March 2011 PMID 20961685

Central sensitization: implications for the diagnosis and treatment of pain.

Clifford J Woolf

Mentions

75
Peak: 5 in Nov 2020
across 6 sources since Oct 2019

Extended reach

25,362
potential audience

Total likes

42

Video views

87

Mentions per month

Oct 2019 – Nov 2025

Where it's discussed

  • Facebook26 posts
  • News23 articles
  • X / Twitter14 posts
  • Blogs9 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions collectively display strong agreement on the relevance of central sensitization, with specific mentions of clinical features, such as visceral pain hypersensitivity, and methodological considerations like stimulus types. The tone includes curiosity and technical depth, emphasizing the article's potential influence on understanding and managing chronic pain conditions.

AgreementModerate agreement

Most discussions acknowledge the importance of central sensitization in understanding pain, indicating general agreement with the article's implications.

InterestHigh interest

Comments show high curiosity about clinical applications and related topics like visceral pain and hormonal influences.

EngagementHigh engagement

Several posts delve into detailed concepts such as visceral hypersensitivity and synaptic changes, reflecting deep engagement.

ImpactModerate impact

Participants highlight the significance of the research for future diagnosis and treatment, suggesting a moderate but noteworthy impact.

Abstract in brief

  • Central sensitization is a reversible process where nerve pathways become more excitable, leading to increased pain sensitivity such as allodynia and hyperalgesia, detectable through experiments and imaging, and linked to various chronic pain conditions.
  • Clinical evidence suggests that central sensitization contributes to conditions like fibromyalgia, osteoarthritis, migraines, and neuropathic pain, often without inflammation or nerve damage, and explains their similar symptoms and responses to certain pain medications.
  • Key research questions include whether some individuals are genetically predisposed to central sensitization, which could increase their risk for pain-related conditions and chronic pain, highlighting the need for diagnostic criteria to better tailor treatments targeting this process.]

Top posts

Most liked on X and Bluesky
LePubScientifique
@LePubScientifiq · X

Central sensitization: implications for the diagnosis and treatment of pain A nice review to wet your appetite before tomorrow's Le Pub with @Farmer_MindBody - Fuzzy Pain Diagnoses #pain #chronicpain #lepubhb #lepub @laurarathbone @Pijninfo https://t.co/Bqv3wtnTtp

Nov 4, 2020 · 27 likes · 4 shares · 2,224 followers View post →
Thomas Dekkers | Spinal Specialist Physiotherapist
@TDekkersPhysio · X

Other Refs and images: Martin Hoeghs JOSPT series on pain https://t.co/aOmtymx2vc https://t.co/r05owRVh4u https://t.co/NXUxsasjhV

May 1, 2024 · 8 likes · 2 shares · 7,491 followers View post →
*sigh*
@visionsbypsyche · X

…(PMDD): the role of menstrual phase and sex hormones https://t.co/HwR5qZPnc3 Central sensitization: Implications for the diagnosis and treatment of pain https://t.co/QKdb6QoiLn Alterations of GABA and glutamate–glutamine levels in PMDD https://t.co/i8DHiqhcqZ

Aug 9, 2025 · 5 likes · 1 share · 1,300 followers View post →
shun ishii
@shu_ni_shii · X

OA患者は、関節部だけでなく遠隔部位でも圧痛閾値の低下や時間の経過に伴う疼痛増強(時間的加重)が出現しやすいようです。術前の中枢性感作の評価をTKA後の予後予測と疼痛予防のために実施した方がよさそうですね! https://t.co/lLK1I2rlCd https://t.co/uumQIydOqQ

Nov 6, 2025 · 1 like · 1,103 followers View post →
Alejandro ruiz barrios
@Ruizbarrios27 · X

@RoyLaTouche La sensibilización central se manifiesta como hipersensibilidad al dolor, sobretodo alodinia táctil dinámica, hiperalgesia o por presión secundaria, y percepciones posteriores. Puede provocarse fácil y rápidamente #FisiocogLaSalle https://t.co/HJpAGZV9jy

Jan 12, 2023 · 1 like · 2 followers View post →
Laura Rathbone
@laurarathbone · X

RT @LePubScientifiq: Central sensitization: implications for the diagnosis and treatment of pain A nice review to wet your appetite befor…

Nov 4, 2020 · 4 shares · 4,205 followers View post →

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IdeaPitch · Apr 19, 2022 11 views
shun ishii
@shu_ni_shii · X

OA患者は、関節部だけでなく遠隔部位でも圧痛閾値の低下や時間の経過に伴う疼痛増強(時間的加重)が出現しやすいようです。術前の中枢性感作の評価をTKA後の予後予測と疼痛予防のために実施した方がよさそうですね! https://t.co/lLK1I2rlCd https://t.co/uumQIydOqQ

Nov 6, 2025 · 1 like · 1,103 followers View post →
Highly Motivated Person
@hiimchiralkthx · X

RT @visionsbypsyche: …(PMDD): the role of menstrual phase and sex hormones https://t.co/HwR5qZPnc3 Central sensitization: Implications fo…

Aug 9, 2025 · 1 share · 1,464 followers View post →
*sigh*
@visionsbypsyche · X

…(PMDD): the role of menstrual phase and sex hormones https://t.co/HwR5qZPnc3 Central sensitization: Implications for the diagnosis and treatment of pain https://t.co/QKdb6QoiLn Alterations of GABA and glutamate–glutamine levels in PMDD https://t.co/i8DHiqhcqZ

Aug 9, 2025 · 5 likes · 1 share · 1,300 followers View post →
Yvan Sonjon
@yvansonjon.bsky.social · Bluesky

Et nous manquons encore de proxy fiable en clinique pour s’assurer de ces changements synaptiques.

Feb 13, 2025 View post →
Junior Espinoza
@espinozapy_ · X

RT @PhysioMeScience: Central sensitization: Implications for the diagnosis and treatment of pain https://t.co/yq2q8t3tZ4 https://t.co/az9E…

Jul 3, 2024 · 33 shares · 91 followers View post →
swim.bike.run.physio
@B_ROCKS83 · X

RT @TDekkersPhysio: Other Refs and images: Martin Hoeghs JOSPT series on pain https://t.co/aOmtymx2vc https://t.co/r05owRVh4u https://t…

May 3, 2024 · 2 shares · 26 followers View post →
Thomas Dekkers | Spinal Specialist Physiotherapist
@TDekkersPhysio · X

Other Refs and images: Martin Hoeghs JOSPT series on pain https://t.co/aOmtymx2vc https://t.co/r05owRVh4u https://t.co/NXUxsasjhV

May 1, 2024 · 8 likes · 2 shares · 7,491 followers View post →
Stephen C Hegarty
@SCHegarty · X

Although I’m familiar with the topic, this manuscript was a challenging read. Something that stuck with me is the concept of visceral pain hypersensitivity. Nociplastic changes occur in the gut too. https://t.co/WeMMrYHOyy

Oct 2, 2023 · 25 followers View post →
Alejandro ruiz barrios
@Ruizbarrios27 · X

@RoyLaTouche La sensibilización central se manifiesta como hipersensibilidad al dolor, sobretodo alodinia táctil dinámica, hiperalgesia o por presión secundaria, y percepciones posteriores. Puede provocarse fácil y rápidamente #FisiocogLaSalle https://t.co/HJpAGZV9jy

Jan 12, 2023 · 1 like · 2 followers View post →
Steph Poulton
@Steph_Poulton · X

RT @LePubScientifiq: Central sensitization: implications for the diagnosis and treatment of pain A nice review to wet your appetite befor…

Nov 4, 2020 · 4 shares · 446 followers View post →
Tina
@LivingWellPain · X

RT @LePubScientifiq: Central sensitization: implications for the diagnosis and treatment of pain A nice review to wet your appetite befor…

Nov 4, 2020 · 4 shares · 2,639 followers View post →
TheMeaningofPain
@tmopain · X

RT @LePubScientifiq: Central sensitization: implications for the diagnosis and treatment of pain A nice review to wet your appetite befor…

Nov 4, 2020 · 4 shares · 1,961 followers View post →
Laura Rathbone
@laurarathbone · X

RT @LePubScientifiq: Central sensitization: implications for the diagnosis and treatment of pain A nice review to wet your appetite befor…

Nov 4, 2020 · 4 shares · 4,205 followers View post →
LePubScientifique
@LePubScientifiq · X

Central sensitization: implications for the diagnosis and treatment of pain A nice review to wet your appetite before tomorrow's Le Pub with @Farmer_MindBody - Fuzzy Pain Diagnoses #pain #chronicpain #lepubhb #lepub @laurarathbone @Pijninfo https://t.co/Bqv3wtnTtp

Nov 4, 2020 · 27 likes · 4 shares · 2,224 followers View post →
thinkin_mkdeabh
@thinkin_mkdeabh · X

@marklaslett_NZ @DerekGriffin86 Because you use a different kind of stimulus (the patient rarely goes to the clinic because he feels pain when hit by a pinprick) you may miss the homosynaptic facilitation which is supposed to be involved in temporal summation: https://t.co/VdDOMvgABu

Jul 26, 2020 · 2,181 followers View post →