In this study on the brains of drug addicts, researchers found that the expectation of the drug caused more release of the feel-good neurotransmitter dopamine than the actual drug itself. https://t.co/LtNQLXSODs This is how the addiction is formed.
Addiction: beyond dopamine reward circuitry.
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Jul 2022 – Jun 2025Where it's discussed
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AI synopsis
What people are saying
The discussion demonstrates moderate engagement with posts mentioning how drug cues can trigger dopamine surges more than the drugs, exemplified by phrases like 'how addiction is formed' and references to brain activity, emphasizing the importance of conditioned responses and neurochemical processes in addiction.
Most discussions agree that the article sheds important light on the complex role of dopamine in addiction, as seen in comments about how the expectation of drug effects can trigger large dopamine releases more than the drugs themselves.
The posts show moderate interest, with some users highlighting the significance of understanding how craving and conditioned responses influence addiction.
Comments reflect some engagement, including references to scientific concepts like dopamine release and neural mechanisms, indicating a deeper level of discussion.
The conversations suggest the article has a noteworthy impact on understanding addiction’s neurobiological basis, which could influence future research and treatments.
Abstract in brief
- The review discusses how dopamine (DA) is known for its role in drug reward, but in addicted individuals, the expected DA response to drugs is actually blunted, even though drug cues can trigger strong DA responses linked to craving.
- This discrepancy between the reduced pharmacological effects and the heightened responses to drug cues may lead addicts to keep seeking drugs in hope of achieving the expected reward, contributing to continued use despite diminished direct drug effects.
- Additionally, addicted individuals show lower levels of D2 receptors in the striatum and decreased activity in brain regions responsible for decision-making and impulse control, which may cause a dominance of reward and conditioned responses over self-control, fostering compulsive drug use.
Top posts
Most liked on X and BlueskyVolkow, N. D., Wang, G. J., Fowler, J. S., & Telang, F. (2011). Addiction: Beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences. Salamone, J. D., & Correa, M. (2012). The mysterious motivational functions of mesolimbic dopamine.
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Volkow, N. D., Wang, G. J., Fowler, J. S., & Telang, F. (2011). Addiction: Beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences. Salamone, J. D., & Correa, M. (2012). The mysterious motivational functions of mesolimbic dopamine.
In this study on the brains of drug addicts, researchers found that the expectation of the drug caused more release of the feel-good neurotransmitter dopamine than the actual drug itself. https://t.co/LtNQLXSODs This is how the addiction is formed.