Long-term persistence of hormonal adaptations to weight loss.: Social discussions and analytics

The Best Way to Maintain Weight Loss Forever

Liftwsarah · Jun 29, 2025 100,454 views

Long-Term Hormonal Changes After Weight Loss and Their Impact on Regain

After a 10-week very-low-energy diet, hormones regulating appetite and weight, such as leptin and insulin, decreased while hunger hormones increased. These changes persist a year post-weight loss, often contributing to…

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Metabolism!

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Long-Term Metabolic Changes After The Biggest Loser Competition

This video discusses the persistent metabolic adaptation observed six years after "The Biggest Loser" competition, including changes in resting metabolic rate and body composition, and their potential role in weight…

Liza Che · Apr 22, 2025 7,140 views

Long-term Metabolic Effects After Extreme Weight Loss Shows Persistent Adaptation

The study investigates long-term changes in metabolic rate and body composition among "The Biggest Loser" contestants. Six years post-competition, significant weight regain was coupled with a sustained decrease in…

Нутрициолог Мария Сафина · Aug 7, 2025 780 views

Understanding Weight Loss Challenges and Hormonal Effects on Hunger

Why does losing weight often make you feel hungrier and why is it so hard to keep the weight off? This video explains the science behind the body's counterattack against weight loss, set point theory, and the roles of…

Klementina · Oct 3, 2025 725 views

Understanding Hormonal Adaptations During Weight Loss and Plateaus

Many hormones involved in regulating appetite and body weight decrease after significant weight loss, leading to persistent hormonal changes. This can promote weight regain, highlighting the need for long-term…

Nutrisi dan Kesehatan · Feb 21, 2025 546 views

Challenges in Sustaining Weight Loss in Obesity Management

One of the greatest challenges in reversing obesity is maintaining weight loss. A study analyzed the likelihood of obese individuals achieving normal body weight, revealing low success rates and questioning the…

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Understanding Hormonal Changes and Weight Loss After Menopause

Menopause is a biological stage where traditional dieting and exercise often fail because they ignore hormonal impacts. This video explains how hormones like estrogen, insulin, and cortisol influence weight management…

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Why Your Caloric Deficit Isn't Working & Why it Never Will

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Understanding Weight Regain: Biological Mechanisms Explained

Obesity is a significant challenge in today's society, with weight regain presenting a major obstacle following weight loss. This video explores the biological factors, including changes in fat cell size and hormone…

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Effective Strategies for Long-Term Weight Loss Maintenance in Obese Adults

This video discusses approaches for maintaining weight loss in obese adults, highlighting behavioral programs and medication treatments like orlistat. Emphasis is on strategies proven effective over a year, including…

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Healthy Weight Loss: Scientific Insights and Long-Term Strategies

Rina prioritized healthy weight loss through balanced eating, regular exercise, and consultation with healthcare professionals, emphasizing sustainable methods over rapid, risky solutions.

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How Dieting Can Increase Fat and Redistribute Body Composition

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Intermittent Fasting as an Alternative for Managing Type 2 Diabetes

This case series from Toronto highlights how intermittent fasting can help reduce insulin resistance in type 2 diabetes, allowing some patients to stop insulin while maintaining blood sugar stability. Patients…

UXHealth · Jan 17, 2021 59 views

Exposing Diet Scams and How They Undermine Weight Loss Efforts

95 diets fail and pile on more kilos. Shocking science from Harvard and NIH proves it. This video exposes how diets tank your metabolism, spike hunger, and fuel a 72 billion dollar scam. Learn effective, sustainable…

Divergion · Apr 16, 2025 17 views

Understanding the Limitations of Dieting and Weight Regain Factors

Dieting is the most common weight loss method but often results in weight regain due to biological adaptations affecting energy balance. Long-term strategies must address these persistent biological responses.

Coach Marc Louvrier · Sep 3, 2025 9 views

TJ Jurkiewicz | Fat Loss Coach

@TheFitnessJurk · X

Jul 22, 2025 · 5,985 followers View post →

Slobodan Peric

@JayJoJoJr · X

@Elitiker Stimmt, es ist keine echte Adipositastherapie wenn man sich nicht das gesamte weitere Leben stärker quälen muss als andere in der Umgebung um trotzdem schlechtere Ergebnisse zu erreichen

May 14, 2025 · 418 followers View post →

Sports Chiropractic

@Chiropractor954 · X

Starving isn't the key to weight loss. Embrace balance and health! A well-known study that critiques the effectiveness of starvation or extreme caloric restriction for weight loss is “Long-term Persistence of Hormonal Adaptations to Weight Loss” by Fothergill et al. (2016) https://t.co/YzvrYiELXD

Jan 3, 2025 · 22 followers View post →

Canon

@Canon95858 · X

Sumithran P, et al. "Long-term persistence of hormonal adaptations to weight loss." New England Journal of Medicine, 2011. https://t.co/dX447ecqPU

Jul 4, 2024 · 38 followers View post →

Kevin Hall

@KevinH_PhD · X

@DoctorTro Not ideal, but here’s some support of my guess that the drugs have a persistent effect on appetite: in patients not taking these medications appetite ratings increasing above baseline after weight loss. https://t.co/kogmU5bQ3W https://t.co/LwkSiydoGR

Feb 18, 2024 · 4 likes · 37,717 followers View post →

Michael Mindrum, MD

@MichaelMindrum · X

@HealthBugle @ScepticalDoctor powerful defenses against weight loss (Hall modeled a ⬆️100 kcal/day appetite & ⬇️25 kcal/day in energy expenditure per kg of loss) & long term hormonal adaptations (NEJM). Thus pharmacotherapy & bariatric can be compliment above methods you describe. https://t.co/RTtJs0BJqa.

Feb 4, 2024 · 9,567 followers View post →

Reijo Laatikainen

@Reijo_RD_FIN · X

@MikaelFogelholm @flowtiina @justsopivasti Ulla ei taida juurikaan olla Twitteriä, joten laitan evidenssin jonka satun tietämään. Tässä näyttöä vain vuoden seurannasta. https://t.co/pMYDpAhcDq Lisäksi voisi tsekata Biggest Loser -tutkimuksen 6 v tuloksia, onko siellä tietoa

Jan 9, 2024 · 2 likes · 4,614 followers View post →

Michael Albert, MD

@MichaelAlbertMD · X

More evidence that we may not entirely understand the physiological significance of circulating gastrointestinal peptides. The new data conflicts with a long-standing belief supported by Sumithran et al., 2011. https://t.co/S12BJkgkLf https://t.co/MCGF4lRe8U

May 28, 2023 · 13 likes · 15,904 followers View post →

moath saleh

@moathsaleh · X

@aalshehrimd قد تكون الحمية ضارة وتؤثر على استجابة الجسم للجوع وفي هذه الدراسة تم قياس هرمونات الجوع والشبع ثم عمل حمية للمشاركين لمدة ١٠ اسابيع فقط وبعدها تم ايقاف الحمية ثم بعد ذلك بسنة تم قياس هرموناتهم لم ترجع للمستوى الطبيعي،ومازالو عرضة لزيادة الوزن مرة اخرى https://t.co/dah6NyFQNN

May 7, 2023 · 128 followers View post →

Andy Grannell

@Grannell_ · X

@LuaWilkinson Last one! (there are too many) https://t.co/NPp0VLfT4h

Nov 7, 2022 · 3 likes · 985 followers View post →

Iasonas Theodoropoulos

@BodybuildingSc5 · X

https://t.co/vgNUx065uo

Oct 3, 2022 · 1 like · 15 followers View post →

ichi matsumoto

@ichi1matsu · X

食事制限で、急激に痩せると、体が食欲増進させてちゃんとリバウンドするように働くよという内容今では、肥満はリスクだけど、体重を維持するためのバックアップがいっぱいあり、体重減の維持のためには、今までより強い空腹感と戦う必要がありそうだ。 https://t.co/gtEN6mNkkF

Aug 9, 2022 · 68 followers View post →

C☻Chihiro

@oki_13_love · X

RT @mam1kawa: ちょっと古い研究だけど面白いなあ体重減少に対する末梢ホルモンの変化の長期経過減量すると肥満に関わるホルモンの量が変わり、食欲が増す。これは減量後1年たっても維持される。 https://t.co/L4UBwinYtW

May 20, 2022 · 4 shares · 54 followers View post →

さんどのめし

@minami_minami44 · X

RT @mam1kawa: ちょっと古い研究だけど面白いなあ体重減少に対する末梢ホルモンの変化の長期経過減量すると肥満に関わるホルモンの量が変わり、食欲が増す。これは減量後1年たっても維持される。 https://t.co/L4UBwinYtW

May 20, 2022 · 4 shares · 33 followers View post →

あるごん

@Argon_18th · X

RT @mam1kawa: ちょっと古い研究だけど面白いなあ体重減少に対する末梢ホルモンの変化の長期経過減量すると肥満に関わるホルモンの量が変わり、食欲が増す。これは減量後1年たっても維持される。 https://t.co/L4UBwinYtW

May 20, 2022 · 4 shares · 1,642 followers View post →

市川衛 @医療の「翻訳家」

@mam1kawa · X

ちょっと古い研究だけど面白いなあ体重減少に対する末梢ホルモンの変化の長期経過減量すると肥満に関わるホルモンの量が変わり、食欲が増す。これは減量後1年たっても維持される。 https://t.co/L4UBwinYtW

May 20, 2022 · 14 likes · 4 shares · 11,432 followers View post →

DoctorDueDiligence

@DueDoctor · X

@hoffmb03 @hubermanlab https://t.co/LrNvTZ4CkL

Apr 16, 2022 · 8,396 followers View post →

Bracho

@bracho86 · X

@hubermanlab @hubermanlab please check a study made on 2011 - Analytic Article: "Long-term persistence of hormonal adaptations to Weight Loss" ans one made on 2006 by Barbara V. Howard

Apr 12, 2022 · 323 followers View post →

balshumet.bsky.social

@Balshumet · X

@jasonbjorn1814 @jkfecke @LargesseBIA @ChrisSerong https://t.co/TAbYrZa9UN Unfortunately, as far as we can tell, *no*. https://t.co/996iP5jBbi "...six years after the original study, they found that adiponectin and T3 went up, but leptin and T4 stayed low, as did resting metabolic rate."

Apr 4, 2022 · 883 followers View post →

Find me at http://barrydeutsch.bsky.social

@barrydeutsch · X

@90TJM @MuseofIre @Sargonnis @gower_bob @siegelka @JCACharles "There seem to be societal, environmental and personal causes of weight gain that overlap." Physiological causes should definitely be on that list (and are possibly the most important element.) https://t.co/bUbBfhWL9X https://t.co/X8liHrmA1W

Apr 3, 2022 · 7,887 followers View post →

Find me at http://barrydeutsch.bsky.social

@barrydeutsch · X

@Sargonnis @siegelka @gower_bob @JCACharles Nope, no one's said that. It's not true that if calorie deficits lead to weight loss (which they do), then it must be the case that "psychology" is the culprit. Physiological factors are hugely important. https://t.co/bUbBfhWL9X https://t.co/UsG3Vm7Kny

Apr 3, 2022 · 7,887 followers View post →

Michael Albert, MD

@MichaelAlbertMD · X

Another one of my favorites: why you struggle to lose weight sustainably => the body defends against sustained weight loss. Long term persistence of hormonal changes in wt loss promote weight relapse and support elevated energy homeostasis. https://t.co/62Jfit1WGj https://t.co/tjTeJcdzLy

Feb 16, 2022 · 8 likes · 15,904 followers View post →

しょこら２０２１

@mupo2021 · X

RT @muscle_penguin_: (62/347)#論文マラソン超低エネルギー食を食べた人のホルモンはどう変わる？ 50人の肥満患者に超低エネルギー食(最初は500-550kcal)で開始し、10週まで続けた。レプチン(食欲↓)を減らし、グレリン(食欲↑)を増や…

Feb 14, 2022 · 2 shares · 288 followers View post →

カオル@日常用/1型糖尿病

@5g8HWyeTxtA9gUY · X

RT @muscle_penguin_: (62/347)#論文マラソン超低エネルギー食を食べた人のホルモンはどう変わる？ 50人の肥満患者に超低エネルギー食(最初は500-550kcal)で開始し、10週まで続けた。レプチン(食欲↓)を減らし、グレリン(食欲↑)を増や…

Feb 14, 2022 · 2 shares · 612 followers View post →

筋肉博士

@muscle_penguin_ · X

(62/347)#論文マラソン超低エネルギー食を食べた人のホルモンはどう変わる？ 50人の肥満患者に超低エネルギー食(最初は500-550kcal)で開始し、10週まで続けた。レプチン(食欲↓)を減らし、グレリン(食欲↑)を増やし、主観的な食欲を増やした。 https://t.co/5hkTbRIUXa

Feb 14, 2022 · 27 likes · 2 shares · 35,610 followers View post →

Raphe Cheli

@RapheCheli · X

@alanlawlor @DrNadolsky That wasn't what I was referring to. This article may help explain. https://t.co/P3xAxGm2xG

Sep 20, 2021 · 8 followers View post →

Linda

@wordfinga · X

RT @DrMArdissino: @mmamas1973 https://t.co/5yLuXnLySj this one of the papers that explores something I find very interesting - endocrine ad…

Jul 15, 2021 · 1 share · 4,595 followers View post →

Maddalena Ardissino

@DrMArdissino · X

@mmamas1973 https://t.co/5yLuXnLySj this one of the papers that explores something I find very interesting - endocrine adaptation to weight loss effectively attempts to encourage regain. Suggests that genetically (or epigenetically?) patients with obesity actually have a higher ‘set point’.

Jul 15, 2021 · 1 like · 1 share · 945 followers View post →

Josh Beckman

@JoshuaBeckmanMD · X

@mmamas1973 Narrator says half right https://t.co/7SODP9R08m

Jul 15, 2021 · 1 like · 2,157 followers View post →

NaO

@spikeoutOXY · X