The metabolic burden of creatine synthesis.

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Rene Sugar

@renesugar · X

The metabolic burden of creatine synthesis #MECFS #LongCovid https://t.co/NqH26yPFze

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Vitalholis

@vitalholis · X

Les sources : https://t.co/URLfM3aGY0 https://t.co/JGFjuxaPip https://t.co/8uUWK2b75e https://t.co/rUHijTQ7Sc https://t.co/HZG0uoDcnf https://t.co/o2wwAeaciw https://t.co/a9xUmnhxO1 https://t.co/5hF4Y7NvuN https://t.co/soTcUhdorc https://t.co/emFDUqCbxi

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Rene Sugar

@renesugar · X

@IsabelRamirezRD @Naomi_D_Harvey @KatBoniface The metabolic burden of creatine synthesis https://t.co/NqH26yPFze "Mitochondrial mutagenesis as well as functional consequences could be normalized by increasing intracellular creatine levels." https://t.co/c2YxyFpMg4

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "However, creatine synthesis does account for approximately 40% of all of the labile methyl groups provided by S-adenosylmethionine (SAM) and,"

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "Creatine synthesis requires three amino acids: glycine, methionine and arginine, and three enzymes: L-arginine:glycine amidinotransferase (AGAT), methionine adenosyltransferase (MAT) and guanidinoacetate methyl-transferase (GAMT)."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "as such, places an appreciable burden on the provision of such methyl groups, either from the diet or via de novo methylneogenesis."

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Rene Sugar

@renesugar · X

@IsabelRamirezRD @Naomi_D_Harvey @KatBoniface The metabolic burden of creatine synthesis https://t.co/NqH26yPFze "Mitochondrial mutagenesis as well as functional consequences could be normalized by increasing intracellular creatine levels." https://t.co/c2YxyFpMg4

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Rene Sugar

@renesugar · X

@subversivepsych The metabolic burden of creatine synthesis https://t.co/NqH26yPFze https://t.co/4P0MJCgaph "creatine synthesis does account for approximately 40% of all of the labile methyl groups"

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Diane Langdon

@diane_idaho · X

@maxlugavere I am homozygous for 3 methylation SNPs (MTHFR C667T, MTRR and SHMT). Per Chris Masterjohn, creatinine synthesis takes up nearly half of a person’s available methylation capacity. Excess creatinine is peed out so take in AM to avoid nighttime urination. https://t.co/AmlMfmvwb7

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Nutrem

@MxNutrem · X

También hay que mencionar que si consumes creatina, pero no mantienes una buena masa muscular. La creatina no se irá al músculo y las mitocondrias, sino que se excretara como creatinina. https://t.co/WNvzW48xOc

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Maitreya

@Mithreu · X

RT @renesugar: https://t.co/4P0MJCgaph "Creatine synthesis is, therefore, a quantitatively major pathway in amino acid metabolism and impo…

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Rhi

@rhirhiarhii · X

RT @renesugar: The metabolic burden of creatine synthesis #MECFS #LongCovid https://t.co/NqH26yPFze

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Mg2+ Papi, the BowTied Mg2+

@Grimhood · X

RT @renesugar: The metabolic burden of creatine synthesis #MECFS #LongCovid https://t.co/NqH26yPFze

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Rene Sugar

@renesugar · X

The metabolic burden of creatine synthesis #MECFS #LongCovid https://t.co/WeTuxuktRP

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Richard

@PGC1a_RB · X

RT @renesugar: The metabolic burden of creatine synthesis #MECFS #LongCovid https://t.co/NqH26yPFze

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "Creatine synthesis is, therefore, a quantitatively major pathway in amino acid metabolism and imposes an appreciable burden on the metabolism of methionine and of arginine."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "Creatine synthesis consumes some 20–30% of arginine’s amidino groups, whether provided in the diet or synthesized within the body."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "as such, places an appreciable burden on the provision of such methyl groups, either from the diet or via de novo methylneogenesis."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "However, creatine synthesis does account for approximately 40% of all of the labile methyl groups provided by S-adenosylmethionine (SAM) and,"

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "Creatine synthesis does not appear to place a major burden on glycine metabolism in adults since this amino acid is readily synthesized."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "However, since dietary creatine is only provided in animal products, principally in meat and fish, virtually all of the creatine loss in vegetarians must be replaced via endogenous synthesis."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "Creatinine loss is lower in females and in older age groups because of lower muscle mass." "Approximately half of this creatine lost to creatinine can be replaced, in omnivorous individuals, by dietary creatine."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "The entire glycine molecule is consumed in creatine synthesis but only the methyl and amidino groups, respectively, from methionine and arginine." "Creatinine loss averages approximately 2 g (14.6 mmol) for 70 kg males in the 20- to 39-year age group."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "Creatine synthesis requires three amino acids: glycine, methionine and arginine, and three enzymes: L-arginine:glycine amidinotransferase (AGAT), methionine adenosyltransferase (MAT) and guanidinoacetate methyl-transferase (GAMT)."

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Rene Sugar

@renesugar · X

https://t.co/4P0MJCgaph "Creatine synthesis is required in adult animals to replace creatine that is spontaneously converted to creatinine and excreted in the urine." "Additionally, in growing animals it is necessary to provide creatine to the expanding tissue mass."

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Rene Sugar

@renesugar · X

The metabolic burden of creatine synthesis #MECFS #LongCovid https://t.co/NqH26yPFze

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DrAlvaroBustamante

@DrAlvaroBustam · X

3) J. T. Brosnan et al. ´The metabolic burden of creatine synthesis`. Amino Acids. 2011, pp. 1325-31

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Nikolas Korasidis

@Renelvon · X

@Rainmaker1973 The daily loss for the average male is 2-3g, so the comparison to 5g is exaggeration. Also, the body makes creative from other amino acids. Glycine is probably the one most people need help with. https://t.co/YP2vtw1OLF

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Says who ?

@sayswhomostdef · X

RT @vitalholis: Les sources : https://t.co/URLfM3aGY0 https://t.co/JGFjuxaPip https://t.co/8uUWK2b75e https://t.co/rUHijTQ7Sc https://t.co/…

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Vitalholis

@vitalholis · X

Les sources : https://t.co/URLfM3aGY0 https://t.co/JGFjuxaPip https://t.co/8uUWK2b75e https://t.co/rUHijTQ7Sc https://t.co/HZG0uoDcnf https://t.co/o2wwAeaciw https://t.co/a9xUmnhxO1 https://t.co/5hF4Y7NvuN https://t.co/soTcUhdorc https://t.co/emFDUqCbxi

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ParkerAD

@Par_3erAD · X

@JylleanS @jason_gutt @jordanbpeterson There is only one main pathway from creatine synthesis, methyltransferase reactions, that is considered to impose a genuinely significant burden on the human body. Creatine production is expected to consume 40% of the S-Adenosyl methionine gained from diet.https://t.co/D6i088C9Dp

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Slobodan Fuletic

@sloba116 · X

@Tarunashree1 https://t.co/NCLOPpYqlA

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Adam Ramos

@AdamRamos441 · X

@TasteGrass I swear that shit was making my hair thin out. I just eat steak, eggs and milk everyday. I take ZMA and glycine before bed. https://t.co/rWNrgGW9CD

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Jared Polowick

@jaredpolowick · X

@conorverbruggen @aled_zachary https://t.co/b0VbO22zsX https://t.co/U92FeJvlRA https://t.co/i95qIGxCcD

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Redztruthseeker - Aarush

@RedzTruthSeeker · X

@Yashovardhan_13 @CognitiveDiss0 56/n:Creatine is a non-essential nutrient that humans can make from other amino acids ( https://t.co/30jg9br8Xc).

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Redztruthseeker - Aarush

@RedzTruthSeeker · X

@Yashovardhan_13 @CognitiveDiss0 If athletes need Creatine, one can suppliment like most athletes do..as far as PB diet lacking creatine is concerned Its an non-essential nutrient that humans can make from other amino acids : https://t.co/30jg9b9xyC