Psychosom Med September 2011 PMID 21862825

The nocebo effect and its relevance for clinical practice.

Luana Colloca, Franklin G Miller

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What people are saying

Discussions highlight the importance of the nocebo effect based on research evidence, with mentions of specific studies like Colloca and Miller’s 2011 paper, utilizing words like 'powerful' and emphasizing practical implications. The tone is scholarly yet accessible, demonstrating both curiosity and a recognition of the clinical significance of ethically managing patient information to minimize adverse effects.

AgreementModerate agreement

Most comments acknowledge the significance of the nocebo effect, citing research evidence and emphasizing its relevance in practice.

InterestModerate interest

Discussions demonstrate a moderate level of curiosity, with references to studies and specific authors, indicating genuine interest.

EngagementModerate engagement

Participants engage by mentioning their own knowledge, sharing sources, and discussing practical implications, reflecting active involvement.

ImpactModerate impact

The emphasis on the powerful influence of the nocebo effect and the importance of communication strategies suggests recognition of its meaningful impact on clinical outcomes.

Abstract in brief

The nocebo effect occurs when negative expectations, often shaped by information about side effects, lead to worse health outcomes and affect patient adherence and quality of life.
Research shows that how information is presented during clinical trials and the consent process can significantly influence these adverse responses, with neurobiological processes also playing a role.
The article highlights the importance of developing ethical communication strategies in clinical practice to minimize nocebo effects and improve patient care.]

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All mentions

Understanding Nocebo Effects in Clinical Practice and Patient Care

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Neuroscience of Placebo Effects and Pain Relief Mechanisms

Placebo effects are beneficial responses driven by the brain's interpretation of treatment context, influenced by learning, expectations, and social factors. Neuroscience research highlights brain systems and…

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Based Neanderthal

@NiceNeanderthal · X

RT @IntegralAnswers: 12/ 3.Colloca L, Miller FG. “The nocebo effect and its relevance for clinical practice.” JAMA. 2011;306(8): 853-854.

Oct 14, 2025 · 1 share · 1,958 followers View post →

IntegralAnswers

@IntegralAnswers · X

12/ 3.Colloca L, Miller FG. “The nocebo effect and its relevance for clinical practice.” JAMA. 2011;306(8): 853-854.

Oct 14, 2025 · 3 likes · 1 share · 8,565 followers View post →

Fruitascade

@Through_Leaves · X

@MrsLocke5 @sbaroncohen Nocebo effects can be very powerful, and there is a lot of research evidence as well - see for example: https://t.co/1esBa4MKO7.

Sep 11, 2023 · 128 followers View post →

Illusion Buster

@bobw075 · X

Nocebo effect #noceboeffect The nocebo effect and its relevance for clinical practice Luana Colloca et al. Psychosom Med. 2011 Sep. https://t.co/VVVqh5JB10

Mar 26, 2023 · 160 followers View post →