call me the party in the genome if you know what I'm saying? We proliferate cytokines through the nuclear envelope and ectopically express cyclin like nobodies business! They call me bud out here, we regenerate! Drab goonage, that's why I call 'em!
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope https://www.biorxiv.org/content/10.1101/2024.02.14.580336v1
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope https://www.biorxiv.org/content/10.1101/2024.02.14.580336v1
Nuclear pores safeguard the integrity of the nuclear envelope https://www.biorxiv.org/content/10.1101/2024.02.05.578890v1
Nuclear pores safeguard the integrity of the nuclear envelope https://www.biorxiv.org/content/10.1101/2024.02.05.578890v1
Manipulation of the Nuclear Envelope-Associated Protein SLAPDuring Mammalian Brain Development Affects Cortical Lamination and Exploratory Behavior https://www.biorxiv.org/content/10.1101/2024.01.31.578288v1
Manipulation of the Nuclear Envelope-Associated Protein SLAPDuring Mammalian Brain Development Affects Cortical Lamination and Exploratory Behavior https://www.biorxiv.org/content/10.1101/2024.01.31.578288v1
Tolokh, I. S., ..., Onufriev, A. V. (2023). Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of #Drosophila interphase chromatin. Epigenetics Chromatin 16(1): 21. epigeneticsandchromatin.biomedcentral.com/articles/10....
In general, eukaryotic nuclear DNA can’t be cleaved with restriction enzymes (typically which are cloned out of bacteria) because of protective epigenetic modifications (mainly methylation), managed transport of proteins in and out of the nuclear envelope, and proteases, among other reasons
Relationship Between Irregularities of the Nuclear Envelope and Mitochondria in HeLa cells Observed with Electron Microscopy https://www.biorxiv.org/content/10.1101/2023.11.14.567016v1
Relationship Between Irregularities of the Nuclear Envelope and Mitochondria in HeLa cells Observed with Electron Microscopy https://www.biorxiv.org/content/10.1101/2023.11.14.567016v1
Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope https://www.biorxiv.org/content/10.1101/2023.11.13.566812v1
Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope https://www.biorxiv.org/content/10.1101/2023.11.13.566812v1
Physcomitrium patens SUN2 Mediates MTOC Association with the Nuclear Envelope and Facilitates Chromosome Alignment during Spindle Assembly: doi.org/10.1093/pcp/...
Unexpectedly, we found that Piezo (PEZO-1 in worms) channels are located within the nuclear envelope, and that PEZO-1 is essential for the synapsis checkpoint.
Pairing Centers interact with the nuclear envelope to mediate chromosome movements during early prophase. These promote pairing and regulate synapsis. (Telomeres play analogous roles in most eukaryotes).
Chemically induced proximity reveals mechanotransduction of a meiotic checkpoint at the nuclear envelope https://www.biorxiv.org/content/10.1101/2023.10.28.564506v1
Chemically induced proximity reveals mechanotransduction of a meiotic checkpoint at the nuclear envelope https://www.biorxiv.org/content/10.1101/2023.10.28.564506v1
Today is the University of Cambridge Dept. Of Pharmacology Away Day & Anne Janssen from Delphine Larrieu’s group kicks us off talking about the nuclear envelope & ageing-related disease
#IntrinsicallyDisorderedProteins in the center of the pore of the nuclear envelope can form spaghetti-like barrier permeable for cellular factors but blocking viruses and pathogens https://press.uni-mainz.de/how-wiggly-spaghetti-guard-the-genome/ #biophysics @LemkeLab @imbmainz...
https://t.co/FI6KJK3YQS "At the end of cell division, the NE has reformed as a closed ... the observed inhibition of nuclear assembly by fusion inhibitors and the ..."
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