PubHawk
October 2011 PMID 21990298

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Eric A Klein, Ian M Thompson, Catherine M Tangen, John J Crowley, M Scott Lucia, Phyllis J Goodman, Lori M Minasian, Leslie G Ford, Howard L Parnes, J Michael Gaziano, Daniel D Karp, Michael M Lieber, Philip J Walther, Laurence Klotz, J Kellogg Parsons

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Mentions

221
Peak: 3 in Feb 2022
across 5 sources since Jul 2021

Extended reach

86,763
potential audience

Total likes

100

Video views

4,409

Mentions per month

Jul 2021 – Oct 2025

Where it's discussed

  • News128 articles
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  • YouTube2 videos

AI synopsis

What people are saying

Discussions reflect a balanced concern about the study's results, with examples like references to hazard ratios and debates over the biological plausibility, using tone and language that reveal cautious interest and critical analysis of the research's implications.

AgreementModerate agreement

Most discussions acknowledge the findings that vitamin E supplementation may increase prostate cancer risk, showing a general consensus.

InterestModerate interest

Posts express moderate interest, with some critics and skeptics questioning the evidence or emphasizing need for caution.

EngagementModerate engagement

Comments include references to methodology and implications, signifying active engagement and analysis.

ImpactModerate impact

The discussions highlight the significance of the study, warning about potential risks of supplement use and influencing public perceptions.

Abstract in brief

  • The SELECT trial initially found no significant reduction in prostate cancer risk with selenium or vitamin E supplements, but there was a non-significant trend suggesting vitamin E might increase risk.
  • Longer follow-up data showed that men taking vitamin E had a slightly higher incidence of prostate cancer (hazard ratio of 1.17), while selenium did not significantly affect risk.
  • This extended analysis, involving over 54,000 additional person-years and 521 new cases, suggests that vitamin E might be associated with a modest increase in prostate cancer risk, emphasizing the need for cautious use of supplements.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Eric Klein
@EricKleinMD · X

The SELECT trial showed the same outcome for prostate cancer https://t.co/cBAQ9uAypW. Vitamins are biologically active substances that can be harmful in high doses. https://t.co/lxJzZVmQWr

Oct 18, 2023 · 14 likes · 1 share · 4,283 followers View post →
Reiner 
@erlesen · X

Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial https://t.co/DDZ2nb454R Conclusion: "Dietary supplementation with (400 IU per day) vitamin E (400 IU per day) significantly increased the risk of prostate cancer among healthy men"

Feb 27, 2022 · 6 likes · 2 shares · 7,863 followers View post →
Juhani Knuuti
@JuhaniKnuuti · X

@Reijo_RD_FIN @SiiriSimola Juuri näin. Mutta antioksidanttiuskovaiset ovat kokonaan torjuneet kliinisen näytön suurten annosten haitoista. Tässä muutama julkaisu asiasta: https://t.co/evz0d5GOX4 https://t.co/Axj0Ra05Pq https://t.co/7f5BHliMZT https://t.co/WTHt9JMFSr https://t.co/ptaIU85K6Q

Sep 13, 2023 · 3 likes · 9,399 followers View post →
Talia Wegman MD, PhD
@taliawegman · X

@BailleresMer Por ejemplo, la vitamina E aumenta el riesgo de cáncer de próstata https://t.co/SaqEW68dmn

Sep 11, 2021 · 2 likes · 13,370 followers View post →
RaphaelaPro
@ProRaphaela · X

#Stereoisomerie Ist ein natürliches Vitamin gleich einem im Labor hergestellten Vitamin? all rac-alpha-tocopherly acetat = Vitamin E? Und wenn nicht was zeigt uns diese Studie? Vergleiche Thalidomid (Contergan) https://t.co/WrVyGGwTlb https://t.co/szMmG5ZSbd

Jun 21, 2022 · 2 likes · 1 share · 7 followers View post →
د. وضاح عرفات
@Arab_Oncologist · X

استخدام فيتامين E يزيد خطر الإصابة بسرطان البروستات في ٣٥ ألف مريض في دراسة SELECT أدى استخدام فيتامين E إلى زيادة هطر سرطان البروستات hazard ratio [HR], 1.17; 99% CI, 1.004-1.36, P = .008) https://t.co/TjM4mm16Ns

Jan 1, 2022 · 1 like · 1 share · 1,290 followers View post →

All mentions

Andrew Vickers
@VickersBiostats · X

@AAMortazavi @DrNeilStone see https://t.co/JNjPFyKnq3 and https://t.co/wuw9hSxBtk and https://t.co/zpZKfLqk9M and https://t.co/0jCn1wWNFj

Oct 8, 2025 · 5,751 followers View post →
Prabal Gupta| Fitness Professional
@coach_prabal · X

References: 1-https://t.co/ryIQKcCRCQ 2-https://t.co/QZ5OLCW5BH 3-https://t.co/pD14e7KkRJ 4-https://t.co/BdGSF0s4KN 5-https://t.co/qMV7wchyzT 6-https://t.co/KzMaww1EQ1 Found useful? Don't forget to bookmark and RT.

Sep 15, 2024 · 76 followers View post →
kleber dal toe
@kleberdaltoe · X

@ZattarRafael Evidencia pra suplementar isso aí é baixíssima. No máximo um estudo caso controle que é gerador de hipótese. Tem evidências semelhantes que alguns suplementos aumentam risco de cancer de próstata. Selenio e vit E. Fica ligado https://t.co/7yMYaiDvgm

Nov 5, 2023 · 17 followers View post →
Nick James also on @Prof-Nick-James.bsky.social
@Prof_Nick_James · X

RT @EricKleinMD: The SELECT trial showed the same outcome for prostate cancer https://t.co/cBAQ9uAypW. Vitamins are biologically active su…

Oct 18, 2023 · 1 share · 5,660 followers View post →
Eric Klein
@EricKleinMD · X

The SELECT trial showed the same outcome for prostate cancer https://t.co/cBAQ9uAypW. Vitamins are biologically active substances that can be harmful in high doses. https://t.co/lxJzZVmQWr

Oct 18, 2023 · 14 likes · 1 share · 4,283 followers View post →
Juhani Knuuti
@JuhaniKnuuti · X

@Reijo_RD_FIN @SiiriSimola Juuri näin. Mutta antioksidanttiuskovaiset ovat kokonaan torjuneet kliinisen näytön suurten annosten haitoista. Tässä muutama julkaisu asiasta: https://t.co/evz0d5GOX4 https://t.co/Axj0Ra05Pq https://t.co/7f5BHliMZT https://t.co/WTHt9JMFSr https://t.co/ptaIU85K6Q

Sep 13, 2023 · 3 likes · 9,399 followers View post →
Juhani Knuuti
@JuhaniKnuuti · X

@Sarah_Finestein @SiiriSimola Kannattaisi malttaa ennen kuin nolaa itsensä osoittamalla tietämättömyytensä. Minä olen koko ajan puhunut kliinisestä näytöstä. Opiskele alkuun vaikka nämä: https://t.co/evz0d5GOX4 https://t.co/Axj0Ra05Pq https://t.co/7f5BHliMZT https://t.co/WTHt9JMFSr https://t.co/ptaIU85K6Q

Sep 13, 2023 · 9,399 followers View post →
Ralf
@derralfbaer · X

@Thorsten_Runge_ @vmuecke_k @montag_blauer Medizin und Aktien sind auch zwei verschiedene paar Stiefel. Eine weitere Zusammenfassung: https://t.co/sjfNFf1cJT Und hier alles zur Gänze (u.a. Methodik etc.) https://t.co/zKJIyI49kx

Jun 6, 2023 · 2,005 followers View post →
Iasonas Theodoropoulos
@BodybuildingSc5 · X

Citations: 1. https://t.co/njiIiUoMRm 2. https://t.co/QnHPbI9QEs 3. https://t.co/bNFgE5MGM3 4. https://t.co/G3wWfore5a 5. https://t.co/882BhFHfzT 6. https://t.co/Lq9ZBaSLrL

Mar 10, 2023 · 15 followers View post →
Anna-Sophie Prosquill
@dieprosquill · X

RT @ProRaphaela: #Stereoisomerie Ist ein natürliches Vitamin gleich einem im Labor hergestellten Vitamin? all rac-alpha-tocopherly acetat…

Jun 21, 2022 · 1 share · 63 followers View post →
RaphaelaPro
@ProRaphaela · X

#Stereoisomerie Ist ein natürliches Vitamin gleich einem im Labor hergestellten Vitamin? all rac-alpha-tocopherly acetat = Vitamin E? Und wenn nicht was zeigt uns diese Studie? Vergleiche Thalidomid (Contergan) https://t.co/WrVyGGwTlb https://t.co/szMmG5ZSbd

Jun 21, 2022 · 2 likes · 1 share · 7 followers View post →
Reiner 
@erlesen · X

RT @erlesen: Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial https://t.co/DDZ2nb454R Conclusio…

Feb 28, 2022 · 2 shares · 7,863 followers View post →
Marcia S Newman
@marciasgreen · X

RT @erlesen: Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial https://t.co/DDZ2nb454R Conclusio…

Feb 28, 2022 · 2 shares · 4,969 followers View post →
Reiner 
@erlesen · X

Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial https://t.co/DDZ2nb454R Conclusion: "Dietary supplementation with (400 IU per day) vitamin E (400 IU per day) significantly increased the risk of prostate cancer among healthy men"

Feb 27, 2022 · 6 likes · 2 shares · 7,863 followers View post →
Dr. Ava Edwards. PharmD, PhD (Integrity & Ethics)
@AvaEdwardsNC · X

RT @Arab_Oncologist: استخدام فيتامين E يزيد خطر الإصابة بسرطان البروستات في ٣٥ ألف مريض في دراسة SELECT أدى استخدام فيتامين E إلى زيادة هط…

Jan 1, 2022 · 1 share · 10,181 followers View post →
د. وضاح عرفات
@Arab_Oncologist · X

استخدام فيتامين E يزيد خطر الإصابة بسرطان البروستات في ٣٥ ألف مريض في دراسة SELECT أدى استخدام فيتامين E إلى زيادة هطر سرطان البروستات hazard ratio [HR], 1.17; 99% CI, 1.004-1.36, P = .008) https://t.co/TjM4mm16Ns

Jan 1, 2022 · 1 like · 1 share · 1,290 followers View post →
Talia Wegman MD, PhD
@taliawegman · X

@BailleresMer Por ejemplo, la vitamina E aumenta el riesgo de cáncer de próstata https://t.co/SaqEW68dmn

Sep 11, 2021 · 2 likes · 13,370 followers View post →
Rad Onc Commentary
@radoncpub · X

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) https://t.co/sKMMu2WwbB

Jul 2, 2021 · 120 followers View post →