N Engl J Med May 2010 PMID 20427778

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.

Arun J Sanyal, Naga Chalasani, Kris V Kowdley, Arthur McCullough, Anna Mae Diehl, Nathan M Bass, Brent A Neuschwander-Tetri, Joel E Lavine, James Tonascia, Aynur Unalp, Mark Van Natta, Jeanne Clark, Elizabeth M Brunt, David E Kleiner, Jay H Hoofnagle

Mentions

34
Peak: 1 in Jun 2020
across 5 sources since Jun 2020

Extended reach

26,451
potential audience

Total likes

1,639

Video views

13,412

Mentions per month

Jun 2020 – Oct 2025

Where it's discussed

  • News12 articles
  • X / Twitter8 posts
  • Facebook8 posts
  • YouTube3 videos
  • Blogs3 articles

AI synopsis

What people are saying

Discussions reflect a balanced recognition of the study’s significance, with mentions of previous trials like PIVENS and how vitamin E showed clear benefits. The tone, referencing established guidelines and prior research, underscores a moderate but thoughtful engagement that recognizes the study's role in shaping clinical understanding.

AgreementModerate agreement

Most discussions acknowledge the study's findings, especially noting vitamin E's benefits and pioglitazone's lack of primary improvements, reflecting general agreement.

InterestModerate interest

Participants show some interest, referencing previous studies like PIVENS and the inclusion of this research in guidelines, indicating engagement with the topic's relevance.

EngagementModerate engagement

Discussions range from referencing specific trial data to discussing broader implications, suggesting moderate but meaningful engagement.

ImpactModerate impact

The posts highlight the importance of the findings, especially regarding treatment options for NASH, suggesting the study might influence future treatments and guidelines.

Abstract in brief

  • This study tested the effects of pioglitazone and vitamin E versus placebo on adults with nonalcoholic steatohepatitis (NASH), a liver disease with no current standard treatment, over a period of 96 weeks.
  • Vitamin E significantly improved NASH-related liver features compared to placebo, while pioglitazone showed no significant benefit for the primary liver improvements; both treatments reduced liver fat and inflammation, but only vitamin E improved fibrosis scores.
  • Patients on pioglitazone gained more weight, and side effects were similar across all groups; overall, vitamin E was more effective than placebo, whereas pioglitazone did not demonstrate additional benefits for NASH in this study.

Top posts

Most liked on X and Bluesky
Yaron Rotman
@NASH_and_coffee · X

@KMccommis @FrogHarmless @Chrest_brett @JohnSpeakman4 @SA_Diabetes In the PIVENS trial (non diabetics with #NASH) there was only partial decrease in weight between wk 96 (end of pioglitazone treatment) and 120 (end of follow-up). https://t.co/vepEVVYvs0 https://t.co/aq6EGNXbb0

Mar 18, 2021 · 4 likes · 1,548 followers View post →
Yaron Rotman
@NASH_and_coffee · X

@rlanham1963 @EricTopol This was studied by multiple groups, including the @NIDDKgov-funded PIVENS trial (link) and studies from us. It is also included in the guidelines. https://t.co/mt4XrcYvJ4

Feb 21, 2025 · 1 like · 1,548 followers View post →
にいやん
@niiyan51 · X

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis https://t.co/frMzJPAZUx

Jan 1, 2025 · 1 like · 1,076 followers View post →
Jim Trevaskis
@jimmytrevaskis · X

The NASH CRN was excited about the potential but ultimately conservatism in industry won out and interest in expanding use of exenatide waned. The NASH CRN went on to run the first Phase 2 NASH study using pioglitazone and vitamin E. https://t.co/fXaDl5LPNO

Jun 12, 2024 · 1 like · 942 followers View post →
Juan Pablo (JP) Arab, MD 
@juanpabloarab · X

@NanMd Respecto a la vitamina E, el estudio clásico es el PIVENS en NEJM. La dosis fue de 800 UI al día por 96 semanas (2 años) https://t.co/xV4j05bjVQ

Jun 3, 2020 · 5,459 followers View post →
хлібці електрохарчувальні
@nothingtodowth · X

@romannotroman ви кидали лінк на той самий healthline коли писали про вітамін д… https://t.co/LxkjrARiBb https://t.co/M5VxXBmHAH https://t.co/a8jpY69L0B https://t.co/2qTdVDOfQw

Dec 11, 2022 · 1,134 followers View post →

All mentions

Yaron Rotman
@NASH_and_coffee · X

@rlanham1963 @EricTopol This was studied by multiple groups, including the @NIDDKgov-funded PIVENS trial (link) and studies from us. It is also included in the guidelines. https://t.co/mt4XrcYvJ4

Feb 21, 2025 · 1 like · 1,548 followers View post →
にいやん
@niiyan51 · X

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis https://t.co/frMzJPAZUx

Jan 1, 2025 · 1 like · 1,076 followers View post →
InfinaLife
@InfinaLife · X

"Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes. There was no benefit of pioglitazone vs. placebo for the primary outcome" Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis https://t.co/CqhniEqH6H

Jul 15, 2024 · 1,091 followers View post →
Jim Trevaskis
@jimmytrevaskis · X

The NASH CRN was excited about the potential but ultimately conservatism in industry won out and interest in expanding use of exenatide waned. The NASH CRN went on to run the first Phase 2 NASH study using pioglitazone and vitamin E. https://t.co/fXaDl5LPNO

Jun 12, 2024 · 1 like · 942 followers View post →
хлібці електрохарчувальні
@nothingtodowth · X

@romannotroman ви кидали лінк на той самий healthline коли писали про вітамін д… https://t.co/LxkjrARiBb https://t.co/M5VxXBmHAH https://t.co/a8jpY69L0B https://t.co/2qTdVDOfQw

Dec 11, 2022 · 1,134 followers View post →
Yaron Rotman
@NASH_and_coffee · X

@KMccommis @FrogHarmless @Chrest_brett @JohnSpeakman4 @SA_Diabetes In the PIVENS trial (non diabetics with #NASH) there was only partial decrease in weight between wk 96 (end of pioglitazone treatment) and 120 (end of follow-up). https://t.co/vepEVVYvs0 https://t.co/aq6EGNXbb0

Mar 18, 2021 · 4 likes · 1,548 followers View post →
名前
@akkiii0830 · X

https://t.co/j3k2m5Ew26 Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

Oct 11, 2020 · 243 followers View post →
Juan Pablo (JP) Arab, MD 
@juanpabloarab · X

@NanMd Respecto a la vitamina E, el estudio clásico es el PIVENS en NEJM. La dosis fue de 800 UI al día por 96 semanas (2 años) https://t.co/xV4j05bjVQ

Jun 3, 2020 · 5,459 followers View post →