Proc Natl Acad Sci U S A September 2011 PMID 21402948

Addiction: beyond dopamine reward circuitry.

Nora D Volkow, Gene-Jack Wang, Joanna S Fowler, Dardo Tomasi, Frank Telang

Mentions

47
Peak: 1 in Jul 2022
across 5 sources since Jul 2022

Extended reach

2,979
potential audience

Total likes

106

Video views

2,730

Mentions per month

Jul 2022 – Jun 2025

Where it's discussed

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AI synopsis

What people are saying

The discussion demonstrates moderate engagement with posts mentioning how drug cues can trigger dopamine surges more than the drugs, exemplified by phrases like 'how addiction is formed' and references to brain activity, emphasizing the importance of conditioned responses and neurochemical processes in addiction.

AgreementModerate agreement

Most discussions agree that the article sheds important light on the complex role of dopamine in addiction, as seen in comments about how the expectation of drug effects can trigger large dopamine releases more than the drugs themselves.

InterestModerate interest

The posts show moderate interest, with some users highlighting the significance of understanding how craving and conditioned responses influence addiction.

EngagementModerate engagement

Comments reflect some engagement, including references to scientific concepts like dopamine release and neural mechanisms, indicating a deeper level of discussion.

ImpactModerate impact

The conversations suggest the article has a noteworthy impact on understanding addiction’s neurobiological basis, which could influence future research and treatments.

Abstract in brief

  • The review discusses how dopamine (DA) is known for its role in drug reward, but in addicted individuals, the expected DA response to drugs is actually blunted, even though drug cues can trigger strong DA responses linked to craving.
  • This discrepancy between the reduced pharmacological effects and the heightened responses to drug cues may lead addicts to keep seeking drugs in hope of achieving the expected reward, contributing to continued use despite diminished direct drug effects.
  • Additionally, addicted individuals show lower levels of D2 receptors in the striatum and decreased activity in brain regions responsible for decision-making and impulse control, which may cause a dominance of reward and conditioned responses over self-control, fostering compulsive drug use.

Top posts

Most liked on X and Bluesky
Waju
@TheHunku · X

In this study on the brains of drug addicts, researchers found that the expectation of the drug caused more release of the feel-good neurotransmitter dopamine than the actual drug itself. https://t.co/LtNQLXSODs This is how the addiction is formed.

Jul 11, 2022 · 3 likes · 223 followers View post →
iae
@lalelcute · X

Volkow, N. D., Wang, G. J., Fowler, J. S., & Telang, F. (2011). Addiction: Beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences. Salamone, J. D., & Correa, M. (2012). The mysterious motivational functions of mesolimbic dopamine.

Oct 22, 2024 · 27 followers View post →

All mentions

iae
@lalelcute · X

Volkow, N. D., Wang, G. J., Fowler, J. S., & Telang, F. (2011). Addiction: Beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences. Salamone, J. D., & Correa, M. (2012). The mysterious motivational functions of mesolimbic dopamine.

Oct 22, 2024 · 27 followers View post →
Waju
@TheHunku · X

In this study on the brains of drug addicts, researchers found that the expectation of the drug caused more release of the feel-good neurotransmitter dopamine than the actual drug itself. https://t.co/LtNQLXSODs This is how the addiction is formed.

Jul 11, 2022 · 3 likes · 223 followers View post →