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Discussions consistently underline that colchicine has a narrow therapeutic window and can be extremely toxic, with examples like references to its potential for fatal overdose and misuse in treatments for COVID-19, which reflect both concern and the need for careful management. The tone varies from cautionary to urgent, emphasizing both danger and the importance of proper monitoring, which underscores the high impact of the topic.
Most discussions emphasize the serious toxicity and dangers of colchicine, supporting the article’s warning about its narrow safety margin.
The posts demonstrate high interest by highlighting specific cases, risks, and chemical properties of colchicine, showing engagement with the subject matter.
Many users reference detailed information, such as overdose risks, therapeutic index, and toxicity cases, indicating deep engagement.
The conversations stress the importance of awareness and careful use, suggesting this discussion could influence clinical practice and safety protocols.
Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancient drug" for the well-know toxicity https://t.co/H77ILEY2la @BogochIsaac @Dr_YFinkelstein https://t.co/zlMZO2Uw0d
Principalmente levando em conta o uso fora do ambiente hospitalar como sugere o estudo do MHI, e também por ser um medicamento q se usado de forma errada pode apresentar efeitos colaterais importantes https://t.co/dg3WqmFNN6
@emezones NOTA: la toxicidad por colchicina puede presentarse en varias formas, desde diarreas hasta falla multiorgánica y muerte. Quienes se han Mal acostumbrado a la auto y sobre medicación (ivermectina), sepan la colchicina puede ser peligrosa. https://t.co/9ZBK1KnY9R
Another resource on toxicity https://t.co/WnWTjrbMQ5
@Rubrum_Cato @CatDocMD It's a very nasty OD with narrow therapeutic window & a problem for peds ingestions in low doses A decent overview: https://t.co/zSyFSpfCkK
it would take ~4 L of water, ~3 lbs of sugar, but only a tiny tiny tiny amount of the toxin tetanospasmin to kill me. why are some compounds so deadly?
Colchicine is used to prevent or treat gout attacks by addressing inflammatory arthritis caused by crystalized monosodium urate deposits. It affects the molecular pathology by preventing microtubule formation, impacting…
In this video, we go over four deadly poisons to reveal the cellular mechanisms of how they kill. We also explore their medicinal uses and highlight animals that exhibit immunity. Additionally, we discuss colchicine…
This video explores the mechanisms of action of colchicine in drug discovery. It discusses its therapeutic uses, particularly in treating gout, highlighting recent studies and clinical trial results that reveal novel…
#Colchicine toxicity-AKI, colitis, pancytopenia, MSOF. Of 140 reported deaths in US FDA database 60 were due to co-administration with macrolide. Rx supportive. It is dialyzable, so HD can be used in severe cases with AKI. https://t.co/NPcBQiTpfn #nephtwitter
For a more complete overview: https://t.co/h1YvFNn0UE
Colchicine poisoning: the dark side of an ancient drug https://t.co/IPm4uFV2nI
RT @sciApril: it would take ~4 L of water, ~3 lbs of sugar, but only a tiny tiny tiny amount of the toxin tetanospasmin to kill me. why are…
RT @sciApril: it would take ~4 L of water, ~3 lbs of sugar, but only a tiny tiny tiny amount of the toxin tetanospasmin to kill me. why are…
it would take ~4 L of water, ~3 lbs of sugar, but only a tiny tiny tiny amount of the toxin tetanospasmin to kill me. why are some compounds so deadly?
RT @thebiozone: this lily contains the cytoskeleton disruptor colchicine! We talk about this deadly compound as well as 3 others in our la…
RT @thebiozone: this lily contains the cytoskeleton disruptor colchicine! We talk about this deadly compound as well as 3 others in our la…
this lily contains the cytoskeleton disruptor colchicine! We talk about this deadly compound as well as 3 others in our latest video 'deadly poisons and how they kill you'
@Rubrum_Cato @CatDocMD It's a very nasty OD with narrow therapeutic window & a problem for peds ingestions in low doses A decent overview: https://t.co/zSyFSpfCkK
@boltyboy Colchicine has a very low therapeutic index - it can be extremely toxic and even fatal at doses not that much higher than typical therapeutic doses. It should NEVER be an OTC drug. https://t.co/izOhaZKBrl
コルヒチン中毒総説 https://t.co/aVd5YlCUYY https://t.co/Te0baEbQCy 一般の人には手に入りにくいものの、これは事故を招く危険なツイート https://t.co/BjnQOufk8a
@YoniFreedhoff I’ll wait for the vaccine thanks. https://t.co/ocJ8eDgZ3f
RT @AnGeLaUyEn: @emezones NOTA: la toxicidad por colchicina puede presentarse en varias formas, desde diarreas hasta falla multiorgánica y…
ICYMI: https://t.co/kcMIVbf9kA "Although colchicine poisoning is relatively uncommon, it is imperative to recognize its features as it is associated with a high mortality rate when missed."
RT @AnGeLaUyEn: @emezones NOTA: la toxicidad por colchicina puede presentarse en varias formas, desde diarreas hasta falla multiorgánica y…
RT @AnGeLaUyEn: @emezones NOTA: la toxicidad por colchicina puede presentarse en varias formas, desde diarreas hasta falla multiorgánica y…
@emezones NOTA: la toxicidad por colchicina puede presentarse en varias formas, desde diarreas hasta falla multiorgánica y muerte. Quienes se han Mal acostumbrado a la auto y sobre medicación (ivermectina), sepan la colchicina puede ser peligrosa. https://t.co/9ZBK1KnY9R
Moreover, many think that colchicine or ivermectin may be an option without sufficient evidence as they are considered “safe”. Although their incidence is low, these are examples of serious adverse effects: 1. https://t.co/uYBBcylXbp 2. https://t.co/j6h0OoAAJT
Enfim, espero que os dados sejam bons. Caso se torne parte do tratamento, tomemos cuidado ao prescrever! Para quem quiser ler um pouco mais sobre: https://t.co/6hqCWWSxsb
@mazzettam Attenzione è terapia che va attentamente monitorata dal medico e non presa autonomamente perché è facile il sovradosaggio con conseguenze rovinose e letali. https://t.co/AcyX7YrJ5i
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
Principalmente levando em conta o uso fora do ambiente hospitalar como sugere o estudo do MHI, e também por ser um medicamento q se usado de forma errada pode apresentar efeitos colaterais importantes https://t.co/dg3WqmFNN6
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
@Guigodu @rmapalacios @Minsa_Peru “No clear cut distinction between non-toxic, toxic and lethal doses” : https://t.co/DzJKP5iQID
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
Colchicine has a narrow therapeutic window, and we must weigh benefit against toxicity. Awaiting peer-review publication see our paper "Colchicine Poisoning: The Dark Side of an Ancient Drug" for the well-know toxicity https://t.co/H77ILEY2la @Dr_YFinkelstein @matthewherper https://t.co/smjPpydVEx
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @DrToddLee: Another resource on toxicity https://t.co/WnWTjrbMQ5
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
@pomeranian99 @TVietor08 Unfortunately, colchicine is kinda infamous for its toxicity. https://t.co/2GpRb5SIPX
RT @DrToddLee: Another resource on toxicity https://t.co/WnWTjrbMQ5
RT @DrToddLee: Another resource on toxicity https://t.co/WnWTjrbMQ5
RT @DrToddLee: Another resource on toxicity https://t.co/WnWTjrbMQ5
Another resource on toxicity https://t.co/WnWTjrbMQ5
RT @ERtox: Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancie…
Colchicine is a great drug in low doses, but there are big risks. See our paper "Colchicine poisoning: the dark side of an ancient drug" for the well-know toxicity https://t.co/H77ILEY2la @BogochIsaac @Dr_YFinkelstein https://t.co/zlMZO2Uw0d
RT @bioMioSoftware: https://t.co/ACKKGxJG4N "has a narrow therapeutic index, w/ no clear-cut distinction between nontoxic, toxic, & lethal…
Colchicine poisoning: the dark side of an ancient drug https://t.co/INzIpacADy
RT @bioMioSoftware: https://t.co/ACKKGxJG4N "has a narrow therapeutic index, w/ no clear-cut distinction between nontoxic, toxic, & lethal…
https://t.co/ACKKGxJG4N "has a narrow therapeutic index, w/ no clear-cut distinction between nontoxic, toxic, & lethal doses, causing substantial confusion among clinicians." There was talk abt using colchicine 4 coronavirus, based on this it seems like a bad idea @HealthyFellow
@mortenoxe @schneiderleonid @jctardif_mhi Just google (colchicine toxic) ≈ 1.350.000 results Colchicine poisoning: the dark side of an ancient drug. - NCBI Colchicine: Beware of toxicity and interactions - Medsafe Colchicine: extremely toxic in overdose ...
What is highly complicating situation, around the world. Colchicine Poisoning: The Dark Side of an Ancient Drug https://t.co/MC7GpHZnzg