@KMccommis @FrogHarmless @Chrest_brett @JohnSpeakman4 @SA_Diabetes In the PIVENS trial (non diabetics with #NASH) there was only partial decrease in weight between wk 96 (end of pioglitazone treatment) and 120 (end of follow-up). https://t.co/vepEVVYvs0 https://t.co/aq6EGNXbb0
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.
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Jun 2020 – Oct 2025Where it's discussed
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News12 articles
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X / Twitter8 posts
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Facebook8 posts
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YouTube3 videos
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Blogs3 articles
AI synopsis
What people are saying
Discussions reflect a balanced recognition of the study’s significance, with mentions of previous trials like PIVENS and how vitamin E showed clear benefits. The tone, referencing established guidelines and prior research, underscores a moderate but thoughtful engagement that recognizes the study's role in shaping clinical understanding.
Most discussions acknowledge the study's findings, especially noting vitamin E's benefits and pioglitazone's lack of primary improvements, reflecting general agreement.
Participants show some interest, referencing previous studies like PIVENS and the inclusion of this research in guidelines, indicating engagement with the topic's relevance.
Discussions range from referencing specific trial data to discussing broader implications, suggesting moderate but meaningful engagement.
The posts highlight the importance of the findings, especially regarding treatment options for NASH, suggesting the study might influence future treatments and guidelines.
Abstract in brief
- This study tested the effects of pioglitazone and vitamin E versus placebo on adults with nonalcoholic steatohepatitis (NASH), a liver disease with no current standard treatment, over a period of 96 weeks.
- Vitamin E significantly improved NASH-related liver features compared to placebo, while pioglitazone showed no significant benefit for the primary liver improvements; both treatments reduced liver fat and inflammation, but only vitamin E improved fibrosis scores.
- Patients on pioglitazone gained more weight, and side effects were similar across all groups; overall, vitamin E was more effective than placebo, whereas pioglitazone did not demonstrate additional benefits for NASH in this study.
Top posts
Most liked on X and Bluesky@rlanham1963 @EricTopol This was studied by multiple groups, including the @NIDDKgov-funded PIVENS trial (link) and studies from us. It is also included in the guidelines. https://t.co/mt4XrcYvJ4
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis https://t.co/frMzJPAZUx
The NASH CRN was excited about the potential but ultimately conservatism in industry won out and interest in expanding use of exenatide waned. The NASH CRN went on to run the first Phase 2 NASH study using pioglitazone and vitamin E. https://t.co/fXaDl5LPNO
@NanMd Respecto a la vitamina E, el estudio clásico es el PIVENS en NEJM. La dosis fue de 800 UI al día por 96 semanas (2 años) https://t.co/xV4j05bjVQ
@romannotroman ви кидали лінк на той самий healthline коли писали про вітамін д… https://t.co/LxkjrARiBb https://t.co/M5VxXBmHAH https://t.co/a8jpY69L0B https://t.co/2qTdVDOfQw
All mentions
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@rlanham1963 @EricTopol This was studied by multiple groups, including the @NIDDKgov-funded PIVENS trial (link) and studies from us. It is also included in the guidelines. https://t.co/mt4XrcYvJ4
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis https://t.co/frMzJPAZUx
"Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes. There was no benefit of pioglitazone vs. placebo for the primary outcome" Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis https://t.co/CqhniEqH6H
The NASH CRN was excited about the potential but ultimately conservatism in industry won out and interest in expanding use of exenatide waned. The NASH CRN went on to run the first Phase 2 NASH study using pioglitazone and vitamin E. https://t.co/fXaDl5LPNO
@romannotroman ви кидали лінк на той самий healthline коли писали про вітамін д… https://t.co/LxkjrARiBb https://t.co/M5VxXBmHAH https://t.co/a8jpY69L0B https://t.co/2qTdVDOfQw
@KMccommis @FrogHarmless @Chrest_brett @JohnSpeakman4 @SA_Diabetes In the PIVENS trial (non diabetics with #NASH) there was only partial decrease in weight between wk 96 (end of pioglitazone treatment) and 120 (end of follow-up). https://t.co/vepEVVYvs0 https://t.co/aq6EGNXbb0
https://t.co/j3k2m5Ew26 Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
@NanMd Respecto a la vitamina E, el estudio clásico es el PIVENS en NEJM. La dosis fue de 800 UI al día por 96 semanas (2 años) https://t.co/xV4j05bjVQ
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