October 2011 PMID 21949380

Human sweet taste receptor mediates acid-induced sweetness of miraculin.

Ayako Koizumi, Asami Tsuchiya, Ken-ichiro Nakajima, Keisuke Ito, Tohru Terada, Akiko Shimizu-Ibuka, Loïc Briand, Tomiko Asakura, Takumi Misaka, Keiko Abe

Mentions

29
Peak: 1 in Sep 2021
across 5 sources since Sep 2021

Extended reach

116,433
potential audience

Total likes

4,205

Video views

96,861

Mentions per month

Sep 2021 – Jul 2025

Where it's discussed

  • Blogs11 articles
  • News10 articles
  • Facebook4 posts
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a cautious but intrigued attitude toward the research, mentioning molecular interactions like 'acid-activated receptors' and potential applications such as 'taste modification,' with words like 'important' and 'fascinating' indicating their recognition of its scientific significance.

AgreementModerate agreement

Most discussions acknowledge the findings, with some expressing curiosity about the receptor mechanisms, indicating general support.

InterestModerate interest

Posts show moderate interest, referencing molecular interactions and potential implications, but without strong emotional language.

EngagementModerate engagement

Comments include mentions of receptor behavior and taste modification, demonstrating some depth but not overly detailed analysis.

ImpactModerate impact

The discussions suggest the findings could influence taste science and food industry applications, reflecting a moderate perceived impact.

Abstract in brief

  • The study explores how miraculin (MCL), a protein from red berries, can turn sour tastes into sweet ones by interacting with human sweet taste receptors (hT1R2 and hT1R3), especially under acidic conditions.
  • Researchers used a cell-based assay to show that MCL activates these receptors in a pH-dependent manner, becoming more effective as the solution becomes more acidic, and that this activation repeats with each application of acid.
  • Molecular analysis suggests that MCL acts as an antagonist at neutral pH but switches to an agonist in acidic environments, likely explaining its ability to modify taste sensations from sour to sweet.]

Top posts

Most liked on X and Bluesky
マサキ㌠
@Masaki_ponpoko · X

不活性化したミラクリンが甘味受容体に結合すると甘味物質に対する応答が阻害されるってことは甘味感じにくくなるんだ…(蜂蜜の甘味はそこまで変化しなかった) メモ https://t.co/qAVmj5ZtK1 https://t.co/CzypCjIaJh

Nov 16, 2023 · 2 likes · 19,559 followers View post →
ケミクックげん
@ChemicalCooking · X

東大の研究によるとヒト甘味受容体に結合したミラクリンが酸性になると、ヒト甘味受容体を活性化させることで、酸っぱいものが甘く感じられるみたいですね。 参考:Human sweet taste receptor mediates acid-induced sweetness of miraculin https://t.co/Dxh9FNxdjJ

Sep 13, 2021 · 14 followers View post →

All mentions

マサキ㌠
@Masaki_ponpoko · X

不活性化したミラクリンが甘味受容体に結合すると甘味物質に対する応答が阻害されるってことは甘味感じにくくなるんだ…(蜂蜜の甘味はそこまで変化しなかった) メモ https://t.co/qAVmj5ZtK1 https://t.co/CzypCjIaJh

Nov 16, 2023 · 2 likes · 19,559 followers View post →
ケミクックげん
@ChemicalCooking · X

東大の研究によるとヒト甘味受容体に結合したミラクリンが酸性になると、ヒト甘味受容体を活性化させることで、酸っぱいものが甘く感じられるみたいですね。 参考:Human sweet taste receptor mediates acid-induced sweetness of miraculin https://t.co/Dxh9FNxdjJ

Sep 13, 2021 · 14 followers View post →