Am J Physiol Regul Integr Comp Physiol September 2011 PMID 21677272

Biology's response to dieting: the impetus for weight regain.

Paul S Maclean, Audrey Bergouignan, Marc-Andre Cornier, Matthew R Jackman

Mentions

153
Peak: 19 in Aug 2025
across 5 sources since Jan 2018

Extended reach

43,615,572
potential audience

Total likes

37,579

Video views

43,541,123

Mentions per month

Jan 2018 – Oct 2025

Where it's discussed

  • News80 articles
  • Facebook24 posts
  • X / Twitter23 posts
  • YouTube14 videos
  • Blogs12 articles

AI synopsis

What people are saying

The group consistently emphasizes that weight regain is driven by biological responses, with posts like 'the biological response involves comprehensive, persistent adaptations' and personal stories revealing struggles with sustaining weight loss. The tone combines scientific references and personal reflection, which underscores the widespread recognition of the complexity of long-term weight management.

AgreementModerate agreement

Most discussion participants acknowledge and support the scientific consensus that biological responses complicate long-term weight loss.

InterestHigh interest

Posts demonstrate a high level of curiosity, with many referencing detailed physiological and psychological factors and sharing personal stories.

EngagementModerate engagement

Many contributions include retweets, references to studies, comparisons with personal experiences, and nuanced discussions about metabolic and emotional factors.

ImpactModerate impact

The discussions highlight an awareness of the biological challenges surrounding weight management, which could influence public perceptions and future research focus.

Abstract in brief

  • Dieting is the most common method for weight loss among obese individuals, but it often leads to weight regain, highlighting the challenges in achieving long-term success.
  • The review discusses the biological factors that contribute to weight regain, including adaptations that occur with energy-restricted diets and how these impact energy balance.
  • It suggests that effective long-term weight loss strategies must be as comprehensive and persistent as the biological adaptations that lead to weight regain.

Top posts

Most liked on X and Bluesky
komm, süssy tod
@punished3liza · X

"The preponderance of evidence [suggests] biological response to weight loss involves comprehensive, persistent, and redundant adaptations in energy homeostasis and that these adaptations underlie the high recidivism rate in obesity therapeutics." https://t.co/djZV2HPAST

May 13, 2024 · 12 likes · 3 shares · 6,043 followers View post →
Alicia Painter
@AliArthPainter · X

@realpeteyb123 Medication, health conditions, struggling to exercise, lack of low calorie nutritious food etc. Even without these factors, they're unlikely to keep the weight off. https://t.co/m86fPTmcOK

Jul 7, 2023 · 9 likes · 3,470 followers View post →
Dani Trainer
@Dani_trainer_ · X

1/6 ¿Por qué es tan difícil mantener el peso después de una dieta?

Dec 4, 2024 · 7 likes · 18,444 followers View post →
Mikki Williden PhD
@MikkiWilliden · X

Biology's response to dieting: the impetus for weight regain https://t.co/mY6GjXd0kh

Apr 12, 2023 · 2 likes · 2,243 followers View post →
Harry Minot
@HarryMinot · X

@PrimeDP10 @DoubleDeezze Sigh. More trollishness from a person who would impose his personal experience (and his internalized fat-phobia) upon others. He ought to do some reading: https://t.co/i0vehBqZxK

Mar 1, 2019 · 2 likes · 1,605 followers View post →
Dani Trainer
@Dani_trainer_ · X

Así es: el reto no es solo bajar peso, sino luego no recuperar esa pérdida. Incluso personas con sobrepeso 1º pierden kilos con relativa facilidad, pero 1 año después del adelgazamiento, el 80% vuelve al peso inicial. (2 años después el 85%, y 3 el 95%) https://t.co/lCcjEtM2DS

Jul 7, 2023 · 1 like · 18,444 followers View post →

All mentions

Dani Trainer
@Dani_trainer_ · X

1/6 ¿Por qué es tan difícil mantener el peso después de una dieta?

Dec 4, 2024 · 7 likes · 18,444 followers View post →
ari
@kryptosari · X

https://t.co/o1eO4Re0aD

Sep 23, 2024 · 2,386 followers View post →
Charles
@Mr_Indigo · X

RT @punished3liza: "The preponderance of evidence [suggests] biological response to weight loss involves comprehensive, persistent, and red…

May 13, 2024 · 3 shares · 290 followers View post →
Of Quartz
@PunishedQuartz · X

RT @punished3liza: "The preponderance of evidence [suggests] biological response to weight loss involves comprehensive, persistent, and red…

May 13, 2024 · 3 shares · 571 followers View post →
The Evening Primrose
@TheEveningPrim1 · X

RT @punished3liza: "The preponderance of evidence [suggests] biological response to weight loss involves comprehensive, persistent, and red…

May 13, 2024 · 3 shares · 174 followers View post →
komm, süssy tod
@punished3liza · X

"The preponderance of evidence [suggests] biological response to weight loss involves comprehensive, persistent, and redundant adaptations in energy homeostasis and that these adaptations underlie the high recidivism rate in obesity therapeutics." https://t.co/djZV2HPAST

May 13, 2024 · 12 likes · 3 shares · 6,043 followers View post →
Sports Nutrition Digest
@snutridigest · X

What contributes to our bodies energy needs

Oct 9, 2023 · 169 followers View post →
Alicia Painter
@AliArthPainter · X

@realpeteyb123 Medication, health conditions, struggling to exercise, lack of low calorie nutritious food etc. Even without these factors, they're unlikely to keep the weight off. https://t.co/m86fPTmcOK

Jul 7, 2023 · 9 likes · 3,470 followers View post →
Dani Trainer
@Dani_trainer_ · X

Así es: el reto no es solo bajar peso, sino luego no recuperar esa pérdida. Incluso personas con sobrepeso 1º pierden kilos con relativa facilidad, pero 1 año después del adelgazamiento, el 80% vuelve al peso inicial. (2 años después el 85%, y 3 el 95%) https://t.co/lCcjEtM2DS

Jul 7, 2023 · 1 like · 18,444 followers View post →
Mikki Williden PhD
@MikkiWilliden · X

Biology's response to dieting: the impetus for weight regain https://t.co/mY6GjXd0kh

Apr 12, 2023 · 2 likes · 2,243 followers View post →
Pavel Dournov
@pavluxa · X

Great piece from the Huberman podcast, with several cool insights: The Science of Eating for Health https://t.co/qoQU9htwuw paper links in video description. A key one https://t.co/VpbifdQUX9

Feb 5, 2023 · 231 followers View post →
Jae Rosario
@thoughtsbyjae_ · X

You will regain some of the weight you lost. This is just the reality of weight loss. Your body doesn't want to lose weight. https://t.co/aItWtcCOhf

Aug 8, 2022 · 2,102 followers View post →
cardiosthenics
@cardiosthenics · X

RT @doctordiego1: El problema no es perder peso. El problema es mantenerlo. https://t.co/Lk9vSUveKB

Nov 14, 2021 · 1 share · 102 followers View post →
Diego Guerra
@doctordiego1 · X

El problema no es perder peso. El problema es mantenerlo. https://t.co/Lk9vSUveKB

Nov 14, 2021 · 1 like · 1 share · 769 followers View post →
Bart Jooris
@BartJooris · X

@Christo63100802 @Tony_Furniere U weet het dus beter dan wat wetenschappelijke studies al jaren aantonen? https://t.co/CkfD3uqjmJ https://t.co/lnwazdMaDD https://t.co/m2T0DgYrga https://t.co/KHhPCpCXwt

Apr 30, 2021 · 284 followers View post →
Jan Vyjidak
@janvyjidak · X

RT @dr_kevinlee: @KurtLass1 https://t.co/9XAzXSLoQy

Mar 19, 2021 · 1 share · 4,152 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

@KurtLass1 https://t.co/9XAzXSLoQy

Mar 19, 2021 · 1 share · 5,446 followers View post →
Simone
@simonejharding · X

@FloralDesignsF1 @thefatdoctoruk @BioLayne I listened to a podcast way back by Layne. He cited a paper https://t.co/AYGw0mvAe6 & he’s is no doubt about the metabolic challenges. The psych/embodied/social are omitted but still, nutritionists have insight into the endpoints.

Feb 20, 2021 · 1 like · 954 followers View post →
Guillaume Baissette
@GuillaumePsy · X

D'autant plus qu'une forte perte de poids entraîne des changements métaboliques favorisant la reprise de poids et l'apparition de comportements boulimiques. https://t.co/xtv5lJkBh3 #TCA https://t.co/Ont6w81ui8

Feb 13, 2020 · 1 like · 90 followers View post →
Harry Minot
@HarryMinot · X

@PrimeDP10 @DoubleDeezze Sigh. More trollishness from a person who would impose his personal experience (and his internalized fat-phobia) upon others. He ought to do some reading: https://t.co/i0vehBqZxK

Mar 1, 2019 · 2 likes · 1,605 followers View post →
.
@masonpelt · X

Biology's response to dieting: the impetus for weight regain. https://t.co/kL9X8Gfwr7

Feb 23, 2019 · 4,817 followers View post →
Kdlkop
@kdlkop99 · X

Biology's response to dieting: the impetus for weight regain | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology https://t.co/M1zWQsdpxk

Jan 30, 2019 · 38 followers View post →
Harry Minot
@HarryMinot · X

@monicakriete You’ve probably also seen this one. As a fat boy I was put on my first (non-consensual) diet at age 11. It made me fatter. Subsequent weight-loss attempts, resulting from my internalization of the oppression, had the same effect.. https://t.co/i0vehBqZxK https://t.co/nFH5jXudsM

Jan 29, 2019 · 1,605 followers View post →