PubHawk
Science September 2011 PMID 21778362

Synaptic pruning by microglia is necessary for normal brain development.

Rosa C Paolicelli, Giulia Bolasco, Francesca Pagani, Laura Maggi, Maria Scianni, Patrizia Panzanelli, Maurizio Giustetto, Tiago Alves Ferreira, Eva Guiducci, Laura Dumas, Davide Ragozzino, Cornelius T Gross

Full text PDF Download social card

Mentions

67
Peak: 6 in Mar 2022
across 5 sources since Jan 2019

Extended reach

120,863
potential audience

Total likes

145

Video views

16,400

Mentions per month

Jan 2019 – Aug 2024

Where it's discussed

  • News30 articles
  • X / Twitter24 posts
  • Blogs9 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The group shows strong agreement on the crucial role of microglia, with posts emphasizing how synaptic pruning shapes the brain's neural networks, such as noting microglia's active role in eliminating excess connections. Words like 'necessary,' 'scavenging functions,' and 'critical for normal development' convey deep engagement and understanding, underlining the significance of the research for neurodevelopmental science.

AgreementModerate agreement

Most discussions acknowledge the importance of microglia in brain development, reinforcing the publication's findings.

InterestHigh interest

The posts demonstrate high curiosity, referencing specific processes like synaptic pruning and microglia's roles.

EngagementModerate engagement

Some contributions delve into the biological mechanisms and significance, indicating a moderate level of engagement.

ImpactModerate impact

The discussion reflects recognition of the study’s potential impact on understanding neurodevelopmental processes.

Abstract in brief

  • Microglia are immune cells that move around the brain and help clean up damaged cells, but their exact role in a healthy, developing brain was less understood.
  • The study shows that microglia actively remove excess or unnecessary synapses (connections between neurons) during the postnatal development in mice, playing a key role in shaping the brain’s neural network.
  • This process of synaptic pruning by microglia is important for normal brain development, and problems with microglia function might contribute to neurodevelopmental disorders with abnormal brain connectivity.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Dr. Thomas Ichim
@exosome · X

Microglia mediate synaptic pruning $tsoi https://t.co/FSoXZbVNVO

Mar 12, 2022 · 10 likes · 3 shares · 35,193 followers View post →
Eyo
@eyolab · X

@SabanLab Sure. So many data but here are a few: https://t.co/R1ILDUa8CO; https://t.co/kTuSbwdu9H [Fig. 1]; https://t.co/3Yh8xJnH0z. Pretty much any developmental quantification of MG density shows a reduction in MG numbers from a peak at ~ P14/15 and a decline from ~P20/21.

May 6, 2022 · 5,979 followers View post →
ニューロドクター乱夢
@hichachu · X

Synaptic pruning by microglia is necessary for normal brain development シナプス刈り込みとは、必要なシナプス結合だけが強められ、不要なシナプス結合は除去される現象である。発生、発達期の動物の脳内ではある段階になると神経結合（シナプス）が形成され始める。 https://t.co/nQqwPv9AEC

Jul 8, 2023 · 4,260 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Aug 21, 2024 · 8 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

May 26, 2021 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Feb 4, 2020 · 8 shares · 3,151 followers View post →

All mentions

Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Aug 21, 2024 · 8 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Dec 15, 2023 · 19 shares · 3,151 followers View post →
ニューロドクター乱夢
@hichachu · X

Synaptic pruning by microglia is necessary for normal brain development シナプス刈り込みとは、必要なシナプス結合だけが強められ、不要なシナプス結合は除去される現象である。発生、発達期の動物の脳内ではある段階になると神経結合（シナプス）が形成され始める。 https://t.co/nQqwPv9AEC

Jul 8, 2023 · 4,260 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Jun 25, 2023 · 8 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Jan 27, 2023 · 19 shares · 3,151 followers View post →
Eyo
@eyolab · X

@SabanLab Sure. So many data but here are a few: https://t.co/R1ILDUa8CO; https://t.co/kTuSbwdu9H [Fig. 1]; https://t.co/3Yh8xJnH0z. Pretty much any developmental quantification of MG density shows a reduction in MG numbers from a peak at ~ P14/15 and a decline from ~P20/21.

May 6, 2022 · 5,979 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

May 4, 2022 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Mar 27, 2022 · 19 shares · 3,151 followers View post →
Thamarasee Jeewandara
@Jeew333T · X

Microglia are highly motile phagocytic cells that infiltrate and take up residence in the developing brain, where they are thought to provide surveillance and scavenging functions, with now known postnatal synaptic pruning for normal brain development

Mar 17, 2022 · 1,281 followers View post →
proteinpartners
@proteinpartners · X

RT @exosome: Microglia mediate synaptic pruning $tsoi https://t.co/FSoXZbVNVO

Mar 12, 2022 · 3 shares · 22 followers View post →
M_R
@EQCheckRao · X

RT @exosome: Microglia mediate synaptic pruning $tsoi https://t.co/FSoXZbVNVO

Mar 12, 2022 · 3 shares · 463 followers View post →
Dr. Thomas Ichim
@exosome · X

Microglia mediate synaptic pruning $tsoi https://t.co/FSoXZbVNVO

Mar 12, 2022 · 10 likes · 3 shares · 35,193 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Mar 11, 2022 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Feb 5, 2022 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Oct 19, 2021 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Sep 15, 2021 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Aug 29, 2021 · 8 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

May 26, 2021 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Jan 22, 2021 · 8 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Feb 4, 2020 · 8 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

Sep 27, 2019 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

May 14, 2019 · 8 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. http://t.co/uaMwqBWInY @LivesInThought

May 11, 2019 · 19 shares · 3,151 followers View post →
Άντζελα
@SouthernGemGal · X

RT @SouthernGemGal: Synaptic pruning by microglia is necessary for normal brain development. https://t.co/uaMwqBWInY

Jan 24, 2019 · 8 shares · 3,151 followers View post →