n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials.
The discussions demonstrate high engagement and interest by referencing specific research trials, data interpretations, and potential biases. Posters use strong language like 'propagandized' and 'garbage in, garbage out,' highlighting how the study questions established beliefs and industry influences, which underscores the potential impact on dietary recommendations and scientific debates.
AgreementModerate agreement
Most discussions support the findings, emphasizing that increasing n6 PUFAs may not be beneficial and could be harmful, indicating a general consensus with the study's conclusions.
InterestHigh interest
The discussions are highly engaging, involving detailed references to specific trials, data analyses, and debates about biases, showing strong interest in the research implications.
EngagementHigh engagement
Many posters critically analyze methodologies, point out data discrepancies, share mechanistic insights, and reference detailed studies, reflecting deep engagement.
ImpactModerate impact
The social discussions challenge common dietary advice and question industry practices, indicating the findings could influence future dietary guidelines and public perceptions.
Abstract in brief
A comprehensive review of randomized controlled trials indicates that diets rich in mixed n3 and n6 polyunsaturated fatty acids (PUFAs) are associated with a significant reduction in coronary heart disease (CHD) risk and nonfatal myocardial infarction compared to diets high only in n6 PUFA.
Increasing only n6 PUFA intake, especially when replacing trans fats (TFA) and saturated fats (SFA) without increasing n3 PUFA, may not lower CHD risk and could even raise the likelihood of death related to CHD.
The findings challenge the common dietary advice to mainly increase n6 PUFA consumption, suggesting that balanced n3 and n6 intake may be more effective for heart health than n6-focused diets.]
1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine & high linoleic acid seed oils instead of animal foods "rich" in saturated fats? https://t.co/gL5mdKeFN3
Oct 17, 2021 · 63 likes · 12 shares · 8,601 followersView post →
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Raphael Sirtoli
@raphaels7 · X
1/
https://t.co/gL5mdKeFN3 n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials (Ramsden et al. 2010) https://t.co/QoHVMBk2tR https://t.co/8RXEGC89Zw
Jun 21, 2023 · 23 likes · 3 shares · 8,601 followersView post →
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Tucker Goodrich
@TuckerGoodrich · X
We have a bunch of them. The fact that the "sceptics" are ignorant doesn't mean we must be.
"n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials"
https://t.co/GaJHElExeG https://t.co/w1YFGNRCVX
Jan 29, 2021 · 11 likes · 28,304 followersView post →
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Tucker Goodrich
@TuckerGoodrich · X
Because it's been shown to be in multiple human RCTs.
"n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials"
https://t.co/GaJHElExeG https://t.co/ESC6Xsy87e
Dec 11, 2020 · 9 likes · 1 share · 28,304 followersView post →
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Tucker Goodrich
@TuckerGoodrich · X
This is despite the fact that we know that seed oils increase heart disease.
"n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials"
https://t.co/GaJHElExeG
Jan 22, 2021 · 8 likes · 28,304 followersView post →
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Raphael Sirtoli
@raphaels7 · X
"Although STARS had 3 study arms & a pre-intervention drug trial, it was included in [@Dmozaffarian] meta-analysis [https://t.co/bkyvK8MCsY] while the RCOT was excluded for containing ‘multiple interventions'" https://t.co/gL5mdKeFN3
tricks Dariush uses to push industrial sludge https://t.co/LaDDIlyFer
Oct 18, 2021 · 8 likes · 2 shares · 8,601 followersView post →
I explore the role of saturated fat in our health, reviewing historical context and key research. This analysis challenges the belief that saturated fat is harmful and examines its complex relationship with coronary…
Since years, we are told to replace butter with plant oils. But what if this advice is based on flawed studies from the 1960s? This video uncovers the myth surrounding seed oils and explains why the real concern lies…
For decades weve been told to replace butter with vegetable oils for a healthy heart. But what if this advice was based on flawed old studies? This video debunks the seed oil myth and emphasizes the importance of…
Oct 6, 2025 · 1 like · 1 share · 17 followersView post →
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oncdoc
@oncdoc7 · X
n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials | British Journal of Nutrition | Cambridge Core - https://t.co/Tr82Wj8T7l
@hubermanlab @BioLayne I have some notes:
https://t.co/fFkhlIICqL
https://t.co/sKyCqQ2tsc
https://t.co/8qVR0uH2gE
https://t.co/xhmZR36br7
https://t.co/MsZFfBhE2V
RT @raphaels7: 1/
https://t.co/gL5mdKeFN3 n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on…
Jun 21, 2023 · 3 shares · 681 followersView post →
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Seed Oil Disrespecter™️
@SeedOilDsrspctr · X
RT @raphaels7: 1/
https://t.co/gL5mdKeFN3 n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on…
Jun 21, 2023 · 3 shares · 108,515 followersView post →
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Raphael Sirtoli
@raphaels7 · X
1/
https://t.co/gL5mdKeFN3 n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials (Ramsden et al. 2010) https://t.co/QoHVMBk2tR https://t.co/8RXEGC89Zw
Jun 21, 2023 · 23 likes · 3 shares · 8,601 followersView post →
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The Ancestral Doc
@j_t_2390 · X
@JohnnyScott234 @kevtharris @FusionProgGuy @ElieJarrougeMD @Dr__Guess @NutritionMadeS3 We have mechanistic data on all of the above, and the hazard/risk/odds ratios are MUCH higher.
Here's a meta-analysis of RCTs, showing omega-6 actually INCREASES coronary artery disease -https://t.co/vnTeJ5kYbm
And here is the landmark study analyzing "hidden" or ignored data in the widely quoted studies that actually demonstrated the opposite of the stated conclusions.
https://t.co/v5DGnV2mq1
@SentientBlobBob @rocksrocks_9 @Drlipid @gcfmd https://t.co/v5DGnV2mq1
Garbage in, garbage out, I prefer deep dive into the whole data set which shows n-6 FAs are not cardioprotective, neutral at best. Publication bias and editorial bias results in non sequitur conclusions. This study analyzes the full data sets from RCTs
"RCTs that substituted n-6 PUFA for [trans] and [saturated fatty acids] without simultaneously increasing n-3 PUFA produced an increase in risk of death that approached statistical significance." https://t.co/LPHs4Vg2jH
May 21, 2022 · 3 likes · 91,579 followersView post →
RT @raphaels7: "Although STARS had 3 study arms & a pre-intervention drug trial, it was included in [@Dmozaffarian] meta-analysis [https://…
Oct 18, 2021 · 2 shares · 6,701 followersView post →
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Raphael Sirtoli
@raphaels7 · X
"Although STARS had 3 study arms & a pre-intervention drug trial, it was included in [@Dmozaffarian] meta-analysis [https://t.co/bkyvK8MCsY] while the RCOT was excluded for containing ‘multiple interventions'" https://t.co/gL5mdKeFN3
tricks Dariush uses to push industrial sludge https://t.co/LaDDIlyFer
Oct 18, 2021 · 8 likes · 2 shares · 8,601 followersView post →
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Raphael Sirtoli
@raphaels7 · X
https://t.co/gL5mdKeFN3 found a small mistake in Ramsden's review
He states that the Rose Corn Oil trial participants consumed 64 g/d of corn oil. Actually they started at 74 g/d and went down to an average of 50 g/d over 2 years
Oct 18, 2021 · 1 like · 8,601 followersView post →
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Karlis Baltais
@karlisbaltais · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 18, 2021 · 12 shares · 65 followersView post →
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Clare Noelle
@ClareNoelle · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 49 followersView post →
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Nicolas de Cues
@NickdeCusa · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 4,372 followersView post →
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Vlad Dracul
@themetaguy · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 171 followersView post →
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sars
@kappsity · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 163 followersView post →
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David Lipman
@DavidLipman6 · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 703 followersView post →
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Raoul Duke
@Raoul_duke123 · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 310 followersView post →
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P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 295,537 followersView post →
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KanLi NDn - Holistic Approach, Learn & Teach
@CalinNadasan · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 140 followersView post →
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Satire Konto
@no_5302 · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 744 followersView post →
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DiscoStew
@DiscoStew66 · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 10,791 followersView post →
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Andrew Miles
@MilesHighLife · X
RT @raphaels7: 1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine…
Oct 17, 2021 · 12 shares · 1,448 followersView post →
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Raphael Sirtoli
@raphaels7 · X
1/ how, have industrial sludge companies & cabals of pseudoscientists, successfully propagandized you into buying margarine & high linoleic acid seed oils instead of animal foods "rich" in saturated fats? https://t.co/gL5mdKeFN3
Oct 17, 2021 · 63 likes · 12 shares · 8,601 followersView post →
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DiscoStew
@DiscoStew66 · X
“Advice to specifically increase n-6 PUFA intake, based on mixed n-3/n-6 RCT data, is unlikely to provide the intended benefits, and may actually increase the risks of CHD and death.”
https://t.co/r8eZVXcatQ
May 11, 2021 · 4 likes · 10,791 followersView post →
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Harmless Frog
@FrogHarmless · X
@ScepticalDoctor @erreyedoc @DrNadolsky @fire_bottle @TuckerGoodrich Also of interest: n-6 interventions do nothing (at best), but n-3 + n-6 interventions seem helpful, which is consistent also with marine oil supplement trials. The active ingredient appears to be n-3, not n-6 (of which we already have plenty).
https://t.co/jidhyUDZWb
We have a bunch of them. The fact that the "sceptics" are ignorant doesn't mean we must be.
"n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials"
https://t.co/GaJHElExeG https://t.co/w1YFGNRCVX
Jan 29, 2021 · 11 likes · 28,304 followersView post →
TG
Tucker Goodrich
@TuckerGoodrich · X
This is despite the fact that we know that seed oils increase heart disease.
"n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials"
https://t.co/GaJHElExeG
Jan 22, 2021 · 8 likes · 28,304 followersView post →
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Don Tidwell
@tidwell_don · X
RT @TuckerGoodrich: Because it's been shown to be in multiple human RCTs.
"n-6 fatty acid-specific and mixed polyunsaturate dietary interv…
Dec 11, 2020 · 1 share · 2,803 followersView post →
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Tucker Goodrich
@TuckerGoodrich · X
Because it's been shown to be in multiple human RCTs.
"n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials"
https://t.co/GaJHElExeG https://t.co/ESC6Xsy87e
Dec 11, 2020 · 9 likes · 1 share · 28,304 followersView post →
TG
Tucker Goodrich
@TuckerGoodrich · X
@IdanOnTweeter @AviBittMD No. See here:
"By contrast, the increased CHD risks from n-6 specific PUFA diets in our meta-analysis may be underestimated as n-6 PUFA also replaced substantial quantities of TFA (Table 3)."
https://t.co/GaJHElExeG
Dec 8, 2020 · 1 like · 28,304 followersView post →
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Libertas
@Libertas2008 · X
@KetoCarnivore This is the guy whose famous study on fats and heart disease (10.1371/journal.pmed.1000252) was massively criticized by everyone's favorite group of investigators (10.1017/S0007114510004010).
Here are a few excerpts. https://t.co/9KYNLC0rQv
doi:10.1017/S0007114510004010. 14. Jakobsen MU et al. “Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies ...
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