Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.co/sx5FtVvSk5
Apixaban in patients with atrial fibrillation.
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Jun 2019 – Oct 2025Where it's discussed
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AI synopsis
What people are saying
The collective discussions show strong support for apixaban's efficacy and safety, citing notable trials like AVERROES with phrases such as 'less effective at preventing stroke' and 'bleeding risk is comparable,' which highlight detailed analysis and cautious evaluation of data. The tone and word choice reflect thoughtful engagement with clinical evidence, emphasizing both the consistency and limitations of current research.
Most discussions reference the AVERROES trial and support the effectiveness of apixaban, showing general agreement with the publication's findings.
There is moderate curiosity about new anticoagulants, their safety, and comparison data, indicating steady-level interest.
Many participants delve into detailed interpretations of trials like AVERROES and BAFTA, with some sharing clinical insights, demonstrating high engagement.
While the discussions are thorough, they mainly reinforce existing evidence and clinical practices, implying a moderate but meaningful impact.
Abstract in brief
- Apixaban significantly reduced the occurrence of stroke and systemic embolism compared to aspirin in patients with atrial fibrillation who were unsuitable for vitamin K antagonists, with a hazard ratio of 0.45.
- The study was stopped early due to the clear benefits seen with apixaban, which included lower rates of hospitalization for cardiovascular causes compared to aspirin (12.6% vs. 15.9% per year).
- Both treatment groups had similar rates of major bleeding, indicating that apixaban is a safer option without a significant increase in bleeding risk.
Top posts
Most liked on X and BlueskySimultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with Atrial Fibrillation and Peripheral Artery Disease - https://t.co/HcLJEZcF8s #EHJPharmacotherapy https://t.co/BCyd7vmjNF
Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use OCEANIC-AF Randomized Clinical Trial OAC-naive patients had a significantly smaller increase in stroke or systemic embolism with asundexian https://t.co/55ftteOfim https://t.co/L8xkzlVhmC
Direct-acting oral anticoagulants prevent stroke in patients with atrial fibrillation but carry the risk of bleeding. Read a summary of "Asundexian versus apixaban in patients with atrial fibrillation" in the May 2025 SM&A: https://t.co/gy6chMvLvn https://t.co/ifXTnOk1d5
@willsuh76 Based on the AVERROES trial, I’d go with full dose Apixiban (unless pt has 2/3 of Cr >1.5, age >80 or weight<60 kg then 2.5 mg BID). In AVERROES, aspirin and apixiban had the same rate of bleeding. https://t.co/lHT35p62Dy
Asundexian versus Apixaban in Patients with Atrial Fibrillation treatment with asundexian at a dose of 50 mg once daily was associated with a higher incidence of stroke or systemic embolism than treatment with apixaban https://t.co/69UQWJr6rc https://t.co/Ny1jTpw102
All mentions
Anticoagulation Strategies in Atrial Fibrillation Management
This Harvard Medical School video discusses anticoagulation in atrial fibrillation, focusing on patient selection, risk assessment with the CHA2DS2Vasc score, and bleeding risk management, emphasizing stroke prevention…
Effectiveness of DOACs in Atrial Fibrillation Management
This week’s podcast reviews significant trials including NOAH-AFNET 6 and ARTESiA that highlight the role of direct oral anticoagulants (DOACs) in preventing ischemic stroke among patients with device-detected atrial…
Effectiveness and safety of rivaroxaban vs. apixaban in patients with atrial fibrillation and peripheral artery disease https://t.co/yKRPx6fPhR
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @MattiaGalli10: Effectiveness and safety of rivaroxaban vs. apixaban in patients with atrial fibrillation and peripheral artery disease…
RT @MattiaGalli10: Effectiveness and safety of rivaroxaban vs. apixaban in patients with atrial fibrillation and peripheral artery disease…
RT @MattiaGalli10: Effectiveness and safety of rivaroxaban vs. apixaban in patients with atrial fibrillation and peripheral artery disease…
Effectiveness and safety of rivaroxaban vs. apixaban in patients with atrial fibrillation and peripheral artery disease @EditorEHJCVP @FeliceGragnano @pyrpyris @ESC_Journals https://t.co/8cb6WJnJIr
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
Effectiveness and safety of rivaroxaban vs. apixaban in patients with atrial fibrillation and peripheral artery disease https://t.co/EzBTkMXw1q #ESC2025
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
DOACの比較研究が出てきています。アピキサバンの安全性が高い結果。Effectiveness and safety of rivaroxaban vs. apixaban in patients with atrial fibrillation and peripheral artery disease https://t.co/4NXOoOjSBY
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
RT @ESC_Journals: Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with A…
Simultaneous publication during #ESCCongress Effectiveness and safety of Rivaroxaban versus Apixaban in patients with Atrial Fibrillation and Peripheral Artery Disease - https://t.co/HcLJEZcF8s #EHJPharmacotherapy https://t.co/BCyd7vmjNF
RT @drbennisahmed: Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use OCEANIC-AF Randomi…
Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use OCEANIC-AF Randomized Clinical Trial OAC-naive patients had a significantly smaller increase in stroke or systemic embolism with asundexian https://t.co/55ftteOfim https://t.co/L8xkzlVhmC
I've been skeptical of this view based on findings from AVERROES (which didn't show higher risk of bleeding w/ apix vs ASA), though data were too imprecise to permit strong inferences. https://t.co/TIGmxzVJTF
RT @_Anesthesiology: Direct-acting oral anticoagulants prevent stroke in patients with atrial fibrillation but carry the risk of bleeding.…
Direct-acting oral anticoagulants prevent stroke in patients with atrial fibrillation but carry the risk of bleeding. Read a summary of "Asundexian versus apixaban in patients with atrial fibrillation" in the May 2025 SM&A: https://t.co/gy6chMvLvn https://t.co/ifXTnOk1d5
Trend up+11: Benkhoff M, ..., Polzin A (N Engl J Med) __Asundexian versus Apixaban in Patients with Atrial Fibrillation__ https://t.co/eLy7S3mLvU
RT @SeeFisch: YOU WILL HEAR OF A FACTOR XI INHIBITOR FOR A FIB. WE do NOT THINK THIS WILL BE A GOOD DRUG Asundexian versus Apixaban in Pat…
YOU WILL HEAR OF A FACTOR XI INHIBITOR FOR A FIB. WE do NOT THINK THIS WILL BE A GOOD DRUG Asundexian versus Apixaban in Patients with Atrial Fibrillation | New England Journal of Medicine https://t.co/CSuKLC2JpI
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @Montecoya: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/lRcxiUbDhh
RT @Montecoya: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/lRcxiUbDhh
Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/lRcxiUbDhh
RT @DFCapodanno: The OCEANIC-AF trial, comparing asundexian to apixaban in patients with atrial fibrillation was halted early due to a sign…
Asundexian versus Apixaban in Patients with Atrial Fibrillation | New England Journal of Medicine https://t.co/jiQlivlRIv
Asundexian - Factor XIa inhibitor versus Apixaban in Patients with Atrial Fibrillation | @NEJM Asundexian is associated with higher stroke or embolism vs. Apixaban @TTUHSCSurgery https://t.co/lCrbiFrGE0
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
次世代のDOACとして期待されたアスンデキシアンとアピキサバンとの心房細動患者に対する比較(非劣性) Asundexian versus Apixaban in Patients with Atrial Fibrillation | New England Journal of Medicine https://t.co/kAfXGviR9x
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @bryanacotton1: XI vs X inhibitor RCT:
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
Asundexian versus Apixaban in Patients with Atrial Fibrillation | New England Journal of Medicine https://t.co/fJJ4WOXLdx
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
Asundexian versus Apixaban in Patients with Atrial Fibrillation treatment with asundexian at a dose of 50 mg once daily was associated with a higher incidence of stroke or systemic embolism than treatment with apixaban https://t.co/69UQWJr6rc https://t.co/Ny1jTpw102
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
XI vs X inhibitor RCT:
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
Asundexian versus Apixaban in Patients with Atrial Fibrillation | New England Journal of Medicine https://t.co/M4gpdS4xDI
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.c…
Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation https://t.co/dZPaihNNp6 #Cardiology https://t.co/sx5FtVvSk5
Explore the latest WG on #Thrombosis Paper of the Month!Our commentary dives into the OCEANIC-AF trial, comparing #asundexian and apixaban in #atrialFibrillation patients. Insights on efficacy, safety, and future directions await.
RT @DrSinyigaya: Comparison of Watchman procedure with new oral anti-coagulants (Apixaban)—in patients with atrial fibrillation: A network…
How happen with the results of AVERROES trial? It never occurred? Can we forget it? https://t.co/GHb2MhMtyn https://t.co/6SnPKjaYXp
RT @ValleAlfonso:
RT @ValleAlfonso:
RT @juanjolopezn: Asundexian versus Apixaban in Patients with Atrial Fibrillation #atrialfibrillation #asundexian #apixaban @NEJM https://t…
Asundexian versus Apixaban in Patients with Atrial Fibrillation #atrialfibrillation #asundexian #apixaban @NEJM https://t.co/L8NF09YWRx
RT @dralexvakili: Honored to have participated as a principal site investigator, researcher and clinical research site in the Oceanic -AF A…
RT @DrDamluji: Asundexian versus Apixaban in Patients with Atrial Fibrillation: @NEJM
Honored to have participated as a principal site investigator, researcher and clinical research site in the Oceanic -AF Asundexian versus Apixaban in Patients with Atrial Fibrillation clinical trial published in the NEJM September 1 issue. Unfortunately, the data did not pan out
RT @NEJM:
RT @ValleAlfonso:
Asundexian versus Apixaban in Patients with Atrial Fibrillation | New England Journal of Medicine https://t.co/BmnRTR0LsR
Asundexian versus Apixaban in Patients with Atrial Fibrillation | NEJM #asundexian didn’t do the job..
RT @NEJM: Original Article: Asundexian versus Apixaban in Patients with Atrial Fibrillation (OCEANIC-AF) https://t.co/dZPaihNNp6 #ESCardi…
RT @DFCapodanno: The OCEANIC-AF trial, comparing asundexian to apixaban in patients with atrial fibrillation was halted early due to a sign…
Asundexian versus Apixaban in Patients with Atrial Fibrillation #science #publication #research #journal https://t.co/tpM6OqcGuU
RT @NEJM:
@Ricky_Turgeon You have data on apixaban vs Asa in af (https://t.co/UfgSKh1dY0) though they had to be OAC ineligible…
RT @pinacol: デザインを解説した論文(https://t.co/o9i7Z3jbuy)を読むに、ARTESIA試験でアスピリンを対照にしたのは、この試験(https://t.co/dRuJpX0O29)で心房細動でアピキサバンvsアスピリンはこういう結果だったけど、…
デザインを解説した論文(https://t.co/o9i7Z3jbuy)を読むに、ARTESIA試験でアスピリンを対照にしたのは、この試験(https://t.co/dRuJpX0O29)で心房細動でアピキサバンvsアスピリンはこういう結果だったけど、AHREではどうなんだろうという疑問があったからかな。
Apixaban does not increase bleeding compared with ASA in warfarin intolerable AF patients. Apixaban increase bleeding compared with ASA in subclinical AF. https://t.co/BjDTornsDp
@SantasEnrique @secardiologia @SVCardio @clinica_sec Estos resultados van en contra de lo que mostró AVERROES, con 10 veces mas
@MutazAlkalbani Never aspirin based on the AVERROES trial. Less effective at preventing stroke with the same bleeding risk as apixaban. https://t.co/tdwClZtsZj
@MedFactChecks @TotoMynell @TheSGEM @stephanamayer @ravigarg415 @Hamishmcmack "High risk population"? Based on what evidence? The risk of ICH with apixaban is likely no different from that of aspirin. https://t.co/YfvYBJZODL
@matthewherper @bradloncar @BentheFidler The article, says they enrolled people with stroke but not specifically AF. If I were developing a drug in this space these days, I'd spend time studying AVVEROES but focusing on patients unwilling or unable to take DOACs. Much harder obviously today https://t.co/WfXuAspCNG
@spraguepond The AVERROES trial showed that the risk of serious bleeding complications is equal with apixaban compared to aspirin, and provides much greater protection against stroke. https://t.co/YpiIeFtLGY The issue is - why switch to aspirin instead of reducing the dose of Eliquis as rec?
Will take a long time to adjust the way we think about aspirin! 10 years haven't moved the needle much https://t.co/56mkzxNSW3 #CardioTwitter https://t.co/H6dPnfkfKx
Finally, don't forget AVERROES findings where ASA was compared to apixaban https://t.co/56mkzxNSW3
5/15 More contemporary data comparing aspirin x anticoagulation (BAFTA – Warf x Aspirin (https://t.co/LGPV1rlkd4) and AVERROES – Apixaban x Aspirin (https://t.co/tyxKtLMGPq)) saw similar bleeding and increased rates of embolism with Aspirin. So less is not more, in this case
@cardskrish Excellent point - will be a discussion with the patient but if you follow prior apixaban vs aspirin, it is likely to be similar https://t.co/PGZdmbYiaM Situation is harder when patients can only afford warfarin
RT @DrDerekConnolly: @Trisha_the_doc @doc_hnaqvi and we know that aspirin has no role in older patients with NVAF after studies like BAFTA…
@Trisha_the_doc @doc_hnaqvi and we know that aspirin has no role in older patients with NVAF after studies like BAFTA and Averroes https://t.co/SMA7rh6xV7
@willsuh76 Based on the AVERROES trial, I’d go with full dose Apixiban (unless pt has 2/3 of Cr >1.5, age >80 or weight<60 kg then 2.5 mg BID). In AVERROES, aspirin and apixiban had the same rate of bleeding. https://t.co/lHT35p62Dy
@bmorecardiology @drjohnm @ATRIUMRx @MKIttlesonMD There is also similar data that suggests ASA does not decrease bleed risk in AF compared to apixaban: https://t.co/RidYMhmJMK
@TYWangMD Havent seen the trial results. But based on this: https://t.co/PGZdmbYiaM Would always go with DOAC over a procedure, a shaky pathophys, a nidus for thrombi, and dapt
@savodoc @drstephenpettit @drjasondungu @JGrapsa @Apple ...bleeding risk not different between aspirin and a NOAC, so in this case I would recommend a NOAC. @venkmurthy will have views about Apple Watch - but at present I wouldn’t recommend it for this patient... https://t.co/wEpMehNDO1
@RodrigoEstvez1 @miguelpinon_73 @aidanraneymd @HeartDrHanna @dngibson2 @joewalshmd The bleeding risk of apixiban was no worse than aspirin in Averoes https://t.co/YJi0MbhpfN
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