@tony_burnetti @LugerLab @macroliter @halvorz @MercerLab @HiCryoEM I guess we can agree that eukaryotes evolved from an archaeal host. Archaeal RNA polymerases are quite similar to eukaryotic ones. The 12 core subunits of euk Pols all are homologous to arch. Pol subunits, which is nicely described in DOI: 10.1038/nrmicro2507 (2/n)
Evolution of multisubunit RNA polymerases in the three domains of life.
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Jun 2022 – Aug 2025Where it's discussed
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The discussions demonstrate a shared understanding that archaeal RNA polymerases resemble eukaryotic ones, supported by references to homologous subunits and detailed research, with tone that reflects agreement and appreciation for scientific detail.
The discussion strongly agrees with the idea that eukaryotes evolved from an archaeal ancestor, as evidenced by the acknowledgment of structural similarities and homologous subunits.
Participants show moderate interest by referencing details like homologous subunits and specific research, indicating engagement but not extensive debate.
The mention of a specific DOI and the brief elaboration on structural similarities suggest some depth of engagement, though it remains relatively straightforward.
The comments reinforce a consensus about evolutionary relationships, which could influence ongoing research and understanding, reflecting a slight but meaningful impact.
Abstract in brief
- RNA polymerases (RNAPs) are essential for transcription in all living organisms, showcasing similarities in structure and function despite the diversity of organisms, from bacteria to humans.
- Recent research has advanced our understanding of RNAPs' molecular composition and mechanism, shedding light on their evolution and how factors interact during transcription.
- The paper discusses the evolutionary conservation and distinctions of RNAPs across the three domains of life and presents the 'elongation first' hypothesis regarding the evolution of transcriptional regulation.
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Evolution and Structure of RNA Polymerases Across Life Domains
RNA polymerases are essential for transcription in all organisms, showing conserved structures despite diversity. Recent research highlights their molecular composition, evolution, and interactions, providing insights…
Evolution of Multisubunit RNA Polymerases Across Life Domains
RNA polymerases are essential for transcription in all living organisms, sharing structural similarities despite diversity. Recent research advances our understanding of their evolution, molecular composition, and…
@tony_burnetti @LugerLab @macroliter @halvorz @MercerLab @HiCryoEM I guess we can agree that eukaryotes evolved from an archaeal host. Archaeal RNA polymerases are quite similar to eukaryotic ones. The 12 core subunits of euk Pols all are homologous to arch. Pol subunits, which is nicely described in DOI: 10.1038/nrmicro2507 (2/n)
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